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This meeting took place in 2009



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Dendritic Cells (Z2)


Organizer(s) Giorgio Trinchieri, Gwendalyn J. Randolph and Sebastian Amigorena
March 29—April 3, 2009
Fairmont Banff Springs • Banff, Alberta Canada
Abstract Deadline: Dec 2, 2008
Late Abstract Deadline: Dec 31, 2008
Scholarship Deadline: Dec 2, 2008
Early Registration Deadline: Jan 29, 2009

Sponsored by Novo Nordisk A/S


Summary of Meeting:
The current studies on Dendritic Cells (DCs) have confirmed not only their major role as antigen presenting cells in adaptive immunity but also their important functions in the initiation of the innate resistance and inflammatory responses. Thus, DCs function as an important bridge between innate resistance and adaptive immunity either through cellular interactions or secretion of pro-inflammatory and immunoregulatory cytokines. The origin and migration pattern of DCs as well as their sharing of hematopoietic lineages, functions, and receptors with other phagocytic cell types such as monocytes and macrophages is a subject of intense investigation. The special characteristics of antigen processing and expression of immunoregulatory gene products in DCs are central in their ability to either activate or tolerize T cells and in their in vivo functions in degenerative, autoimmune and infectious diseases as well as in cancer. In this symposium, the following aspects of DC biology will be emphasized: (1) DC precursors and relation with monocyte and macrophages; (2) receptors, phagocytosis, and antigen presentation; (3) regulation of type I IFN production; (4) DCs in tolerance, immunity, and T cell activation; and (5) DCs in cancer and other diseases.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, MARCH 29

15:00—19:30
Registration

Van Horne Foyer
18:30—19:30
Refreshments

Van Horne Foyer
19:30—21:30
Keynote Session (Joint)
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom
* Jenny P.Y. Ting, University of North Carolina at Chapel Hill, USA

* Giorgio Trinchieri, NCI, National Institutes of Health, USA

Shizuo Akira, Osaka University, Japan
TLRs and Inflammation

Ira Mellman, Genentech, Inc., USA
Cell Biology of Antigen Processing by Dendritic Cells


MONDAY, MARCH 30

07:00—08:00
Breakfast

Mezzanine 2
07:00—08:00
Poster Setup

Mezzanine 2
08:00—11:30
Phagocytosis and Antigen Presentation
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom C, Shaughnessy/Beatty
* Ira Mellman, Genentech, Inc., USA

Sebastian Amigorena, Institut Curie, France
A New Soluble Ligand of DCSign Present in Human Semen Inhibits HIV Trans-Infection of T Cells

David G. Russell, Cornell University, USA
Reprogramming Phagosomal Function in Macrophages and Dendritic Cells

Jose A. Villadangos, University of Melbourne, Australia
Antigen Presentation Specializations in the Dendritic Cell Network

Romina S. Goldszmid, NCI, National Institutes of Health, USA
Short Talk: Host ER-Parasitophorous Vacuole Interaction Provides a Route of Entry for Antigen Cross-Presentation in Toxoplasma Infected Dendritic Cells

Bali Pulendran, Emory University, USA
Modulating Vaccine Responses with Innate Immunity

08:00—11:15
TLRs - I
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom A,B
* Siamon Gordon, University of Oxford, UK

Bruce A. Beutler, University of Texas Southwestern Medical Center, USA
Mutagenesis in the Analysis of Pathogen Sensing Pathways

Luke A. J. O'Neill, Trinity Biomedical Sciences Institute, Ireland
The IL-1 Receptor / Toll-Like Receptor Superfamily: 10 Years of Progress

Ruslan Medzhitov, HHMI/Yale University School of Medicine, USA
A Mechanism of an Allergen-Induced Immune Response

Eicke Latz, University of Bonn, Germany
Pattern Recognition + Nalp3 Inflammasome

Sarah Ewald, Stanford University, USA
Short Talk: The Ectodomain of Toll-like Receptor 9 is Cleaved to Generate a Functional Receptor

Markus G. Manz, University Hospital Zürich, Switzerland
Short Talk: Human Bone Marrow Multipotent Mesenchymal Stromal Cells Sense TLR4-Agonists and Subsequently Enhance Myelopoiesis

Stephanie C. Eisenbarth, Yale University, USA
Short Talk: Activation of Adaptive Immunity but not Th2 Differentiation by the Nalp3 Inflammasome

09:20—09:40
Coffee Break

Van Horne Foyer
11:30—12:30
Lunch

Mezzanine 2
12:00—14:30
Poster Session 1

Mezzanine 2
12:00—17:00
Poster Viewing

Mezzanine 2
14:30—16:30
Workshop 1: Antigen Presentation and T Cell Activation

Van Horne Ballroom C
* Sebastian Amigorena, Institut Curie, France

Sofia Bogiatzi, Institut Curie, France
Reciprocal Inhibition of the TSLP and Th17 Immune Pathways

Anuradha Ray, University of Pittsburgh School of Medicine, USA
Dual c-kit-Stem Cell Factor Upregulation by Allergens in Dendritic Cells Promotes IL-6 but Limits IL-12 Impacting T Helper Cell Differentiation and Allergic Asthma

Thomas Duhen, Agonox, USA
Identification and Characterization of IL-22-Only Producing CD4+ T Cells: Role of Plasmacytoid DC for their Differentiation

Guillaume Hoeffel, Singapore Immunology Network, Singapore
HIV Antigen Crosspresentation Pathways from Apoptotic, Infected CD4+ T Cells, in Plasmacytoid Dendritic Cell

Roger V. Belizaire, Washington University in St. Louis, USA
Exogenous Antigen Enters the Major Histocompatibility Complex (MHC) Class I Processing and Presentation Pathway via Multiple Endocytic Compartments with Distinct Molecular and Proteolytic Requirements

Roberto A. Maldonado, Selecta Biosciences, USA
Rapamycin- and TGFbeta-Treated Dendritic Cells Induce Tolerance and de novo Differentiation of Regulatory T Cells in vitro and in vivo

Mireille H. Lahoud, Burnet Institute, Australia
Clec9A on the Surface of Dendritic Cells is a Dead Cell Recognition Molecule

David Sancho, CNIC-Fundación Centro Nacional de Investigaciones Cardiovasculares, Spain
Identification of a Dendritic Cell Receptor that Couples Sensing of Necrosis to Immunity

14:30—16:30
Workshop 1: TLR and Other Pathogen Sensors

Van Horne Ballroom A,B
Michael Carty, Trinity College Dublin, Ireland
Regulation of TRIF- dependent TLR Signaling by the Adaptor SARM

Ping Zhang, University of Alabama, Birmingham, USA
TLR2-dependent Modulation of Osteoclastogenesis by Porphyromonas gingivalis

Brendan J. Jenkins, Hudson Institute of Medical Research, Australia
Interplay between the Interleukin-6 Cytokine Family and Toll-like Receptors in Inflammation and Gastric Tumorigenesis

Jaime Pascual, Sanford-Burnham Medical Research Institute, USA
Molecular Mimicry in Innate Immunity: Crystal Structure of a Bacteria TIR Virulence Factor

Kathryn J. Moore, New York University Medical Center, USA
CD36 Ligands Promote Sterile Inflammation through Assembly of a TLR 4 and 6 Heterodimer

Emily L. Lowe, University of California, Los Angeles, USA
TLR2 is Protective in Colitis-associated Colorectal Cancer

Yue Guan, University of Illinois at Urbana-Champaign, USA
Human Toll-like Receptors 10 and 1 Share Common Mechanisms of Innate Immune Sensing but not Signaling

Anca Dorhoi, Max Planck Institute for Infection Biology, Germany
The Adaptor Protein CARD9 is Essential for Tuberculosis Control

16:30—17:00
Coffee Available

Van Horne Foyer
17:00—19:00
DCs in Tolerance, Immunity, and T Cell Differentiation
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom C, Shaughnessy/Beatty
* Bali Pulendran, Emory University, USA

Daniel J. Cua, Merck Research Laboratories, USA
The IL-23/IL-17 Axis

Yong-Jun Liu, Sanofi, USA
Thymic Stromal Lymphopoietin Program Dendritic Cells to Induce TH2 Inflammation through a Unique Set of Signal Codes

Erica L. Granger, Pennsylvania State College of Medicine, USA
Short Talk: Persistence of MHC Class I-Restricted Antigen Presentation Following Acute Virus Infection Requires Direct and then Cross Presentation

Vijay K. Kuchroo, Brigham and Women's Hospital, Harvard Medical School, USA
Tim-3 and Expansion of Regulatory Antigen Presenting Cells

17:00—19:00
TLRs - II
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom A,B
* Luke A. J. O'Neill, Trinity Biomedical Sciences Institute, Ireland

Siamon Gordon, University of Oxford, UK
Regulation of Macrophage Function by Surface Receptors and TH2 Cytokines

Ann Marshak-Rothstein, University of Massachusetts Medical School, USA
BCR, TLR and IFNaR Regulation of Autoreactive B Cells

Arthur M. Krieg, Checkmate Pharmaceuticals, USA
Therapeutic Usage of Nucleic Acid TLR Agonists

Wajahat Z. Mehal, Yale University, USA
Short Talk: Acetaminophen Induced Hepatotoxicity is Dependent on TLR7/9 and the NALP3 Inflammasome

19:00
On Own for Dinner


TUESDAY, MARCH 31

07:00—08:00
Breakfast

Mezzanine 2
08:00—11:15
Dendritic Cell Precursors
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom C, Shaughnessy/Beatty
* Gwendalyn J. Randolph, Washington University, USA

Carlos Ardavin, National Center for Biotechnology, Spain
Monocyte-Derived Dendritic Cells

Steffen Jung, Weizmann Institute of Science, Israel
Probing Origins and in vivo Functions of Dendritic Cells

Markus G. Manz, University Hospital Zürich, Switzerland
Lymphoid-Organ Dendritic Cell Homeostasis in Steady-State and Inflammation

Kang Liu, Columbia University Medical Center, USA
Short Talk: Dendritic Cell Development and Homeostasis in vivo

Boris Reizis, New York University Langone Medical Center, USA
Plasmacytoid Dendritic Cell Differentiation

Florent Ginhoux, Singapore Immunology Network, Singapore
Short Talk: Flt3 and Id2-Dependent CD103+ DCs in Non-Lymphoid Tissues Form a Specific DC Lineage Related to Lymphoid CD8+ DCs

08:00—11:15
NLR/NBD-LRR Proteins, Pathways and Diseases
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom A,B
* Jürg Tschopp, University of Lausanne, Switzerland

Jonathan D.G. Jones, Sainsbury Laboratory, UK
Using Pathogen Effectors to Understand Host Resistance Mechanisms

Jenny P.Y. Ting, University of North Carolina at Chapel Hill, USA
NLR in Diseases and Health

Vishva M. Dixit, Genentech, Inc., USA
The Inflammasone: A Dynamic Caspase Activating Apparatus

John C. Reed, F. Hoffmann-La Roche AG, Switzerland
Linking Innate Immunity with the Cell Death Machinery: Interactions of NLR and Bcl-2 Family Proteins

Tara L. Roberts, Queensland Institute of Medical Research, Australia
Short Talk: The Role of HIN200 Family Proteins in the Response to Cytosolic DNA

T. Sam Xiao, Case Western Reserve University, USA
Short Talk: The Structure of NALP1/NLRP1 Leucine-rich Repeats Illustrates a Potential Ligand-binding Site

09:20—09:40
Coffee Break

Van Horne Foyer
11:15
On Own for Lunch

11:15—13:00
Poster Setup

Mezzanine 2
13:00—22:00
Poster Viewing

Mezzanine 2
16:30—17:00
Coffee Available

Van Horne Foyer
17:00—19:00
Recent Advances
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom C, Shaughnessy/Beatty
* Maria Rescigno, European Institute of Oncology, Italy

Dominique Kaiserlian, INSERM-U851, France
Role of Liver Plasmacytoid DC in Oral Tolerance

Yvette van Kooyk, Vrije University Medical Center, Netherlands
Targeting of DC by Glycosylated Antigens

Ana-Maria Lennon-Duménil, Curie Institute, France
Coordinated Regulation of Antigen Presentation and Dendritic Cell Migration

17:00—19:00
NLR/NBD-LRR Proteins, Pathways and Diseases - II
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom A,B
* Vishva M. Dixit, Genentech, Inc., USA

Jürg Tschopp, University of Lausanne, Switzerland
Malarial Hemozoin is a Nalp3 Inflammasome Activating Danger Signal

Gabriel Nuñez, University of Michigan, USA
Function of Nod-Like Receptors in Innate Immunity

Dana Philpott, University of Toronto, Canada
Nod Proteins and the Interaction of Innate and Adaptive Immunity

Koichi S. Kobayashi, Texas A&M Health Science Center, USA
Short Talk: The Role of Nod2-Rip2 Signaling Pathway in the Regulation of Commensal Microbiota in the Intestine

19:00—20:00
Social Hour with Lite Bites

Mezzanine 2
19:30—22:00
Poster Session 2

Mezzanine 2

WEDNESDAY, APRIL 1

07:00—08:00
Breakfast

Mezzanine 2
08:00—11:15
Dendritic Cells in Disease
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom C, Shaughnessy/Beatty
* Yong-Jun Liu, Sanofi, USA

Miriam Merad, Mount Sinai School of Medicine, USA
Origin of Dendritic Cell Diversity Controls Tissue Immunity

Gwendalyn J. Randolph, Washington University, USA
Monocytes, Dendritic Cells, and their Migration in Atherosclerosis

Jerry Aldridge, St. Jude Children's Research Hospital, USA
Short Talk: tipDCs — The Necessary Evil of Lethal Influenza Infection

Maria Rescigno, European Institute of Oncology, Italy
DCs in Intestinal Disease

Giorgio Trinchieri, NCI, National Institutes of Health, USA
TLR Signaling in DC: Lessons from Fibroblasts

Vanja Sisirak, Columbia University, USA
Short Talk: Breast Tumor Environment Alters Human Plasmacytoid Dendritic Cells Functions

08:00—11:15
Viral Sensors
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom A,B
* Shizuo Akira, Osaka University, Japan

Takashi Fujita, Institute for Virus Research, Kyoto University, Japan
Solution Structures of MDA5 and LGP2 C-Terminal Domains: Identification of the RNA Recognition Loop in RIG-I Like Receptors

Hong-Bing Shu, Wuhan University, China
Virus-Triggered Signaling Pathways

Caetano Reis e Sousa, Francis Crick Institute, UK
Innate Anti-Viral Responses

Kate A. Fitzgerald, University of Massachusetts Medical School, USA
Molecular Mechanisms of DNA Sensing

Stephanie J. DeWitte-Orr, McMaster University, Canada
Short Talk: Scavenger Class A-Like Receptor (SLR): A Pathogen Recognition Receptor Mediating DsRNA-Induced Antiviral Responses

Axel Kirchhofer, Gene Center, Germany
Short Talk: Structural and Functional Analysis of RIG-I Like Helicases

09:20—09:40
Coffee Break

Van Horne Foyer
11:15
On Own for Lunch

11:15—13:00
Poster Setup

Mezzanine 2
13:00—22:00
Poster Viewing

Mezzanine 2
14:30—16:30
Workshop 2: Systems Biology of Dendritic Cells

Supported by the Society for Mathematical Biology and the NIH-funded PRiME (Program for Research on Immune Modeling and Experimentation) Initiative
The immune system acts across multiple scales of space and time involving complex interactions and feedback. Computational modeling provides a framework to integrate observational data collected from multiple modes of experimentation and can provide insight into immune cell function in health and disease. Computational approaches have been increasingly applied to problems in immunology, providing methods that range from the inference of transcriptional programs to the prediction of drug treatment effects on viral dynamics. This workshop will cover recent advances and potential applications of computational modeling and methods to dendritic cells.

Shaughnessy/Beatty
Sonja I. Buschow, Nijmegen Centre for Molecular Life Sciences (NCMLS) St. Radboud UMC, Netherlands
DC-ATLAS: Dissecting Signal Transduction in the Dendritic Cell with a Systems Biology Approach

Laszlo Nagy, Sanford-Burnham Medical Research Institute at Lake Nona, USA
Interrelated Nuclear Receptor Signaling Connects Lipids, the Genome and Immune Function in Dendritic Cells

* Uri Hershberg, Drexel University, USA
Transcriptional Cascades in Dendritic Cells during Anti-Viral Responses

Simeone Marino, University of Michigan Medical School, USA
Roles of Dendritic Cells in the Immune Response to Bacterial and Viral Infections

Burkhard Ludewig, Kantonsspital St. Gallen, Switzerland
A Systems Immunological Approach to Plasmacytoid Dendritic Cell Function in Cytophatic Virus Infection

Elodie Segura, Walter and Elizabeth Hall Institute, Australia
Novel Functional Specialization of Dendritic Cell Subsets Revealed by Plasma Membrane Comparative Proteomic Analysis

14:30—16:30
Workshop 2: NLR and Other Pathogen Sensors

Van Horne Ballroom A,B
* Gordon D. Brown, University of Aberdeen, UK

Olaf Groß, Universitätsklinikum Freiburg, Germany
Adjuvanticity of the Synthetic Cord Factor Analog TDB for subunit M. tuberculosis Vaccination Requires Card9-dependent Innate Immune Activation

Tilmann Bürckstümmer, Haplogen Genomics, Austria
An Orthogonal Proteomic/Genomic Screen Identifies DSIRE as Cytoplasmic DNA Sensor for the Inflammasome

Paul G. Thomas, St. Jude Children's Research Hospital, USA
NLRP3 (NALP3/CIAS1/Cryopyrin) Mediates Key Innate and Healing Responses to Influenza A Virus via the Regulation of Caspase-1

Joseph A. Duncan, University of North Carolina, Chapel Hill, USA
Staphylococcus aureus a-hemolysin Induces IL-1B Production and Inflammatory Cell Death through Activation of Host NLRP3

Monique Willart, Ghent University, Belgium

Edward A. Miao, University of North Carolina at Chapel Hill, USA
NLRC4 is an Innate Immune Detector of the Bacterial Type III Secretion Apparatus

Takeshi Ichinohe, Yale University School of Medicine, USA
Inflammasome Recognition of Influenza Virus is Essential for Adaptive Immune Responses

Fengyi Wan, Johns Hopkins Bloomberg School of Public Health, USA
Ribosomal Protein S3: A Novel Non-Rel Subunit of NF-kappaB Confers Regulatory Specificity

14:30—16:30
Workshop 3: RLH and Other Pathogen Sensors

Van Horne Ballroom C
* T. Sam Xiao, Case Western Reserve University, USA

William J. Kaiser, Emory University School of Medicine, USA
RHIM-dependent Control of NF-kappaB and Cell Death Activation via the DNA-dependent Activator of Interferon Regulatory Factors (DAI/ZBP1/DLM-1)

Pingwei Li, Texas A&M University, USA
The RIG-I Like Receptor LGP2 Recognizes the Termini of Double-Stranded RNA

Julien Pothlichet, Institut Pasteur, France
A Comprehensive Study of Human RIG-I Single-Nucleotide Polymorphisms (SNPs) Identifies Two Variants with a Major Functional Impact on Antiviral Host Response

Mehul S. Suthar, University of Washington, USA
The RLR Signaling Pathway is Essential in Triggering an Innate Immune Response to WNV Infection

Szu-Ting Chen, University of North Carolina at Chapel Hill, Taiwan
CLEC5A, A Pattern Recognition Receptor to Flavivirus

Terry K. Means, Massachusetts General Hospital, USA
RNAi Identifies an Important Role for Scavenger Receptors in Fungal Immunity

Juergen M. Ruland, Technical University of Munich, Germany

16:30—17:00
Coffee Available

Van Horne Foyer
17:00—19:00
Regulation of Type I Interferon Production
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom C, Shaughnessy/Beatty
* Giorgio Trinchieri, NCI, National Institutes of Health, USA

Keiko Ozato, NICHD, National Institutes of Health, USA
Molecular Mechanism of Type I Interferon Transcription in Dendritic Cells

Gunther Hartmann, Universitätsklinikum Bonn, Germany
Ligands for RIG-I: Induction of IFN by siRNA

Elina I. Zuniga, University of California, San Diego, USA
Short Talk: Persistent Virus Infection Inhibits Type I Interferon Production by Plasmacytoid Dendritic Cells to Facilitate Opportunistic Infections

Wei Cao, UT MD Anderson Cancer Center, USA
Short Talk: Identification of a Biological Ligand for Human Plasmacytoid Dendritic Cell Receptor ILT7

17:00—19:00
Evolution of Pattern Recognition Molecules
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom A,B
* Max D. Cooper, Emory University, USA
Evolution of LRR- Based Variable Lymphocyte Receptors

Jules A. Hoffmann, Institute of Cellular and Molecular Biology, France
Drosophila Pathogen Sensors

Frederick M. Ausubel, Massachusetts General Hospital, USA
Innate Immunity in C. elegans

Qing Zhang, Sanford-Burnham Medical Research Institute, USA
Short Talk: Direct Connector Genes Give Rise to Novel Topology of the Innate Immune Network in Amphioxus

19:00—20:00
Social Hour with Lite Bites

Mezzanine 2
19:30—22:00
Poster Session 3

Mezzanine 2

THURSDAY, APRIL 2

07:00—08:00
Breakfast

Mezzanine 2
07:00—08:00
Poster Setup

Mezzanine 2
08:00—11:15
PRRs in Dendritic Cells and Macrophages (Joint)
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom
* Daniel Kastner, National Institutes of Health, USA

Marco Colonna, Washington University School of Medicine, USA
A Novel Signaling Pathway for Myeloid Cells Proliferation and Survival

Gordon D. Brown, University of Aberdeen, UK
Lessons form Dectin-1: Insights Into Chronic Fungal Infection

Alan Sher, NIAID, National Institutes of Health, USA
Th1/Th2 Polarizing Functions of Dendritic Cells in the Immune Response to Parasites

Christine A. Biron, Brown University, USA
Changing Access to STATs in the Regulation of Type 1 IFN Effects on Immune Cell Subsets

Stephen M. Hedrick, University of California, San Diego, USA
Short Talk: FoxO3 Controls the Magnitude of T Cell Immune Responses by Modulating Dendritic Cell Function

Nora A. Barrett, Brigham and Women's Hospital, USA
Short Talk: Dectin-2 Recognition of House Dust Mite Triggers Cysteinyl Leukotriene Generation by Dendritic Cells

09:20—09:40
Coffee Break

Van Horne Foyer
11:15—12:00
Lunch

Mezzanine 2
12:00—14:30
Poster Session 4

Mezzanine 2
12:00—17:00
Poster Viewing

Mezzanine 2
14:30—16:30
Workshop 3: Differentiation, Trafficking and Function of DC

Van Horne Ballroom C
* Gwendalyn J. Randolph, Washington University, USA

Aymeric Rivollier, Lund University, Sweden
Monocytes are Precursors of F4/80highCD11cint Macrophage-Like Cells and CD11chighF4/80int Dendritic Cells in the Mouse Colon

Michael D. Gunn, Duke University Medical Center, USA
Blood-derived Inflammatory Dendritic Cells in Lymph Nodes Stimulate Acute Th1 Immune Responses

Guy Shakhar, Weizmann Institute of Science, Israel
Visualizing DC Mobilization in the Skin of Live Mice Suggests how DCs Travel Inside Lymphatics and how Their Intravasation is Regulated

Emma Lo Kuan, Benaroya Research Institute, USA
DC Trafficking from Perinodal Adipose Tissues to Lymph Nodes

Cherié L. Butts, Biogen, USA
Regulation of Dendritic Cell Function by Progesterone

Scott B. Drutman, New York University School of Medicine, USA
Mature Dendritic Cells Exhibit a Broad Capacity for Antigen Capture and Presentation that can be Modulated by their Distribution

Marcin T. Kortylewski, Beckman Research Institute, City of Hope, USA
Stat3 Targeting in Dendritic Cells Eliminates a Major Brake for TLR9 Agonist-Based Immunotherapy

Nicolas Chevrier, Harvard University, USA
Large Non-Coding RNAs: New Players in the Toll-like Receptor Pathways

14:30—16:30
Workshop 4: PAMP Sensors and Diseases

Van Horne Ballroom A,B
* Daniela I. Verthelyi, U.S. Food and Drug Administration, USA

John Vincent Forrester, University of Aberdeen, UK
A Role for Dectin-1 in T-cell Mediated Autoimmune Inflammation

Seth L. Masters, Walter and Eliza Hall Institute, Australia
Mutations Affecting The Interleukin-1 Receptor Antagonist (IL-1Ra) Cause A New Autoinflammatory Disease

Kathleen Azzam Smoak, NIEHS, National Institutes of Health, USA
Myeloid Differentiation Primary Response Protein 88 Couples Reverse Cholesterol Transport to Inflammation

Christophe M. Filippi, La Jolla Institute for Allergy and Immunology, USA
Virus Utilizes TLR2 to Enhance CD4+CD25+ Regulatory T Cells in vivo and Confer them with Protective Capacity in Autoimmune Diabetes

Anna-Marie Fairhurst, Singapore Immunology Network, Singapore
Innate Mechanisms in Autoimmunity

Menno P. J. de Winther, Academic Medical Center, Netherlands
Myeloid Type I Interferon Signaling Promotes Atherogenesis

Li Wen, Yale University, USA
The Role of Gut Flora through MyD88 in Type 1 Diabetes Development in NOD Mice

Jessica Gage, University of Ottawa Heart Institute, Canada
Specific Loss of Toll-like Receptor 2 on Bone Marrow Derived Cells Decreases Atherosclerosis in LDL Receptor Null Mice

16:30—17:00
Coffee Available

Van Horne Foyer
17:00—18:40
Dendritic Cells in Cancer and Cancer Therapy
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom C, Shaughnessy/Beatty
* Ralph M. Steinman, Rockefeller University, USA

* Sebastian Amigorena, Institut Curie, France

Jacques F. Banchereau, The Jackson Laboratory for Genomic Medicine, USA
Cancer Associated Dendritic Cells

Guido Kroemer, Cordeliers Research Center, France
Immunogenic Cell Death for Optimal Anti-Cancer Chemotherapy

Carl G. Figdor, Radboud University Medical Center, Netherlands
Human Plasmacytoid Dendritic Cells in Cancer and Cancer Therapy

17:00—19:00
SNPs, Clinical Diseases and Pattern Recognition Molecules/Sensors
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom A,B
* Alan Sher, NIAID, National Institutes of Health, USA

Adrian V. S. Hill, Jenner Institute, University of Oxford, UK
Innate Immunity Polymorphisms and Susceptibility to Human Infectious Diseases

Judy H. Cho, Icahn School of Medicine at Mount Sinai, USA
NOD2, Innate Immunity and Human Diseases

Daniel Kastner, National Institutes of Health, USA
Horror Autoinflammaticus: The Molecular Pathophysiology of Autoinflammatory Disease

18:40—19:15
Concluding Remarks
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom C, Shaughnessy/Beatty
Ralph M. Steinman, Rockefeller University, USA
Dendritic Cells: Translating Innate to Adaptive Immunity to Help Discover Vaccines

19:15—20:15
Social Hour with Lite Bites

Mezzanine 2
20:15—23:00
Entertainment

Mezzanine 2

FRIDAY, APRIL 3

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13AI082769-01




We gratefully acknowledge additional support for this conference from:

European Journal of Immunology
NIH funded, PRiME (Program for Research on Immune Modeling and Experimentation) initiative
Novo Nordisk A/S
Society for Mathematical Biology


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Cell Press Royal Society of Chemistry

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