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This meeting took place in 2009



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Innate, Adaptive and Regulatory Immune Responses to Intestinal Microbiota (A6)


Organizer(s) R. Balfour Sartor, Lloyd F. Mayer, Charles O. Elson and Scott Plevy
January 13—18, 2009
Sagebrush Inn & Suites • Taos, New Mexico USA
Abstract Deadline: Sep 18, 2008
Late Abstract Deadline: Oct 15, 2008
Scholarship Deadline: Sep 18, 2008
Early Registration Deadline: Nov 13, 2008

Supported by the Directors' Fund

Summary of Meeting:
Recent studies have demonstrated the key role of mucosal defenses and immunoregulation in maintaining homeostasis in the distal intestine in concert with the commensal microbiota. This meeting discusses the latest information regarding the protective and effector innate and adaptive immune responses to the commensal intestinal microbiota that lead to mucosal homeostasis vs. chronic immune-mediated intestinal inflammation. We highlight the protective role of innate mucosal immune responses induced by ligation of toll- like receptors (TLR) to activate NF-kappaB and other signaling pathways. Mechanisms of bacterial killing by epithelial and phagocytic cells are explored. The interface of antigen presenting cell/ T cell activation leading to effector or regulatory T cell function in the intestine is examined with a particular emphasis on bacterial antigen-specific responses. Finally, biomedical applications of these basic research observations are explored. These basic and translational studies have direct implications for understanding the pathophysiology of chronic intestinal inflammation such as Crohn’s disease, ulcerative colitis and pouchitis and emphasize innate and adaptive immunoregulatory mechanisms that mediate mucosal homeostasis in a hostile environment. Major unresolved issues in mucosal immunology are as follows: (1) understanding how epithelial cells coexist with commensal intestinal bacteria, yet recognize the pathogenic organisms; (2) understanding how effector mechanisms in innate immune cells and T cells are appropriately downregulated; and (3) how understanding of basic immune regulation and inflammation can lead to the development of novel therapeutic agents for chronic inflammatory bowel diseases. This meeting presents state of the art lectures on the most recent research on innate, adaptive and regulatory immune responses to commensal bacteria, promotes interdisciplinary research interactions and explores several novel therapeutic approaches derived from recent pathogenic insights.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


TUESDAY, JANUARY 13

15:00—19:30
Registration

Chamisa Lobby
18:30—19:30
Refreshments

Chamisa Ballroom 2
19:30—20:00
Welcoming Remarks

Chamisa Ballroom 2
R. Balfour Sartor, University of North Carolina at Chapel Hill, USA
Welcoming Remarks: An Overview of the Intestinal Microbiota and Mechanisms of Host/ Microbial Interactions


WEDNESDAY, JANUARY 14

07:00—08:00
Breakfast

Los Vaqueros
08:00—11:15
Protective Role of Innate Mucosal Immune Responses to Commensal Microbiota
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Lloyd F. Mayer, Mount Sinai Medical Center, USA

Scott Plevy, Janssen, USA
Protective Role of Heme Oxygenase and PI3 Kinase Isoforms

Maria T. Abreu, University of Miami, Miller School of Medicine, USA
Mucosal TLR Regulation of Epithelial Integrity and Malignancy

Eyal Raz, University of California, San Diego, USA
Gut, Germs and Genes: The Tumorigenic Triad

Andrea Cerutti, Mount Sinai School of Medicine, USA
Regulation of IgA Switching by Epithelial Cells in Response to Bacterial Stimuli

Sergio A. Lira, Mount Sinai School of Medicine, USA
Short Talk: TLRs, Chemokines and Intestinal Homeostasis

Nouara Lhocine, Institut Pasteur, France
Short Talk: PIMS Modulates Immune Tolerance to Commensal Bacteria by Regulating Drosophila Imd Pathway

09:20—09:40
Coffee Break

Chamisa Lobby
11:15
On Own for Lunch

11:15—13:00
Poster Setup

Chamisa Ballroom 2
13:00—22:00
Poster Viewing

Chamisa Ballroom 2
16:30—17:00
Coffee Available

Chamisa Lobby
17:00—19:00
Activation and Regulation of Mucosal NF-kappaB
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Maria T. Abreu, University of Miami, Miller School of Medicine, USA

Christian Jobin, University of Florida, USA
Host/Microbes Interaction: Lessons from Gnotobiotic Murine and Zebrafish NF-kB Reporter Gene System

Averil I. Ma, University of California, San Francisco, USA
Ubiquitin and Innate Immunity: ABIN-1 and TNF Responses

Maria del Carmen Alonso Cotoner, Massachusetts General Hospital and Harvard Medical School, USA
Short Talk: GEF-H1 Mediates NOD1 Dependent NF-kB Activation Initiated by Shigella Flexneri Effectors

Wen Zhou, University of Texas Southwestern Medical Center, USA
Short Talk: Deletion of FoxO4 Elevates Susceptibility of Mice to Trinitrobenzene Sulfonic Acid-Induced Colitis

Jun Sun, University of Rochester, USA
Short Talk: Vitamin D Receptor Negatively Regulates in vivo NF-kappaB Activity in the Normal Colon and during Bacterial-Induced Intestinal Inflammation

19:00—20:00
Social Hour with Lite Bites

Chamisa Ballroom 2
19:30—22:00
Poster Session 1

Chamisa Ballroom 2

THURSDAY, JANUARY 15

07:00—08:00
Breakfast

Los Vaqueros
08:00—11:15
Mechanisms of Bacterial Killing by Epithelial and Phagocytic Cells
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* R. Balfour Sartor, University of North Carolina at Chapel Hill, USA

Ramnik Xavier, Massachusetts General Hospital and Broad Institute, USA
Autophagy – Defender of the Cytoplasm

Jan Wehkamp, Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Germany
Antimicrobial Host Defense: from Epithelial Stem Cells to Chronic Inflammation

Lora V. Hooper, University of Texas Southwestern Medical Center, USA
Innate Defense of Gut Epithelial Surfaces

Arlette Darfeuille-Michaud, Université d'Auvergne, France
Crohn’s Disease-Associated Adherent-Invasive E. coli: Mechanisms of Intestinal Colonization, Evasion of Intracellular Killing and Development of Gut Inflammation

Ye Yang, University of Oregon, USA
Short Talk: IAP (Intestinal Alkaline Phosphatase) Up-Regulated by LPS Detoxifies LPS to Prevent Inflammation in Response to the Gut Microbiota

Ajay S. Gulati, University of North Carolina, Chapel Hill, USA
Short Talk: Effects of Murine Strain Variation on Intestinal Antimicrobial Peptide Expression

09:20—09:40
Coffee Break

Chamisa Lobby
11:15
On Own for Lunch

11:15—13:00
Poster Setup

Chamisa Ballroom 2
13:00—22:00
Poster Viewing

Chamisa Ballroom 2
16:30—17:00
Coffee Available

Chamisa Lobby
17:00—19:00
Dendritic Cell Function at Mucosal Surfaces
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Scott Plevy, Janssen, USA

Hans-Christian Reinecker, Massachusetts General Hospital, USA
Dendritic Cell Function at the Mucosal Surfaces

Peter Velázquez, Indiana University School of Medicine - South Bend, USA
Short Talk: Delineating Mucosal Dendritic Cell Networks via Intravital Microscopy

Jacqueline Perrigoue, University of Pennsylvania, USA
Short Talk: Delineating Requirements for Antigen Presentation in the Intestine: Dendritic Cells and Beyond

Ting Feng, Harvard Medical School, USA
Short Talk: Regulation of Toll-like Receptor 5 Gene Expression in Mucosal Dendritic Cells

R. William DePaolo, University of Washington, USA
Short Talk: Regulation of Intestinal Immunity to Yersinia Enterocolitica by TLR1&TLR6

InYoung Kim, University of Chicago, USA
Short Talk: The Role of Hsp70 in Intestinal Immune Homeostasis

19:00—20:00
Social Hour with Lite Bites

Chamisa Ballroom 2
19:30—22:00
Poster Session 2

Chamisa Ballroom 2

FRIDAY, JANUARY 16

07:00—08:00
Breakfast

Los Vaqueros
08:00—11:15
Effector T Cell Responses in Intestinal Inflammation
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Charles O. Elson, University of Alabama, USA

Casey T. Weaver, University of Alabama at Birmingham, USA
Late Plasticity in Th17 Development: a Basis for Revised Models of Intestinal Inflammtion

Fiona M. Powrie, University of Oxford, UK
IL-23 and Intestinal Homeostasis

Bana Jabri, University of Chicago, USA
Innate-Mediated Tolerance by TLR6: a Journey from Yersinia Pestis in the Gut

Jesús Rivera-Nieves, Inflammatory Bowel Disease Center, USA
Recruitment of T Cells to Chronically Inflamed Small Intestine

Anisa S. Ismail, Princeton University, USA
Short Talk: Reciprocal Interactions between Commensal Bacteria and gamma delta Intraepithelial Lymphocytes during Mucosal Injury

Kim Phung Le Nguyen, University of California, San Diego, USA
Short Talk: Induction of Th17: Is It too Early for a Paradigm?

09:20—09:40
Coffee Break

Chamisa Lobby
11:15
On Own for Lunch

11:15—13:00
Poster Setup

Chamisa Ballroom 2
13:00—22:00
Poster Viewing

Chamisa Ballroom 2
16:30—17:00
Coffee Available

Chamisa Lobby
17:00—19:00
Microbial Activation of Immune-Mediated Intestinal Inflammation
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Casey T. Weaver, University of Alabama at Birmingham, USA

Charles O. Elson, University of Alabama, USA
Flagellin-Specific T Cell Responses in Experimental Colitis

Sandra Kim, University of North Carolina, Chapel Hill, USA
Functional Characteristics of Escherichia Coli in Immune-Mediated Experimental Colitis

Jochen Mattner, Cincinnati Children's Hospital Medical Center, USA
The Role of Alphaproteobacteria in the Induction of Autoimmunity

Wendy S. Garrett, Harvard School of Public Health, USA
Short Talk: Communicable Ulcerative Colitis Induced by T-bet Deficiency in the Innate Immune System

19:00—20:00
Social Hour with Lite Bites

Chamisa Ballroom 2
19:30—22:00
Poster Session 3

Chamisa Ballroom 2

SATURDAY, JANUARY 17

07:00—08:00
Breakfast

Los Vaqueros
08:00—11:15
Regulation of Mucosal Immune Response to Microbial Components
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Bana Jabri, University of Chicago, USA

Craig L. Maynard, University of Alabama at Birmingham, USA
Development of Gut-Protective Regulatory T Cells

Vijay K. Kuchroo, Brigham and Women's Hospital, Harvard Medical School, USA
Tregs and Th17 Cells: Role of Induction and Regulation of Tissue Inflammation

Yasmine Belkaid, NIAID, National Institutes of Health, USA
Modulation of Foxp3+ Regulatory T Cells by Microbes

William A. Faubion, Mayo Clinic, USA
PRR Inhibition of Treg Apoptosis and the Pathigenesis of Crohn’s Disease

Betsy C. Taylor, University of Pennsylvania, USA
Short Talk: TSLP Regulates Intestinal Immunity and Inflammation

09:20—09:40
Coffee Break

Chamisa Lobby
11:15
On Own for Lunch

16:30—17:00
Coffee Available

Chamisa Lobby
17:00—19:00
Translation of Basic Research to Biomedical Applications
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Scott Plevy, Janssen, USA

Rene de Waal Malefyt, Merck Research Labs, USA
The Role of IL-23 and Th17 Cells in Chronic Immune Mediated Inflammatory Diseases

Kevan C. Herold, Yale University, USA
Induction of CD8+ Regulatory T Cells with Anti-CD3 Monoclonal Antibody

Huabao Xiong, Mount Sinai School of Medicine, USA
Blocking the TLR Signaling Pathway using TLR Peptides in the Treatment of Colitis

Edwin F. de Zoeten, Children's Hospital of Philadelphia, USA
Short Talk: Regulation of Foxp3+ Regulatory T Cells (Treg) by Small Molecule Targeting of HDAC6, Enhances Treg Function and Ameliorates Development of IBD in Murine Models

19:00—20:00
Social Hour with Lite Bites

Chamisa Ballroom 2
20:00—23:00
Entertainment

Chamisa Ballroom 2

SUNDAY, JANUARY 18

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13AI079896-01




We gratefully acknowledge additional support for this conference from:

Crohn's & Colitis Foundation of America

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Schering-Plough Research Institute


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Cell Press
United European Gastroenterology Federation


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676