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This meeting took place in 2009


Here are the related meetings in 2018:
Immunological Memory: Innate, Adaptive and Beyond (X1)

For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

Immunologic Memory and Host Defense (B6)


Organizer(s) Daniel C. Douek, Robert A. Seder, Stephen P. Schoenberger and Susan M. Kaech
February 8—13, 2009
Keystone Resort • Keystone, Colorado USA
Abstract Deadline: Oct 8, 2008
Late Abstract Deadline: Nov 6, 2008
Scholarship Deadline: Oct 8, 2008
Early Registration Deadline: Dec 8, 2008

Supported by the Directors' Fund

Summary of Meeting:
Immune memory has a critical role in mediating protection against infections as well as potentiating certain allergic and autoimmune diseases. Hence a thorough understanding of the cellular and molecular mechanisms regulating adaptive immune memory will have important clinical application. In this regard, there has been great progress in understanding how the innate immune response influences adaptive immunity. Furthermore, improved methods to visualize immune responses in vivo, characterize the phenotypic and functional properties of adaptive immune responses and how lymphoid and non-lymphoid compartments influence the maintenance of such responses has substantially improved our understanding in this area. However, major hurdles still relate to difficulties in eliciting sustained T cell responses sufficient to mediate protection in humans with current vaccines. The goal of the meeting will be to focus on basic mechanisms for how T and B cells are programmed to induce and sustain immunity. The program is designed to integrate information from mouse, non-human primate and human studies to encompass all relevant areas related to control of memory T and B cell responses. In summary, this meeting should facilitate translational research that will impact vaccines and interventions for infectious disease, cancer and autoimmune/allergic disease.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, FEBRUARY 8

15:00—19:30
Registration

Longs Peak Foyer
18:30—19:30
Refreshments

Longs Peak Foyer
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Grays Peak / Longs Peak
* Robert A. Seder, NIAID, National Institutes of Health, USA

* Susan M. Kaech, Yale University School of Medicine, USA

Rafi Ahmed, Emory University School of Medicine, USA
Immunologic Memory of T Cells


MONDAY, FEBRUARY 9

07:00—08:00
Breakfast

Quandary 1-3
08:00—11:00
Innate Influence on Adaptive Memory
Meeting has ended...abstracts no longer viewable online.

Grays Peak / Longs Peak
* Robert A. Seder, NIAID, National Institutes of Health, USA
Innate Influence on the Quality of T Cell Responses

Bali Pulendran, Emory University, USA
Modulating Vaccine Responses with Innate Immunity

Jürg Tschopp, University of Lausanne, Switzerland
The Inflammasome

Murali Krishna Kaja, University of Washington, USA
Innate Influence on T Cells

Joseph C. Sun, Memorial Sloan Kettering Cancer Center, USA
Short Talk: Adaptive Immune Features of Natural Killer Cells

09:20—09:40
Coffee Break

Longs Peak Foyer
11:00
On Own for Lunch

11:00—13:00
Poster Setup

Quandary 1-3
13:00—22:00
Poster Viewing

Quandary 1-3
14:30—16:30
Workshop 1: Measuring Events in Immune Activation

Grays Peak / Longs Peak
* Rafick-Pierre Sékaly, Case Western Reserve University, USA
FOXO3A: A Critical Integrator of Signals Leading to B and T Cell Memory

Dietmar Zehn, Technical University of Munich, Germany
CD8 Response Kinetics

Inka Albrecht, German Rheumatism Research Center, Germany
Twist1 Acts as an Internal Brake of Th1 Induced Chronic Inflammation

Spencer Stonier, MD Anderson Cancer Center, USA
Characterization of Cell Surface IL-15 Expression by Myeloid Cell Populations

Michael Quigley, Bristol-Myers Squibb Company, USA
Gene Expression Profiling of Tetramer-sorted Human T Cells can Distinguish Functionality and Disease Outcome in HIV

David Farrar, University of Texas Southwestern Medical Center, USA
Dynamic Programming of Effector and Central Memory CD8+ T cells by IL-12 and IFN-a

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Memory T Cell Subsets and Host Defense
Meeting has ended...abstracts no longer viewable online.

Grays Peak / Longs Peak
* Alexander Y. Rudensky, HHMI/Memorial Sloan Kettering Cancer Center, USA
Molecular Control of Regulatory T Cells

Federica Sallusto, Università della Svizzera Italiana & ETH Zurich, Switzerland
Th17 Cells and Host Defense

E. John Wherry, University of Pennsylvania, USA
Coregulation of CD8+ T Cell Exhaustion during Chronic Viral Infection by Multiple Inhibitory Receptors

Nathan W. Schmidt, University of Louisville, USA
Short Talk: Memory CD8 T Cell Responses Exceeding a Large, but Definable Threshold Provide Long-term Immunity to Malaria

19:00—20:00
Social Hour with Lite Bites

Quandary 1-3
19:30—22:00
Poster Session 1

Quandary 1-3

TUESDAY, FEBRUARY 10

07:00—08:00
Breakfast

Quandary 1-3
08:00—11:00
T Cells: Homeostasis and Maintenance
Meeting has ended...abstracts no longer viewable online.

Grays Peak / Longs Peak
* Marc K. Jenkins, University of Minnesota Medical School, USA
Mechanisms of Immune Memory by Bacterial Antigen-specific CD4+ T Cells

Gabrielle T. Belz, Walter and Eliza Hall Institute of Medical Research, Australia
Coordinate Regulation of Effector and Memory Expansion and Differentiation

Annette Oxenius, Institute for Microbiology, ETH Zürich, Switzerland
T Cell Responses in Chronic Viral Infections

Stephen C. Jameson, University of Minnesota Medical School, USA
Pre-existing Antigen Specific Memory Like Cells in Unprimed Mice

Carmen Gerlach, Harvard Medical School, USA
Short Talk: Effector and Memory CD8+ T Cells Constitute a Single Lineage

09:20—09:40
Coffee Break

Longs Peak Foyer
11:00
On Own for Lunch

11:00—13:00
Poster Setup

Quandary 1-3
13:00—22:00
Poster Viewing

Quandary 1-3
14:30—16:30
Workshop 2: Vaccines and T Cell Memory

Grays Peak / Longs Peak
* Mark K. Slifka, Oregon National Primate Research Center, Oregon Health & Science University, USA
Will Viral Virulence Dictate the Level of Immunological Memory to Orthopoxviruses?

* Mario Roederer, NIAID, National Institutes of Health, USA
The Unique Immunogenicity Profile of Aerosol Vaccination in Nonhuman Primates

Rene A. Van Lier, Academic Medical Center, Netherlands
Human CMV Infection Induces Rapid and Lasting Changes in Gene Expression in the CD8+ T Cell Compartment

Cheryl H. Rozanski, Roswell Park Cancer Institute, USA
CD28 Supports Normal Plasma Cell Survival and Interactions with the Microenvironment

Kylie Quinn, Monash University, Australia
Priming of CD4+ T Cells with Protein and Poly I:C Increases Subsequent Boosting of CD8+ but not CD4+ T Cell Responses

Derek Trobaugh, University of Massachusetts Medical School, USA
Qualitative and Quantitative Differences in Effector Functions of Virus-specific and -Cross-reactive T Cells in Mice Immunized with Related Flaviviruses

Lindsay E. Edwards, University of Colorado Denver and National Jewish Health, USA
Generation of Protective CD8+ T cell Memory in CD4+ Deficient Hosts

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Tissues, Traffic and Circulation
Meeting has ended...abstracts no longer viewable online.

Grays Peak / Longs Peak
David L. Woodland, Keystone Symposia on Molecular and Cellular Biology, USA
Site-Specific Control of T Cell Memory

Andrea Cerutti, Mount Sinai School of Medicine, USA
Role of Innate Signaling Networks in Mucosal Immunoglobulin Heavy Chain Class Switching

* Daniel C. Douek, NIAID, National Institutes of Health, USA
Tissue-Specific Differences and T Cell Loss in HIV Infection

James J. Campbell, Brigham and Women's Hospital, USA
Short Talk: Specificity and Dissemination of Antigen-Experienced, Tissue-Tropic T Lymphocytes

19:00—20:00
Social Hour with Lite Bites

Quandary 1-3
19:30—22:00
Poster Session 2

Quandary 1-3

WEDNESDAY, FEBRUARY 11

07:00—08:00
Breakfast

Quandary 1-3
08:00—11:00
Memory B Cell Differentiation
Meeting has ended...abstracts no longer viewable online.

Grays Peak / Longs Peak
* Stuart G. Tangye, Garvan Institute of Medical Research, Australia
Cytokine Signaling in Human B Cell Differentiation

Mark J. Shlomchik, University of Pittsburgh School of Medicine, USA
Intrinsic Properties of Memory B Cells

John C. Cambier, University of Colorado SOM, USA
Molecular Basis of B Cell Anergy and its Disruption by Innate and T Cell-Derived Signals

Ross M. Kedl, University of Colorado Denver, USA
Navigating the Boundary between Innate and Adaptive Immune Responses

Kim Good-Jacobson, Monash University, Australia
Short Talk: Role of PD-1 in Memory B Cell Formation and Responses

09:20—09:40
Coffee Break

Longs Peak Foyer
11:00
On Own for Lunch

11:00—13:00
Poster Setup

Quandary 1-3
13:00—22:00
Poster Viewing

Quandary 1-3
16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
The Genetics and Biochemistry of Memory
Meeting has ended...abstracts no longer viewable online.

Grays Peak / Longs Peak
Steven L. Reiner, Columbia University, USA
Inducing the T Cell Fates Required for Immunity

Donna L. Farber, Columbia University Medical Center, USA
Biochemical Signaling Pathways for Memory CD4 T Cell Recall and Homeostasis

* Susan M. Kaech, Yale University School of Medicine, USA
Regulation of CD8 T Cell Memory Induction

Erika L. Pearce, Max Planck Institute of Immunobiology and Epigenetics, Germany
Short Talk: Enhancing CD8 T Cell Memory by Modulating Fatty Acid Metabolism

19:00—20:00
Social Hour with Lite Bites

Quandary 1-3
19:30—22:00
Poster Session 3

Quandary 1-3

THURSDAY, FEBRUARY 12

07:00—08:00
Breakfast

Quandary 1-3
08:00—11:00
T Cells: Differentiation and Functional Capacity
Meeting has ended...abstracts no longer viewable online.

Grays Peak / Longs Peak
John T. Harty, University of Iowa, USA
Controlling Memory CD8 T Cell Differentiation

Rose Zamoyska, University of Edinburgh, UK
The Influence of Signal Strength on the Differentiation of Effector and Memory T Cells

* Stephen P. Schoenberger, La Jolla Institute for Allergy and Immunology, USA
How to Make a Memory CD8 T Cell

Yasmine Belkaid, NIAID, National Institutes of Health, USA
Plasticity of Regulatory T Cells During Infection

Ryan T. Sowell, Rush University Medical Center, USA
Short Talk: CD27 is Preferentially Required for Generation and Maintenance of Some Memory CD8 T Cell Subsets

09:20—09:40
Coffee Break

Longs Peak Foyer
11:00
On Own for Lunch

14:30—16:30
Workshop 3: Immunodominance and TCR Repertoire

Grays Peak / Longs Peak
* David Price, Cardiff University School of Medicine, UK
Deconvoluting Adaptive T Cell Immunity: Clonotype Selection and Biological Outcome

* Bridie Day, University of Melbourne, Australia
Investigating the Determinants of Antigen-Specific TCR Repertoire Diversity

Rebekka Ariane Duhen, EACRI Providence Cancer Center, USA
Repertoire Analysis of Human Naive and Memory CD4+ T Cells Reveals Affinity Maturation during the Immune Response

Pradyot Dash, St Jude Children's Research Hospital, USA
Influenza A KbPB1703 Epitope Specific CD8 T Cell Receptor Chain Repertoire Analysis: Priming with Fewer Epitopes Broadens Recruitment of the Influenza KbPB1703 Repertoire

Laurent Malherbe, Blood Center of Wisconsin, USA
Stability of MHC Class II:Peptide Complexes Governs Th Cell Clonal Selection

Vanessa Venturi, University of New South Wales, Australia
A Molecular Basis for the Sharing of T Cell Receptor beta-Chains

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—18:45
Why Memory Might Be Important: Cancer, Autoimmunity and Vaccines
Meeting has ended...abstracts no longer viewable online.

Grays Peak / Longs Peak
* Nicholas P. Restifo, NCI, National Institutes of Health, USA
T Cell Control of Cancer

Matthias G. von Herrath, Novo Nordisk and La Jolla Institute for Allergy and Immunology, USA
Memory to beta Cells - Good or Bad?

Kanta Subbarao, NIAID, National Institutes of Health, USA
Active and Passive Immunization Against Avian Influenza Viruses

18:45—19:30
Concluding Remarks
Meeting has ended...abstracts no longer viewable online.

Grays Peak / Longs Peak
Peter C. Doherty, University of Melbourne, Australia
Looking Back at Memory

19:00—20:00
Social Hour with Lite Bites

Quandary 1-3
20:00—23:00
Entertainment

Quandary 1-3

FRIDAY, FEBRUARY 13

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13AI079895-01




We gratefully acknowledge additional support for this conference from:

European Journal of Immunology JDRF

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Cell Press

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676