Keystone Resort Floorplan

Registered Attendees


Registered attendees (and speakers, organizers, etc.) will have access to the following items from their Account page:

  • Abstracts from speakers and poster sessions, including the joint meeting abstracts, available 30 days prior to the meeting (You can edit your own abstract from My Account page as well)

    NOTE: Abstract authors/submitters may choose to not have their abstract available online and in the secure mobile app until a week before the meeting.

  • Full participant list, including joint meeting participants
  • Printable Invoices and Invitation Letters
  • Scholarship Information
  • Lodging Information

Login to My Account page

This meeting took place in 2009



For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

Tuberculosis: Biology, Pathology and Therapy (B3)


Organizer(s) JoAnne L. Flynn, David G. Russell and Thomas N.A. Dick
January 25—30, 2009
Keystone Resort • Keystone, Colorado USA
Abstract Deadline: Sep 29, 2008
Late Abstract Deadline: Oct 29, 2008
Scholarship Deadline: Sep 29, 2008
Early Registration Deadline: Nov 25, 2008

Part of the Keystone Symposia Global Health Series, Supported by the Bill & Melinda Gates Foundation. Sponsored by GlaxoSmithKline.

Summary of Meeting:
Tuberculosis kills 2 million people per year worldwide. Although great strides have been made in the past decade in understanding Mycobacterium tuberculosis, the complexity of the disease necessitates a multi-pronged approach. Translating insights related to host-pathogen interplay and bacterial physiology into treatments is complex, requiring academics and industrial scientists to come together in new and creative ways. In humans the infection is persistent and chronic, yet reactivates into fulminating progressive disease. This, and the shortage of appropriate animal models, form major obstacles to identifying factors that determine disease progression and the extensive pathology associated with transmission. This meeting will focus on basic mechanisms of pathogenesis of Mycobacterium tuberculosis, and how the balance of control of infection within the granuloma is influenced by host and bacterial factors. We will also focus on translating basic mechanistic findings to the development of therapies, and a workshop highlighting academic-industrial partnerships is planned.

View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, JANUARY 25

15:00—19:30
Registration

Longs Peak Foyer
18:30—19:30
Refreshments

Longs Peak Foyer
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* JoAnne L. Flynn, University of Pittsburgh School of Medicine, USA

Douglas B. Young, Imperial College London, UK
The Best Laid Schemes of Mice and Men . . .

20:30—21:00
Orientation for New Attendees and New Investigators
Keystone Symposia's Chief Scientific Officer, Dr. Andy Robertson, to lead discussion in a "What to Expect during your Attendance" for interested delegates.

Grays Peak/Longs Peak

MONDAY, JANUARY 26

07:00—08:00
Breakfast

Red Cloud/Shavano
08:00—11:15
Life and Death within the Phagocyte
Meeting has ended...abstracts no longer viewable online.

Grays Peak/Longs Peak
Vojo Deretic, University of New Mexico Health Sciences Center, USA
Autophagy: a Cell Sanitation, Survival and Death Process

* David G. Russell, Cornell University, USA
Mycobacterium Tuberculosis and the Intracellular Environment

Ulrich E. Schaible, Research Center Borstel, Germany
Host Innate Defense and Mycobacterial Virulence

Sabine Ehrt, Weill Cornell Medical College, USA
Mycobacterial Survival Strategies in the Phagosome

Volker Briken, University of Maryland, USA
Short Talk: Molecular Mechanism of Mycobacterium tuberculosis nuoG Mediated Host Macrophage Apoptosis Inhibition

Frédéric Altare, Unité INSERM U892, France
Short Talk: Nutrient-Rich Reservoir for M. Tuberculosis Persistence

09:20—09:40
Coffee Break

Longs Peak Foyer
11:15
On Own for Lunch

11:15—13:00
Poster Setup

Red Cloud/Shavano
13:00—22:00
Poster Viewing

Red Cloud/Shavano
16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Early/Innate Immune Responses to TB
Meeting has ended...abstracts no longer viewable online.

Grays Peak/Longs Peak
* Valerie F. Quesniaux, Centre National de la Recherche Scientifique, France
Toll-Like Receptors in Tuberculosis

Clifford V. Harding, Case Western Reserve University, USA
Regulation of APCs and Class II MHC by TLR2 and Mycobacterium tuberculosis

Stefan Ehlers, Research Center Borstel, Germany
Short Talk: Non-Classical Macrophage Activation in Experimental TB – Consequences for Reactivation and Lung Pathology

Padmini Salgame, Rutgers University, USA
Short Talk: Coexisting Helminth Infection Induces Inhibition of Pulmonary Anti-Tuberculosis Defense

19:00—20:00
Social Hour with Lite Bites

Red Cloud/Shavano
19:30—22:00
Poster Session 1

Red Cloud/Shavano

TUESDAY, JANUARY 27

07:00—08:00
Breakfast

Red Cloud/Shavano
08:00—11:00
Key Pathways in Bacterial Metabolism
Meeting has ended...abstracts no longer viewable online.

Grays Peak/Longs Peak
Christopher M. Sassetti, University of Massachusetts Medical School, USA
Carbon Metabolism Comes Full Circle

* Valerie Mizrahi, University of Cape Town, South Africa
Novel and Vulnerable Pathways of DNA Metabolism in Mycobacteria

Jeffery S. Cox, University of California, Berkeley, USA
Protein Secretion, Novel and Conserved Systems

Carolyn R. Bertozzi, Stanford University, USA
Mycobacterial Sulfation Pathways

Koen Andries, Tibotec, Belgium
Short Talk: ATP Synthase, A New Validated Target for TB Treatment

09:20—09:40
Coffee Break

Longs Peak Foyer
11:00
On Own for Lunch

11:15—13:00
Poster Setup

Red Cloud/Shavano
13:00—22:00
Poster Viewing

Red Cloud/Shavano
14:30—16:30
Workshop on TB Drug Discovery: Connecting Academia and Industry
Summary: In this 2 hour workshop gaps in TB drug discovery and issues around Academia-Industry collaborations will be discussed. This will be done in the format of a podium discussion with audience participation. 12 representatives from academia, industry, the TB Alliance and the Gates Foundation will form the podium discussion group . After a short introduction by Thomas Dick (Novartis), Koen Andries (Tibotec) will briefly address one of the major questions in TB drug discovery, namely the approach issue ‘target-vs-cell-based screens’. Chris Earl (Bio Ventures for Global Health) will talk about biotech solutions for neglected disease. Jose Garcia-Bustos (GSK) and Tanjore Balganesh (Astrazeneca) will present a few slides on ‘Views from Industry’ to highlight issues and gaps from the industry side. After that, Clif Barry (NIH) and Jim Sacchettini (Texas A&M) will present a few slides on ‘Views from Academia’. Each short presentation is expected to raise key issues and questions in order to stimulate / guide the discussion.

Grays Peak / Longs Peak
* Thomas N.A. Dick, New Jersey Medical School - Rutgers, The State University of New Jersey, USA
Introduction: Connecting Academia and Industry

* Ken Duncan, Bill & Melinda Gates Foundation, USA

Koen Andries, Tibotec, Belgium
Filling the Gap: What can YOU do?

Christopher D. Earl, BIO Ventures for Global Health, USA
Building Biotech Solutions for Diseases of the Developing World

Jose F. Garcia-Bustos, GlaxoSmithKline, Spain
and

Clifton E. Barry III, NIAID, National Institutes of Health, USA
and

James C. Sacchettini, Texas A & M University, USA
How Can We Improve Academia - Industry Interaction 2: Views from Academia

M. Gerard Waters, Novartis, USA

Makoto Matsumoto, Otsuka Pharmaceutical Co. Ltd., Japan

Veronique Anne Dartois, Public Health Research Institute, USA

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Pathology and Transmission of Tuberculosis
Meeting has ended...abstracts no longer viewable online.

Grays Peak/Longs Peak
* Gilla Kaplan, Bill & Melinda Gates Foundation, USA

Elizabeth L. Corbett, London School of Hygiene and Tropical Medicine/Malawi-Liverpool-Wellcome Trust Clinical Research Programme, Malawi
TB Transmission and Susceptibility

Henry Charles Mwandumba, Liverpool School of Tropical Medicine, UK
Conditions in the Human Lung during Active Tuberculosis

Denise Kirschner, University of Michigan, USA
A Multi-Scale Peek at Granuloma Formation in TB

19:00—20:00
Social Hour with Lite Bites

Red Cloud/Shavano
19:30—22:00
Poster Session 2

Red Cloud/Shavano

WEDNESDAY, JANUARY 28

07:00—08:00
Breakfast

Red Cloud/Shavano
08:00—11:00
Insights from Animal Models: New Approaches
Meeting has ended...abstracts no longer viewable online.

Grays Peak/Longs Peak
Lalita Ramakrishnan, University of Cambridge, UK
A Forward Genetic Screen in the Zebrafish Reveals a Human TB Susceptibility Locus

David S. Schneider, Stanford University School of Medicine, USA
Balancing Resistance and Tolerance During Infections in the Fly

* JoAnne L. Flynn, University of Pittsburgh School of Medicine, USA
Non-Human Primate Model of Tuberculosis. What can we learn about TB?

Gilla Kaplan, Bill & Melinda Gates Foundation, USA
Host and Pathogen Contribution to Pathology

09:20—09:40
Coffee Break

Longs Peak Foyer
11:00—13:00
Poster Setup

Red Cloud/Shavano
11:00—14:00
Symposium on Tuberculosis Databases and Bioinformatics Tools

Grays Peak/Longs Peak
* Gary K. Schoolnik, Stanford University, USA
Welcome, Workshop Goals

Adamandia Kapopoulou, Ecole Polytechnique Federale de Lausanne, Switzerland
Tuberculist

James Galagan, Broad Institute of Massachusetts Institute of Technology and Harvard, USA
TBDatabase: A Database that Integrates Expression and Genomics Data and which Provides Suites of Bioinformatics Tools

Barry A. Bunin, Collaborative Drug Discovery Inc., USA
Collaborative Drug Discovery Database

Thomas R. Holton, University of California, Los Angeles, USA
WebTB.org and the TB Structural Genomics Consortium: Tools for searching and annotating the TB genome

Shubhada Godbole, University of Texas Southwestern Medical Center, USA
BioHealthBase: A Comprehensive Integrated Database and Analysis Resource for TB Research

Kristin Kremer, National Institute of Public Health and the Environment, Netherlands
Usefulness of DNA Fingerprint Databases to Study the Epidemiology and Phylogeny of TB

Stefan Niemann, Research Center Borstel, Germany
MIRU-VNTRplus Database: Online Identification of Clinical Isolates Based on Reference Collections and Analysis of Molecular Typing Data

* Gary K. Schoolnik, Stanford University, USA
Discussion: Unmet Bioinformatic Needs; How can they be Addressed?

13:00—22:00
Poster Viewing

Red Cloud/Shavano
16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Bacterial Response to the Evolving Host Environments
Meeting has ended...abstracts no longer viewable online.

Grays Peak/Longs Peak
* Eric J. Rubin, Harvard School of Public Health, USA
The Essential Irony of Tuberculosis

Helena I. M. Boshoff, NIAID, National Institutes of Health, USA
Nitroimidazoles for TB: Mechanism of Killing

William R. Bishai, Johns Hopkins School of Medicine and K-RITH, USA
Slipping the Host a Mycobacterial Mickey Finn

Adrie J. C. Steyn, KwaZulu-Natal Research Institute for Tuberculosis and HIV, South Africa
Short Talk: Mycobacterium tuberculosis WhiB3 maintains Intrabacterial Redox Homeostasis by Modulating Virulence Lipid Anabolism to Subvert Macrophage Function

19:00—20:00
Social Hour with Lite Bites

Red Cloud/Shavano
19:30—22:00
Poster Session 3

Red Cloud/Shavano

THURSDAY, JANUARY 29

07:00—08:00
Breakfast

Red Cloud/Shavano
07:00—08:00
Poster Setup

Red Cloud/Shavano
08:00—11:00
Action and Reaction in the Immune Control of Tuberculosis
Meeting has ended...abstracts no longer viewable online.

Grays Peak/Longs Peak
* Michael Stephen Glickman, Memorial Sloan-Kettering Institute, USA
Discovery of a Novel Pathway that Integrates rRNA Transcription with DNA damage

Gary K. Schoolnik, Stanford University, USA
Mycobacterium tuberculosis (Mtb)Expression Signatures of Host Immune Status

Heran Darwin, New York University School of Medicine, USA
Discovery of a Ubiquitin-Like Protein Involved in the Proteasome Pathway of Mycobacterium tuberculosis

Shahin Shafiani, Center for Infectious Disease Research, USA
Short Talk: Pathogen-Specific Regulatory T Cells Impair Protective Immunity in Tuberculosis

Tige R. Rustad, Seattle BioMed, USA
Short Talk: The DosR Regulon and the Enduring Hypoxic Response: Identification, Regulation and In Vivo Relevance

09:20—09:40
Coffee Break

Longs Peak Foyer
11:00—12:00
Lunch

Quandary Peaks
12:00—14:30
Poster Session 4

Red Cloud/Shavano
12:00—17:00
Poster Viewing

Red Cloud/Shavano
16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Bacterial Physiology and Drug Targets
Meeting has ended...abstracts no longer viewable online.

Grays Peak/Longs Peak
Thomas N.A. Dick, New Jersey Medical School - Rutgers, The State University of New Jersey, USA
One Plus One does not Equal Two: In Vitro – in Vivo Disconnect in TB Drug Discovery

* James C. Sacchettini, Texas A & M University, USA
Mtb Whole Genome Sequencing: Detecting Drug-Pathogen Interactions

Clifton E. Barry III, NIAID, National Institutes of Health, USA
Rethinking the Concept of a Good TB Drug “Target”

19:00—20:00
Social Hour with Lite Bites

Red Cloud/Shavano
20:00—23:00
Entertainment

Red Cloud/Shavano

FRIDAY, JANUARY 30

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13AI079894-01




We gratefully acknowledge additional support for this conference from:

Bill & Melinda Gates Foundation GlaxoSmithKline
Tibotec, Inc.
 

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Novartis Institute for Tropical Diseases Pte Ltd


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676