Granlibakken Tahoe Floorplan

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This meeting took place in 2009



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Pathogenesis and Immune Regulation in Helminth Infections (B4)


Organizer(s) Rick M. Maizels, Maria Yazdanbakhsh and Thomas A. Wynn
February 1—5, 2009
Granlibakken Tahoe • Tahoe City, California USA
Abstract Deadline: Oct 1, 2008
Late Abstract Deadline: Oct 30, 2008
Scholarship Deadline: Oct 1, 2008
Early Registration Deadline: Dec 1, 2008

Part of the Keystone Symposia Global Health Series, Supported by the Bill & Melinda Gates Foundation

Summary of Meeting:
The immunology of parasitic helminths is now attracting intense interest, due to the exciting and intricate relationship between immunity and pathogenesis, the proposed significance of regulatory immune controls in modulating both infection and disease, including allergies and autoimmunity, and the application of new molecular tools to the field situation. Currently, research aims to trace how helminths manipulate host immune cell populations, identify molecular mediators and receptor pathways involved in the host-pathogen dialogue, and design new interventions for control of infection in both human and animal contexts. This meeting will bring together scientists from many different countries (particularly those highly prevalent for helminth diseases), bridging from reductionist model systems, which offer proof of principle, to the epidemiological scale in which major insights are gained from natural infection settings. New questions from field and laboratory research will be generated, promoting the integration of different strands of inquiry and paving the way for new strategies for disease control.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, FEBRUARY 1

15:00—19:30
Registration

Pre Function
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake
Daniel G. Colley, University of Georgia, USA
Helminth Research in the 21st Century: 8 Down - 92 to Go


MONDAY, FEBRUARY 2

07:00—08:00
Breakfast

Granhall
08:00—11:15
New Developments in Immunology of Helminth Diseases
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake
* Murray E. Selkirk, Imperial College London, UK

Maria Yazdanbakhsh, Leiden University Medical Center, Netherlands
The Regulatory Network in Human Helminth Infections

* Thomas B. Nutman, NIAID, National Institutes of Health, USA
Clinically Inapparent but Immunologically Measurable Bystander Effects of Tissue-Invasive Helminth Infections on other Infectious Diseases of Humans

Philip J. Cooper, Hospital Pedro Vicente Maldonado, Ecuador
Short Talk: Human Chronic Infections with Ascaris lumbricoides Affect Cytokine Production and Gene Expression

Markus Mohrs, Trudeau Institute, USA
Short Talk: Omega-1, a Glycoprotein Secreted by Schistosoma mansoni Eggs, Drives Th2 Responses

Alison M. Elliott, London School of Hygiene & Tropical Medicine, UK
The Impact of Maternal Helminth Infection and of De-Worming in Pregnancy on Infant Response to BCG and tetanus immunisation

Peter J. Hotez, George Washington University, USA
Vaccination Against Human Helminth Parasites

09:20—09:40
Coffee Break

Pre Function
11:15
On Own for Lunch

11:15—13:00
Poster Setup

Bay
13:00—22:00
Poster Viewing

Bay
14:30—16:30
Workshop 1: Stimulation of Anti-Helminth Responsiveness

Mountain/Lake
* Taniawati Supali, Faculty of Medicine University of Indonesia, Indonesia

Ayola A. Adegnika, Albert Schweitzer Hospital, of Lambaréné, Gabon
Schistosoma haematobium Infection Impairs Human Blood Dendritic Cell Function

Carmen Aranzamendi, Rijksinstituut voor Volksgezondheid en Milieu, Netherlands
Trichinella spiralis Excretory/Secretory Antigen Inhibits DC Maturation: A Role of for TLR4 and CD14

Caroline M.W. van Stijn, VU Medical Center, Netherlands
Schistosoma mansoni Adult Worm Glycolipids Induce Maturation of Human Monocytes Derived Dendritic Cells

Katie Smith, Cardiff Institute of Infection and Immunity, UK
Tolerogenic Dendritic Cells in Chronic Helminth Infection

Jacqueline Perrigoue, University of Pennsylvania, USA
Innate Immunity to Intestinal Helminths: Looking Beyond Dendritic Cells

David Voehringer, University Hospital of Erlangen, Germany
Basophil Effector Function and Homeostasis during Helminth Infection

Rachel A. Lawrence, Royal Veterinary College, UK
Deficiency in Mannose-Binding Lectin -A and/or -C Prevents Parasite Clearance and Development of Anti-Parasite IgM

* Mark John Taylor, Liverpool School of Tropical Medicine, UK
Wolbachia Lipoproteins as Drivers of Innate and Adaptive Inflammatory Pathogenesis of Lymphatic Filariasis and Onchocerciasis

16:30—17:00
Coffee Available

Pre Function
17:00—19:00
Helminth Stimulation of the Immune System
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake
Achim M. Hoerauf, University Hospital Bonn, Germany
Stimulation of the Host Immune System by Filariae and their Wolbachia endosymbionts

Nicola L. Harris, École Polytechnique Fédérale de Lausanne, Switzerland
Short Talk: Parasite Products Bypass the Need for TSLP in TH2 Immune Responses by Directly Modulating Dendritic Cell Function

Padraic Fallon, Trinity College Dublin, Ireland
Helminth Drivers of Innate and Adaptive Immunity

Richard M. Locksley, HHMI/University of California, San Francisco, USA
Tracking the Host Response in Helminth Immunity

19:00—20:00
Dinner

Granhall
20:00—22:00
Poster Session 1

Bay
20:00—21:00
Social Hour

Pre-Function

TUESDAY, FEBRUARY 3

07:00—08:00
Breakfast

Granhall
08:00—11:15
Helminth Modulation of T Cell Activity
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake
* Rachel A. Lawrence, Royal Veterinary College, UK

* Edward J. Pearce, Max Planck Institute of Immunobiology and Epigenetics, Germany
Induction and Regulation of the Th2 Response to Helminths

Graham S. Le Gros, Malaghan Institute of Medical Research, New Zealand
Rewriting the Paradigm for IL4/STAT6 in Th2 Differentiation and Protective Immunity against Helminth Infection

Nienke van der Werf, University of Edinburgh, UK
Short Talk: Induction and Maintenance of Regulatory and Effector T Cell Responses during chronic helminth infection

Marc Peter Hübner, Uniformed Services University, USA
Short Talk: Inhibition of Type I Diabetes in Filaria Infected NOD Mice is Associated with a Th2 Shift and Induction of Regulatory T Cells

William C. Gause, Rutgers New Jersey Medical School, USA
Characterization of Effector Mechanisms Leading to Resistance during a Peripheral Memory Th2 Type Response

Richard M. Maizels, University of Edinburgh, UK
Regulatory Cells Induced by Helminth Parasites

09:20—09:40
Coffee Break

Pre Function
11:15
On Own for Lunch

11:15—13:00
Poster Setup

Bay
13:00—22:00
Poster Viewing

Bay
16:30—17:00
Coffee Available

Pre Function
17:00—19:00
Pathogenesis and Immunity in Helminth Infection
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake
* Richard M. Locksley, HHMI/University of California, San Francisco, USA

Thomas A. Wynn, Pfizer, USA
Dissecting "Alternative" Activation: The Role of Macrophages and Other Targets of IL-4/IL-13 Signaling

Miguel J. Stadecker, Tufts University School of Medicine, USA
Induction and Regulation of the Pathogenic Th17 Response in Schistosomiasis

Mara Shainheit, Tufts University-Sackler School, USA
Short Talk: Dendritic Cell IL-23 and IL-1 Production in Response to Schistosome Eggs Induces Th17 Cells in a Mouse Strain Prone to Severe Immunopathology

David Artis, Cornell University, USA
Regulation of Immunity and Infection following Gastrointestinal Nematode Infection

19:00—20:00
Dinner

Granhall
20:00—22:00
Poster Session 2

Bay
20:00—21:00
Social Hour

Pre-Function

WEDNESDAY, FEBRUARY 4

07:00—08:00
Breakfast

Granhall
08:00—11:15
Inflammatory Diseases and Helminth Infection
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake
* Sabine Specht, University Hospital Bonn, Germany

Anne Cooke, University of Cambridge, UK
Helminth Modulation of Autoimmune Diabetes

Cathryn Nagler, University of Chicago, USA
Intestinal Helminth Infection Compromises Oral and Parenteral Vaccine Efficacy

De' Broski R. Herbert, University of Pennsylvania, USA
Short Talk: Essential Role for IL-4/13 Activated Epithelia in Host Protection Against GI Nematodes

P'ng Loke, New York University School of Medicine, USA
Short Talk: Characterization of the Colon for Th17/Th22 Cells and by Transcriptional Profiling during Trichuris trichiura Infection in a Patient with Ulcerative Colitis

Klaus J. Erb, Boehringer Ingelheim, Germany
How can Infection with Helmintths Protect from Allergic Disorders?

* Judith E. Allen, University of Manchester, UK
Helminth-Elicited Macrophages in Th2-Mediated Inflammation

09:20—09:40
Coffee Break

Pre Function
11:15
On Own for Lunch

14:30—16:30
Workshop 2: Helminth Genomes: Promise and Practise

Mountain/Lake
Alvaro Juan Díaz, Facultad de Quimica, Universidad de la Republica, Uruguay, Uruguay
Surface Mucins of Larval Echinococcus Granulosus: Carbohydrate Structural Elucidation and Effects on Macrophage Phenotype

* Irma M. Van Die, VU University Medical Center, Netherlands
Schistosome Glycans Modulate Dendritic Cell Function

Irma Schabussova, Center for Physiology, Pathophysiology & Immunology, Austria
Novel O-Methylated Glycans from Toxocara Activate Dendritic Cells via TLR2, Selectively Inhibiting TLR4 Responsiveness and IL-12p70 Production

Moniek H J Meevissen, Leiden University Medical Centre, Netherlands
The GalNAcbeta1-4GlcNAc-Containing Glycoprotein kappa5 from S. Mansoni Egg Secretions Induces Granuloma Formation in a Pulmonary Mouse Model

Jose Lozano-Torres, Wageningen University, Netherlands
A Nematode Venom Allergen/ASP-Like Protein Interacts with a Cathepsin-Like Protein in the Host and is Required for Plant-Parasitism

Sara Lustigman, New York Blood Center, USA
The Onchocerca volvulus Recombinant Ov-ASP-1 Protein has Immunostimulatory Properties in vivo and in vitro

Soraya Gaze, Fiocruz - Centro de Pesquisas Rene Rahcou, Brazil
Excretory/Secretory Products from Necator americanus that Bind to Natural Killer Cells and Induce IFN-gamma Secretion

* Kleoniki Gounaris, Imperial College London, UK
Secreted Proteins of Trichinella spiralis Modulate Purinergic Signalling and Leukocyte Function

16:30—17:00
Coffee Available

Pre Function
17:00—19:00
Helminths and Defined Products in Therapy of Disease
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake
* Cornelis H. Hokke, Leiden University Medical Center, Netherlands

Daniel G. Blount, University of Nottingham, UK
The Costs and Potential Benefits of Hookworm Infection

Danielle Smyth, Queensland Institute of Medical Research, Australia
Short Talk: New Lessons from Old Parasites: Using Hookworm Antigen to Treat IBD

Joel V. Weinstock, Tufts Medical Center, USA
Helminth Suppression of Antigenic T Cell Responses in the Gut of Murine Colitis

William Harnett, Strathclyde Institute for Pharmacy and Biomedical Sciences, UK
Immunomodulatory Properties of the Filarial Nematode Secreted Product, ES-62

19:00—20:00
Social Hour

Granhall
20:00—21:00
Dinner

Granhall
20:00—23:00
Entertainment

Granhall

THURSDAY, FEBRUARY 5

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13AI081464-01




We gratefully acknowledge additional support for this conference from:

Bill & Melinda Gates Foundation Burroughs Wellcome Fund
Scynexis, Inc.
 

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Cell Press
United European Gastroenterology Federation


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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