Fairmont Banff Springs Floorplan

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This meeting took place in 2009



For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

Obesity: Novel Aspects of the Regulation of Body Weight (J4)


Organizer(s) Randy J. Seeley, Mark W. Sleeman and I. Sadaf Farooqi
January 20—25, 2009
Fairmont Banff Springs • Banff, Alberta Canada
Abstract Deadline: Sep 23, 2008
Late Abstract Deadline: Oct 23, 2008
Scholarship Deadline: Sep 23, 2008
Early Registration Deadline: Nov 20, 2008

Supported by the Directors' Fund


Summary of Meeting:
Obesity remains among the most daunting health problems facing the developed world. Despite the rising prevalence of obesity, the biological systems that serve to match caloric intake to caloric expenditure are robust and make permanent weight loss difficult to achieve. Current research points to a multitude of factors that contribute to this regulation. Identifying the processes that are most amenable for therapeutic intervention is a crucial research goal. To that end, this conference will focus on the latest work identifying novel genes, hormones and signaling cascades that regulate energy balance. The program will also emphasize a wide range of new strategies for using this new information to produce safe and effective therapies to prevent or treat obesity.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


TUESDAY, JANUARY 20

15:00—19:30
Registration

Van Horne Foyer
18:30—19:30
Refreshments

Van Horne Foyer
19:30—20:30
Keynote Address (Joint)
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom A,B
Bruce M. Spiegelman, Harvard Medical School, USA
Transcriptional Control of Adipogenesis and Energy Balance


WEDNESDAY, JANUARY 21

07:00—08:00
Breakfast

Mezzanine 2
08:00—11:15
Genetics of Obesity and Diabetes (Joint)
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom A,B
* Randy J. Seeley, University of Michigan, USA

Philippe Froguel, Imperial College of London, UK
GWA Enlighten Obesity and Diabetes Physiology

Jeffrey M. Friedman, Rockefeller University, USA
Talk Title to be Determined

Eric Schadt, Mount Sinai School of Medicine, USA
In silico Alternatives to Association Studies

Andrew Hattersley, Peninsula Medical School, UK
What have we Learnt from Finding the BMI and Obesity Gene FTO?

Satya Dash, University of Cambridge, UK
Short Talk: An Inherited Disorder of Glucose Transporter 4 Translocation in a Family with Acanthosis Nigricans, Post-prandial Hyperinsulinemia and a Truncation Mutation in TBC1D4

Cecilia Lindgren, Oxford University, UK
Short Talk: Analysis of Genome-Wide Scans Identifies Potential Novel Common Susceptibility Loci for Central Obesity

09:20—09:40
Coffee Break

Van Horne Foyer
11:15
On Own for Lunch

11:15—13:00
Poster Setup

Mezzanine 2
13:00—22:00
Poster Viewing

Mezzanine 2
16:30—17:00
Coffee Available

Van Horne Foyer
17:00—19:00
New Advances in CNS Regulation of Energy Balance
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom C
* Kevin L. Grove, Novo Nordisk and Oregon National Primate Research Center, USA

Mathias Treier, Max-Delbrueck-Center for Molecular Medicine, Germany
A Bsx Positive Hypothalamic Neuronal Network Regulates Locomotory Behaviour and Food Intake

Anthony R. Means, Duke University, USA
Hypothalamic CaMKK2 Contributes to the Regulation of Energy Balance

Lori M. Zeltser, Columbia University, USA
Ontogeny of Neuronal Lineages in the Arcuate Nucleus

Frank Thomas Wunderlich, Max Planck Institute for Neurological Research, Germany
Short Talk: Enhanced Stat3 Activation in POMC Neurons Provokes Negative Feedback Inhibition of Leptin and Insulin Signaling in Obesity

17:00—19:00
Roles of Cytokines, Lipid Mediators, and Inflammation I
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom A,B
Steven E. Shoelson, Harvard Medical School, Joslin Diabetes Center, USA
Immunological Effects of Obesity and Targeted Reversal to Treat Insulin Resistance and Diabetes

Alon Chen, Weizmann Institute of Science, Israel
Urocortins, New Peptides Involved in beta Cell Regulation and Glucose Homeostasis

* Barbara B. Kahn, Beth Israel Deaconess Medical Center, Harvard Medical School, USA
Glucose Sensing in the Adipocyte: Role for Carbohydrate Response Element Binding Protein (ChREBP)

Stephan Wueest, University Children's Hospital, Switzerland
Short Talk: Basal Lipolysis, not the Degree of Insulin Resistance, Differentiates Large from Small Isolated Adipocytes in High-Fat Fed Mice

19:00—20:00
Social Hour with Lite Bites

Mezzanine 2
19:30—22:00
Poster Session 1

Mezzanine 2

THURSDAY, JANUARY 22

07:00—08:00
Breakfast

Mezzanine 2
07:00—08:00
Poster Setup

Mezzanine 2
08:00—11:15
Insulin Resistance and Lipotoxicity (Joint)
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom A,B
* Kitt F. Petersen, Yale University School of Medicine, USA

Gerald I. Shulman, HHMI/Yale University School of Medicine, USA
Molecular Mechanisms of Insulin Resistance

Jay D. Horton, University of Texas Southwestern Medical Center, USA
Hepatic Steatosis and SREBP Pathway

Sonia Caprio, Yale University School of Medicine, USA
Ectopic Fat Distribution and Insulin Resistance in Obese Adolescents: Does it Matter?

Ronald M. Evans, Howard Hughes Medical Institute, Salk Institute, USA
Nuclear Receptors: Engineering Metabolism to Enhance Athletic Performance

Qunfeng Jiang, Karolinska Institutet, Sweden
Short Talk: In-vivo Metabolic Studies in Muscle-Specific Calcineurin Transgenic Mice

Christopher L. Karp, Bill & Melinda Gates Foundation, USA
Short Talk: Regulation of Energy Metabolism by the RP105/TLR Axis

09:20—09:40
Coffee Break

Van Horne Foyer
11:15—12:00
Lunch

Mezzanine 2
12:00—14:30
Poster Session 2

Mezzanine 2
12:00—17:00
Poster Viewing

Mezzanine 2
16:30—17:00
Coffee Available

Van Horne Foyer
17:00—19:00
The Role of Vasculature in the Development and Treatment of Obesity
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom C
* Herbert Herzog, Garvan Institute, Australia

Gavin O. Thurston, Regeneron Pharmaceuticals Inc., USA
Regulation of Angiogenesis

Maria Ann Rupnick, Children's Hospital/Brigham & Women's Hospital, USA
Angiogenic Inhibitors to Treat Obesity

Randy J. Seeley, University of Michigan, USA

William R. Munday, The Scripps Research Institute, USA
Short Talk: Novel Mechanism of Adipogenesis: Linking Stress and NPY to Progenitor Cells

17:00—19:00
Roles of Cytokines, Lipid Mediators, and Inflammation II
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom A,B
* Clay F. Semenkovich, Washington University School of Medicine, USA
Genotoxic Stress, Lipogenesis and the Metabolic Syndrome

Samuel Klein, Washington University School of Medicine, USA
Metabolic Implications of Visceral Fat and Nonalcoholic Fatty Liver Disease in Obesity

Michael Karin, University of California, San Diego, USA
Lipid Activation of Stress-Responsive Kinases and Insulin Resistance

19:00
On Own for Dinner


FRIDAY, JANUARY 23

07:00—08:00
Breakfast

Mezzanine 2
08:00—11:00
Developmental and Epigenetic Determinants of Obesity
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom C
* Yoshihiro Ogawa, Kyushu University, Japan

Emma Whitelaw, Queensland Institute of Medical Research, Australia
How Lifetime Influences Epigenotype within and across Generations

Jonathan R. Seckl, University of Edinburgh School of Clinical Sciences & Community Health, UK
In Utero Glucocorticoid ‘Programming’ of Metabolic Syndrome Risk

Kevin L. Grove, Novo Nordisk and Oregon National Primate Research Center, USA
Development of Neuropeptide Systems that Regulate Metabolism

Clive W. Coen, King's College London, UK
Short Talk: Developmental Programming of Appetite and Obesity: Role of Leptin

08:00—11:15
Insulin Resistance and Lipotoxicity II
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom A,B
Michael P. Czech, University of Massachusetts Medical School, USA
RNAi-Based Therapeutic Strategies Targeting Inflammation and Metabolic Disease

* Amira Klip, Hospital for Sick Children, Canada
Lipotoxicity-Induced Insulin Resistance at Different Levels in Muscle Cells

Domenico Accili, Columbia University, USA
Insulin Resistance: A Critical Reappraisal

Gökhan S. Hotamisligil, Harvard University, USA
ER Stress, Inflammation and Lipotoxicity in Metabolic Regulation

Varman T. Samuel, Yale University, USA
Short Talk: Fasting Hyperglycemia in Type 2 Diabetes Mellitus Develops Without Increased Expression of Phosphoenolpuyrvate Carboxykinase or Glucose 6-Phosphatase

Megan Moriarty, University of Colorado, Denver, USA
Short Talk: Partial Knock-Down of p85alpha In Vivo with Anti-Sense Oligonucleotide Improves Insulin Sensitivity in Diet-induced Obese Mice

09:20—09:40
Coffee Break

Van Horne Foyer
11:00
On Own for Lunch

11:00—13:00
Poster Setup

Mezzanine 2
13:00—22:00
Poster Viewing

Mezzanine 2
16:30—17:00
Coffee Available

Van Horne Foyer
17:00—19:00
Are We What We Eat? Metabolic Regulation of Energy Balance
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom C
* I. Sadaf Farooqi, University of Cambridge, UK

Christopher B. Newgard, Duke University Medical Center, USA
Mechanisms of Nutritional Modulation of Insulin Action

Eleftheria Maratos-Flier, Beth Israel Deaconess Medical Center, USA
Molecular Insights from the Study of Ketogenic Diets -- The Role of FGF21 in Metabolism

Steven A. Kliewer, University of Texas Southwestern Medical Center, USA
Regulation of Metabolism by Endocrine FGFs

Zivjena Vucetic, University of Pennsylvannia, USA
Short Talk: Epigenetic Reprogramming of Dopaminergic Reward Circuitry by Pre- and Postnatal Diet

17:00—19:00
Beta-Cell Function, Failure and Protection
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom A,B
Klaus H. Kaestner, University of Pennsylvania School of Medicine, USA
HNF-4 in Beta-Cell Proliferation and Glucose Homeostasis

* Susan Bonner-Weir, Joslin Diabetes Center, USA
Islet Cell Progenitors

Steven E. Kahn, VA Puget Sound Health Care System and University of Washington, USA
ß-Cell Loss in Type 2 Diabetes

Richard G. Kibbey, Yale University, USA
Short Talk: Glucose Toxicity Induces Alpha-Cell Dysregulation that Leads to Hyperglycemia

19:00—20:00
Social Hour with Lite Bites

Mezzanine 2
19:30—22:00
Poster Session 3

Mezzanine 2

SATURDAY, JANUARY 24

07:00—08:00
Breakfast

Mezzanine 2
08:00—11:15
Advances in Treatment and Therapeutic Intervention in Obesity and Diabetes (Joint)
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom A,B
* Steven E. Kahn, VA Puget Sound Health Care System and University of Washington, USA

Lee M. Kaplan, Massachusetts General Hospital, USA
Physiological Responses to Bariatric Surgery

D. Grahame Hardie, University of Dundee, UK
AMPK – an Energy Sensor and a Drug Target in Diabetes and the Metabolic Syndrome

* Laurie J. Goodyear, Joslin Diabetes Center, Harvard Medical School, USA
Exercise and Diabetes: The Emerging Roles of AMPK and AMPK-related Kinases

Richard D. DiMarchi, Indiana University, USA
Chemical Biotechnology Applied to Endocrine Hormones

Jian Yang, University of South Alabama College of Medicine, USA
Short Talk: AMP-Activated Protein Kinase Suppresses LXR-Dependent Sterol Regulatory Element-Binding Protein-1c Transcription in Rat Hepatoma McA-RH7777 Cells

Tamer Coskun, Eli Lilly & Company, USA
Short Talk: FGF21 Corrects Obesity in Mice

09:20—09:40
Coffee Break

Van Horne Foyer
11:15
On Own for Lunch

16:30—17:00
Coffee Available

Van Horne Foyer
17:00—19:00
New Ways in which the Gut Regulates Metabolic Functions
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom C
* Lee M. Kaplan, Massachusetts General Hospital, USA

Mark W. Sleeman, Monash University, Australia
Gut Hormones and the Regulation of Metabolism

Matthias H. Tschöp, Helmholtz Zentrum München and Technische Universität München, Germany
The Gut-Brain Axis in the Control of Peripheral Metabolic Processes

Daniel J. Drucker, Lunenfeld-Tanenbaum Research Institute, Canada
The GLP-2R; An Essential Mediator of Energy Absorption

Gilles Mithieux, INSERM, France
Short Talk: Intestinal Gluconeogenesis is a Key in Insulin Sensitivity after Gastric Bypass in Mice

17:00—19:00
Mitochondria/ROS/SIRTs
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom A,B
* Samuel Klein, Washington University School of Medicine, USA

Kitt F. Petersen, Yale University School of Medicine, USA
Lipid Mediated Insulin Resistance

David A. Sinclair, Harvard Medical School, USA
Sirtuins as Modulators of Metabolism and Longevity

Marc R. Montminy, The Salk Institute for Biological Studies, USA
Regulation of Hepatic Gluconeogenesis by the CREB Coactivator TORC2 and the Forkhead Transcription Factor FOXO1

Julia Szendroedi, University Düsseldorf, Germany
Short Talk: Mitochondrial Dysfunction in the Liver of Patients with Type 2 Diabetes

19:00—20:00
Social Hour with Lite Bites

Mezzanine 2
20:00—23:00
Entertainment

Mezzanine 2

SUNDAY, JANUARY 25

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 5R13DK076500-03




We gratefully acknowledge additional support for this conference from:

Lilly Singapore Centre for Drug Discovery Regeneron Pharmaceuticals, Inc.

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Regeneron Pharmaceuticals, Inc.


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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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Phone:+1 970-262-2690

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