Beaver Run Resort Floorplan

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This meeting took place in 2008



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Metabolism and Cardiovascular Risk (S2)


Organizer(s) E. Dale Abel, Ira J. Goldberg and Karin E. Bornfeldt
September 23—28, 2008
Beaver Run Resort • Breckenridge, Colorado USA
Abstract Deadline: Jun 24, 2008
Late Abstract Deadline: Jul 24, 2008
Scholarship Deadline: May 22, 2008
Early Registration Deadline: Jul 24, 2008

Supported by the Directors' Fund

Summary of Meeting:
Cardiovascular disease is the major cause of mortality in developed countries and emerging economies worldwide. Important risk factors include diabetes, obesity, and dyslipidemia. Given the growing worldwide epidemic of obesity and the metabolic syndrome, there is a critical need to understand the biological mechanisms that confer this increased risk. The most current research in this area has identified important mechanisms linking dyslipidemia and inflammation to the development of atherosclerosis, the role of adipokines in linking metabolic dysfunction and cardiovascular disease, and the role of insulin resistance and mitochondrial dysfunction in the pathogenesis of cardiac dysfunction. Recent genome-wide association studies have identified novel genetic loci that may link metabolic disorders with increased risk. The goals of this meeting are to present the latest data on: (1) genetic studies linking metabolism and cardiovascular risk; (2) new insights into the mechanisms linking insulin resistance with atherosclerosis and cardiac dysfunction; and (3) new insights into the role of altered insulin signaling and lipotoxicity in promoting cardiovascular disease in individuals with diabetes and the metabolic syndrome. The program will catalyze interactions that are likely to lead to new approaches to tackle the translation of fundamental observations to the prevention of cardiovascular disease in these vulnerable populations.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


TUESDAY, SEPTEMBER 23

15:00—19:30
Registration

Foyer
18:30—19:30
Refreshments

Foyer
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Peak 5
* E. Dale Abel, University of Iowa, Carver College of Medicine, USA

Ruth McPherson, University of Ottawa Heart Institute, Canada
Genetic Insights into Coronary Artery Disease

20:30—21:00
Orientation for New Attendees and New Investigators
Keystone Symposia's Chief Scientific Officer, Dr. Andy Robertson, to lead discussion in a "What to Expect during your Attendance" for interested delegates.

Peak 5

WEDNESDAY, SEPTEMBER 24

07:00—08:00
Breakfast

Peaks 1-4
08:00—11:15
New Genetic Insights Linking Metabolism and Cardiovascular Risk
Meeting has ended...abstracts no longer viewable online.

Peak 5
Markku Laakso, Kuopio University Central Hospital, Finland
Genetics of Type 2 Diabetes

* Alan D. Attie, University of Wisconsin-Madison, USA
Genes, Gene Networks, and Type 2 Diabetes

Aldons J. Lusis, University of California, Los Angeles, USA
Systems Biology of Cardiovascular Disease

Zhiguang Su, The Jackson Laboratory, USA
Short Talk: Obesity, Adiponectin, and HDL are Controlled by Common Genetic Factors in the Mouse

Sudha B. Biddinger, Boston Children's Hospital, Harvard Medical School, USA
Short Talk: Hepatic Insulin Resistance Suppresses Cholesterologenic Gene Expression by Inhibiting SREBP-2

09:20—09:40
Coffee Break

Foyer
11:15—13:00
Poster Setup

Peaks 1-4
11:15
On Own for Lunch

13:00—22:00
Poster Viewing

Peaks 1-4
16:30—17:00
Coffee Available

Foyer
17:00—19:00
Adipocytokines and Cardiovascular Risk
Meeting has ended...abstracts no longer viewable online.

Peak 5
* Scott A. Summers, Duke-NUS Graduate Medical School, Singapore

Kenneth Walsh, Boston University School of Medicine, USA
Adiponectin and Cardiac Injury

Daniel T. Eitzman, University of Michigan, USA
Visceral Adipose Tissue and Atherosclerosis

Cuihua Zhang, University of Missouri-Columbia, USA
TNF-Alpha and Vascular Dysfunction

Anne Marie Minihane, Hugh Sinclair Nutrition Group, UK
Short Talk: Influence of a Leptin Receptor Gene Variant on Postprandial Triglyceride Metabolism: Impact of Gender

19:00—20:00
Social Hour with Lite Bites

Peaks 1-4
19:30—22:00
Poster Session 1

Peaks 1-4

THURSDAY, SEPTEMBER 25

07:00—08:00
Breakfast

Peaks 1-4
08:00—11:15
Insulin and Akt Signaling in the Heart and Vasculature
Meeting has ended...abstracts no longer viewable online.

Peak 5
* Kenneth Walsh, Boston University School of Medicine, USA

E. Dale Abel, University of Iowa, Carver College of Medicine, USA
Insulin and Growth Factor Regulation of Cardiac Mitochondria

Anthony Rosenzweig, Massachusetts General Hospital, USA
Akt and SGK Signaling in the Heart

William C. Sessa, Yale University School of Medicine, USA
Role of Akt in the vasculature

Paul Huang, Massachusetts General Hospital, USA
eNOS, Metabolic Diseases, and Cardiovascular Risk

Elena Galkina, Eastern Virginia Medical School, USA
Short Talk: Accelerated Atherosclerosis in Insulin Receptor/Insulin Receptor Substrate-1 Double Heterozygous ApoE Knockout Mice

Carlos Fernández-Hernando, New York University School of Medicine, USA
Short Talk: Endothelial Caveolin-1 Regulates the Progression of Atherosclerosis by Controlling LDL Infiltration, Expression of Vascular Adhesion Molecules and Production of Nitric Oxide

09:20—09:40
Coffee Break

Foyer
11:15—12:00
Lunch

Peaks 1-4
12:00—14:30
Poster Session 2

Peaks 1-4
14:30—16:30
Workshop: Hot Topics in Cardiac and Vascular Metabolism

Peak 5
* Ira J. Goldberg, New York University, USA

* Karin E. Bornfeldt, University of Washington School of Medicine, USA

Peter C. Lucas, University of Pittsburgh School of Medicine, USA
The CARMA3-Bcl10-MALT1 Signalosome as a mediator of Angiotensin II-dependent NF-kappaB activation and atherogenesis

Jenny E. Kanter, University of Washington, USA
Macrophage Long-Chain acyl-CoA Synthetase 1 Plays an Important Role in Lipid Loading by Inhibiting Cholesterol Efflux via ATP-Binding Cassette Transporter 1

Heiko Bugger, Heart Center Freiburg University, Germany
Increased Myocardial Fatty Acid Uptake by Acyl-CoA Synthetase 1 Impairs Mitochondrial Function and Dynamics

Xiaoyue Pan, SUNY Downstate Medical Center, USA
Clock is Required for Diurnal and Food-Entrained Regulation of Plasma Lipids and Lipoproteins

Zoltan P. Arany, University of Pennsylvania, USA
Regulation of VEGF and Angiogenesis by the Transcriptional Coactivator PGC-1alpha

Denis J. Glenn, University of California, San Francisco, USA
Transgenic Expression of DGAT1 in Cardiac Myocytes Results in Cardiac Steatosis

Adam R. Wende, University of Alabama at Birmingham, USA
Short-term, Cardiac Specific Overexpression of GLUT4 does not Rescue Metabolic and Contractile Dysfunction in the Diabetic Heart

Leo Timmers, University Medical Center Utrecht, Netherlands
Cardioprotective Effects of Exenatide, a Glucagon-Like Peptide 1 Receptor Agonist

16:30—17:00
Coffee Available

Foyer
17:00—19:00
Signaling Mechanisms Regulating Mitochondrial Function and Metabolism
Meeting has ended...abstracts no longer viewable online.

Peak 5
* Margaret P. Chandler, National Institutes of Health, USA

Daniel P. Kelly, University of Pennsylvania, USA
PGC1, Mitochondria and Cardiac Dysfunction in Insulin Resistance and Diabetes

Jiandie Lin, University of Michigan Medical School, USA
Transcriptional Networks in the Control of Energy Metabolism

Martin E. Young, University of Alabama at Birmingham, USA
Circadian Clocks and Cardiac Metabolism

Michael N. Sack, NHLBI, National Institutes of Health, USA
Short Talk: PGC-1alpha Integrates Insulin Signaling, Mitochondrial Regulation and Bioenergetic Function in Skeletal Muscle

19:00
On Own for Dinner


FRIDAY, SEPTEMBER 26

07:00—08:00
Breakfast

Peaks 1-4
08:00—11:15
Inflammation, Lipids and Other Risk Factors
Meeting has ended...abstracts no longer viewable online.

Peak 5
Christopher K. Glass, University of California, San Diego, USA
Transcriptional Regulation of Macrophage Function

* Ajay Chawla, University of California, San Francisco, USA
Macrophage Activation in Obesity and Insulin Resistance

Kitt F. Petersen, Yale University School of Medicine, USA
Lipid-Mediated Insulin Resistance

Li Wang, University of Connecticut, USA
Nuclear Receptor SHP in Metabolic Regulation

Michael G. Usher, University of Michigan, USA
Short Talk: The Mineralocorticoid Receptor Controls Macrophage Polarization in Cardiovascular Inflammation

Ming-Dong Wang, University of Ottawa Heart Institute, Canada
Short Talk: SR-BI Deficiency in Macrophage Labeled with LDL-Derived Cholesterol Leads to Reduced in vivo Reverse Cholesterol Transport

09:20—09:40
Coffee Break

Foyer
11:15—13:00
Poster Setup

Peaks 1-4
11:15
On Own for Lunch

13:00—22:00
Poster Viewing

Peaks 1-4
16:30—17:00
Coffee Available

Foyer
17:00—19:15
Vascular Metabolism
Meeting has ended...abstracts no longer viewable online.

Peak 5
* Alan R. Tall, Columbia University, USA

Ira J. Goldberg, New York University, USA
Glucose and Lipids in Cardiovascular Diseases

Clay F. Semenkovich, Washington University School of Medicine, USA
Vascular Metabolism and Atherosclerosis

Jerry L. Nadler, Eastern Virginia Medical School, USA
Inflammatory Mechanisms Linking Metabolic Changes and Atherosclerosis

Cecilia M. Giachelli, University of Washington, USA
Regulation of Vascular Calcification

19:15—20:15
Social Hour with Lite Bites

Peaks 1-4
19:30—22:00
Open Viewing Poster Sessions 1 & 2

Peaks 1-4

SATURDAY, SEPTEMBER 27

07:00—08:00
Breakfast

Peaks 1-4
08:00—11:15
Lipid Signaling and Lipotoxicity
Meeting has ended...abstracts no longer viewable online.

Peak 5
* Mahmood Hussain†, SUNY Downstate Medical Center, USA

Rudolf Zechner, University of Graz, Austria
Adipose Triglyceride Lipase

* Jean E. Schaffer, Washington University School of Medicine, USA
Lipotoxicity: Mapping the Response to Metabolic Stress

Jay W. Heinecke, University of Washington School of Medicine, USA
Proteomics Implicates a Macrophage Sterol-Regulated Network in Atherogenesis

Scott A. Summers, Duke-NUS Graduate Medical School, Singapore
Ceramides, Insulin Resistance, and Metabolic Disease

Luuk Jon Rijzewijk, Vrije Universiteit University Medical Center, Netherlands
Short Talk: The Phenotype of Human Diabetic-Lipotoxic Cardiomyopathy and the Effects of Anti-Steatotic PPARgamma-Agonist Therapy: Studies with PET and MRI/MRS

Babak Razani, Washington University School Of Medicine, USA
Short Talk: Cardiac Fatty Acid Synthase Mediates Survival with Acute Stress

09:20—09:40
Coffee Break

Foyer
11:15
On Own for Lunch

16:30—17:00
Coffee Available

Foyer
17:00—19:00
Molecular Mechanisms of Atherosclerosis
Meeting has ended...abstracts no longer viewable online.

Peak 5
Alan R. Tall, Columbia University, USA
Anti-Atherogenic Mechanisms of HDL

* Karin E. Bornfeldt, University of Washington School of Medicine, USA
Diabetes-Accelerated Atherosclerosis: Evidence from a Mouse Model

Edward A. Fisher, New York University School of Medicine, USA
Regulation of Atherosclerosis Regression in Novel Mouse Models and the Effects of Hyperglycemia

Jason Voogt, Amyris Inc, USA
Short Talk: In vivo Effects of Two ApoA-1 Mimetics on Plasma Cholesterol Flux, de novo Cholesterol Synthesis and Reverse Cholesterol Transport

19:00—20:00
Social Hour with Lite Bites

Peaks 1-4
20:00—23:00
Entertainment

Peaks 1-4

SUNDAY, SEPTEMBER 28

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 5R13DK076500-03




We gratefully acknowledge additional support for this conference from:

Seahorse Bioscience, Inc.

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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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