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Fairmont Hotel Vancouver Floorplan

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This meeting took place in 2014


Here are the related meetings in 2015:
Obesity and the Metabolic Syndrome: Mitochondria and Energy Expenditure (X7)

For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

Obesity: A Multisystems Perspective (J2)


Organizer(s) Roger D. Cone, Barbara Cannon and Lee M. Kaplan
January 12—17, 2014
Fairmont Hotel Vancouver • Vancouver, British Columbia Canada
Discounted Abstract Deadline: Oct 4, 2013
Abstract Deadline: Oct 29, 2013
Scholarship Deadline: Oct 4, 2013
Discounted Registration Deadline: Nov 14, 2013

Supported by the Directors' Fund


Summary of Meeting:
This meeting will cover the latest discoveries on the role of multiple organ systems in the process of energy homeostasis and obesity. In addition to the role of the central nervous system and white adipose tissue (WAT) depots, this meeting will examine the role of WAT development, brown fat, the microbiome, gut-brain signaling and circadian rhythms in the development of obesity. Bariatric surgery and the latest pharmaceutical approaches to obesity treatment will also be considered, as will the latest genetic approaches to both common and rare syndromic obesity. Joint sessions with the Keystone Symposia meeting on Challenges and Opportunities in Diabetes Research and Treatment will include “The Role of Brown Adipose Tissue in Thermogenesis and Glucose Uptake” and “Mechanisms Underlying the Efficacy of Bariatric Surgery.” This meeting will bring together a diverse array of leading scientists from the U.S., Europe and Japan to talk about breaking discoveries in a very broad array of physiological processes relevant to obesity and its treatment. The goal of the meeting will be to provide participants with an update on cutting-edge developments in the field, as well as with a broader perspective on the biology of obesity. The anticipated outcome is the development of new, and potentially interdisciplinary, research collaborations and directions.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, JANUARY 12

16:00—20:00
Arrival and Registration


MONDAY, JANUARY 13

07:30—08:30
Breakfast

08:30—09:30
Keynote Session (Joint)
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

C. Ronald Kahn, Joslin Diabetes Center and Harvard Medical School, USA
An Increasing Web of Interactions in Diabetes and Obesity

09:30—10:00
Coffee Break

10:00—12:15
Development of Adipose Tissue
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Christian Wolfrum, Institute of Food Nutrition and Health, Switzerland

Jonathan M. Graff, University of Texas Southwestern Medical Center, USA
Adipose Stem Cells: Give Me a Pill Not a Treadmill

Peter Arner, Karolinska Institutet, Sweden
Bone Marrow as a Source of Adipocytes in Adult Humans

Matt Rodeheffer, Yale University, USA
Cellular Mechanisms of Adipogenesis in vivo

David A. Guertin, University of Massachusetts Medical School, USA
Short Talk: New Insights into the Origins and Programming of Adipocyte Development

Dwight J. Klemm, University of Colorado Denver Anschutz Medical Center, USA
Short Talk: De Novo Generation of Adipocytes from Bone Marrow in Human Adipose Tissue

10:00—12:30
Metabolic Control in Liver
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Masato Kasuga, National Center for Global Health and Medicine, Japan

Rebecca A. Haeusler, Columbia University, USA
Regulation of Metabolic Flux by FoxOs during the Fasting–Refeeding Transition

Morris J. Birnbaum, Pfizer, Inc, USA
The Control of Hepatic Metabolism by Insulin

Kei Sakamoto, Nestlé Institute of Health Sciences SA, Switzerland
LKB1-SIK Signaling Pathway in the Control of Hepatic Gluconeogenesis

David J. Lloyd, Amgen, Inc., USA
Short Talk: Small Molecule Disruption of the GKRP-GK Interaction Accompanied with Glucose Lowering Efficacy

Hans-Ulrich Häring, Eberhard-Karls University Tübingen, Germany
Subphenotypes in Prediabetes: Role of Fatty Liver and Brain Insulin Resistance

12:15—13:00
Poster Setup

13:00—22:00
Poster Viewing

12:15—14:30
On Own for Lunch and Recreation

14:30—16:30
Workshop 1: Obesity Drug Discovery

* Minmin Wang, Lilly China R&D Center, China

Lex H.T. Van der Ploeg, Rhythm Pharmaceuticals, USA
Melanocortin 4 Receptor Agonists for the Treatment of Obesity

David Maggs, GI Dynamics, Inc., USA
Endobarrier Therapy for Obesity and Diabetes

Lotte Bjerre Knudsen, Novo Nordisk A/S, Denmark
Liraglutide Lowers Body Weight through CART, NPY and AgRP

Yong Xu, Baylor College of Medicine, USA
Targeting Hypothalamic Steroid Receptor Co-Activator-1 to Treat Diet-Induced Obesity

Zachary R. Patterson, Carleton University, Canada
Novel GOAT Inhibitor, CF801, Reduces Acylated Ghrelin and Body Weight in C57/BL6J Male Mice: A Potential Treatment for Obesity Related Disorders

Susan Cellitti, Genomics Institute of the Novartis Research Foundation, USA
A Novel GLP-1-FGF21 Fusion Protein for the Treatment of Diabetes and Obesity

14:30—16:30
Workshop 1: Inflammation and Insulin Sensitivity

* Anna Krook, Karolinska Institutet, Sweden

Tine Hannibal, University of Copenhagen, Denmark
Investigating the Role of Plasmacytoid Dendritic Cells in Inflammation Associated with Diabetes

Jan Mauer, Max Planck Institute for Neurological Research, Germany
Novel Aspects of Macrophage IL-6-Signaling in Obesity-Associated Inflammation

Tadasuke Komori, Wakayama Medical University, Japan
Oncostatin M Protects against Obesity and Related Metabolic Disorders in Mice

Aurèle Besse-Patin, Institut de Recherches Cliniques de Montréal, IRCM, Canada
Loss of Pgc-1alpha Expression in Aging Mouse Muscle Potentiates Glucose Intolerance and Systemic Inflammation

Yan-Shan Dai, Central South University, China
NFATc3 Is Required for Pancreatic beta-Cell Function and Adipose Tissue Inflammation

Darren C. Henstridge, Baker IDI Heart and Diabetes Institute, Australia
HSP72 Prevents Peripheral Tissue Lipotoxicity and Preserves Insulin Sensitivity by Increasing Oxidative Metabolism in Skeletal Muscle

16:30—17:00
Coffee Available

17:00—19:15
Role of Brown Adipose Tissue in Thermogenesis and Glucose Uptake (Joint)
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Jan Nedergaard, Stockholm University, Sweden

* Alexander S. Banks, Harvard Medical School, USA

Barbara Cannon, Stockholm University, Sweden
Brown adipose tissue and thermogenesis

Joerg Heeren, University Medical Center Hamburg-Eppendorf, Germany
Brown Adipose Tissue and a Potential Role in Resolution of the Metabolic Syndrome

Masayuki Saito, Tenshi College, Japan
Brown Adipose Tissue as a Regulator of Energy Expenditure and Body Fatness in Humans

Antonio J. Vidal-Puig, University of Cambridge, UK
BMP8b and Thermogenesis

19:15—20:15
Social Hour with Lite Bites

19:30—22:00
Poster Session 1


TUESDAY, JANUARY 14

07:30—08:30
Breakfast

08:00—08:30
Poster Setup

08:30—19:00
Poster Viewing

08:30—11:45
Mechanisms Underlying the Efficacy of Bariatric Surgery (Joint)
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* C. Ronald Kahn, Joslin Diabetes Center and Harvard Medical School, USA

* Laurent Gautron, University of Texas Southwestern Medical Center, USA

Lee M. Kaplan, Massachusetts General Hospital, USA
Molecular Mechanisms of Response to Roux-en-Y Gastric Bypass

Blandine Laferrère, St. Luke's-Roosevelt, Columbia University, USA
Mechanism of Diabetes Remission after Gastric Bypass Surgery: Not Just Weight Loss

Carel Le Roux, University College Dublin, Ireland
Gastro Intestinal Regulation of Appetitive Drives

Hans-Rudolf Berthoud, Pennington Biomedical Research Center, USA
Neural Mechanisms of Gastric Bypass

Nicholas Stylopoulos, Harvard Medical School and Boston Children's Hospital, USA
Short Talk: Bypassing Diabetes by Reprogramming Intestinal Metabolism

Thomas Alexander Lutz, University of Zürich, Switzerland
Short Talk: GLP-1 Contributes to Improved Vascular Reactivity after Roux-en-Y Gastric Bypass Surgery (RYGB)

09:50—10:10
Coffee Break

11:45—12:30
Lunch

12:00—14:30
Poster Session 2

14:30—16:30
Workshop 2: Hypothalamic Development and Maternal Effects

Richard B. Simerly, University of Southern California, USA
Hypothalamic Development

Kevin L. Grove, Novo Nordisk and Oregon National Primate Research Center, USA
Effects of Maternal Overnutrition

Lori M. Zeltser, Columbia University, USA
Early Intervention in a Mouse Model of Childhood Obesity

* William F. Colmers, University of Alberta, Canada
Talk Title Unknown

Sebastien G. Bouret, University of Southern California, USA
Molecular Mechanisms Involved in Hypothalamic Development

14:30—16:30
Workshop 2: Advances in the Diabetes Drug Pipeline

Avirup Bose, Novartis Institutes for Biomedical Research Inc., USA
FGF21 Pharmacology: Implications for T2D and Beyond?

Philip J. Larsen, Sanofi-Aventis, Germany
Diabetes Therapy of Tomorrow: Beyond Glycemic Control

Anish Konkar, MedImmune, Inc., USA
Leveraging Gut Peptides for the Treatment of Type 2 Diabetes

* Cristina M. Rondinone, MedImmune, USA
Biologics: The Future of Cardiometabolic Medicines?

Alessandro Pocai, Janssen, Pharmaceutical Companies of Johnson & Johnson, USA
Glucagon Agonism to Treat Diabetes

Yoshiyuki Tsujihata, Takeda Pharmaceutical Company, Ltd., Japan
Efficacy of Mono and Combination Therapy with GPR40/FFAR1 Agonist Fasiglifam in Animal Models Suggest Potential New Treatment for Type 2 Diabetes

* Bei B. Zhang, Lilly China Research and Development Co., Ltd., China
Challenges and Opportunities in Diabetes Drug Discovery

16:30—17:00
Coffee Available

17:00—18:45
Role of the Gut Microbiota in Obesity and Metabolic Disorders
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Helen Cox, King's College London, UK

Frank J. Gonzalez, National Institutes of Health, USA
Microbiome and Intestinal Farnesoid X Receptor in the Control of Obesity

Martin J. Blaser, New York University School of Medicine, USA
Effects of Early Life Antibiotics on Developmental Phenotypes

Patrice D. Cani, Université Catholique de Louvain, Belgium
Cross-Talks between Host Intestinal Epithelial Cells and Gut Microbes Controls Energy Homeostasis

17:00—18:45
Diabetes and Neurodegenerative Disorders
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Morris F. White, Boston Children's Hospital, Harvard Medical School, USA
IRS Signaling Balances Metabolic Homeostasis and Neurodegeneration

Linda Partridge, Max Planck Institute for Biology of Ageing, Germany
Nutrient-Sensing Pathways and Aging

Ana Maria Cuervo, Albert Einstein College of Medicine, USA
The Dual Function of Autophagy in Aging and Age-Related Disorders

18:45—
On Own for Dinner


WEDNESDAY, JANUARY 15

07:30—08:30
Breakfast

08:30—11:45
Genetics of Obesity and Metabolic Traits
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Elizabeth K. Speliotes, University of Michigan, USA

Struan F. A. Grant, Children’s Hospital of Philadelphia Research Institute, USA
Genetics of Common Paediatric Obesity

Cristen J. Willer, University of Michigan, USA
Genetic Architecture of Obesity: Lessons Learned from Lipids

I. Sadaf Farooqi, University of Cambridge, UK
Genetic Basis of Severe Obesity

Abhimanyu Garg, University of Texas Southwestern Medical Center, USA
Genetic Basis of Lipodystrophies

Marcelo Nobrega, University of Chicago, USA
Short Talk: Obesity-Associated Variants within FTO Form Long-Range Functional Connections with IRX3

Christopher Lelliott, Wellcome Trust Sanger Institute, UK
Short Talk: Discovery of Novel Genes Relevant for Metabolic Homeostasis by the Sanger Mouse Genetics Project

08:30—11:30
Nutrigenomics
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Simeon Taylor, University of Maryland School of Medicine, USA

Christopher B. Newgard, Duke University Medical Center, USA
Intermediary Metabolism and Insulin Resistance

Murielle M. Veniant, Amgen Inc., USA
FGF21, a Potential Therapeutic for Type 2 Diabetes

Feifan Guo, Institutes for Nutritional Sciences, Sibs, CAS, China
Branched Chain Amino Acids and Metabolic Signaling

Wataru Ogawa, Kobe University, Japan
Novel Variants of PGC1alpha and Muscle Energy Efficiency

Alexander S. Banks, Harvard Medical School, USA
Short Talk: Both Erk and Cdk5 Kinases Control the Diabetogenic Actions of PPARgamma

Christian Bjorbaek, Beth Israel Deaconess Medical Center, USA
Short Talk: Hypothalamic AgRP Neurons and the Central Melanocortin System are Mediators of Leptin’s Anti-Diabetic Actions

09:50—10:10
Coffee Break

11:45—13:00
Poster Setup

13:00—22:00
Poster Viewing

11:45—17:00
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

17:00—19:00
CNS Control of Energy Homeostasis
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Jens C. Brüning, Max Planck Institute for Metabolism Research, Germany

Scott Sternson, HHMI/Janelia Farm Research Campus, USA
Neural Circuits that Control Feeding Behavior

Roger D. Cone, Vanderbilt University, USA
Novel Allosteric Modulators and Signaling Modalities of the Melanocortin-4 Receptor

Michael Rosenbaum, Columbia University Medical College, USA
Leptin Depletion and Repletion

Peter K. Jackson, Stanford University, USA
Short Talk: Neuropeptide Y Family Receptors Traffic via the Bardet-Biedl Syndromepathway to Signal in Neuronal Primary Cilia

17:00—19:00
Insulin Sensitivity in the CV System
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Juleen R. Zierath, Karolinska Institutet, Sweden

Alan R. Tall, Columbia University, USA
Diabetes and Obesity Promote Myelopoiesis and Atherogenesis

E. Dale Abel, University of Iowa, Carver College of Medicine, USA
Myocardial Insulin Signaling, Hyperinsulinemia and Heart Failure

Sekar Kathiresan, Massachusetts General Hospital, USA
Diabetes and Cardiovascular Disease: Is there a Causal Link in Humans?

In-Kyu Lee, Kyungpook National University Hospital, South Korea
Short Talk: The Role of PDK4 in Vascular Calcification

19:00—20:00
Social Hour with Lite Bites

19:30—22:00
Poster Session 3


THURSDAY, JANUARY 16

07:30—08:30
Breakfast

08:30—11:45
Circadian Rhythms, Obesity and Metabolic Disorders
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Joseph T. Bass, Northwestern University, USA
Circadian Integration of Mitochondrial Oxidative Function and Behavior

Eve Van Cauter, University of Chicago, USA
Sleep Disturbances and Obesity

* Satchidananda Panda, The Salk Institute for Biological Studies, USA
Rhythmic Feeding and Fasting Prevents Metabolic Diseases in Mice

Joseph S. Takahashi, HHMI/University of Texas Southwestern Medical Center, USA
Molecular Mechanisms of the Mammalian Circadian Clock

Zach Philip Gerhart-Hines, University of Pennsylvania, USA
Short Talk: The Nuclear Receptor Rev-erb? Controls Circadian Thermogenic Plasticity

Rosa van den Berg, Leiden University Medical Center, Netherlands
Short Talk: Circadian Rhythm Modulates Body Fat Mass through Regulation of Brown Adipose Tissue Function

08:30—11:30
Diabetes and Cancer
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Lily Q. Dong, University of Texas Health Science Center, USA

Derek Leroith, Mount Sinai School of Medicine, USA
Diabetes and Cancer: The Role of Insulin and IGFs

Timothy E. McGraw, Weill Medical College of Cornell University, USA
Cancer Metabolism

Kathryn E. Wellen, University of Pennsylvania, USA
Metabolic Reprogramming in Cancer Cells: Links to the Epigenome

Li Qiang, Columbia University Medical Center, USA
Short Talk: Deficiency of Deleted in Breast Cancer 1 Increases Risks for Metabolic Disorders through Activation of Stearoyl-Coenzyme A Desaturase 1

11:45—12:30
Joint Workshop: NIH Funding Opportunities through NIDDK

Carol Renfrew Haft, NIDDK, National Institutes of Health, USA

Aaron Pawlyk, NIDDK, National Institutes of Health, USA

09:50—10:10
Coffee Break

12:30—14:30
On Own for Lunch and Recreation

14:30—16:30
Workshop 3: Late Breaking Results

* Lora K. Heisler, University of Aberdeen, UK

Brian Finan, Helmholtz Center Munich, Germany
Molecular Cold Mimicry via TRPM8 Modulation Amplifies Thermogenesis by Influencing the Adrenergic Axis

Diego V. Bohórquez, Duke University Medical Center, USA
A Gut-Brain Neurocircuit Unveiled

Jayne F. Martin Carli, Columbia University Medical Center, USA
Functional Analysis of Potential Modifiers of Leptin Production Identified by GWAS

Chen Liu, University of Texas Southwestern Medical Center, USA
A Paradoxical Orexigenic 5HT2CR Circuit in Forebrain Sim1 Neurons

Joseph H. Nadeau, Pacific Northwest Research Institute, USA
Fractal Genetics, Gene Interactions and Systems Properties of Diet Induced Metabolic Conditions

Maja Storm Engelstoft, Copenhagen University, Denmark
Identical Nutrient Metabolite Sensors Stimulate GLP-1 Release and Inhibit Ghrelin Release through Differential, Cell-Specific G Protein Coupling

Eugenia Morselli, University of Texas Southwestern Medical Center, USA
Hypothalamic PGC-1alpha Protects against High Fat Diet Exposure by Regulating ER alpha

Arian F. Baquero, Oregon National Primate Research Center, USA
ATP-Sensitive Potassium Channels (KATP) Are Essential for the Switch in Leptin Signaling to its Inhibitory Actions on NPY/AgRP Neurons during Development

16:30—17:00
Coffee Available

17:00—19:15
All Kinds of -kines
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Sheila Collins, Sanford-Burnham Medical Research Institute, USA

Steven A. Kliewer, University of Texas Southwestern Medical Center, USA
FGF21: From Feast to Famine to Pharmacology

Ruth E. Gimeno, Eli Lilly & Company, USA
Secreted Proteins as Therapeutic Targets for Metabolic Disorders

Jaemyoung Suh, The Salk Institute for Biological Studies, USA
New Roles for FGF1 in Metabolic Homeostasis and Insulin Sensitization

Rajesh R. Rao, Dana-Farber Cancer Institute/Harvard Medical School, USA
Short Talk: Identification of a Novel PGC-1alpha4-Dependent Myokine that Regulates Adipose Tissue Thermogenesis, Energy Homeostasis and Inflammation

Nicholas Douris, Beth Israel Deaconess Medical Center, Harvard Medical School, USA
Short Talk: The Sympathetic Nervous System Mediates Systemic Adaptation to the Ketogenic Diet

17:00—19:00
Approaches to Beta Cell Failure in Type 2 Diabetes
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Susumu Seino, Kobe University Graduate School of Medicine, Japan
Cell Signaling in Insulin Secretion: Novel Mechanisms of cAMP Action

Domenico Accili, Columbia University, USA
beta-Cell Dedifferentiation and beta-Cell Failure

* Andrew F. Stewart, Mount Sinai School of Medicine, USA
Beta Cell Expansion Strategies

Tsai-Hsiu Tess Lu, Max-Planck Institute of Immunobiology and Epigenetics, Germany
Short Talk: PRC2 Stabilizes Functional Beta-Cell Transcriptional Program and Prevents Terminal Dedifferentiation

19:00—20:00
Social Hour with Lite Bites

20:00—23:00
Entertainment


FRIDAY, JANUARY 17

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge additional support for this conference from:

AdipoGen International Research Diets, Inc.

We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 5R13DK084688-05

The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Biochemical Society / Biochemical Journal

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Amanda Deem, Assistant Director of Development, Email: AmandaD@keystonesymposia.org,
Phone:+1 970-262-2668

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676