Keystone Resort Floorplan

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This meeting took place in 2018


Here are the related meetings in 2019:
Neurodegenerative Diseases: New Insights and Therapeutic Opportunities (Z2)

For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

Advances in Neurodegenerative Disease Research and Therapy (Z3)


Organizer(s) Li Gan, Leonard Petrucelli and Morgan H. Sheng
June 17—21, 2018
Keystone Resort • Keystone, Colorado USA
Discounted Abstract Deadline: Feb 15, 2018
Abstract Deadline: Mar 15, 2018
Scholarship Deadline: Feb 15, 2018
Discounted Registration Deadline: Apr 18, 2018

Sponsored by Ionis Pharmaceuticals, Inc., Merck & Co., Inc., Nestlé Institute of Health Sciences, Roche and Takeda Pharmaceutical Company Limited


Summary of Meeting:
As the world population ages, neurodegenerative diseases are becoming the new epidemic in both developed and developing countries. Progress made in human genetics has revealed increasingly more disease-associated genes for Alzheimer’s disease (AD), Parkinson’s disease (PD), Frontotemoral dementia (FTD), amyotrophic lateral sclerosis (ALS) and other neurodegenerative disorders. These discoveries have linked neurodegenerative diseases with several common key biological processes that have so far been under-studied, including RNA metabolism, protein trafficking and innate immune responses. By focusing on these emerging areas in neurodegenerative disease research, this conference seeks to challenge the current research paradigms and to inspire in-depth discussion and exploration. The program assembles leaders from various fields to facilitate interactions between groups using diverse approaches, by providing a platform to cross-fertilize ideas and to encourage new collaborations that could lead to novel mechanisms and therapeutic targets against neurodegenerative diseases.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


The meeting will begin on Sunday, June 17 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, June 21 with a closing plenary session from 17:00 to 19:15, followed by a social hour and entertainment. We recommend return travel on Friday, June 22 in order to fully experience the meeting.

SUNDAY, JUNE 17

16:00—20:00
Arrival and Registration

Longs Peak Foyer
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Longs Peak Foyer

MONDAY, JUNE 18

07:30—08:30
Breakfast

Colorado Rockies Ballroom
08:30—09:30
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online.

Quandary Peak
* Li Gan, University of California, San Francisco, USA

Huda Y. Zoghbi, HHMI/Baylor College of Medicine, USA
Insights From Rare Disorders Shed Light on Common Neurodegenerative Diseases

08:30—09:30
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online.

Grays/Longs Peak
* Marco Prinz, University of Freiburg, Germany

Dorian B. McGavern, NINDS, National Institutes of Health, USA
CNS Myeloid Cell Dynamics Under Steady State and Inflammatory Conditions

09:30—12:00
Genetics to Epigenetics in Neurodegenerative Diseases
Meeting has ended...abstracts no longer viewable online.

Quandary Peak
* Leonard Petrucelli, Mayo Clinic Jacksonville, USA

John Hardy, University College London, Institute of Neurology, UK
Genomics and Pathways to Neurodegeneration

Coffee Break

Catherine Marquer, Columbia University, USA
Short Talk: Excess Synaptojanin 1 Drives Age-Dependent Cognitive Deficits, a Unifying Mechanism for Individuals at High Risk of Alzheimer's Disease

Alison Goate, Mount Sinai School of Medicine, USA
Genetic Studies Implicate Microglial Function in Alzheimer's Disease Risk

Li-Huei Tsai, Massachusetts Institute of Technology, USA
Transcriptomic Analysis at Single Cell Resolution in Neurodegeneration

John D. Fryer, Mayo Clinic, USA
Short Talk: Translational Profiling of Microglia Reveals a Shared apoE Pathway Common to Aging, Amyloid and Tau Pathology

09:30—12:00
Immune Privilege, Blood-Brain Barrier and Microglia I
Meeting has ended...abstracts no longer viewable online.

Grays/Longs Peak
* Knut Biber, AbbVie Deutschland GmbH & Co. KG, Germany

Josef Priller, Charité – Universitätsmedizin Berlin, Germany
From Bone Marrow to Brain: How Myeloid Cells Can Enter the CNS

Coffee Break

Jonathan Kipnis, University of Virginia, USA
Lymphatics in the CNS and Their Role in Neurological Diseases

Richard Daneman, University of California, San Diego, USA
Regulation of the Blood-Brain Barrier in Health and Disease

Karen De Vlaminck, Vrije Universiteit Brussel, Belgium
Short Talk: The Fate and Dynamics of Microglia, Border Macrophages and Infiltrating Monocytes during the Onset and Resolution of Infectious Neuroinflammation

Cayce Dorrier, University of California, San Diego, USA
Short Talk: The Role of the Fibrotic Scar in Repair following Neuroinflammation

12:00—17:00
On Own for Lunch

12:00—13:00
Poster Setup

Colorado Rockies Ballroom
13:00—22:00
Poster Viewing

Colorado Rockies Ballroom
16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Aging in Health and Disease
Meeting has ended...abstracts no longer viewable online.

Quandary Peak
* Morgan H. Sheng, Genentech, Inc., USA

Andrew G. Dillin, University of California, Berkeley, USA
Aging in Protein, Homeostasis and Stress

Ana Maria Cuervo, Albert Einstein College of Medicine, USA
Contribution of Aging of Selective Autophagy to Neurodegeneration

Tony Wyss-Coray, Stanford University School of Medicine, USA
Dissecting the Role of Cerebrovascular Dysfunction in Brain Aging

Edward Giniger, NINDS, National Institutes of Health, USA
Short Talk: Separating the Roles of Autophagy, Immunity and Aging in Neurodegeneration

17:00—19:00
Immune Privilege, Blood-Brain Barrier and Microglia II
Meeting has ended...abstracts no longer viewable online.

Grays/Longs Peak
* Bart J.L. Eggen, University Medical Center Groningen, Netherlands

Marco Prinz, University of Freiburg, Germany
Myeloid Cell Activation and Kinetics in the Brain

Doron Merkler, University of Geneva, Switzerland
Interaction between Neurons, Phagocytes and T Cells in Neuroinflammation

Michal Schwartz, Weizmann Institute of Science, Israel
Fighting Alzheimer's Disease by Unleashing the Innate and Adaptive Immune Cells

Zhen Xu, Shenzhen University, China
Short Talk: Repopulated Microglia Are Solely Derived from the Proliferation of Residual Microglia after Acute Depletion

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Colorado Rockies Ballroom
19:30—22:00
Poster Session 1

Colorado Rockies Ballroom

TUESDAY, JUNE 19

07:30—08:30
Breakfast

Colorado Rockies Ballroom
08:30—11:45
Innate Immunity
Meeting has ended...abstracts no longer viewable online.

Quandary Peak
* David M. Holtzman, Washington University, USA

Adriano M. Aguzzi, University Hospital of Zürich, Switzerland
Protein Aggregation and Pathways of Toxicity

Christian Haass, Ludwig-Maximilians University Munich, Germany
Loss of TREM2 Function Increases Amyloid Seeding but Reduces Plaque-Associated ApoE

Matthew A. Cooper, University of Queensland, Australia
Short Talk: Pharmacological Inhibition of the NLRP3 Inflammasome Prevents Synuclein Pathology and Dopaminergic Degeneration in Parkinson's Disease

Coffee Break

Christopher K. Glass, University of California, San Diego, USA
Genomic Approaches to Dissect Innate Immunity in Neurodegeneration

Li Gan, University of California, San Francisco, USA
Microglia in Tau Proteostasis and Toxicity

Andrew B. West, University of Alabama at Birmingham, USA
Short Talk: LRRK2 Mediates the Recruitment of Monocyte-Derived Macrophages to the Brain in Neurodegeneration

08:30—11:45
Cross-Talk of Microglia with Other CNS Cells
Meeting has ended...abstracts no longer viewable online.

Grays/Longs Peak
* Katrin Kierdorf, Uniklinik Freiburg, Germany

Mikael Simons, Technische Universität München, Germany
Cholesterol Metabolisms as Key Regulator of Phagocyte Function during Remyelination

Francisco J. Quintana, Harvard Medical School, USA
Astrocytes and Microglia

Coffee Break

Anna Victoria Molofsky, University of California, San Francisco, USA
Astrocyte-Microglial Communication in Developmental Synapse Remodeling

Burkhard Becher, University of Zurich, Switzerland
T Cell Entry into the CNS: How Myelin Is Presented

Courtney Malo, Mayo Clinic, USA
Short Talk: MHC Class I Expression by Microglia Is Required for Generating a Complete Antigen-Specific CD8 T Cell Response in the CNS

Phi T. Nguyen, University of California, San Francisco, USA
Short Talk: The IL-33-IL1RL1 Signaling Axis Coordinates Remodeling and Integration of Adult-Born Neurons in the Hippocampus

11:45—17:00
On Own for Lunch

11:45—13:00
Poster Setup

Colorado Rockies Ballroom
13:00—22:00
Poster Viewing

Colorado Rockies Ballroom
16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Neuronal and Network Dysfunction in Neurodegeneration
Meeting has ended...abstracts no longer viewable online.

Quandary Peak
* Li-Huei Tsai, Massachusetts Institute of Technology, USA

Huaxi Xu, Sanford Burnham Prebys Medical Discovery Institute, USA
A Novel Mechanism for Memory/Synaptic Dysfunction in Tauopathy

Zayd M. Khaliq, NINDS, National Institutes of Health, USA
Dendritic Ca2+ Signaling in Substantia Nigra Dopamine Neuron Subpopulations

Morgan H. Sheng, Genentech, Inc., USA
Mechanisms of Synapse Loss Revealed by Proteomic Analysis of Post-Synaptic Density in Tauopathy Mouse Model

Keran Ma, University of California, San Francisco, USA
Short Talk: Nav1.1-Overexpressing Interneuron Transplants Restore Brain Rhythms and Cognition in a Mouse Model of Alzheimer's Disease

17:00—19:00
Myeloid Cells and Neuroinflammation
Meeting has ended...abstracts no longer viewable online.

Grays/Longs Peak
* Erik H.W.G.M. Boddeke, University of Groningen, Netherlands

Masaaki Murakami, Hokkaido University, Japan
Neural Stimulations Modulate the Formation of Immune Cell Gateways into the CNS

Akihiko Yoshimura, Keio University, Japan
Regulation of Inflammation after Stroke by Macrophages and Regulatory T Cells

Robyn S. Klein, Washington University School of Medicine, USA
Trm-Derived IFNg Causes Microglial-Mediated Spatial Learning Defects during Recovery from Differentially Neurotropic Flaviviruses

Kevin G. Burfeind, Oregon Health & Science University, USA
Short Talk: Infiltrating Myeloid Cells in the Central Nervous System Mediate Cancer Cachexia

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Colorado Rockies Ballroom
19:30—22:00
Poster Session 2

Colorado Rockies Ballroom

WEDNESDAY, JUNE 20

07:30—08:30
Breakfast

Colorado Rockies Ballroom
08:30—11:45
Protein Trafficking and Degradation
Meeting has ended...abstracts no longer viewable online.

Quandary Peak
* Tony Wyss-Coray, Stanford University School of Medicine, USA

Baris Bingol, Genentech, Inc., USA
Lysosomal Degradation in Parkinson’s Disease

Guojun Bu, Mayo Clinic, USA
Central and Peripheral ApoE4 in Cognition and Dementia

Michael E. Ward, NINDS, National Institutes of Health, USA
Short Talk: Progranulin Mediates Endolysosomal Recruitment of the RNP-Associated Protein ANXA11

Coffee Break

David M. Holtzman, Washington University, USA
Effects of ApoE in Tau-Mediated Neurodegeneration

Jaehong Suh, Harvard Medical School, USA
Short Talk: Role of Ataxin-1 in BACE1 Expression and Axonal Targeting in the Cerebrum

R. Jeremy Nichols, Parkinson's Institute, USA
Short Talk: SQSTM1/p62 Is a Novel Substrate of the Parkinson's Disease Kinase LRRK2 that Activates its Kinase Domain and Enhances Neuronal Toxicity

Naruhiko Sahara, National Institute of Radiological Sciences, Japan
Short Talk: Neuroinflammatory Process during Pathogenesis of Tauopathy in rTg4510 Mice

08:30—11:45
Imaging of the Healthy and Diseased CNS
Meeting has ended...abstracts no longer viewable online.

Grays/Longs Peak
* Sophia Bardehle, Merck, USA

Wenbiao Gan, Skirball Institute Program of Molecular Neurobiology, USA
The Role of Microglia in Learning-Dependent Synaptic Plasticity

Martin Kerschensteiner, Ludwig Maximilians University Munich, Germany
In vivo Analysis of Phagocyte Phenotypes and Effector Function

Coffee Break

Melanie Meyer-Luehmann, University of Freiburg, Germany
Microglia Contribution to the Propagation of Abeta Pathology

Francesca Peri, European Molecular Biology Laboratory, Germany
Microglia and Neuronal Interactions

Anna Mechling, Roche Innovation Center Basel, Hoffmann-La Roche Ltd., Switzerland
Short Talk: Pivotal Role of Microglial TREM2 in Remyelination as Revealed by Multiparametric Magnetic Resonance Imaging in the Cuprizone Mouse Model

Vijayasree V. Giridharan, University of Texas Health Science Center, USA
Short Talk: Imaging of Microglial Activation in Experimental Bacterial Meningitis using PET/CT

11:45—17:00
On Own for Lunch

11:45—13:00
Poster Setup

Colorado Rockies Ballroom
13:00—22:00
Poster Viewing

Colorado Rockies Ballroom
16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Disease Modeling
Meeting has ended...abstracts no longer viewable online.

Quandary Peak
* Jeffrey D. Rothstein, Johns Hopkins University, USA

Leslie M. Thompson, University of California, Irvine, USA
A Systems Biology Approach to Understanding ALS Pathogenesis in iPSC-Derived Motor Neurons

Albert R. La Spada, Duke University, USA
Deconstructing Polyglutamine Neurodegeneration: From Pathways of Neuron Demise to Therapeutic Intervention

Yadong Huang, Gladstone Institutes/UCSF, USA
Modeling and Drug Screening of AD Using Patients-Derived iPSCs

Michael Lee, University of Minnesota, USA
Short Talk: Dissociation of Amyloid Dependent Cognitive Deficits and Neurodegeneration

17:00—19:00
Myeloid Cells as Targets of Drug Discovery and Biomarkers
Meeting has ended...abstracts no longer viewable online.

Grays/Longs Peak
* Andrea Crotti, Biogen, USA

Irene Knuesel, Roche Innovation Center Basel, Switzerland
Therapeutic Effects of Anti-Amyloid-Beta Immunotherapy on Myeloid Cell Transcriptome

David R. Owen, Imperial College London, UK
Imaging Microglia in Humans

Paul R. Ormel, University Medical Center Utrecht, Netherlands
Short Talk: Comparison of Three Human Microglia Models to Study Schizophrenia

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Colorado Rockies Ballroom
19:30—22:00
Poster Session 3

Colorado Rockies Ballroom

THURSDAY, JUNE 21

07:30—08:30
Breakfast

Colorado Rockies Ballroom
08:30—11:45
RNA Metabolisms and New Mechanisms of Toxicity
Meeting has ended...abstracts no longer viewable online.

Quandary Peak
* Yadong Huang, Gladstone Institutes/UCSF, USA

Wolfdieter Springer, Mayo Clinic, USA
Short Talk: Relevance of PINK1-Parkin Mitophagy in Stress, Aging and Disease

Christopher D. Link, University of Colorado, USA
Short Talk: Knockdown of TDP-43 in Astrocytes Induces Immune Activation

Jeffrey D. Rothstein, Johns Hopkins University, USA
Nuclear Transport as an Unexpected Fundamental Defect in Familial and Sporadic Neurodegeneration

Zevik Melamed, University of California, San Diego, USA
Short Talk: RNA Processing Alteration and the Link to Neurodegeneration in ALS/FTD

Coffee Break

Leonard Petrucelli, Mayo Clinic Jacksonville, USA
C9 Biology and Biomarkers

Bess Frost, Barshop Institute for Longevity and Aging Studies, USA
Jump Around, Jump Around: Transposable Element Activation in Tauopathy

Xin Qi, Case Western Reserve University, USA
Short Talk: ATAD3A Oligomerization Causes Neurodegeneration by Coupling Mitochondrial Fragmentation and Bioenergetics Defects

08:30—11:45
Myeloid Gene Regulation
Meeting has ended...abstracts no longer viewable online.

Grays/Longs Peak
* Inge R. Holtman, University of California, San Diego, USA

Oleg Butovsky, Harvard Medical School, USA
Dual Faces of Dr. Jekyll Microglia: Degenerating Neurons Cannot "Hyde"

Ido Amit, Weizmann Institute, Israel
The Power of ONE: Immunology in the Age of Single Cell Genomics

Coffee Break

Marco Colonna, Washington University School of Medicine, USA
TREM2, Microglia and Neurodegeneration

Bahareh Ajami, Stanford University School of Medicine, USA
Single-Cell Mass Cytometry Reveals Molecular Signatures of Inflammation in Contrasting Models of Neuroinflammation versus Neurodegeneration

Kendra Lechtenberg, Stanford University, USA
Short Talk: Profiling Microglia-Specific Transcriptional Changes after Ischemic Stroke

Carole Lara Veiga Sousa, Luxembourg Institute of Health, Luxembourg
Short Talk: Molecular Profiling of Microglia in Steady State and Under Inflammatory Conditions at Single-Cell Level

11:45—17:00
On Own for Lunch

14:30—16:30
Workshop: Systems Approach and Functional Genomics

Quandary Peak
* Martin Kampmann, University of California, San Francisco, USA
Elucidating Cellular Mechanisms and Therapeutic Strategies for Neurodegenerative Diseases with CRISPRi and CRISPRa

Taisuke Kato, Niigata University, Japan
Phenotypic Suppression of DRPLA Model Mice using CRISPR / Cas9 System

Jiyoen Kim, Baylor College of Medicine, USA
Identifying Therapeutic Targets for Alzheimer's Disease: A Cross-Species Genetic Screen for Molecules that Lower Tau Levels

Alan E. Renton, Icahn School of Medicine at Mount Sinai, USA
Alzheimer's Disease Sequencing Project: Age Extremes x APOE Genotype Sampling for Genetic Discovery

Tara E. Tracy, University of California, San Francisco, USA
Spatiotemporal Mapping of the Tau Interactome in Human iPSC-Derived Neurons

Tal Nuriel, Columbia University Medical Center, USA
Utilizing Systems Biology Approaches to Elucidate the Effects of APOE4 Expression in an AD-Vulnerable Brain Region

Rakshita A. Charan, University of Pennsylvania, USA
Identification and Characterization of Frontotemporal Dementia Risk Factor TMEM106B Interacting Proteins

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Biomarker and Therapeutics
Meeting has ended...abstracts no longer viewable online.

Quandary Peak
* Li Gan, University of California, San Francisco, USA

David V. Hansen, Genentech, Inc., USA
Short Talk: Assessing and Modulating Microglial Activation States in Alzheimer’s Disease Tissues and Models

Xu Chen, Gladstone Institute of Neurological Disease, USA
Short Talk: Tau Secretion and Propagation is Regulated by p300/CBP via Autophagy-Lysosomal Pathway

C. Frank Bennett, Ionis Pharmaceuticals, Inc., USA
Antisense Oligonucleotide-Based Therapies for Neurological Diseases

Rita Balice-Gordon, Sanofi, Inc., USA
Translational Challenges in Neuroscience Drug Development

Tracy Cole, Ionis Pharmaceuticals, Inc., USA
Short Talk: Human SNCA Antisense Oligonucleotides Reduce CNS and CSF Alpha-Synuclein Levels in a Non-Human Primate Model, Supporting their Use for Treatment of Synucleinopathies

17:00—18:45
Microglia and CNS Diseases
Meeting has ended...abstracts no longer viewable online.

Grays/Longs Peak
* Annett Halle, German Center for Neurodegenerative Diseases, Germany

Shane Antony Liddelow, New York University Langone Medical Center, USA
What Do Reactive Astrocytes Do?

Florent Ginhoux, Singapore Immunology Network, Singapore
Microglia Heterogeneity

Philip L. De Jager, Columbia University Medical Center, USA
The Genetic and Population Architecture of Aged Human Microglia: Role in Accelerating Tau Pathology and Cognitive Decline

19:00—19:15
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Meeting has ended...abstracts no longer viewable online.

Quandary Peak
18:45—19:00
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Meeting has ended...abstracts no longer viewable online.

Grays/Longs Peak
19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Colorado Rockies Ballroom
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Colorado Rockies Ballroom

FRIDAY, JUNE 22

 
Departure


*Session Chair †Invited, not yet responded.


We gratefully acknowledge support for this conference from:


Directors' Fund

These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.

Keystone Symposia thanks our Sponsors for generously supporting this meeting:

Ionis Pharmaceuticals, Inc. Merck & Co., Inc.
Nestlé Institute of Health Sciences Roche
Takeda Pharmaceutical Company Limited
 

We gratefully acknowledge additional support from these exhibitors at this conference:

Alzheimer's Research UK Dementia Consortium
Please stop by to meet these exhibitors during the conference.

We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13NS106976-01

Funding for this conference was made possible (in part) by 1R13NS106976-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


National Institutes of Health

Grant No. 1R13NS106977-01

Funding for this conference was made possible (in part) by 1R13NS106977-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

We gratefully acknowledge additional support for this conference from:

Charles River Tocris Bioscience

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Ionis Pharmaceuticals, Inc.


Sanofi US

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations

If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676