Keystone Symposia Conference | NF-kappaB in Inflammation and Disease

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Tuesday, January 5
3:00 - 7:30 PM	Registration	Zia Concourse
6:30 - 7:30 PM	Refreshments	Zia Concourse
7:30 - 8:30 PM	Keynote Address Registered attendees for this meeting can view Abstracts for this session starting on 12/05/2009	Anasazi Ballroom
	* Michelle A. Kelliher, University of Massachusetts Medical School, USA
	Vishva M. Dixit, Genentech, Inc., USA Deubiquitinases in NF-kappaB Regulation
Wednesday, January 6
7:00 - 8:00 AM	Breakfast	Eldorado Court
8:00 - 11:00 AM	Regulation of the NF-kappaB Pathway Registered attendees for this meeting can view Abstracts for this session starting on 12/05/2009	Anasazi Ballroom
	* Michael Karin, University of California, San Diego, USA
	Zhijian James Chen, University of Texas Southwestern Medical Center, USA Innate Immunity Triggered by Cytosolic DNA and RNA
	Ivan Dikic, Goethe University Medical School, Germany Linear Ubiquitin Binding Domains in NFêB activation
	Kazuhiro Iwai, Osaka University, Japan Short Talk: Linear Polyubiquitination: A Newly Identified Regulator of NF-kappaB Signaling
	David Komander, MRC Laboratory of Molecular Biology, UK Short Talk: Two-Sided Ubiquitin Binding Explains Specificity of the TAB2 NZF Domain
	Hao Wu, Weill Medical College of Cornell University, USA Structural and Functional Analyses of Protein Complexes in Immune and Inflammatory Pathways
9:20 - 9:40 AM	Coffee Break	Zia Concourse
11:00 AM- 1:00 PM	Poster Setup	Sunset Room/Eldorado Court
11:00 AM-	On Own for Lunch and Recreation
1:00 - 10:00 PM	Poster Viewing	Sunset Room/Eldorado Court
2:30 - 4:30 PM	Workshop 1: NF-kappaB Regulation	Anasazi Ballroom
	* Zhijian James Chen, University of Texas Southwestern Medical Center, USA
	Trevor William Siggers, Brigham & Women's Hospital, Harvard Medical School, USA Examining the DNA Binding Specificity Landscape of NF-kB Dimers using Protein-Binding Microarrays
	Noula D. Shembade, University of Miami Sylvester Comprehensive Cancer Centre, USA A20 Downregulates NF-kappaB Signaling by Disrupting E2:E3 Ubiquitin Enzyme Complexes
	Alain Chariot, University of Liege, CHU, Belgium New Insights on the BCL-3 Oncogene through Interactomic Studies
	Mireille Y. Delhase, Nagoya City University Medical School, Japan Insights into the Anti-Apoptotic Function of the Protein Kinase TBK1
	Dirk Brenner, Princess Margaret Hospital, Canada Phosphorylation of CARMA1 by HPK1 is Critical for NF-kappaB Activation in T Cells
	Markus Brechmann, German Cancer Research Center, Germany Genetic Screening for Phosphatases that Regulate NF-kappB Activity in T Lymphocytes
4:30 - 5:00 PM	Coffee Available	Zia Concourse
5:00 - 7:00 PM	Transcriptional Regulation by NF-kappaB Registered attendees for this meeting can view Abstracts for this session starting on 12/05/2009	Anasazi Ballroom
	* David Baltimore, California Institute of Technology, USA
	Gioacchino Natoli, IEO, European Institute of Oncology, Italy The Epigenome and the Control of the NF-kB Transcriptional Responses in Innate Immunity and Inflammation
	Sankar Ghosh, Columbia University, USA Regulation of p65/RelA Transcriptional Activity by IkappaBbeta
	Alexander Hoffmann, University of California, San Diego, USA Short Talk: Two Faces of IkBs in Gene Control: Regulating NFkB Dimer Generation and Dynamic Control of Dimer Activity
	Michael R.H. White, University of Liverpool, UK Short Talk: Control of Gene Expression by NF-kappaB Oscillations: A Source and Function for Cellular Heterogeneity?
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Eldorado Court/Sunset Room
7:30 - 10:00 PM	Poster Session 1 Registered attendees for this meeting can view Abstracts for this session starting on 12/05/2009	Sunset Room/Eldorado Court
Thursday, January 7
7:00 - 8:00 AM	Breakfast	Eldorado Court
8:00 - 11:00 AM	Innate Immune Receptor Signaling to NF-kappaB Registered attendees for this meeting can view Abstracts for this session starting on 12/05/2009	Anasazi Ballroom
	* Vishva M. Dixit, Genentech, Inc., USA
	Jürg Tschopp, University of Lausanne, Switzerland The NALP3 Inflammasome: A Sensor for Metabolic Danger
	Michelle A. Kelliher, University of Massachusetts Medical School, USA Rip Proteins in Innate Immune Responses
	Laurence Arbibe, Institut Pasteur, France Innate Immune Subversion by Chromatin Manipulation: A New Face of Host-Bacterial Pathogen Interaction
	Jun-Ichiro Inoue, Institute of Medical Science, University of Tokyo, Japan Short Talk: Two Mechanistically and Temporally Distinct NF-kappaB Activation Pathways in IL-1 Signaling
	Mikyoung Chang, MD Anderson Cancer Center, USA Short Talk: Peli1 Facilitates TRIF-Dependent Toll-like Receptor Signaling and Proinflammatory Cytokine Production
9:20 - 9:40 AM	Coffee Break	Zia Concourse
11:00 AM- 1:00 PM	Poster Setup	Sunset Room/Eldorado Court
11:00 AM-	On Own for Lunch and Recreation
1:00 - 10:00 PM	Poster Viewing	Sunset Room/Eldorado Court
2:30 - 4:30 PM	Workshop 2: NF-kappaB and Innate Immunity	Anasazi Ballroom
	* Gioacchino Natoli, IEO, European Institute of Oncology, Italy
	Ido Amit, Massachusetts Institute of Technology, USA Unbiased Reconstruction of a Mammalian Transcriptional Network Mediating Pathogen Responses
	Mathieu J.M. Bertrand, VIB / Ghent University, Belgium Cellular Inhibitors of Apoptosis cIAP1 and cIAP2 are Required for Innate Immunity Signaling by the Pattern Recognition Receptors NOD1 and NOD2
	Ee Tsin Wong, Institute of Molecular and Cell Biology, Singapore Identification of a Factor Essential for Toll-like Receptor Signaling
	Christine S. Cheng, University of California, San Diego, USA The NF-kappaB p50 Homodimer is a Regulator of Interferon Regulatory Elements (IRE) and Anti-Viral Innate Immune Responses
	Marc Riemann, Leibniz Institute for Age Research - Fritz Lipmann Institute, Germany Role of RelA and RelB in Medullary Thymic Epithelial Cells for the Establishment of Immunological Self-Tolerance
	Lawrence P. Kane, University of Pittsburgh, USA Recruitment of the IKK Complex to TCR Microclusters during T Cell Activation
4:30 - 5:00 PM	Coffee Available	Zia Concourse
5:00 - 7:00 PM	NF-kappaB in the Immune Response Registered attendees for this meeting can view Abstracts for this session starting on 12/05/2009	Anasazi Ballroom
	* Sankar Ghosh, Columbia University, USA
	David Baltimore, California Institute of Technology, USA MicroRNAs and Regulation of NF-kB
	Margot Thome, University of Lausanne, Switzerland Role of the MALT1 Protease Activity in Lymphocyte Activation and Lymphoma Development
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Eldorado Court/Sunset Room
7:30 - 10:00 PM	Poster Session 2 Registered attendees for this meeting can view Abstracts for this session starting on 12/05/2009	Sunset Room/Eldorado Court
Friday, January 8
7:00 - 8:00 AM	Breakfast	Eldorado Court
8:00 - 11:00 AM	NF-kappaB in Disease Registered attendees for this meeting can view Abstracts for this session starting on 12/05/2009	Anasazi Ballroom
	* Jürg Tschopp, University of Lausanne, Switzerland
	Manolis Pasparakis, University of Cologne, Germany IKK/NF-kappaB Signaling in Mouse Models of Inflammatory Disease
	Jorge Moscat, University of Cincinnati College of Medicine, USA The p62/aPKC Regulation of NF-kappaB in Cancer and Obesity-Induced Inflammation
	Etienne Meylan, Koch Institute for Integrative Cancer Research at MIT, USA NF-kappaB Signaling in a Mouse Model of Lung Adenocarcinoma
	Daniela S. Basseres, University of North Carolina at Chapel Hill, USA Role of p65/RelA in Ras-Induced Lung Tumorigenesis
9:20 - 9:40 AM	Coffee Break	Zia Concourse
11:00 AM- 1:00 PM	Poster Setup	Sunset Room/Eldorado Court
11:00 AM-	On Own for Lunch and Recreation
1:00 - 10:00 PM	Poster Viewing	Sunset Room/Eldorado Court
4:30 - 5:00 PM	Coffee Available	Zia Concourse
5:00 - 7:00 PM	NF-kappaB and Inhibitors in Preclinical Models Registered attendees for this meeting can view Abstracts for this session starting on 12/05/2009	Anasazi Ballroom
	* Inder M. Verma, The Salk Institute, USA NF-kB: Regulation and Function
	Steven E. Shoelson, Harvard Medical School, Joslin Diabetes Center, USA Roles of NF-kappaB in the Pathogenesis and Potential Treatment of Type 2 Diabetes
	Friedrich Thaiss, University Hospital, Germany Short Talk: Resolution of Renal Inflammation: A New Role for IKK2/ NF-kappaB Pathway in Nephrotoxic Nephritis
	Lih-Ling Lin, Pfizer Pharmaceuticals, USA Targeting TPL-2 and IKK-2 for Treating Rheumatoid Arthritis
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Eldorado Court/Sunset Room
7:30 - 10:00 PM	Poster Session 3 Registered attendees for this meeting can view Abstracts for this session starting on 12/05/2009	Sunset Room/Eldorado Court
Saturday, January 9
7:00 - 8:00 AM	Breakfast	Eldorado Court
8:00 - 11:00 AM	NF-kappaB and Cancer Registered attendees for this meeting can view Abstracts for this session starting on 12/05/2009	Anasazi Ballroom
	Michael Karin, University of California, San Diego, USA IKK Signaling in Cancer
	Yinon M. Ben-Neriah, Hebrew University, Hadassah Medical School, Israel Intricate Control of the p53 Tumor Suppressor Function in the Gut via an Inflammatory Response
	William C. Hahn, Harvard Medical School, USA Non-Canonical IKB Kinases and Cancer
	Laura Pasqualucci, Columbia University, USA Mutations of Multiple Signaling Proteins Deregulate NF-kappaB in Diffuse Large B-Cell Lymphoma
9:20 - 9:40 AM	Coffee Break	Zia Concourse
11:00 AM-	On Own for Lunch and Recreation
2:30 - 4:30 PM	Workshop 3: NF-kappaB in Disease Pathogenesis	Anasazi Ballroom
	* Yinon M. Ben-Neriah, Hebrew University, Hadassah Medical School, Israel
	Michael Lattke, Ulm University, Germany Astrocyte-Specific IKK2 Activation is Sufficient to Induce Neuroinflammation and Results in Impaired Brain Development
	Daniel Starczynowski, BC Cancer Research Centre, Canada miR-145 and miR-146a Mediate the Pathogenesis of 5q- Syndrome by Targeting TRAF6 Signaling
	Paul D. Robbins, University of Pittsburgh, USA Role of IKK/NF-kappaB in Aging
	Geert van Loo, VIB-Ghent University, Belgium Study of A20/tnfaip3 in Mouse Models of Inflammatory Disease
	Dietrich B. Conze, National Cancer Institute, National Institutes of Health, USA Non-Canonical NF-kappB Activation and Abnormal B Cell Accumulation in Mice Expressing Ubiquitin Protein Ligase-Inactive c-IAP2
	Zhaohui Wu, University of Tennessee Health Science Center, USA ATM-Dependent ELKS Ubiquitination Coordinates TAK1-Mediated IKK Activation upon Genotoxic Stress
4:30 - 5:00 PM	Coffee Available	Zia Concourse
5:00 - 7:15 PM	NF-kappaB Response to Genotoxic and Oxidative Stress Registered attendees for this meeting can view Abstracts for this session starting on 12/05/2009	Anasazi Ballroom
	* Michelle A. Kelliher, University of Massachusetts Medical School, USA
	Martin Krönke, Institute of Medical Microbiology, Immunology and Hygiene, Germany TNF Signaling and Regulation of ROS Production
	Richard M. Siegel, National Institutes of Health, USA ROS and Abnormal TNFR1 Signaling in TRAPS
	Renée Johnson, University of Bristol, UK Short Talk: RelA and Mortalin: A Role for NF-kappaB in the Regulation of Mitochondrial Function
	Claus Scheidereit, Max Delbrück Center for Molecular Medicine, Germany Short Talk: Mechanism of IKK Activation by Genotoxic Stress
	Shigeki Miyamoto, University of Wisconsin-Madison, USA Short Talk: SUMO and SUMO Protease Regulation of NF-kB Signaling by DNA Damage
	Manolis Pasparakis, University of Cologne, Germany Concluding Remarks
7:15 - 8:15 PM	Social Hour w/ Lite Bites	Eldorado Court/Sunset Room
8:00 - 11:00 PM	Entertainment	Eldorado Court/Sunset Room
Sunday, January 10
	Departure
*=Session Chair †=Speaker invited, not yet responded.

Keystone Symposia would like to thank the sponsor of this meeting for their generous support:

We gratefully acknowledge additional support for this conference from:

The Directors' Fund

These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.

We gratefully acknowledge the generous grant for this conference provided by:

National Institutes of Health
National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13AI084376-01

The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

We gratefully acknowledge the organizations that provide Keystone Symposia with additional support, such as marketing and advertising...

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In the past 10 years, impressive progress has been made on how the NF- kappaB transcription factor is regulated and how diverse signals frequently use ubiquitin-dependent mechanisms to activate NF- kappaB. Many of the signal transducers and regulatory enzymes have been identified and their essential roles in NF- kappaB regulation revealed through genetic analyses in mice. More recent work highlights the importance of NF- kappaB in innate immune signaling by cell surface Toll-like receptors and cytosolic Nod-like receptors. Although current research clearly implicates NF- kappaB in diabetes, inflammatory diseases and cancer, a challenge for the future will be to reveal the precise molecular and cellular mechanisms of NF- kappaB dysfunction in disease. The realization that NF- kappaB activity is regulated by kinases and ubiquitin modifying enzymes presents multiple opportunities for therapeutic intervention. In addition to highlights from basic research, results from clinical trials using IKK and other NF- kappaB inhibitors are expected to be presented at this meeting.

NF-kappaB in Inflammation and Disease (A1)