Keystone Symposia
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LANGUAGE NOTE: This meeting will be conducted in English.
**Meeting has ended.**



Meeting Program

To view program in "24 hour" time (international) click here.


Friday, January 8
3:00 - 7:30 PM Registration Matterhorn Foyer
6:30 - 7:30 PM Refreshments Matterhorn Foyer
7:30 - 8:30 PM Keynote Address
Registered attendees for this meeting can view Abstracts for this session starting on 12/08/2009
Matterhorn Ballroom
Napoleone Ferrara, Genentech, Inc., USA
The Avastin Story: Challenges and Lessons
Saturday, January 9
7:00 - 8:00 AM Breakfast Schneitter's
8:00 - 11:00 AM Antibody Discovery and Engineering
Registered attendees for this meeting can view Abstracts for this session starting on 12/08/2009
Matterhorn Ballroom
Matthew Sleeman, MedImmune, USA
Antibody Structure Function Relationships
Tillman U. Gerngross, Dartmouth College and CEO and Co-founder of Adimab, USA
Adimab’s Novel Human Antibody Discovery Platform: A New Benchmark for Antibody Discovery Technologies
John R. Desjarlais, Xencor, USA
Creating Novel and Enhanced Antibody Therapeutics through Fc Engineering
James A. Van Deventer, California Institute of Technology, USA
Short Talk: Antibody Fragment Engineering With Non-Canonical Amino Acids
11:00 AM- On Own for Lunch and Recreation
9:20 - 9:40 AM Coffee Break Matterhorn Foyer
4:30 - 5:00 PM Coffee Available Matterhorn Foyer
5:00 - 7:00 PM Protein and Peptide Engineering
Registered attendees for this meeting can view Abstracts for this session starting on 12/08/2009
Matterhorn Ballroom
W. David Shen, Merck & Co., Inc., USA
From Mammalian Cell Display to Cross-Species Display of Antibodies
Clark Pan, Genzyme Corporation, USA
Carbohydrate Engineering of Acid alpha-Glucosidase for Treatment of Pompe Disease
David V. Liu, Massachusetts Institute of Technology, USA
Short Talk: Engineered Interleukin-2 Antagonists for the Inhibition of Regulatory T Cells
7:00 - 8:00 PM Social Hour w/ Lite Bites Grindelwald/Davos
Sunday, January 10
7:00 - 8:00 AM Breakfast Schneitter's
8:00 - 11:00 AM Next Generation Protein-Based Biopharmaceuticals
Registered attendees for this meeting can view Abstracts for this session starting on 12/08/2009
Matterhorn Ballroom
Volker Schellenberger, Amunix Inc., USA
Protein Pharmaceuticals Comprising an XTEN Half-Life Extension Module
Richard J.M. Ross, University of Sheffield, UK
Hormone/Hormone Receptor Fusion Proteins for Improving the Pharmacokinetic/Pharmacodynamic Properties of Hormone Replacement Therapies
Peter D. Senter, Seattle Genetics Inc., USA
Antibody-Drug Conjugates for Cancer Therapy
Chengbin Wu, Abbott Bioresearch Center, USA
Protein Engineering of DVD-Ig: Focusing on Pharmacokinetics, Manufacturing, and Preformulation Studies
Bernd J. Wranik, Genentech, USA
Short Talk: LUZ-Y: An Engineered Antibody Format for the Production of One-Armed and Bispecific Antibodies in Mammalian (CHO) Cells
9:20 - 9:40 AM Coffee Break Matterhorn Foyer
11:00 AM- 1:00 PM Poster Setup Grindelwald/Davos
11:00 AM- On Own for Lunch and Recreation
1:00 - 10:00 PM Poster Viewing Grindelwald/Davos
4:30 - 5:00 PM Coffee Available Matterhorn Foyer
5:00 - 7:00 PM Nucleic Acid-Based Biopharmaceuticals
Registered attendees for this meeting can view Abstracts for this session starting on 12/08/2009
Matterhorn Ballroom
James M. Wilson, University of Pennsylvania, USA
Gene Therapy: Lessons Learned and Opportunities for the Future
C. Frank Bennett, ISIS Pharmaceuticals, Inc., USA
Progress in Antisense Therapeutics
Dinah Sah, Alnylam Pharmaceuticals Inc., USA
Development of RNAi Therapeutics
Pengbo Zhou, Weill Cornell Medical College, USA
Short Talk: Integration of RNAi and Protein Knockout Technology for Efficient Eradication of Cellular Proteins
7:00 - 8:00 PM Social Hour w/ Lite Bites Grindelwald/Davos
7:30 - 10:00 PM Poster Session 1
Registered attendees for this meeting can view Abstracts for this session starting on 12/08/2009
Grindelwald/Davos
Monday, January 11
7:00 - 8:00 AM Breakfast Schneitter's
8:00 - 11:00 AM Cancer and Cancer Supportive Care
Registered attendees for this meeting can view Abstracts for this session starting on 12/08/2009
Matterhorn Ballroom
Michael Reiss, Robert Wood Johnson Medical School, USA
TGF-beta as a New Cancer Therapy Target
Elisabeth G.E. de Vries, Universitair Medisch Centrum Groningen, The Netherlands
Use of Zirconium-89 Labeled Antibodies for Tumor Imaging: Possible Applications for Guiding Targeted Tumor Therapy
Patrick A. Baeuerle, Micromet, Inc., USA
Cancer Therapy by T Cell-Engaging BiTE Antibodies
Antonio Gualberto, Pfizer Oncology, USA
Development of Figitumumab (CP-751,871), a Fully Human Monoclonal Antibody against the IGF-1R
John C. Zwaagstra, Biotechnology Research Institute NRCC, Canada
Short Talk: Design and Efficacy of Single-Chain Traps Targeting Ligands of the Transforming Growth Factor-beta (TGF-beta) Family: The New Generation of Cancer Therapeutics/Diagnostics
9:20 - 9:40 AM Coffee Break Matterhorn Foyer
11:00 AM- On Own for Lunch and Recreation
1:00 - 10:00 PM Poster Viewing Grindelwald/Davos
4:30 - 5:00 PM Coffee Available Matterhorn Foyer
5:00 - 7:00 PM Immune-Mediated Diseases/Transplant
Registered attendees for this meeting can view Abstracts for this session starting on 12/08/2009
Matterhorn Ballroom
C. Randal Mills, Osiris Therapeutics, Inc., USA
Mesenchymal Stem Cells for Treatment of GVHD
Alasdair Coles, University of Cambridge, UK
Anti-CD52 Antibodies for the Treatment of Multiple Sclerosis
Kristine Kikly, Eli Lilly and Company, USA
Anti-BAFF for the Treatment of Rheumatoid Arthritis
7:00 - 8:00 PM Social Hour w/ Lite Bites Grindelwald/Davos
7:30 - 10:00 PM Poster Session Viewing
Registered attendees for this meeting can view Abstracts for this session starting on 12/08/2009
Grindelwald/Davos
Tuesday, January 12
7:00 - 8:00 AM Breakfast Schneitter's
8:00 - 11:00 AM Diabetes
Registered attendees for this meeting can view Abstracts for this session starting on 12/08/2009
Matterhorn Ballroom
Bart Keymeulen, Vrije Universiteit Brussel, Belgium
Preservation of Beta Cell Function in Human Type 1 Diabetes
Sushil G. Rane, National Institutes of Health, USA
Protection from Obesity and Diabetes by Blockade of TGF-beta/Smad3 Signaling
Alexei Kharitonenkov, Eli Lilly and Company, USA
FGF-21 and its Novel Variants to Treat Metabolic Disorders
Lucienne Chatenoud, INSERM, Hopital Necker, France
Restoration of Self Tolerance in Autoimmune Diabetes
Biju Parekkadan, Massachusetts General Hospital, Harvard Medical School, USA
Short Talk: Natural Therapeutics Derived from the Bone Marrow Stroma
9:20 - 9:40 AM Coffee Break Matterhorn Foyer
11:00 AM- On Own for Lunch and Recreation
4:30 - 5:00 PM Coffee Available Matterhorn Foyer
5:00 - 7:00 PM Metabolic and Neurological Disorders
Registered attendees for this meeting can view Abstracts for this session starting on 12/08/2009
Matterhorn Ballroom
Ronald B. DeMattos, Lilly Research Laboratories, USA
Abeta Immunotherapy: The Development of Compound Specific Biomarkers to Aid the Translation of Preclinical to Clinical Studies
Mike Ominsky, Amgen Inc., USA
OPG/RANKL and Sclerostin; Physiological Regulators of Bone Density; Targets for the Treatment of Bone Loss Indications
Marco A. Passini, Genzyme Corporation, USA
Gene and Antisense Oligonucleotide Therapies for Spinal Muscular Atrophy
John Chaddock, Syntaxin Ltd, UK
Short Talk: Clostridial Endopeptidases - A Novel Platform for Therapeutic Proteins
7:00 - 8:00 PM Social Hour w/ Lite Bites Grindelwald/Davos
8:00 - 11:00 PM Entertainment Grindelwald/Davos
Wednesday, January 13
Departure
      *=Session Chair     †=Speaker invited, not yet responded.



Keystone Symposia would like to thank the sponsors of this meeting for their generous support:

We gratefully acknowledge additional support for this conference from:











Amunix Inc.


MedImmune



Merck Vaccine Division



Regeneron Pharmaceuticals, Inc.



Seattle Genetics, Inc.


The Directors' Fund

These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the organizations that provide Keystone Symposia with additional support, such as marketing and advertising...

Click here to view these companies

This meeting will contain eight sessions covering both biotechnology discovery platforms supporting biopharmaceutical product research and development (4 sessions) and specific disease areas where biopharmaceuticals either have or are likely to have a major positive impact on clinical outcomes for patients (4 sessions).