Keystone Symposia Conference | Advances in Molecular Mechanisms of Atherosclerosis

Meeting Program

To view program in "24 hour" time (international) click here.

Friday, February 12
3:00 - 7:30 PM	Registration	Van Horne Foyer
6:30 - 7:30 PM	Refreshments	Van Horne Foyer
7:30 - 8:30 PM	Keynote Address (Joint) Registered attendees for this meeting can view Abstracts for this session starting on 01/12/2010	Van Horne Ballroom A-B
	Carl F. Nathan, Weill Cornell Medical College, USA Non-Resolving Inflammation: Disease, Defense and Therapy
Saturday, February 13
7:00 - 8:00 AM	Breakfast	Mezzanine 2
8:00 - 11:15 AM	Genetics and Functional Genomics of Atherosclerosis Registered attendees for this meeting can view Abstracts for this session starting on 01/12/2010	Van Horne Ballroom C
	Sekar Kathiresan, Massachusetts General Hospital, USA Mapping Genes for Plasma Lipids and Myocardial Infarction in Humans
	Eric Schadt, Pacific Biosciences, USA Moving Toward a Systems Biology Understanding of Complex Human Diseases
	Karen Reue, University of California, Los Angeles, USA Identification of Novel Lipid Metabolism Genes from Spontaneous Mouse Mutants
	* Daniel J. Rader, University of Pennsylvania Medical Center, USA Functional Characterization of Novel Loci Associated with Plasma Lipids
	Yajaira Suárez, New York University School of Medicine, USA Short Talk: TNF-Induced microRNAs Regulate TNF-Induce Expression of E-Selectin and ICAM-1 in Human Endothelial Cells
	Johan Lars Markus Björkegren, Karolinska University Hospital, Sweden Short Talk: Multi-Organ Expression Profiling to Uncover Gene Networks and Modules of Importance to Coronary Artery Disease
Following Session is for The Macrophage (J8)
8:00 - 11:00 AM	Macrophages and Pathogens I Registered attendees for this meeting can view Abstracts for this session starting on 01/12/2010	Van Horne Ballroom A-B
	* De'Broski R. Herbert, Cincinnati Children's Research Foundation, USA
	Lalita Ramakrishnan, University of Washington, USA Macrophages and Infectious Granulomas
	Thirumala-Devi Kanneganti, St. Jude Children's Research Hospital, USA Activation of the NLR Family of Pathogen Detectors
	Sabine Ehrt, Weill Cornell Medical College, USA Mycobacterial Survival Strategies in the Macrophage Phagosome
	Alan Sher, NIAID, National Institutes of Health, USA Poly-IC Treatment Exacerbates Tuberculosis by the Pulmonary Recruitment of a Pathogen-permissive Monocyte/macrophage Population

9:20 - 9:40 AM	Coffee Break	Van Horne Foyer
11:15 AM-	On Own for Lunch and Recreation
11:15 AM- 1:00 PM	Poster Setup	Mezzanine 2
1:00 - 10:00 PM	Poster Viewing	Mezzanine 2
4:30 - 5:00 PM	Coffee Available	Van Horne Foyer
5:00 - 7:15 PM	Signaling and Gene Expression (Joint) Registered attendees for this meeting can view Abstracts for this session starting on 01/12/2010	Van Horne Ballroom A-B
	* Peter Tontonoz, University of California, Los Angeles, USA
	Ruslan M. Medzhitov, Yale University School of Medicine, USA Regulation of Inflammatory Gene Expression in Macrophages
	Linda K. Curtiss, The Scripps Research Institute, USA Atherosclerosis: An Unfortunate Mix of Lipids and Inflammation Whipped Up by Toll-Like Receptors
	Joachim Herz, University of Texas Southwestern Medical Center, USA Cell-Autonomous Atheroprotective Functions of LRP1 in the Vascular Wall
	Petra Keul, University of Duisburg-Essen, Germany Short Talk: Deletion of the S1P Receptor S1P3 Attenuates Macrophage-Driven Inflammation in Atherosclerotic Lesions of S1P3-/-/ApoE -/- Double Knockout Mice
	Jay W. Heinecke†, University of Washington School of Medicine, USA Short Talk: Demonstrating Proteomic Analysis of Macrophage Foam Cells
7:15 - 8:15 PM	Social Hour w/ Lite Bites	Mezzanine 2
7:30 - 10:00 PM	Poster Session 1 Registered attendees for this meeting can view Abstracts for this session starting on 01/12/2010	Mezzanine 2
Sunday, February 14
7:00 - 8:00 AM	Breakfast	Mezzanine 2
8:00 - 11:15 AM	Immune Mechanisms and Atherosclerosis Registered attendees for this meeting can view Abstracts for this session starting on 01/12/2010	Van Horne Ballroom C
	Göran K. Hansson, Karolinska University Hospital, Sweden Interplay of Innate and Adaptive Immune Mechanisms in Atherosclerosis
	* Joseph L. Witztum, University of California, San Diego, USA Oxidation-Specific Epitopes are a Major Target of Innate Immunity
	Ziad Mallat, Inserm U970, Paris Cardiovascular Research Center, France Regulatory T Cell Immunity in Atherosclerosis
	Gwendalyn J. Randolph, Mount Sinai School of Medicine, USA Fate of Monocyte-Derived Cells in Atherosclerotic Plaques versus Sites of Resolving Inflammation
	David Weismann, Center for Molecular Medicine of the Austrian Academy of Sciences, Austria Short Talk: Complement Factor H Binds to Malondialdehyde-Modified Proteins and Inhibits Foam Cell Formation
	Yue Zhao, University of Kentucky, USA Short Talk: The NR4A Orphan Nuclear Receptor NOR1 Mediates Monocyte Adhesion and Atherosclerosis Formation in Mice
Following Session is for The Macrophage (J8)
8:00 - 11:00 AM	Understanding Human Macrophages Registered attendees for this meeting can view Abstracts for this session starting on 01/12/2010	Van Horne Ballroom A-B
	* Peter J. Murray, St. Jude Children's Research Hospital, USA
	Lionel Bohdan Ivashkiv, Hospital for Special Surgery, New York, USA Signal Integration during Macrophage Activation and Cytokine Production

	David Hume, University of Edinburgh, UK Transcriptional Networks in Macrophage Differentiation and Activation
	Menno Van Lookeren Campagne, Genentech, Inc., USA A Central Role for Complement and Liver Kupffer Cells in Host Defense

	Christopher L. Karp, Cincinnati Children's Hospital Research Foundation, USA Pathogen Contact with Human Macrophages
	Molly A. Ingersoll, Mount Sinai School of Medicine, USA Short Talk: Comparison of Gene Expression Profiles between Human and Mouse Monocyte Subsets
9:20 - 9:40 AM	Coffee Break	Van Horne Foyer
11:15 AM-	On Own for Lunch and Recreation
11:15 AM- 1:00 PM	Poster Setup	Mezzanine 2
1:00 - 10:00 PM	Poster Viewing	Mezzanine 2
4:30 - 5:00 PM	Coffee Available	Van Horne Foyer
5:00 - 7:00 PM	Macrophage Movement (Joint) Registered attendees for this meeting can view Abstracts for this session starting on 01/12/2010	Van Horne Ballroom A-B
	* Gerald Krystal, British Columbia Cancer Research Center, Canada
	Israel F. Charo, Gladstone Institute of Cardiovascular Disease, USA Macrophage Movement in Atherosclerosis Lesions
	Frederic Geissmann, Kings College London, UK In vivo Monitoring of Monocyte/Macrophage Traffic
	Steven L. Kunkel, University of Michigan Medical School, USA Writers, Readers, and Erasers: Dynamic Epigenetic Regulation of the Macrophage Phenotype
	Andrea L. Hevener, University of California, Los Angeles, USA Short Talk: Myeloid-specific Deletion of Estrogen Receptor-alpha (ERalpha) Promotes Obesity and Insulin Resistance in Mice
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Mezzanine 2
7:30 - 10:00 PM	Poster Session 2 Registered attendees for this meeting can view Abstracts for this session starting on 01/12/2010	Mezzanine 2
Monday, February 15
7:00 - 8:00 AM	Breakfast	Mezzanine 2
8:00 - 11:15 AM	The Vulnerable Plaque Registered attendees for this meeting can view Abstracts for this session starting on 01/12/2010	Van Horne Ballroom C
	Philippe Boucher, UMR CNRS 7213, University of Strasbourg, France PPAR-gamma Inhibits Vascular Calcification by Controlling an LRP1/beta-Catenin Signaling Pathway
	Peter Libby, Brigham and Women's Hospital, USA Extracellular Matrix Metabolism and Determinants of Plaque Stability
	Garret A. FitzGerald, University of Pennsylvania, USA Cardiovascular Complexity in the Prostanoid System
	* Ira Tabas, Columbia University, USA Mechanisms and Consequences of Macrophage Apoptosis in Atherosclerosis
	Kristiina Satu Susanna Rajamäki, Wihuri Research Institute, Finland Short Talk: Cholesterol Crystals Activate Inflammasome Signaling in Human Macrophages
	Walter S. Speidl, Medical University of Vienna, Austria Short Talk: The Complement Component C5a Induces the Expression of MMP-1 and MMP-9 in Human Macrophages
Following Session is for The Macrophage (J8)
8:00 - 11:00 AM	Sterile Inflammation and Cancer Inflammation Registered attendees for this meeting can view Abstracts for this session starting on 01/12/2010	Van Horne Ballroom A-B
	* Christopher L. Karp, Cincinnati Children's Hospital Research Foundation, USA
	Kenneth L. Rock, University of Massachusetts Medical School, USA The Sterile Inflammatory Response
	Vincenzo Bronte, Istituto Oncologico Veneto, Italy Myeloid-Derived Suppressor Cells
	Thorsten Hagemann, Bart's and the London Queen Mary's Medical School, UK Cancer-Related Inflammation

	Shigekazu Nagata, Kyoto University, Japan Activation of Innate Immune Reaction by Mammalian DNA that Escaped from Degradation


	Antonio Castrillo, Instituto Investigaciones Biomedicas CSIC, Spain Short Talk: LXR Nuclear Receptors Regulate Apoptotic Cell Clearance and Immune Tolerance
9:20 - 9:40 AM	Coffee Break	Van Horne Foyer
11:15 AM-	On Own for Lunch and Recreation
11:15 AM- 1:00 PM	Poster Setup	Mezzanine 2
1:00 - 10:00 PM	Poster Viewing	Mezzanine 2
4:30 - 5:00 PM	Coffee Available	Van Horne Foyer
5:00 - 7:00 PM	Deactivating Macrophage Activity (Joint) Registered attendees for this meeting can view Abstracts for this session starting on 01/12/2010	Van Horne Ballroom A-B
	Peter J. Murray, St. Jude Children's Research Hospital, USA Cytokine-Mediated Deactivation of the Activated Macrophage
	Gerald Krystal, British Columbia Cancer Research Center, Canada The Role of SHIP in Macrophage Skewing and Activation
	* Christopher K. Glass, University of California, San Diego, USA PPAR and LXR-Dependent Repression Pathways that Regulate Inflammation
	Tim Ian Smallie, Kennedy Institute of Rheumatology Division, UK Short Talk: IL-10 Negatively Regulates Macrophage Activation by Inhibiting Transcription Elongation
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Mezzanine 2
7:30 - 10:00 PM	Poster Session 3 Registered attendees for this meeting can view Abstracts for this session starting on 01/12/2010	Mezzanine 2
Tuesday, February 16
7:00 - 8:00 AM	Breakfast	Mezzanine 2
8:00 - 11:15 AM	Cholesterol Homeostasis/Foam Cell Formation Registered attendees for this meeting can view Abstracts for this session starting on 01/12/2010	Van Horne Ballroom C
	* Russell A. DeBose-Boyd, University of Texas Southwestern Medical Center, USA Degradation of HMG CoA Reductase and Cholesterol Metabolism
	Alan R. Tall, Columbia University, USA Role of ABC Transporters in Atherosclerosis and Foam Cell Formation
	Kathryn J. Moore, New York University Medical Center, USA Micro-Managing Macrophage Cholesterol Metabolism
	Edward A. Fisher, New York University School of Medicine, USA HDL and Atherosclerosis Regression: Effects on the Quantity and Quality of Monocyte-Derived Cells in Plaques
	Prakash Gopaldas Chandak, Institute of Molecular Biology and Biochemistry, Austria Short Talk: Adipose Triglyceride Lipase Deficiency Affects Macrophage Morphology and Function and Significantly Reduces Atherosclerosis in LDLR -/- Mice
	Shunxing Rong, Wake Forest University School of Medicine, USA Short Talk: High Polyunsaturated Fatty Acid (PUFA) Diet Unmasks Role of 12/15 Lipoxygenase in Lipid Metabolism and Atherosclerosis
Following Session is for The Macrophage (J8)
8:00 - 11:00 AM	Macrophage and Pathogens II Registered attendees for this meeting can view Abstracts for this session starting on 01/12/2010	Van Horne Ballroom A-B
	* Sabine Ehrt, Weill Cornell Medical College, USA
	De'Broski R. Herbert, Cincinnati Children's Research Foundation, USA Alternatively Activated Macrophages Control Helminth-Driven Immunopathology
	Thomas A. Wynn, National Institutes of Health, USA The Role of IL-4/IL-13 Activated Macrophages in Fibrosis
	Judith E. Allen, University of Edinburgh, UK The Macrophage and the Worm

	Sara R. Cherry, University of Pennsylvania School of Medicine, USA Identification of Intrinsic Innate Immune Mechanisms
9:20 - 9:40 AM	Coffee Break	Van Horne Foyer
11:00 AM-	On Own for Lunch and Recreation
4:30 - 5:00 PM	Coffee Available	Van Horne Foyer
5:00 - 7:00 PM	Metabolism and Macrophages at the Intersection of Metabolic Control (Joint) Registered attendees for this meeting can view Abstracts for this session starting on 01/12/2010	Van Horne Ballroom A-B
	* Russell A. DeBose-Boyd, University of Texas Southwestern Medical Center, USA
	* Ajay Chawla, Stanford University Medical Center, USA PPARs and Macrophage Activation in Health and Disease
	Peter Tontonoz, University of California, Los Angeles, USA Control of Cholesterol Homeostasis by LXRs
	Gökhan S. Hotamisligil, Harvard University School of Public Health, USA The Role of Endoplasmic Reticulum Stress in Atherosclerosis and its Regulation by Lipids
	Hwee Ying Lim, National University of Singapore, Singapore Short Talk: Ezetimibe Restores Lymphatic Vessel Function and Dendritic Cell Migration, in Hypercholesterolemic apoE-Deficient Mice
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Mezzanine 2
8:00 - 11:00 PM	Entertainment	Mezzanine 2
Wednesday, February 17
	Departure
*=Session Chair †=Speaker invited, not yet responded.

We gratefully acknowledge support for this conference from:

The Directors' Fund

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Atherosclerosis, a disease that affects arterial blood vessels, is the major cause of death in developed countries and emerging economies worldwide. The disease is initiated when cholesterol-rich low-density lipoproteins adhere to the walls of arteries, triggering a complex set of reactions involving a variety of cell types including macrophages, endothelial cells, smooth muscle cells, and lymphocytes. This initial lesion progresses to a more complicated atherosclerotic plaque through subsequent cell-cell and cell-lipid interactions that cause chronic inflammation, extracellular alterations, and necrosis. These responses promote plaque disruption, which triggers acute thrombosis resulting in vascular occlusion and myocardial infarction. The goal of this meeting is to provide attendees with the latest advances in the understanding of cellular processes that contribute to atherosclerosis, with particular emphasis on cholesterol metabolism and foam cell formation, genetics, and the immune system. These goals will be significantly enhanced by holding the meeting concurrently with the meeting, The Macrophage: Intersection of Pathogenic and Protective Inflammation. In addition to four atherosclerosis-specific plenary sessions, four joint sessions are planned to highlight major developments in areas of mutual interest to investigators in the fields of atherosclerosis and macrophage biology. Elucidation of mechanisms underlying development of atherosclerosis may reveal new therapeutic strategies to combat the disease. This program will stimulate interactions that are likely to augment and accelerate this process.

Advances in Molecular Mechanisms of Atherosclerosis (J7)