Keystone Symposia Conference | Innate Immunity: Mechanisms Linking with Adaptive Immunity

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Monday, June 7
3:00 - 7:30 PM	Registration	Lower Concourse
6:30 - 7:30 PM	Refreshments	Lower Concourse
7:30 - 8:30 PM	Keynote Address Registered attendees for this meeting can view Abstracts for this session starting on 05/07/2010	Burke Theatre/Beckett Rooms
	* Luke A.J. O'Neill, Trinity College Dublin, Ireland
	Ruslan M. Medzhitov, Yale University School of Medicine, USA Innate Control of Adaptive Immunity
Tuesday, June 8
7:30 - 8:30 AM	Breakfast	At Lodging Location
7:30 - 8:30 AM	Poster Setup	Beckett Rooms/Lower Concourse
8:30 AM- 3:00 PM	Poster Viewing	Beckett Rooms/Lower Concourse
8:30 - 11:45 AM	The Modulation of Innate and Adaptive Immune Responses by Innate Receptors Registered attendees for this meeting can view Abstracts for this session starting on 05/07/2010	Burke Theatre/Beckett Rooms
	Shizuo Akira, Osaka University, Japan Functional Analysis of TLR Inducible Genes by Gene Targeting
	* Alberto Mantovani, Istituto Clinico Humanitas, Italy The Interplay between Cellular and Humoral Innate Immunity: The Long Pentraxin PTX3 as a Paradigm
	Julie Magarian Blander, Mount Sinai School of Medicine, USA Phagosomes and Adaptive Immunity
	* Mihai G. Netea, Radboud University Nijmegen Medical Centre, Netherlands Modulation of Antifungal Immune Responses by Innate Receptors
	Michael C. Abt, University of Pennsylvania, USA Short Talk: Signals Derived from Intestinal Microbial Communities Regulate Anti-Viral Immunity
	Anna M. Hansen, National Institutes of Health, USA Short Talk: An Innate, Non-NK T Cell with Memory-Like Phenotype Produces Large Amounts of IL-17 Independently of IL-6 and IL-21
9:40 - 10:00 AM	Coffee Break	Lower Concourse
11:45 AM- 12:45 PM	Lunch	Dining Hall/Atrium/Java Vaults
12:00 - 2:30 PM	Poster Session 1 Registered attendees for this meeting can view Abstracts for this session starting on 05/07/2010	Beckett Rooms/Lower Concourse
2:30 - 3:00 PM	Coffee Available	Lower Concourse
3:00 - 5:00 PM	Autoimmunity as a Consequence of Innate Immunity Defects Registered attendees for this meeting can view Abstracts for this session starting on 05/07/2010	Burke Theatre/Beckett Rooms
	Robert L. Coffman, Dynavax Technologies, USA Targeting TLR7 and TLR9 in Autoimmune Disease
	* Jos van der Meer, dept general internal medicine, Netherlands The auto-inflammatory syndromes
	* Averil I. Ma, University of California, San Francisco, USA Ubiquitination and Innate Immunity
	Dominik Schenten, Yale University, USA Short Talk: The Role of TLR-Induced IL-6 and IL-1 in the Control of Adaptive Immunity
5:00 PM-	On Own for Dinner
Wednesday, June 9
7:30 - 8:30 AM	Breakfast	At Lodging Location
8:30 - 11:45 AM	Evolution of Innate and Adaptive Immunity Registered attendees for this meeting can view Abstracts for this session starting on 05/07/2010	Burke Theatre/Beckett Rooms
	* Max D. Cooper, Emory University, USA Evolution of the Adaptive Immune System
	* Gary W. Litman, University of South Florida, USA The Evolution of Immune Receptor Diversity
	Jenny P. Ting, University of North Carolina at Chapel Hill, USA NLR Proteins: From Plants to Animals
	Neal Silverman, University of Massachusetts Medical School, USA What the Fly has Taught us about Innate Immunity: New Lessons for NF-kappaB Signaling?
	A. Neil Barclay, University of Oxford, UK Short Talk: The Evolution and Ligands of Macrophage Paired Receptors
	Gregory Ian Vladimer, University of Massachusetts Medical School, USA Short Talk: NLRP12 and Other Inflammasome Components Participate in the Resistance to Yersinia pestis Producing a Potent LPS
9:40 - 10:00 AM	Coffee Break	Lower Concourse
11:45 AM- 12:45 PM	Lunch	Dining Hall/Atrium/Java Vaults
11:45 AM- 12:45 PM	Poster Setup	Beckett Rooms/Lower Concourse
12:45 - 2:45 PM	Workshop	Burke Theatre/Beckett Rooms
	* Averil I. Ma, University of California, San Francisco, USA
	Amy Grace Hise, Case Western Reserve University, USA Innate Immune Host Defense to Fungal Pathogens
	Clare E. Bryant, University of Cambridge, UK Allergen Lipid Binding Proteins (Alps) Sensitise Ligand Induced Activation of TLR4: A Common Mechanism of Allergen Recognition?
	Paul J. Hertzog, Monash Institute of Medical Research, Australia Regulation of Mucosal Immunity by a New Interferon (IFNepsilon) with Unusual Properties Evolved to Protect Reproductive Tract from Bacterial and Viral Infection
	Mirjam Kool, Ghent University / VIB, Belgium An Unexpected Role for Uric Acid as an Inflammatory Mediator of Allergic Asthma
	Susan B. Carpenter, Trinity College Dublin, Ireland TRIL: A Novel Modulator of TLR4 Signaling is also Required for TLR3 Mediated Immune Responses
	Shruti Sharma, University of Massachusetts Medical School, USA Innate Immune Recognition of a Novel AT-rich DNA Motif in the P. falciparum Genome.
2:45 - 3:00 PM	Coffee Available	Lower Concourse
3:00 - 5:00 PM	The Role of Innate Receptors in Adjuvancy Registered attendees for this meeting can view Abstracts for this session starting on 05/07/2010	Burke Theatre/Beckett Rooms
	* Kingston H. G. Mills, Trinity College Dublin, Ireland Activation and Manipulation of TLR and NLR Signalling Pathways in Dendritic Cells for Selective Induction of T Cell Responses
	Alan Sher, NIAID, National Institutes of Health, USA Critical Role for IL-1R Signaling and the Inflammasome in the Th1/Th17 cell Adjuvant Activity of Mycobacteria
	* Bart N. Lambrecht, Ghent University, Belgium Molecular Basis for Alum Adjuvancy
	Sheri Dubey, Merck & Co., Inc., USA Short Talk: Novel TLR9 Agonists Combined with Alum for Use as Vaccine Adjuvants
5:00 - 6:00 PM	Social Hour w/ Lite Bites	Lower Concourse
5:30 - 8:00 PM	Poster Session 2 Registered attendees for this meeting can view Abstracts for this session starting on 05/07/2010	Beckett Rooms/Lower Concourse
Thursday, June 10
7:30 - 8:30 AM	Breakfast	At Lodging Location
7:30 - 8:30 AM	Poster Setup	Beckett Rooms/Lower Concourse
8:30 AM- 3:00 PM	Poster Viewing	Beckett Rooms/Lower Concourse
8:30 - 11:45 AM	Control of T Cell Subsets by Innate Immune Signals Registered attendees for this meeting can view Abstracts for this session starting on 05/07/2010	Burke Theatre/Beckett Rooms
	* Laurence A. Turka, Beth Israel Deaconess/Harvard, USA Regulation of T Lymphocytes by "Innate Immune Pathways"
	Shimon Sakaguchi, Institute for Frontier Medical Sciences, Kyoto University, Japan Regulatory T Cells in Innate and Adaptive Immunity
	Hilde Cheroutre, La Jolla Institute for Allergy and Immunology, USA Omitting Felony by Switching Fate: TGF-beta and Retinoic Acid Mediate Lineage Conversion of CD4 Th Cells to CD8 CTLs
	Ed C. Lavelle, Trinity College Dublin, Ireland
	Aisling Dunne, Trinity College Dublin, Ireland Short Talk: Inflammasome Activation by Adenylate Cyclase Toxin Directs TH17 Responses and Protection Against Bordetella Pertussis
	Mattias Enoksson, Karolinska Institute, Sweden Short Talk: Mast Cells as Novel Sensors of Cell Injury through Interleukin-33 Recognition
9:40 - 10:00 AM	Coffee Break	Lower Concourse
11:45 AM- 12:45 PM	Lunch	Dining Hall/Atrium/Java Vaults
12:00 - 2:30 PM	Poster Session 3 Registered attendees for this meeting can view Abstracts for this session starting on 05/07/2010	Beckett Rooms/Lower Concourse
2:30 - 3:00 PM	Coffee Available	Lower Concourse
3:00 - 5:00 PM	Innate Immune Mechanisms: Molecular and Structural Aspects Registered attendees for this meeting can view Abstracts for this session starting on 05/07/2010	Burke Theatre/Beckett Rooms
	* Luke A.J. O'Neill, Trinity College Dublin, Ireland Novel Components in Innate Immune Signaling
	* Kate A. Fitzgerald, University of Massachusetts Medical School, USA Inflammasomes and Anti-Viral Responses
	Eicke Latz, University of Massachusetts Medical School, USA Regulation of NLRP3 and AIM2 Inflammasome Signaling
	Tilmann Bürckstümmer, Center for Molecular Medicine, Austria Short Talk: Functional Dissection of the TBK1 Molecular Machine
5:00 PM-	On Own for Dinner
Friday, June 11
7:30 - 8:30 AM	Breakfast	At Lodging Location
7:30 AM- 8:30 PM	Poster Setup	Beckett Rooms/Lower Concourse
8:30 AM- 3:00 PM	Poster Viewing	Beckett Rooms/Lower Concourse
8:30 - 11:30 AM	Therapeutic Manipulation of Innate Immunity in Inflammatory Diseases Registered attendees for this meeting can view Abstracts for this session starting on 05/07/2010	Burke Theatre/Beckett Rooms
	* Anthony J. Coyle, Pfizer, USA Role of Type I Interferons in Autoimmune Disease
	Carla Vanina Rothlin, Yale University, USA TAMing Inflammation in vivo
	Nicola La Monica, Idera Pharmaceuticals, USA Synthetic Agonists and Antagonists of Toll-like Receptor 7, 8, and 9
	* Andrew E. Parker, Opsona Therapeutics, Ireland Targeting TLR2 in Ischemic Organ Damage
	Alison A. Humbles, MedImmune, LLC, USA Short Talk: RAGE Deficiency Protects Mice from RSV Infection
	Greg CA Elson, NovImmune, Switzerland Short Talk: Mechanistic Studies Reveal the Mode of Action of Highly Potent TLR4 Neutralizing MAbs
9:40 - 10:00 AM	Coffee Break	Lower Concourse
11:30 AM- 12:30 PM	Lunch	Lower Concourse
12:00 - 2:30 PM	Poster Session 4 Registered attendees for this meeting can view Abstracts for this session starting on 05/07/2010	Beckett Rooms/Lower Concourse
4:30 - 5:00 PM	Coffee Available	Lower Concourse
5:00 - 7:15 PM	Pathogen-Specific Responses Registered attendees for this meeting can view Abstracts for this session starting on 05/07/2010	Burke Theatre/Beckett Rooms
	* Tracy Hussell, Imperial College London, UK The Role of Innate Immunity in Host Defence against Respiratory Pathogens
	Lynda M. Stuart, Massachusetts General Hospital, Harvard Medical School, USA Sensing Bacterial Virulence
	Stefanie N. Vogel, University of Maryland, USA Distinct Roles of Alternatively Activated Macrophages in the Host Response to Bacterial and Viral Infection
	* Andrew G. Bowie, Trinity College Dublin, Ireland Novel Components of Anti-Viral Pattern Recognition Receptor Pathways
7:15 - 7:30 PM	Closing Remarks Registered attendees for this meeting can view Abstracts for this session starting on 05/07/2010	Burke Theatre/Beckett Rooms
	Kate A. Fitzgerald, University of Massachusetts Medical School, USA Closing Remarks
7:30 - 8:00 PM	Social Hour	Grand Dining Hall
8:00 - 9:00 PM	Dinner	Grand Dining Hall
7:30 - 9:00 PM	Entertainment	Grand Dining Hall
Saturday, June 12
	Departure
*=Session Chair †=Speaker invited, not yet responded.

Keystone Symposia would like to thank the sponsor of this meeting for their generous support:

We gratefully acknowledge additional support for this conference from:



	Opsona Therapeutics

We gratefully acknowledge the generous grants for this conference provided by:

National Institutes of Health
National Institute of Allergy and Infectious Diseases (NIAID)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Grant No. 1R13AI088869-01

The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

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In the past 5 years there have been remarkable advances in our understanding of the molecular basis of innate immunity. We now have considerable detail on the major classes of innate immune receptors that sense pathogens and provoke immune and inflammatory responses. These include the Toll-like receptors (TLRs), NOD-like receptors (NLRs) and RIG-I-like receptors (RLRs). The role these receptors play in host defense against microbes has been studied, their signaling pathways elucidated, and their roles in infectious and inflammatory diseases examined in detail. As well as stimulating innate immunity via induction of various effector mechanisms, these receptors also participate in the establishment of adaptive immunity. This occurs via the induction of key cytokines to promote T and B cell development and activation, and also via the induction of co-stimulatory molecules on the surface of dendritic cells, notably CD80 and CD86. A final aspect concerns adjuvancy – microbial or synthetic agents that activate these receptors act as powerful adjuvants required for the establishment of memory responses. This conference will bring together scientists working on innate immune mechanisms activated by these receptors, and will have as a key focus the ability of these receptors and the responses they elicit to promote adaptive immunity. The conference will therefore be of interest to many investigators interested in immunity and the role the immune system plays in disease.

Innate Immunity: Mechanisms Linking with Adaptive Immunity (D3)