Keystone Symposia Conference | Nuclear Receptors: Signaling, Gene Regulation and Cancer

Meeting Program

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Sunday, March 21
3:00 - 7:30 PM	Registration	Longs Peak Foyer
6:30 - 7:30 PM	Refreshments	Longs Peak Foyer
7:30 - 8:30 PM	Keynote Address (Joint) Registered attendees for this meeting can view Abstracts for this session starting on 02/21/2010	Grays/Longs Peaks
	Gideon Dreyfuss, HHMI, University of Pennsylvania School of Medicine, USA RNA-Protein Complexes (RNPs): The Instruments of Post-Transcriptional Gene Regulation
Monday, March 22
7:00 - 8:00 AM	Breakfast	Shavano/Torreys
8:00 - 11:15 AM	Signaling and Physiology Registered attendees for this meeting can view Abstracts for this session starting on 02/21/2010	Grays Peak
	* Kathryn B. Horwitz, University of Colorado Health Sciences Center, USA
	Carole R. Mendelson, University of Texas Southwestern Medical Center, USA Mechanisms in Progesterone Receptor Regulation of Inflammatory Signaling in Pregnancy and Labor
	Sheue-Yann Cheng, National Institutes of Health, USA Novel Signaling of Mutant Thyroid Hormone Receptors in Carcinogenesis
	Cynthia Kenyon, University of California, San Francisco, USA The Nuclear Receptor DAF12 in Aging in C. elegans
	Michael E. Mendelsohn, Molecular Cardiology Research Institute, USA Estrogen Receptor Signaling in the Cardiovascular System
	Jennifer K. Richer, University of Colorado, USA Short Talk: MicroRNAs Differentially Expressed in Luminal versus Triple Negative Breast Cancer Control Estrogen Receptor alpha and Growth Factor Receptor Expression and Aspects of Tumor Metabolism
	Mark G. Obukowicz, Pfizer Inc., USA Short Talk: Dissociated Agonist of the Glucocorticoid Receptor (DAGR): 60 Years in the Making (and of Waiting)
Following Session is for Nuclear Receptors: Development (X8)
8:00 - 11:15 AM	Nuclear Receptors in Development and Disease Registered attendees for this meeting can view Abstracts for this session starting on 02/21/2010	Longs Peak
	* Carl S. Thummel, University of Utah School of Medicine, USA

	Peter Tontonoz, University of California, Los Angeles, USA Liver X Receptors in Metabolism, Inflammation and Disease
	Carlie J. M. de Vries, Academic Medical Center, The Netherlands NR4A Orphan Nuclear Receptors in Vascular Disease
	Joe Thornton, University of Oregon, USA Evolution of Nuclear Receptors
	Henry M. Krause, University of Toronto, Canada Coordination of Developmental Check Points and Metabolism
	Jason M. Tennessen, University of Utah School of Medicine, USA Short Talk: The Drosophila Estrogen-Related Receptor Coordinates Carbohydrate Metabolism with Cell Growth
	Marc R. Van Gilst, Fred Hutchinson Cancer Research Center, USA Short Talk: From the Nematode Nuclear Receptor Milieu, C. elegans NHR-49 Emerges as a Casanova
9:20 - 9:40 AM	Coffee Break	Longs Peak Foyer
11:15 AM-	On Own for Lunch and Recreation
11:15 AM- 1:00 PM	Poster Setup	Shavano/Torreys
1:00 - 10:00 PM	Poster Viewing	Shavano/Torreys
2:30 - 4:30 PM	Workshop 1: Hot Topics: Physiology	Grays Peak
	* Carolyn L. Smith, Baylor College of Medicine, USA
	Iris Z. Jaffe, Tufts-New England Medical Center, USA Mineralocorticoid Receptor Regulation of Vascular Gene Expression: Role in Vascular Function and Disease
	Michihisa Umetani, University of Texas Southwestern Medical Center, USA LXRbeta Promotes Vascular Reendothelialization via a Novel Mechanism Involving non-Nuclear Signaling in Endothelium
	Terry D. Hinds, University of Toledo, USA Discovery of Glucocorticoid Receptor beta in Mice and its Role in Insulin Signaling and Metabolism
	Rasmus Siersbaek, University of Southern Denmark, Denmark Genome-Wide Chromatin-Remodeling during 3T3-L1 Adipocyte Differentiation
	Brian Sandri, University of Minnesota, USA Evidence for a Global Role of the Estrogen- Regulated ZEB1 Transcription Factor in Modulating Adiposity through Regulation of FGF-21
	Jens Tiefenbach, University of Toronto, Canada A live Zebrafish-based Screening System for Human Nuclear Receptors Allows for Tissue Selective Drug Discovery
Following Workshop is for Nuclear Receptors: Development (X8)
2:30 - 4:30 PM	Workshop 1: Hot Topics: Nuclear Receptors in Development and Disease Registered attendees for this meeting can view Abstracts for this session starting on 02/21/2010	Longs Peak
	Lilach Gilboa, Weizmann Institute of Science, Israel Hormonal Coordination of Niche Formation and Germ Line Stem Cell Establishment
	Chris R. Gissendanner, University of Louisiana at Monroe, USA The C. elegans NR4A Nuclear Receptor: Conserved Functions in Cell Proliferation and Cell Differentiation during Organ Morphogenesis
	Wen Xie, University of Pittsburgh, USA Unexpected Hepatotoxicity and Inflammatory Gene Activation in FXR Transgenic Mice
	Wendong Huang, Beckman Research Institute of City of Hope, USA FXR, Liver Repair and Aging
	* Li Wang, University of Utah, USA Nuclear Receptor SHP-dependent Mitochondrial Targeting in Apoptosis Signaling and Tumor Growth
4:30 - 5:00 PM	Coffee Available	Longs Peak Foyer
5:00 - 7:00 PM	Mechanisms of Nuclear Receptor Signaling (Joint) Registered attendees for this meeting can view Abstracts for this session starting on 02/21/2010	Grays/Longs Peaks
	* Donald P. McDonnell, Duke University Medical Center, USA
	Christopher K. Glass, University of California, San Diego, USA Lineage-Determining Transcription Factors Prime Cis-regulatory Elements Required for Ligand-dependent Gene Expression
	Keith R. Yamamoto, University of California, San Francisco, USA Cell and Gene Selectivity of Glucocorticoid Action: DNA Sequences as Specific GR Ligands
	Gordon L. Hager, National Cancer Institute, National Institutes of Health, USA Global Regulation of Chromatin Structure and Gene Expression by Glucocorticoid Receptors
	Jason S. Carroll, Cancer Research UK, UK Short Talk: FoxA1 is the Critical Determinant of ER Binding and Activity in Breast Cancer Cells
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Shavano/Torreys
7:30 - 10:00 PM	Poster Session 1 Registered attendees for this meeting can view Abstracts for this session starting on 02/21/2010	Shavano/Torreys
Tuesday, March 23
7:00 - 8:00 AM	Breakfast	Shavano/Torreys
8:00 - 11:15 AM	Ligands, Cofactors, and Gene Regulation Registered attendees for this meeting can view Abstracts for this session starting on 02/21/2010	Grays Peak
	* Kenneth S. Korach†, NIEHS, National Institutes of Health, USA
	Donald P. McDonnell, Duke University Medical Center, USA The ERRalpha/PGC-1 Complex Links HER2/IGF1 Initiated Signaling Events to the Expression of Target Genes that Impact Breast Cancer Pathogenesis
	Michael G. Rosenfeld, University of California, San Diego, USA Epigenetics: Life, Death, and Tumor Translocations
	Carol A. Lange, University of Minnesota, USA Mechanisms of PR Coupling to MAP Kinases
	Geoffrey L. Greene, University of Chicago, USA Structural Basis of ER Ligand Selectivity
	Kendall W. Nettles, The Scripps Research Institute, USA Short Talk: Coupling of Estrogen Receptor Conformation and Ligand Orientation Determine Graded Signaling Activity
	Wei Xu, University of Wisconsin-Madison, USA Short Talk: “Yin-Yang” Principle for Estrogen Receptor Heterodimers in Breast Cancer: A Targeted Molecular Approach for Therapeutic Development
Following Session is for Nuclear Receptors: Development (X8)
8:00 - 11:15 AM	Metabolic Control and Circadian Rhythms Registered attendees for this meeting can view Abstracts for this session starting on 02/21/2010	Longs Peak
	* Susanne Mandrup, University of Southern Denmark, Denmark

	Urs Albrecht, University of Fribourg, Switzerland The Clock Component Per2 Coordinates Circadian Output by Interaction with Nuclear Receptors

	Ueli Schibler, University of Geneva, Switzerland The Regulation of Circadian Gene Expression in Peripheral Cell Types
	David D. Moore, Baylor College of Medicine, USA Gut Feelings
	Johan Auwerx, Ecole Polytechnique Federale de Lausanne, Switzerland Integrating Metabolic Control by NAD+ Sensors

	Pavlos Pissios, Beth Israel Deaconess Medical Center, USA Short Talk: Regulation of Glucose and Lipid Metabolism by Nicotinamide N-Methyltransferase
	Thomas P. Burris, The Scripps Research Institute, USA Short Talk: Characterization of Synthetic REV-ERB ligands
9:20 - 9:40 AM	Coffee Break	Longs Peak Foyer
11:15 AM-	On Own for Lunch and Recreation
11:15 AM- 1:00 PM	Poster Setup	Shavano/Torreys
1:00 - 10:00 PM	Poster Viewing	Shavano/Torreys
2:30 - 4:30 PM	Workshop 2: Hot Topics: Gene Regulation	Grays Peak
	* Steven K. Nordeen, University of Colorado Health Sciences Center, USA
	Katherine Anne Burns, NIEHS, National Institutes of Health, USA Selective Mutations in the D-domain of Mouse ERalpha Alters Nuclear Translocation and ERalpha’s Non-ERE Gene Regulatory Mechanism
	Nasun Hah, Cornell University, USA Exploring the Direct Estrogen-Regulated Transcriptome in Breast Cancer Cells Using GRO-Seq
	Moray J. Campbell, Roswell Park Cancer Institute, USA VDR Regulation of Histone Modifications and miRNA Combine to Fine-Tune Transcriptional Cycling of Target Genes
	Robert H. Oakley, NIEHS, National Institutes of Health, USA Crosstalk between Glucocorticoid and G Protein-Coupled Receptor Signaling Pathways Mediated by Arrestins
	Joshua D. Stender, University of California, San Diego, USA Control of Pro-Inflammatory Gene Programs by Active Histone Methylation and Demethylation
	Daniel G. Gioeli, University of Virginia, USA CDK9 Regulates AR Activity and Cell Growth through Serine 81 Phosphorylation
Following Workshop is for Nuclear Receptors: Development (X8)
2:30 - 4:30 PM	Workshop 2: Hot Topics: Co-Regulators and Post-Transcriptional Control Registered attendees for this meeting can view Abstracts for this session starting on 02/21/2010	Longs Peak
	Inna I. Astapova, Beth Israel Deaconess Medical Center, USA The Nuclear Corepressor, NCoR, Controls the Set Point of the Thyroid Axis In vivo
	Karine Cecile Gauthier, ENS de Lyon, France The Thyroid Hormone Receptor TRalpha Protects Against Atherosclerosis Development
	Atul Chopra, Baylor College of Medicine, USA Hepatic SRC-2 Regulates Energy Balance by Coordinating Bile Secretion and Dietary Fat Absorption
	Nan Wu, University of Pennsylvania, USA Arf-bp1 and Pam are Novel Regulators of Circadian Rhythm that Target Rev-erbalpha for Degradation
	William Bourguet, Centre de Biochimie Structurale, France A Unique Secondary Structure Switch Controls Constitutive Gene Silencing by Retinoic Acid Receptor
	* Patrick R. Griffin, The Scripps Research Institute, USA HDX of Intact VDR/RXR Heterodimer Reveals Agonist and DNA-Induced Conformational Changes Important for Coactivator Interaction
4:30 - 5:00 PM	Coffee Available	Longs Peak Foyer
5:00 - 7:00 PM	Physiology and Metabolism (Joint) Registered attendees for this meeting can view Abstracts for this session starting on 02/21/2010	Grays/Longs Peaks
	* David J. Mangelsdorf, University of Texas Southwestern Medical Center, USA
	Bruce M. Spiegelman, Harvard Medical School, USA Transcriptional Regulation of Adipogenesis and Energy Homeostasis
	Deborah Clegg, University of Texas Southwestern Medical Center, USA Estrogen, Adipose Tissue, and The Metabolic Syndrome
	Ronald M. Evans, The Salk Institute, USA PPARs in Metabolism and Disease
	Austin J. Cooney, Baylor College of Medicine, USA Short Talk: Regulation of ES Cells and iPS by Nuclear Receptors
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Shavano/Torreys
7:30 - 10:00 PM	Poster Session 2 Registered attendees for this meeting can view Abstracts for this session starting on 02/21/2010	Shavano/Torreys
Wednesday, March 24
7:00 - 8:00 AM	Breakfast	Shavano/Torreys
8:00 - 11:15 AM	Chromatin and Transcription Registered attendees for this meeting can view Abstracts for this session starting on 02/21/2010	Grays Peak
	* Dean P. Edwards, Baylor College of Medicine, USA
	Roland Schüle, Klinikum der Universität Freiburg, Germany Androgen Receptor Function is Regulated by Histone Demethylases: Implication for Prostate Cancer
	W. Lee Kraus, Cornell University, USA Genomic Analyses of Estrogen-Regulated Transcription Reveal New Facets of the Estrogen Signaling Pathway
	Raphael Metivier, Université de Rennes I, France Estrogen Receptor Transcriptional Activity: A Dynamic Integration of Multi-Leveled Information
	Shigeaki Kato, University of Tokyo, Japan Epigenetic Regulators Supporting Nuclear Receptor Function
	Inez Rogatsky, Weill Medical College of Cornell University, USA Short Talk: The Role of GRIP1 in Type I Interferon Signaling and Glucocorticoid-Induced Immunosuppression
	Catharine L. Smith, University of Arizona, USA Short Talk: Histone Deacetylases Function as Glucocorticoid Receptor Coactivators
Following Session is for Nuclear Receptors: Development (X8)
8:00 - 11:15 AM	Cell Fate and Tissue Homeostasis Registered attendees for this meeting can view Abstracts for this session starting on 02/21/2010	Longs Peak
	* Joyce J. Repa, University of Texas Southwestern Medical Center, USA
	Thomas Perlmann, Karolinska Institutet, Ludwig Institute for Cancer Research, Sweden NR4A Orphan Nuclear Receptors Trigger a Neuroprotective Pathway Induced by Elevated Cyclic AMP

	Gary D. Hammer, University of Michigan, USA SF-1/DAX: Adrenocortical Stem/Progenitor Cell Fate and Multipotency
	Frances M. Sladek, University of California, Riverside, USA HNF4alpha Function and Regulation -- New Insights into an Old Receptor
	Erin G. Schuetz, St. Jude Children's Research Hospital, USA Cis and Trans Genetic Variation Affecting Hepatic Nuclear Hormone Receptor Expression
	Jae Woon Lee, Baylor College of Medicine, USA Short Talk: Histone H3-lysine 4 Methyltransferases Specialized for Nuclear Receptor-Mediated Metabolic Homeostasis
	Kai Ge, NIDDK, National Institutes of Health, USA Short Talk: Epigenetic Regulation of PPARgamma and Adipogenesis
9:20 - 9:40 AM	Coffee Break	Longs Peak Foyer
11:15 AM-	On Own for Lunch and Recreation
11:15 AM- 1:00 PM	Poster Setup	Shavano/Torreys
1:00 - 10:00 PM	Poster Viewing	Shavano/Torreys
2:30 - 4:30 PM	Workshop 3: Hot Topics: Signaling and Cancer	Grays Peak
	* Jonna Frasor†, University of Illinois, Chicago, USA
	Shannon T. Bailey, Dana-Farber Cancer Institute, USA Loss of ER-Regulated microRNAs is Fundamental to Hormone-Independent Breast Cancer Cells
	Ruby Dhar, University of Chicago, USA Genome Wide RNAi Screen to Identify Novel Targets for Estrogen Signaling in Breast Cancer
	Zeynep Madak-Erdogan, University of Illinois at Urbana-Champaign, USA Critical Role of ERK2 in Estrogen Receptor alpha (ERalpha)-mediated Regulation of Gene Expression and Proliferation of Breast Cancer Cells
	Lillian J. Eichner, McGill University, Canada miR-378 Induces Metabolic Shift in Breast Cancer Cells via the ERRgamma Transcriptional Pathway
	Jun Qin, Baylor College of Medicine, USA COUP-TFII Regulates Angiogenesis to Promote Tumor Growth and Metastasis
	Matthew J. Schiewer, Thomas Jefferson University, USA Impact of PARP1 on AR Signaling and Therapeutic Response in Prostate Cancer
Following Workshop is for Nuclear Receptors: Development (X8)
2:30 - 4:30 PM	Workshop 3: Hot Topics: Nuclear Receptors in Metabolism Registered attendees for this meeting can view Abstracts for this session starting on 02/21/2010	Longs Peak
	* Carolyn L. Cummins, University of Toronto, Canada
	Kari T. Chambers, Washington University School of Medicine, USA PGC-1beta Regulates Hepatic Energy Metabolism Under ad Libitum Fed Conditions
	Philipp M. Kulozik, German Cancer Research Center, Germany Lack of Hepatic TBL1/TBLR1 Transcriptional Co-Activator Function Promotes Obesity-Related Dyslipidemia
	Hong Soon Kang†, NIEHS, National Institutes of Health, USA Retinoid-Related Orphan Receptor alpha (RORalpha) Positively Regulates Obesity, Hepatic Steatosis, and Inflammation
	Yanqiao Zhang, Northeastern Ohio Universities College of Medicine, USA Identification of Novel Pathways that Control FXR-mediated Hypocholesterolemia
	Katja A. Lamia, The Salk Institute for Biological Studies, USA AMPK Regulates the Circadian Clock by Cryptochrome Phosphorylation and Degradation
4:30 - 5:00 PM	Coffee Available	Longs Peak Foyer
5:00 - 7:15 PM	Coregulators and Gene Expression (Joint) Registered attendees for this meeting can view Abstracts for this session starting on 02/21/2010	Grays/Longs Peaks
	* Carole R. Mendelson, University of Texas Southwestern Medical Center, USA
	Bert W. O'Malley, Baylor College of Medicine, USA NR Coactivators: Physiology and Disease
	Sunil Nagpal, Wyeth Research, USA LXR is a Therapeutic Target for Skin Aging and Dermal Inflammatory Indications
	Mitchell A. Lazar, University of Pennsylvania School of Medicine, USA Epigenetic Regulation of Nuclear Receptor Expression, Cistromes, and Function
	Ralf Kittler, University of Texas Southwestern Medical Center, USA Short Talk: A cis-Regulatory Map for Nuclear Receptors in Breast Cancer
	Ronald N. Margolis, NIDDK, National Institutes of Health, USA Short Talk: dkCOIN: A BIG Solution to Data Integration
7:15 - 8:15 PM	Social Hour w/ Lite Bites	Shavano/Torreys
7:30 - 10:00 PM	Poster Session 3 Registered attendees for this meeting can view Abstracts for this session starting on 02/21/2010	Shavano/Torreys
Thursday, March 25
7:00 - 8:00 AM	Breakfast	Shavano/Torreys
8:00 - 11:15 AM	Steroid Receptors, Signaling and Cancer Registered attendees for this meeting can view Abstracts for this session starting on 02/21/2010	Grays Peak
	* John A. Cidlowski, NIEHS, National Institutes of Health, USA
	Kathryn B. Horwitz, University of Colorado Health Sciences Center, USA Women’s Hormones, Breast Cancer Metastasis and Cancer Stem Cells
	Jan-Åke Gustafsson, Karolinska Institute, Sweden Novel Biological Roles of LXRs
	Karen Elizabeth Knudsen, Thomas Jefferson University, Kimmel Cancer Center, USA New Paradigms in Tumor Suppression: The RB-E2F Axis and Nuclear Receptor Regulation in Cancer
	Charles L. Sawyers, Memorial Sloan-Kettering Cancer Center, USA Overcoming Resistance to Anti-Androgen Therapy in Prostate Cancer
	Yun Qiu, University of Maryland School of Medicine, USA Short Talk: Androgen Receptor Splicing Variants and Castration Resistance in Prostate Cancer
	Suzanne D. Conzen, University of Chicago, USA Short Talk: Identification of a Glucocorticoid Receptor Signature in Primary Human Breast Cancers
Following Session is for Nuclear Receptors: Development (X8)
8:00 - 11:15 AM	Nuclear Receptors in Metabolism Registered attendees for this meeting can view Abstracts for this session starting on 02/21/2010	Longs Peak
	Joyce J. Repa, University of Texas Southwestern Medical Center, USA Nuclear Receptors in Pancreatic Beta Cells
	Steven A. Kliewer, University of Texas Southwestern Medical Center, USA Regulation of Metabolism by Nuclear Receptor-FGF Pathways
	Anastasia Kralli, The Scripps Research Institute, USA ERR Function in Energy Metabolism and Cancer
	* Vincent Giguère, McGill University, Canada Metabolic Gene Networks in Normal and Cancer Cells: One Nuclear Receptor Subfamily to Rule them All
	Carolyn L. Cummins, University of Toronto, Canada Short Talk: LXRbeta is Required for Glucocorticoid-Induced Hyperglycemia and Hepatosteatosis
	Yihong Wan, University of Texas Southwestern Medical Center, USA Short Talk: PGC1beta Mediates PPARgamma Activation of Osteoclastogenesis and Rosiglitazone-Induced Bone Loss
9:20 - 9:40 AM	Coffee Break	Longs Peak Foyer
11:15 AM-	On Own for Lunch and Recreation
4:30 - 5:00 PM	Coffee Available	Longs Peak Foyer
5:00 - 7:00 PM	Nuclear Receptors, Signaling, and Gene Regulation (Joint) Registered attendees for this meeting can view Abstracts for this session starting on 02/21/2010	Grays/Longs Peaks
	* Ronald M. Evans, The Salk Institute, USA
	David J. Mangelsdorf, University of Texas Southwestern Medical Center, USA Nutrient-Sensing and Metabolic Control by Nuclear Receptors
	Benita S. Katzenellenbogen, University of Illinois at Urbana-Champaign, USA Genomics of Estrogen Receptor Signaling in Breast Cancer and Endocrine Resistance
	Myles Brown, Dana Farber Cancer Institute, USA Nuclear Receptor Cistromes and Epigenomes
	Edwin Cheung, Genome Institute of Singapore, Singapore Short Talk: Global and Funcational Analyses of ER-Mediated Long-Range Chromatin Interactions
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Shavano/Torreys
8:00 - 11:00 PM	Entertainment	Shavano/Torreys
Friday, March 26
	Departure
*=Session Chair †=Speaker invited, not yet responded.

We gratefully acknowledge support for this conference from:

The Directors' Fund

These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.

We gratefully acknowledge the generous grants for this conference provided by:

National Institutes of Health
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
National Institute on Aging (NIA)
Grant No. 1R13DK084688-01

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Nuclear receptors (NRs) comprise a large family of ligand-regulated transcription factors that play critical roles in physiology and disease. Much of the focus has been on the nuclear actions of NRs, including interactions with coregulators, modulation of chromatin structure, and regulation of gene expression. Recent studies, however, have also suggested a role for membrane- or cytoplasmic-initiated actions of NRs and crosstalk with other cellular signaling pathways. Current studies are aimed at understanding how the ligand-dependent molecular actions of NRs, including their subcellular localization, binding across the genome, and interaction with the proteome, connect to their roles in physiological and pathophysiological processes, including hormone-regulated cancers. In addition, NRs are being explored as targets for drug development, with many compounds on the market or in ongoing clinical trials. This meeting will highlight recent breakthroughs in NR research, promote interactions between scientists from industry and academia, and provide opportunities for senior scientists to interact with younger researchers and trainees.

Nuclear Receptors: Signaling, Gene Regulation and Cancer (X7)