Keystone Symposia Conference | Developmental Origins and Epigenesis in Human Health and Disease

Meeting Program

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Monday, April 26
3:00 - 7:30 PM	Registration	Stamford Foyer
6:30 - 7:30 PM	Refreshments	Stamford Foyer
7:30 - 7:45 PM	Opening Address and Welcoming Remarks Registered attendees for this meeting can view Abstracts for this session starting on 03/26/2010	Stamford Ballroom
	Chuan Poh Lim, Chairman, Agency for Science Technology and Research (A*STAR), Singapore
7:45 - 8:45 PM	Keynote Address Registered attendees for this meeting can view Abstracts for this session starting on 03/26/2010	Stamford Ballroom
	Adrian P. Bird, University of Edinburgh, UK Investigating the Molecular Basis of Rett Syndrome
Tuesday, April 27
8:00 - 9:00 AM	Breakfast	Canning Ballroom
8:00 - 9:00 AM	Poster Setup	Stamford & Bencoolen Foyer
9:00 AM- 12:00 PM	Mechanisms of Developmental Plasticity Registered attendees for this meeting can view Abstracts for this session starting on 03/26/2010	Stamford Ballroom
	* Anne Ferguson-Smith, University of Cambridge, UK Genomic Imprinting as an Adaptive Model of Developmental Plasticity
	Stephen M. Cohen, Temasek Life Sciences Laboratory, Singapore MicroRNA Functions: Insights from Drosophila Genetics
	Emma Whitelaw, Queensland Institute of Medical Research, Australia Epigenetics and Transgenerational Effects
	John Mattick, University of Queensland, Australia RNA as the Regulator of Epigenetic Memory and the Mediator of Epigenome-Environment Interactions
	Kian Peng Koh, Immune Disease Institute, Harvard Medical School, USA Short Talk: Tet1/Cxxc6 and Related Enzymes, a New Family of 5-Methylcytosine Hydroxylases, Modulate Pluripotency and Cell Lineage Specification in Mouse Embryonic Stem Cells
10:20 - 10:40 AM	Coffee Break	Stamford & Bencoolen Foyer
12:00 - 1:00 PM	Lunch	Canning Ballroom
12:00 - 5:00 PM	Poster Viewing	Stamford & Bencoolen Foyer
12:00 - 2:30 PM	Poster Session 1 Registered attendees for this meeting can view Abstracts for this session starting on 03/26/2010	Stamford & Bencoolen Foyer
2:30 - 3:00 PM	Coffee Available	Stamford & Bencoolen Foyer
3:00 - 5:00 PM	Phenotypic Plasticity in Evolution Registered attendees for this meeting can view Abstracts for this session starting on 03/26/2010	Stamford Ballroom
	* Russell D. Fernald, Stanford University, USA Social Control of the Brain
	Hamish Spencer, University of Otago, New Zealand The Evolution of Phenotypic Plasticity: Insights from Theory
	Chris O'Neill, University of Sydney, Australia Short Talk: Dynamic Changes in Cytosine Methylation Occur during the First Two Cell-Cycles of Embryo Development
	Yijun Ruan†, Genome Institute of Singapore, Singapore Short Talk: Estrogen Induced Chromatin Interaction and Transcription Regulation in Cancer Cells
Wednesday, April 28
8:00 - 9:00 AM	Breakfast	Canning Ballroom
8:00 - 9:00 AM	Poster Setup	Stamford & Bencoolen Foyer
9:00 AM- 12:00 PM	Developmental Influences in Chronic Disease Registered attendees for this meeting can view Abstracts for this session starting on 03/26/2010	Stamford Ballroom
	* Peter Gluckman, University of Auckland, New Zealand The Developmental Contribution to the Risk of Chronic Disease
	Caleb E. Finch, University of Southern California, USA Early Exposure to Infections Accelerates Aging
	Joseph Nadeau, Case Western Reserve University, USA Transgenerational Epigenetic Control of Phenotypic Variation and Disease Risk
	Keith M. Godfrey, University of Southampton, UK Insights into Human Development and Disease from Birth Cohort Studies
10:20 - 10:40 AM	Coffee Break	Stamford & Bencoolen Foyer
12:00 - 1:00 PM	Lunch	Canning Ballroom
12:00 - 5:00 PM	Poster Viewing	Stamford & Bencoolen Foyer
12:30 - 2:30 PM	Poster Session 2 Registered attendees for this meeting can view Abstracts for this session starting on 03/26/2010	Stamford & Bencoolen Foyer
2:30 - 3:00 PM	Coffee Available	Stamford & Bencoolen Foyer
3:00 - 5:00 PM	Neural Development Registered attendees for this meeting can view Abstracts for this session starting on 03/26/2010	Stamford Ballroom
	* Michael Meaney, McGill University, Canada Developmental Influences on Cognitive Processes
	Yi Eve Sun, University of California, Los Angeles, USA DNA Methylation and Neural Cell Fate
	Zhao Xu, Beth Israel Deaconess Medical Center, USA Short Talk: Pathway Discovery in Adipocyte Biology Using Epigenomics
	Assam El-Osta, Baker Heart Research Institute, Australia Short Talk: Persistent Changes in the Epigenetic Code Explaining Hyperglycemic Memory
Thursday, April 29
8:00 - 9:00 AM	Breakfast	Canning Ballroom
9:00 AM- 12:00 PM	Environmental Control of Tissue Differentiation Registered attendees for this meeting can view Abstracts for this session starting on 03/26/2010	Stamford Ballroom
	Zofia Zukowska, Georgetown University, USA Gender-Specific Stress-Induced Programming for Obesity: Role of Neuropeptide Y and Adipose Stem Cells
	Stephen Suomi, National Institute of Child Health and Human Development, NIH, USA Genetic and Environmental Effects on Behavior: Nonhuman Primate Model
	Judy Sng, Singapore Institute of Clinical Sciences, Singapore Control of the Critical Period in Sensory Development
	Jonathan R. Seckl, University of Edinburgh School of Clinical Sciences & Community Health, UK Glucocorticoid 'Programming' of the Brain: From Stress to Liquorice
10:20 - 10:40 AM	Coffee Break	Stamford & Bencoolen Foyer
2:30 - 3:00 PM	Coffee Available	Stamford & Bencoolen Foyer
3:00 - 5:00 PM	Environmental Factors and Developmental Plasticity Registered attendees for this meeting can view Abstracts for this session starting on 03/26/2010	Stamford Ballroom
	* Terrence Forrester, University of the West Indies, Jamaica Human Polyphenisms and Nutritional Adaptation
	Michael Skinner, Washington State University, USA The Environment and Epigenetics on Transgenerational Inheritance
	Robert Waterland, Baylor College of Medicine, USA The Search for Human Metastable Epialleles
	Corrado Spadafora, Istituto Superiore di Sanità (Italian National Institute of Health), Italy Short Talk: Retrotransposons, Reverse Transcriptase and the Genesis of New Genetic Information
5:00 - 7:00 PM	Social Hour w/ Lite Bites	Stamford & Bencoolen Foyer
Friday, April 30
	Departure
*=Session Chair †=Speaker invited, not yet responded.

Keystone Symposia would like to thank the sponsor of this meeting for their generous support:

We gratefully acknowledge additional support for this conference from:


American Society for Human Genetics

We gratefully acknowledge the generous grants for this conference provided by:

National Institutes of Health
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
National Institute of Neurological Disorders and Stroke (NINDS)
Grant No. 1R13HD065349-01

The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

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Developmental plasticity results from the interplay of fetal environment and genetic factors. There is considerable data to indicate that these interactions play an important role in the susceptibility of the individual to the development of chronic diseases such as diabetes, obesity, and to the cognitive capacity of that individual. Evidence suggests that gene/environment interactions may result in epigenetic changes that not only indicate susceptibility to chronic disease, but may play a causative role in the processes. The specific nature of the signaling pathways that dictate these susceptibilities and capacities are not known. This symposium is designed to explore experimental models of development, to understanding the role of epigenetics in regulating important signaling pathways, and to examine the relationship of the fetal environment to normal development and the susceptibility to chronic disease.

Developmental Origins and Epigenesis in Human Health and Disease (D1)