Keystone Symposia Conference | Synapses: Formation, Function and Misfunction

Meeting Program

To view program in "24 hour" time (international) click here.

Sunday, April 11
3:00 - 7:30 PM	Registration	Ballroom Lobby
6:30 - 7:30 PM	Refreshments	Ballroom Lobby
7:30 - 8:30 PM	Keynote Address (Joint) Registered attendees for this meeting can view Abstracts for this session starting on 03/11/2010	Ballroom 2-3
	* Matthew B. Dalva, University of Pennsylvania, USA
	Michael E. Greenberg, Harvard Medical School, USA Signaling Networks that Control Synapse Development and Cognitive Function
Monday, April 12
7:00 - 8:00 AM	Breakfast	Golden Cliff/Eagles
8:00 - 11:15 AM	Circuit Formation Registered attendees for this meeting can view Abstracts for this session starting on 03/11/2010	Ballroom 3
	* Yishi Jin, University of California, San Diego, USA
	Anirvan Ghosh, University of California, San Diego, USA On the Emergence of Synaptic Specificity in Developing Neural Circuits
	Kang Shen, Stanford University, USA Intrinsic and Extrinsic Factors Pattern Synaptic Circuit Assembly in C. elegans
	Silvia Arber, Biozentrum, University of Basel, Friedrich Miescher Institute, Switzerland Mechanisms Controlling Synaptic Specificity in the Motor System
	Hitoshi Sakano, University of Tokyo, Japan Autonomous Topographic Map Formation by Olfactory Axons in Mouse
	Fatiha Boukhtouche, Biozentrum, University of Basel, Switzerland Short Talk: Trans-Synaptic BMP Signaling in the Ponto-Cerebellar Projection System
	Beatriz Rico, Instituto de Neurociencias de Alicante, Spain Short Talk: Control of Cortical GABAergic Circuitry Development by Nrg1/ErbB4 Signalling
Following Session is for Autism (Z4)
8:00 - 11:00 AM	The Autism Phenotype Registered attendees for this meeting can view Abstracts for this session starting on 03/11/2010	Ballroom 2
	* Pat Levitt, Keck School of Medicine, USA
	Joseph Piven, University of North Carolina at Chapel Hill, USA The Syndrome of Autism: Phenomenology

	Patrick Bolton, King's College, London, UK Overview of Medical Conditions Associated with the Autistic Phenotype

	Thomas Portmann, Stanford University, USA Short Talk: Analysis of a Patient-Derived Cellular Model System for Autism Spectrum Disorders
	Elizabeth M. Berry-Kravis, RUSH University Medical Center, USA Autism Phenotype in Fragile X Syndrome: A Door to Molecular Pathways and New Targeted Treatment Strategies
9:20 - 9:40 AM	Coffee Break	Ballroom Lobby
11:15 AM-	On Own for Lunch and Recreation
11:15 AM- 1:00 PM	Poster Setup	Superior/Superior Lobby/Wasatch/Maybird
1:00 - 10:00 PM	Poster Viewing	Superior/Superior Lobby/Wasatch/Maybird
4:30 - 5:00 PM	Coffee Available	Ballroom Lobby
5:00 - 7:00 PM	Synaptic Adhesion and Signaling Registered attendees for this meeting can view Abstracts for this session starting on 03/11/2010	Ballroom 3
	* Thomas L. Schwarz†, Children's Hospital, Boston and Harvard Medical School, USA
	Matthew B. Dalva, University of Pennsylvania, USA Postsynaptic Mechanisms Guiding Synapse Development
	Ann Marie Craig, University of British Columbia, Canada Molecular Assembly of Hippocampal Synapses
	Lisa M. Boulanger, Princeton University, USA Regulation of Synaptic Transmission and Synaptic Plasticity by MHC Class I
	Robby M. Weimer, Genentech, USA Short Talk: Death Receptor 6 (DR6) Regulates Synapse Stability in vivo
Following Session is for Autism (Z4)
5:00 - 7:00 PM	FXS Registered attendees for this meeting can view Abstracts for this session starting on 03/11/2010	Ballroom 2
	* Joseph Piven, University of North Carolina at Chapel Hill, USA
	Randi J. Hagerman, University of California, Davis, USA Molecular Mechanisms of ASD in the Premutation and the Full Mutation

	Mark F. Bear, Massachusetts Institute of Technology, USA Activity Dependent Regulation of Glutamate Receptors and the Neurobiology of FXS
	Claudia Bagni, Catholic University of Leuven, Belgium Molecular Aspects of Mental Retardation: Insights from the Fragile X Syndrome
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Superior/Superior Lobby/Wasatch/Maybird
7:30 - 10:00 PM	Poster Session 1 Registered attendees for this meeting can view Abstracts for this session starting on 03/11/2010	Superior/Superior Lobby/Wasatch/Maybird
Tuesday, April 13
7:00 - 8:00 AM	Breakfast	Golden Cliff/Eagles
8:00 - 11:15 AM	Transynaptic Mechanisms Registered attendees for this meeting can view Abstracts for this session starting on 03/11/2010	Ballroom 3
	* Elva Diaz, University of California Davis School of Medicine, USA
	Hisashi Umemori, University of Michigan, USA Wiring the Functional Brain
	Thomas Biederer, Yale University, USA Synaptic Adhesion Complexes Organize Synapse Development
	Michisuke Yuzaki, School of Medicine, Keio University, Japan Cbln1 and its Receptor: A Unique and Essential Bidirectional Synaptic Organizer Complex
	Vivian Budnik, University of Massachusetts Medical School, USA Trans-Synaptic Transport of a Vesicular Wnt Signal
	Brian D. McCabe, Columbia University, USA Short Talk: Retrograde Robo Signaling Coordinates Synaptic Maturation
	Matthew J. Kennedy, Duke University, USA Short Talk: A Domain for Activity-Triggered Postsynaptic Exocytosis in Dendritic Spines
Following Session is for Autism (Z4)
8:00 - 11:00 AM	15q, CNV and Rare Syndromes Registered attendees for this meeting can view Abstracts for this session starting on 03/11/2010	Ballroom 2

	Carolyn Schanen, A.I. duPont Hospital for Children, USA Increasing Molecular and Phenotypic Complexities of the Chromosome 15q11.2-q13.3 Duplication Syndromes in Autism Spectrum Disorders


	Elisabeth Dykens, Vanderbilt University, USA Prader-Willi Syndrome and Other Disorders
	Matthew W. State, Yale Child Study Center, USA Rare Structural and Sequence Variation in Autism Spectrum Disorders
	Toru Takumi, Hiroshima University, Japan Neurobiology of Chromosome 15 Copy Variants in Mice
	Michael J. Ronemus, Cold Spring Harbor Laboratory, USA Short Talk: Rare and de novo Mutations in the Simons Simplex Collection
9:20 - 9:40 AM	Coffee Break	Ballroom Lobby
11:15 AM-	On Own for Lunch and Recreation
11:15 AM- 1:00 PM	Poster Setup	Superior/Superior Lobby/Wasatch/Maybird
1:00 - 10:00 PM	Poster Viewing	Superior/Superior Lobby/Wasatch/Maybird
4:30 - 5:00 PM	Coffee Available	Ballroom Lobby
5:00 - 7:00 PM	Glia Cells and Synapse Formation Registered attendees for this meeting can view Abstracts for this session starting on 03/11/2010	Ballroom 3
	* Christopher W. Cowan†, University of Texas-Southwestern Medical School, USA
	Cagla Eroglu, Duke University Medical Center, USA How do Astrocytes Induce Central Nervous System Synaptogenesis?
	Philip G. Haydon, Tufts University, USA Glia: Listening and Talking to the Synapse
	Dwight E. Bergles, Johns Hopkins School of Medicine, USA Synaptic Communication between Neurons and Glial Cells in the Mammalian Brain
	Suzanne Paradis, Brandeis University, USA Short Talk: Elucidating the Function of Semaphorin 4D in GABAergic Synapse Formation
Following Session is for Autism (Z4)
5:00 - 7:00 PM	PI3 Kinase Dysfunction Registered attendees for this meeting can view Abstracts for this session starting on 03/11/2010	Ballroom 2
	* Carolyn Schanen, A.I. duPont Hospital for Children, USA
	Alcino J. Silva, University of California, Los Angeles, USA Tsc2 Haploinsufficiency and Gestational Immune Activation: Interactive Effects in Mice
	Pat Levitt, Keck School of Medicine, USA MET Receptor Tyrosine Kinase and Social-Emotional Circuit Wiring Relevant to Autism Spectrum Disorder

	Luis F. Parada, University of Texas Southwestern Medical Center, USA Mouse Models as Translational Tools to Discover Treatments for Autism Spectrum Disorders: Focus on Rapamycin
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Superior/Superior Lobby/Wasatch/Maybird
7:30 - 10:00 PM	Poster Session 2 Registered attendees for this meeting can view Abstracts for this session starting on 03/11/2010	Superior/Superior Lobby/Wasatch/Maybird
Wednesday, April 14
7:00 - 8:00 AM	Breakfast	Golden Cliff/Eagles
8:00 - 11:15 AM	Synaptic and Circuit Function in Neurodevelopmental Disorders (Joint) Registered attendees for this meeting can view Abstracts for this session starting on 03/11/2010	Ballroom 3
	* Peter Scheiffele, Biozentrum, University Basel, Switzerland
	Jennifer Darnell, Rockefeller University, USA HITS-CLIP Identifies Specific Neuronal mRNA Targets of Translational Repression by the Fragile X Mental Retardation Protein, FMRP
	Kimberly M. Huber, University of Texas Southwestern Medical Center, USA Regulation of Synapse Number by Fragile X Mental Retardation Protein
	Ben D. Philpot, University of North Carolina at Chapel Hill, USA Angelman Syndrome and Synaptic Plasticity
	Nils Brose, Max Planck Institute of Experimental Medicine, Germany Genetic Dissection of Neuroligin Function: From Synaptogenesis to Autism
	Jeremy Veenstra-VanderWeele†, Vanderbilt University Medical Center, USA Short Talk: Hyperserotonemia, Enhanced Brain Serotonin Clearance, and Altered Behavior Accompany Knock-In of the Autism-Associated SERT Ala56 Variant
	Kristen Jennifer Brennand, The Salk Institute for Biological Studies, USA Short Talk: Modeling Schizophrenia Using hiPS-Derived Neurons
9:20 - 9:40 AM	Coffee Break	Ballroom Lobby
11:15 AM-	On Own for Lunch and Recreation
4:30 - 5:00 PM	Coffee Available	Ballroom Lobby
5:00 - 7:00 PM	Technology Registered attendees for this meeting can view Abstracts for this session starting on 03/11/2010	Ballroom 3
	* Philip G. Haydon†, Tufts University, USA
	Ed Callaway, The Salk Institute, USA New Rabies-Based Tools for Studies of the Structure and Function of Neural Circuits
	Karl Deisseroth, Stanford University, USA Optogenetics: Development and Application
	Jun Ding, Harvard Medical School, USA Short Talk: Deep Tissue Supraresolution Imaging of Neurons Using Stimulated-Emission Depletion 2-Photon Laser Scanning Microscopy
Following Session is for Autism (Z4)
5:00 - 7:00 PM	Epigenetic Modifiers of Neurodevelopmental Disorders Registered attendees for this meeting can view Abstracts for this session starting on 03/11/2010	Ballroom 2
	* Alcino J. Silva, University of California, Los Angeles, USA
	Moshe Szyf, McGill University, Canada How Early Life Experience Modifies the Epigenome and Affects Mental Health

	Lisa M. Monteggia, University of Texas Southwestern Medical Center, USA Role of MeCP2 and HDACs in Regulating Synapse Function and Behavior
	Courtney A. Miller, The Scripps Research Institute, USA Epigenetics and Memory
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Ballroom 1-2
8:00 - 11:00 PM	Entertainment	Ballroom 1-2
Thursday, April 15
	Departure
*=Session Chair †=Speaker invited, not yet responded.

We gratefully acknowledge support for this conference from:

The Directors' Fund

These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.

We gratefully acknowledge the organizations that provide Keystone Symposia with additional support, such as marketing and advertising...

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During the last half-decade, a host of cellular mechanisms guiding synapse development have been identified. Exciting new links are being forged between our growing understanding of the basic processes and certain diseases. A major driving force in current research of synapses is new technologies. We propose to develop a meeting that would focus on these areas. Our meeting will bring together scientists working on the basic biological questions of how synapses form in model organisms, the development of new technology, and those with interests in understanding the links to human diseases.

Synapses: Formation, Function and Misfunction (Z3)