Keystone Symposia
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LANGUAGE NOTE: This meeting will be conducted in English.
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Meeting Program

To view program in "24 hour" time (international) click here.


Sunday, February 21
3:00 - 7:30 PM Registration De Anza Foyer
6:30 - 7:30 PM Refreshments De Anza I-II
Monday, February 22
7:00 - 8:00 AM Breakfast De Anza I-II
8:00 - 11:00 AM Cell Biology of Cilia and Intraflagellar Transport
Registered attendees for this meeting can view Abstracts for this session starting on 01/21/2010
De Anza III
* Tim Stearns, Stanford University, USA
Joel Rosenbaum, Yale University, USA
Membrane Vesicle Trafficking from the Cytoplasm, to the Flagellum, and into the Medium
Jonathan Scholey, University of California, Davis, USA
IFT and Cilium-Based Signaling: Dissecting the Distal Singlet Pathway
George B. Witman, University of Massachusetts Medical School, USA
Chlamydomonas as a Model for Human Ciliopathies
Gregory Pazour, University of Massachusetts Medical School, USA
Trafficking Proteins to the Ciliary Membrane
Christopher J. Westlake†, Genentech, Inc., USA
Short Talk: Building the Primary Cilium Membrane: Regulation of GEF Trafficking and Activity and a Rab11-Rab8 Cascade
9:20 - 9:40 AM Coffee Break De Anza Foyer
11:00 AM- On Own for Lunch and Recreation
11:00 AM- 1:00 PM Poster Setup De Anza I-II
1:00 - 10:00 PM Poster Viewing De Anza I-II
4:30 - 5:00 PM Coffee Available De Anza Foyer
5:00 - 7:00 PM Bardet-Biedl Syndrome, Alstrom Syndrome, Obesity Syndromes
Registered attendees for this meeting can view Abstracts for this session starting on 01/21/2010
De Anza III
* Jonathan Scholey, University of California, Davis, USA
Val C. Sheffield, University of Iowa, USA
Human Genetics, Function, and Physiology in Bardet-Biedl Syndrome
Maxence V. Nachury, Stanford University School of Medicine, USA
Identification and Functional Characterization of the Tubulin Acetyltransferase in Men and Worms
Juergen K. Naggert, The Jackson Laboratory, USA
Alstrom Syndrome, a Ciliopathy
Wallace Marshall†, University of California, San Francisco, USA
Short Talk: The Flagellar Length Control System
7:00 - 8:00 PM Social Hour w/ Lite Bites De Anza Foyer
7:30 - 10:00 PM Poster Session 1
Registered attendees for this meeting can view Abstracts for this session starting on 01/21/2010
De Anza I-II
Tuesday, February 23
7:00 - 8:00 AM Breakfast De Anza I-II
8:00 - 11:15 AM Morphogen Pathways and Cilia
Registered attendees for this meeting can view Abstracts for this session starting on 01/21/2010
De Anza III
* John Wallingford, University of Texas at Austin, USA
Matthew P. Scott, Stanford University, USA
Hedgehog Transduction through Cilia
Andrew P. McMahon, Harvard University, USA
The Primary Cilium and Hedgehog Signaling
H. Joseph Yost, University of Utah, USA
FGF Signaling Pathways and Heparan Sulfate Proteoglycan Fine Structures Converge at Cilia in the Development of Diverse Epithelia
Martin Blum, University of Hohenheim, Germany
Short Talk: The Nodal Inhibitor Coco Represents the Critical Target of Leftward Flow in Xenopus
Ivan P.G. Moskowitz, University of Chicago, USA
Short Talk: An Allelic Series of Intraflagellar Transport Protein 172 Implicates a Quantitative Loss of Hedgehog Signaling in VACTERL with Hydrocephalus
Jeremy F. Reiter, University of California, San Francisco, USA
Ofd1, a Ciliopathy Gene, Regulates the Length and Distal Structure of Centrioles
9:20 - 9:40 AM Coffee Break De Anza Foyer
11:15 AM- On Own for Lunch and Recreation
11:15 AM- 1:00 PM Poster Setup De Anza I-II
1:00 - 10:00 PM Poster Viewing De Anza I-II
4:30 - 5:00 PM Coffee Available De Anza Foyer
5:00 - 7:00 PM Neural Development
Registered attendees for this meeting can view Abstracts for this session starting on 01/21/2010
De Anza III
* Matthew P. Scott, Stanford University, USA
Kathryn V. Anderson, Memorial Sloan-Kettering Cancer Center, USA
Cilia and Mouse Hedgehog Signaling
Joseph G. Gleeson, University of California, San Diego, USA
Uncovering New Signaling Mechanisms in the Ciliopathy Disorders
Jonathan T. Eggenschwiler†, Princeton University, USA
Short Talk: Broad-Minded Links Ciliary Assembly, Cell Cycle-Related Kinase Function, and Mammalian Hedgehog Signaling
Chris R. Kintner, The Salk Institute, USA
Developmental Mechanisms Specifying Different Cilia Subtypes
7:00 - 8:00 PM Social Hour w/ Lite Bites De Anza Foyer
7:30 - 10:00 PM Poster Session 2
Registered attendees for this meeting can view Abstracts for this session starting on 01/21/2010
De Anza I-II
Wednesday, February 24
7:00 - 8:00 AM Breakfast De Anza I-II
8:00 - 11:15 AM Sensory Events and Cilia
Registered attendees for this meeting can view Abstracts for this session starting on 01/21/2010
De Anza III
* Jeremy F. Reiter, University of California, San Francisco, USA
Piali Sengupta, Brandeis University, USA
Generation and Maintenance of Specialized Sensory Cilia in C. elegans
Abigail Tadenev, Johns Hopkins School of Medicine, USA
Short Talk: Olfactory Phenotypes of BBS8-Null Mice
Jagesh V. Shah, Harvard Medical School, USA
Short Talk: Identification of Signaling Pathways Regulating Primary Cilium Length and Flow-Mediated Adaptation
Tomer Avidor-Reiss, Harvard Medical School, USA
Centriole and Cilia - Formation and Inheritance
Brian Dynlacht, New York University School of Medicine, USA
CP110 and Control of the Centriole and Cilia Biogenesis
John Wallingford, University of Texas at Austin, USA
Planar Cell Polarity and Ciliogenesis
9:20 - 9:40 AM Coffee Break De Anza Foyer
11:15 AM- On Own for Lunch and Recreation
4:30 - 5:00 PM Coffee Available De Anza Foyer
5:00 - 7:15 PM Kidneys, Cysts, and Cystic Diseases
Registered attendees for this meeting can view Abstracts for this session starting on 01/21/2010
De Anza III
* Brian Dynlacht, New York University School of Medicine, USA
Peter C. Harris, Mayo Clinic, USA
Role of Cilia in ADPKD and ARPKD
Friedhelm Hildebrandt, University of Michigan, USA
Genes and Mechanisms of Nephronophthisis-Like Ciliopathies
Peter K. Jackson, Genentech, Inc., USA
A Network of Proteins Mutated in Nephronophthisis, Joubert and Meckel-Gruber Syndromes Organize the Centriole and Primary Cilium
Michel R. Leroux, Simon Fraser University, Canada
Short Talk: Ciliary Transition Zone Proteins are Required for Proper Basal Body Positioning, Structural Integrity of the Ciliary Gate, and Proper Formation of the Axoneme
Rebecca D. Burdine, Princeton University, USA
Short Talk: Seahorse and Kurly are Members of a Cytoplasmic Complex that Functions in Cilia Motility and Downstream Phenotypes
7:15 - 8:15 PM Social Hour w/ Lite Bites De Anza Foyer
Thursday, February 25
7:00 - 8:00 AM Breakfast De Anza I-II
8:00 - 11:00 AM Cell Cycle, Tumor Suppressors, and Cancer
Registered attendees for this meeting can view Abstracts for this session starting on 01/21/2010
De Anza III
* Peter K. Jackson, Genentech, Inc., USA
Elizabeth Petri Henske, Brigham and Women's Hospital, USA
Tuberous Sclerosis, LAM, and the Primary Cilium: Where are the Links?
James G. Umen, The Salk Institute, USA
Short Talk: A Cyclin Dependent Kinase Mutant from Chlamydomonas Reveals a Conserved Role for the Retinoblastoma Tumor Suppressor Pathway in Cilia Biogenesis
Wilhelm Krek, ETH Zurich, Switzerland
Microtubule-Based pVHL Tumor Suppressor Mechanisms: From Primary Cilium Maintenance to Promotion of Error-Free Mitosis
Stephen Doxsey, University of Massachusetts Medical School, USA
The Cilia Protein IFT88 Forms Novel Mitotic Complexes and Functions in Spindle Pole Organization and the Orientation of the Mitotic Spindle and the Plane of Cell Division
Tim Stearns, Stanford University, USA
Centriole Age, Cilium Growth, and Asymmetric Cell Divisions
9:20 - 9:40 AM Coffee Break De Anza Foyer
11:00 AM- On Own for Lunch and Recreation
2:30 - 4:30 PM Workshop: Short Talk Symposium
De Anza III
* Peter K. Jackson, Genentech, Inc., USA
* Tim Stearns, Stanford University, USA
Cosima T. Baldari, University of Siena, Italy
Intraflagellar Transport is Required for Polarized Recycling of the TCR/CD3 Complex to the Immune Synapse
Saikat Mukhopadhyay, Genentech, Inc., USA
Understanding the Role of the Tubby Family Interactome in Primary Ciliary Signaling
Heather H. Ward, University of New Mexico, USA
A Multimeric GTPase Complex is Required for Trafficking Membrane Cystoproteins to Primary Cilia
Marina Bershteyn, Stanford University School of Medicine, USA
MIM and Cortactin Antagonism Regulates Ciliogenesis and Hedgehog Signaling
Sander Basten, University Medical Center Utrecht, the Netherlands
PCD Candidate Gene lrrc50 Predisposes to Testicular Tumors in Zebrafish
Peter G. Czarnecki†, Mayo Clinic, USA
Meckel Syndrome Proteins MKS1 and MKS3 in Ciliary Homeostasis and Wnt Pathway Control
4:30 - 5:00 PM Coffee Available De Anza Foyer
5:00 - 7:00 PM Cilia, Evolution, and Human Disease
Registered attendees for this meeting can view Abstracts for this session starting on 01/21/2010
De Anza III
* Stephen Doxsey, University of Massachusetts Medical School, USA
Arturo Alvarez-Buylla, University of California, San Francisco, USA
Primary Cilia in Neural Stem Cells and Cancer
Mónica Bettencourt Dias, Instituto Gulbenkian de Ciência, Portugal
Centriole Biogenesis and Evolution
Bill Wickstead, University of Oxford, UK
Short Talk: Reconstructing the Evolutionary History of the Centriole from Protein Components
Nicholas Katsanis, Johns Hopkins School of Medicine, USA
Total Mutational Load and Ciliary Disease
7:00 - 8:00 PM Social Hour w/ Lite Bites De Anza Foyer
8:00 - 11:00 PM Entertainment De Anza I-II
Friday, February 26
Departure
      *=Session Chair     †=Speaker invited, not yet responded.



We gratefully acknowledge support for this conference from:


The Directors' Fund

These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the organizations that provide Keystone Symposia with additional support, such as marketing and advertising...

Click here to view these companies

Proteins mediating a host of signaling pathways are organized within primary cilia. Human genetic studies have identified many developmental and degenerative diseases linked to ciliary function. These “ciliopathies” include retinal degeneration, sensory and neurological deficiencies, polycystic kidney disease, and obesity. Molecular genetic studies have connected ciliary transport and assembly mechanisms to developmental pathways, including the Hedgehog pathway, and signaling pathways, including GPCR regulators, but much remains unclear. This meeting will focus on how signaling is organized within cilia. Presentations will span signaling, the cell biology of cilia, human and molecular genetics of ciliopathies, and the biology of ciliated tissues, including morphogen pathways, tissue repair, and links to cell cycle or tumor suppressor control. Drawing on broad expertise and multiple systems, we hope to discuss both well-validated and candidate ciliary genes. The goal is to better define pathways coordinating morphogenesis of ciliated tissue with ciliary assembly and signaling.