Keystone Symposia Conference | Mechanisms of Whole Organ Regeneration

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Sunday, April 1
3:00 - 7:30 PM	Registration	Foyer
6:15 - 7:15 PM	Refreshments	Foyer
7:15 - 8:30 PM	Welcome and Keynote Address (Joint) Registered attendees for this meeting can view Abstracts for this session starting on 03/01/2012	Peaks 1-5
	* Rocky S. Tuan, University of Pittsburgh School of Medicine, USA
	* Alejandro Sánchez Alvarado, HHMI/Stowers Institute for Medical Research, USA
	Allan C. Spradling, HHMI/Carnegie Institute, USA Lessons from Stem Cells on Regeneration and Tissue Engineering
Monday, April 2
7:00 - 8:00 AM	Breakfast	Summit Gallery
8:00 - 11:15 AM	Injury-Activated Regeneration Registered attendees for this meeting can view Abstracts for this session starting on 03/01/2012	Peak 5
	* Phillip A. Newmark, HHMI/University of Illinois at Urbana-Champaign, USA
	Brigitte Galliot, University of Geneva, Switzerland Asymmetric Injury Responses Launch Two Different Types of Regenerative Programs in Hydra
	Alejandro Sánchez Alvarado, HHMI/Stowers Institute for Medical Research, USA Injury, Stem Cells and Regeneration of Body Parts in an Adult Organism
	Elly M. Tanaka, Center for Regenerative Therapies, Dresden, Germany Injury-Associated Signaling Pathways that Initiate Spinal Cord Regeneration in Salamanders
	Roeland Nusse, Stanford University, USA Wnt Signaling, Stem Cells and Tissue Repair
	Matthew D. Keefe, University of Utah, USA Short Talk: Molecular Mechanisms Controlling Exocrine Pancreas Growth and Regeneration
	Juan A. Larraín, P. Universidad Catolica de Chile, Chile Short Talk: Spinal Cord Regeneration in Xenopus
Following Session is for Regenerative Tissue Engineering and Transplantation (Z3)
8:00 - 11:15 AM	Clinical Applications and Challenges I Registered attendees for this meeting can view Abstracts for this session starting on 03/01/2012	Peaks 1-4
	* Ranieri Cancedda, University of Genova, Italy
	* Kenneth R. Chien, Massachusetts General Hospital, USA
	Anthony Atala, Wake Forest University, USA Tissue Engineered Urologic Organs
	Anthony P. Hollander, University of Bristol, UK Tissue-Engineered Cartilage: From the Knee to the Airway
	Maria Siemionow, Cleveland Clinic, USA Composite Facial Allograft Transplantation: Application of Cell-Based Therapies
	Mark E. Fleming, Walter Reed National Military Medical Center, USA Short Talk: Regenerative Medicine Applications in Combat Casualty Care
	Ugo Ripamonti, University of Wiwatersrand, South Africa Short Talk: Grand Challenges for Craniomandibulofacial Reconstruction by Human Recombinant Transforming Growth Factor-beta3
9:20 - 9:40 AM	Coffee Break	Foyer
11:15 AM- 1:00 PM	Poster Setup	Breckenridge Ballroom
11:15 AM-	On Own for Lunch and Recreation
1:00 - 10:00 PM	Poster Viewing	Breckenridge Ballroom
4:30 - 5:00 PM	Coffee Available	Foyer
5:00 - 7:00 PM	Physiological Regeneration Registered attendees for this meeting can view Abstracts for this session starting on 03/01/2012	Peak 5
	* Allan C. Spradling, HHMI/Carnegie Institute, USA
	Jenny Hsieh, University of Texas Southwestern Medical Center at Dallas, USA Timing is Everything: Development of New Neurons in the Adult Brain
	Linheng Li, Stowers Institute for Medical Research, USA Using Surface Markers to Enrich Intestinal Stem Cells Under Homeostatic and Injured Conditions
	Elaine Fuchs, HHMI/Rockefeller University, USA Stem Cells in the Skin: Natural Cycles of Regeneration
	Valentina Greco, Yale School of Medicine, USA Short Talk: Live Imaging Studies of the Stem Cell Niche of the Hair Follicle
Following Session is for Regenerative Tissue Engineering and Transplantation (Z3)
5:00 - 7:00 PM	Clinical Applications and Challenges II Registered attendees for this meeting can view Abstracts for this session starting on 03/01/2012	Peaks 1-4
	* Anthony P. Hollander, University of Bristol, UK

	* Jeffrey M. Gimble, Pennington Biomedical Research Center, USA

	Michelle Leroux Williams, Osiris Therapeutics Inc., USA Therapeutic Applications of Adult Mesenchymal Stem Cells
	W. P. Andrew Lee, Johns Hopkins University School of Medicine, USA Hand Transplantation Using a Cell-Based Protocol to Minimize Immunosuppression
	Pedro M. Baptista, Wake Forest Institute for Regenerative Medicine, USA Short Talk: Human Liver Bioengineering –Turning Science Fiction into Reality
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Breckenridge Ballroom
7:30 - 10:00 PM	Poster Session 1 Registered attendees for this meeting can view Abstracts for this session starting on 03/01/2012	Breckenridge Ballroom
Tuesday, April 3
7:00 - 8:00 AM	Breakfast	Summit Gallery
8:00 - 11:15 AM	Organ Regeneration (Joint). Session Sponsored by Development Registered attendees for this meeting can view Abstracts for this session starting on 03/01/2012	Peaks 1-5
	* Bruno Péault, University of California, Los Angeles, USA
	* Elly M. Tanaka, Center for Regenerative Therapies, Dresden, Germany
	Panagiotis Tsonis, University of Dayton, USA Lens Regeneration in Newts
	Kenneth D. Poss, HHMI/Duke University Medical Center, USA Regeneration in Zebrafish
	Elke A. Ober, National Institute for Medical Research, UK Liver Organogenesis in Zebrafish
	Phillip A. Newmark, HHMI/University of Illinois at Urbana-Champaign, USA Germ Cell Development and Regeneration in Planarians
	Eric Lagasse, University of Pittsburgh, USA Short Talk: The Lymph Node as an Ectopic Transplantation Site for Multiple Epithelial Tissues
	Carolyn E. Adler, Stowers Institute for Medical Research, USA Short Talk: A Novel Transmembrane Protein is Required for Organ Regeneration in Planaria
9:20 - 9:40 AM	Coffee Break	Foyer
11:15 AM- 1:00 PM	Poster Setup	Breckenridge Ballroom
11:15 AM-	On Own for Lunch and Recreation
1:00 - 10:00 PM	Poster Viewing	Breckenridge Ballroom
4:30 - 5:00 PM	Coffee Available	Foyer
5:00 - 7:00 PM	Evolution and Regeneration Registered attendees for this meeting can view Abstracts for this session starting on 03/01/2012	Peak 5
	* Voot Yin, Mount Desert Island Biological Laboratories, USA
	Wallace Marshall, University of California, San Francisco, USA Regeneration and Pattern Formation in a Single Cell
	Alexandra E. Bely, University of Maryland at College Park, USA Evolution of Regeneration Ability: Insights from Annelids
	Ashley W. Seifert, University of Florida, USA Skin Shedding and Tissue Regeneration in African Spiny Mice (Acomys)
	Juliette C. Azimzadeh, University of California San Francisco, USA Short Talk: Centrosomes were Discarded in the Evolution of Planarians
Following Session is for Regenerative Tissue Engineering and Transplantation (Z3)
5:00 - 7:00 PM	Biomaterials, Matrices and Scaffolds I Registered attendees for this meeting can view Abstracts for this session starting on 03/01/2012	Peaks 1-4
	* Molly Stevens, Imperial College London, UK
	Farshid Guilak, Duke University Medical Center, USA Three-Dimensionally Woven Scaffold for Cell-Based Tissue Engineering
	Christine E. Schmidt, University of Texas at Austin, USA Electrically Conducting Polymers for Neural Tissue Engineering
	Samuel I. Stupp, Northwestern University, USA Ordered Filamentous Matrices and Cell-Like Objects for Regenerative Medicine
	Dan McKinnon, University of Colorado, Boulder, USA Short Talk: Dynamically Tunable Hydrogel Materials for Modeling Axon Guidance
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Breckenridge Ballroom
7:30 - 10:00 PM	Poster Session 2 Registered attendees for this meeting can view Abstracts for this session starting on 03/01/2012	Breckenridge Ballroom
Wednesday, April 4
7:00 - 8:00 AM	Breakfast	Summit Gallery
8:00 - 11:15 AM	Aging, Development and Regeneration Registered attendees for this meeting can view Abstracts for this session starting on 03/01/2012	Peak 5
	* Alejandro Sánchez Alvarado, HHMI/Stowers Institute for Medical Research, USA
	Anne Brunet, Stanford University, USA Regeneration in Short-Lived Fish
	Amy J. Wagers, Harvard University, USA Aging and Rejuvenation of Tissue Stem Cells
	Christoph Lepper, Carnegie Institution for Science, USA Age-Dependent Genetic Regulation of Skeletal Muscle Stem Cells
	Bernhard Kühn, Children's Hospital, Boston, USA Short Talk: Cardiomyocyte Proliferation Contributes to Post-Natal Heart Growth in Humans
	Sandra Rieger, Mount Desert Island Biological Laboratory, USA Short Talk: Reciprocal Interactions between Wounds and Peripheral Sensory Axons Promote Zebrafish Fin Regeneration
	Ömer Hidir Yilmaz, Massachusetts General Hospital/Whitehead Institute, USA Short Talk: mTORC1 Signaling in the Paneth Cell Niche Regulates Intestinal Stem Cell Function in Response to Calorie Intake
	Feng Chen, Stanford University, USA Short Talk: The Existing Tracheal System Guides New Branch Growth by Scaffolding and Re-Expression of FGF during Drosophila Tracheal Remodeling
Following Session is for Regenerative Tissue Engineering and Transplantation (Z3)
8:00 - 11:00 AM	Biomaterials, Matrices and Scaffolds II Registered attendees for this meeting can view Abstracts for this session starting on 03/01/2012	Peaks 1-4
	* Anthony Atala, Wake Forest University, USA

	* Christine E. Schmidt, University of Texas at Austin, USA
	Molly Stevens, Imperial College London, UK New Materials-Based Approaches for Tissue Regeneration
	Xiao Hu, Tufts University, USA Silk-Tropoelastin Biomaterial Alloys


	Teruo Okano, Tokyo Women’s Medical University, Japan Cell Sheet Tissue Engineering for 3D Vascularized Tissues
	Lisa A. Fortier, Cornell University College of Veterinary Medicine, USA Equine Articular Cartilage Tissue Engineering

	Agneta Simionescu, Clemson University, USA Short Talk: Diabetes-Related Alterations in Collagen Scaffolds used for Cardiovascular Tissue Engineering; Mitigation with Antioxidants
	Chiara Villa, University of Milan, Italy Short Talk: Thermoresponsive Material for Muscle Cell Sheet Engineering
9:20 - 9:40 AM	Coffee Break	Foyer
11:15 AM-	On Own for Lunch and Recreation
4:30 - 5:00 PM	Coffee Available	Foyer
5:00 - 7:00 PM	Regenerative Biology and Regenerative Medicine Registered attendees for this meeting can view Abstracts for this session starting on 03/01/2012	Peak 5
	* Anne Brunet, Stanford University, USA
	András Simon, Karolinska Institutet, Sweden Reversible Suppression of Neurogenesis in the Adult Vertebrate Brain
	Michele De Luca, University of Modena and Reggio Emilia, Italy Limbal Stem-Cell Therapy and Long-Term Corneal Regeneration
	Olov Andersson, University of California, San Francisco, USA Short Talk: A Chemical Screen in Zebrafish Identifies Adenosine Signaling as a Promoter of Pancreatic Beta-Cell Regeneration
Following Session is for Regenerative Tissue Engineering and Transplantation (Z3)
5:00 - 7:30 PM	Cells and Biological Mechanisms I Registered attendees for this meeting can view Abstracts for this session starting on 03/01/2012	Peaks 1-4
	* Farshid Guilak, Duke University Medical Center, USA
	* Lisa A. Fortier, Cornell University College of Veterinary Medicine, USA
	Rocky S. Tuan, University of Pittsburgh School of Medicine, USA Adult Stem Cells and Nanomaterials in Skeletal Tissue Engineering and Regeneration

	Helen M. Blau, Stanford University, USA Bioengineered Niches to Control Stem Cell Fate and Function
	Kevin C. Eggan, Harvard University, USA Identification and Characterization of Small Reprogramming Molecules
	Kelly R. Stevens, Massachusetts Institute of Technology and Harvard University, USA Short Talk: Multi-Cellular Architecture Regulates Physiologic Function of 3D Engineered Liver Tissue in vitro and after Implantation
	Tamir Rashid, University of Cambridge, UK Reprogrammed Adult Cells for Liver Transplantation
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Breckenridge Ballroom
Thursday, April 5
7:00 - 8:00 AM	Breakfast	Summit Gallery
8:00 - 11:15 AM	Stem Cells and Regeneration Registered attendees for this meeting can view Abstracts for this session starting on 03/01/2012	Peak 5
	* Panagiotis Tsonis, University of Dayton, USA
	Kenneth D. Birnbaum, New York University, USA What is the Origin of Plant Cell Plasticity?
	Jing-Wei Xiong, Peking University, China Zebrafish Heart Regeneration
	Voot Yin, Mount Desert Island Biological Laboratories, USA miRNAs and Regeneration
	Arnout G. Schepers, Hubrecht Institute, Netherlands Short Talk: Direct Demonstration of Lgr5 Stem Cell Activity within Apc-Mutant Intestinal Adenomas
	Gufa Lin, University of Minnesota, USA Short Talk: Imparting Regenerative Capacity to Frog Limbs by Cell Transplantation
Following Session is for Regenerative Tissue Engineering and Transplantation (Z3)
8:00 - 11:15 AM	Cells and Biological Mechanisms II Registered attendees for this meeting can view Abstracts for this session starting on 03/01/2012	Peaks 1-4

	* Rocky S. Tuan, University of Pittsburgh School of Medicine, USA
	* Helen M. Blau, Stanford University, USA
	Bruno Péault, University of California, Los Angeles, USA Prospective Identification of Multi-Lineage Stem Cells Present in Human Adult Organs and Tissues
	Jeffrey M. Gimble, Pennington Biomedical Research Center, USA Immunogenicity and Immunoregulatory Activities of Adipose Tissue-Derived Cells
	Marc Penn, Summa Health System, USA Mechanisms of Stem Cell-Based Repair of the Heart
	Robert Deans, Athersys, Inc., USA Adult Stem Cells for Treatment of Graft Versus Host Disease
	Taymour M. Hammoudi, Georgia Institute of Technology and Emory School of Medicine, USA Short Talk: Novel 3D in vitro Co- and Tri-Culture Platform to Investigate Effects of Paracrine Signaling in Bone Marrow Niche Cells
	Praveen R. Arany, Harvard University, USA Short Talk: Laser Directs Stem Cells Differentiation via TGF-beta1 Activation
9:00 - 9:20 AM	Coffee Break	Foyer
11:15 AM-	On Own for Lunch and Recreation
Following Session is for Regenerative Tissue Engineering and Transplantation (Z3)
2:30 - 4:30 PM	Panel: Crosscutting Topics in Regenerative Medicine: “Stone Soup” for Organ Regeneration (Joint) Registered attendees for this meeting can view Abstracts for this session starting on 03/01/2012 NOTE: A cross-disciplinary panel discussion to identify specific areas of biology and bioengineering that can best benefit from each other in advancing the science and clinical translation of regenerative medicine.	Breckenridge Ballroom
	* Nadya L. Lumelsky, NIDCR, National Institutes of Health, USA
	* Fei Wang, NIAMS, National Institutes of Health, USA

	Farshid Guilak, Duke University Medical Center, USA
	Christine E. Schmidt, University of Texas at Austin, USA
	Samuel I. Stupp, Northwestern University, USA
	Amy J. Wagers, Harvard University, USA
	Rocky S. Tuan, University of Pittsburgh School of Medicine, USA
	Jeffrey M. Gimble, Pennington Biomedical Research Center, USA


	Kenneth R. Chien, Massachusetts General Hospital, USA
	Helen M. Blau, Stanford University, USA
4:30 - 5:00 PM	Coffee Available	Foyer
5:00 - 6:15 PM	New Vistas in Tissue Regeneration and Engineering (Joint) Registered attendees for this meeting can view Abstracts for this session starting on 03/01/2012	Breckenridge Ballroom
	* Kenneth D. Poss, HHMI/Duke University Medical Center, USA
	* Alejandro Sánchez Alvarado, HHMI/Stowers Institute for Medical Research, USA
	Jeremy Brockes, University College London, UK Tumor Suppressor Genes and Limb Regeneration
	Kenneth R. Chien, Massachusetts General Hospital, USA Driving Heart Progenitor Cell Fate and Regeneration in vivo via Chemically Modified mRNA
6:15 - 7:15 PM	Keynote Address (Joint) Registered attendees for this meeting can view Abstracts for this session starting on 03/01/2012	Breckenridge Ballroom
	* Alejandro Sánchez Alvarado, HHMI/Stowers Institute for Medical Research, USA
	* Rocky S. Tuan, University of Pittsburgh School of Medicine, USA
	Susan J. Fisher, University of California, San Francisco, USA Embryonic Stem Cells Related to Regenerative Medicine
7:15 - 8:15 PM	Social Hour w/ Lite Bites	Breckenridge Ballroom
8:00 - 11:00 PM	Entertainment	Breckenridge Ballroom
Friday, April 6
	Departure
*=Session Chair †=Speaker invited, not yet responded.

We gratefully acknowledge support for this conference from:

The Directors' Fund

These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.

We gratefully acknowledge the generous grants for this conference provided by:

National Institutes of Health
National Institute on Aging (NIA)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Grant No. 1R13AG041553-01

The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

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The regeneration of organs and organ systems after injury is widely, but unevenly, distributed among animals. Why organ regeneration is not shared by all animals, and whether mechanisms may or may not be conserved among those animals that can regenerate remain open questions. In recent years, the use of a wider range of model organisms and an increasing ability to use genetic tools to study regeneration has spurred significant progress in our understanding of animal regenerative biology. This meeting aims to delineate the molecular and cellular biological basis of regeneration by highlighting, comparing and contrasting the differences and similarities in regenerative capabilities and mechanisms among diverse animal species. How these biological findings may inform regenerative medicine and stem-cell biology and therapeutics will be considered and discussed. Opportunities for interdisciplinary interactions will be significantly enhanced by the concurrent meeting on Regenerative Tissue Engineering and Transplantation, which will share an opening and closing keynote address as well as two plenary sessions with this meeting.

Mechanisms of Whole Organ Regeneration (Z4)