Keystone Symposia Conference | Regenerative Tissue Engineering and Transplantation

Meeting Program

To view program in "24 hour" time (international) click here.

Sunday, April 1
3:00 - 7:30 PM	Registration	Foyer
6:15 - 7:15 PM	Refreshments	Foyer
7:15 - 8:30 PM	Welcome and Keynote Address (Joint) Registered attendees for this meeting can view Abstracts for this session starting on 03/01/2012	Peaks 1-5
	* Rocky S. Tuan, University of Pittsburgh School of Medicine, USA
	* Alejandro Sánchez Alvarado, HHMI/Stowers Institute for Medical Research, USA
	Allan C. Spradling, HHMI/Carnegie Institute, USA Stem Cells and Tissue Homeostasis
Monday, April 2
7:00 - 8:00 AM	Breakfast	Summit Gallery
8:00 - 11:15 AM	Clinical Applications and Challenges I Registered attendees for this meeting can view Abstracts for this session starting on 03/01/2012	Peaks 1-4
	* Ranieri Cancedda†, University of Genova, Italy
	* Lisa A. Fortier, Cornell University, USA
	Anthony Atala, Wake Forest University, USA Tissue Engineered Urologic Organs
	Anthony P. Hollander, University of Bristol, UK Tissue-Engineered Cartilage: From the Knee to the Airway
	W.P. Andrew Lee, Johns Hopkins University School of Medicine, USA Hand Transplantation Using a Cell-Based Protocol to Minimize Immunosuppression
	Maria Siemionow, Cleveland Clinic, USA Composite Facial Allograft Transplantation: Application of Cell-Based Therapies
	Mark E. Fleming, Walter Reed National Military Medical Center, USA Short Talk: Regenerative Medicine Applications in Combat Casualty Care
	Ugo Ripamonti, University of Wiwatersrand, South Africa Short Talk: Grand Challenges for Craniomandibulofacial Reconstruction by Human Recombinant Transforming Growth Factor-beta3
Following Session is for Whole Organ Regeneration (Z4)
8:00 - 11:15 AM	Injury-Activated Regeneration Registered attendees for this meeting can view Abstracts for this session starting on 03/01/2012	Peak 5
	* Phillip A. Newmark, HHMI/University of Illinois at Urbana-Champaign, USA
	Brigitte Galliot, University of Geneva, Switzerland Asymmetric Injury Responses Launch Two Different Types of Regenerative Programs in Hydra
	Alejandro Sánchez Alvarado, HHMI/Stowers Institute for Medical Research, USA Injury, Stem Cells and Regeneration of Body Parts in an Adult Organism
	Elly M. Tanaka, Center for Regenerative Therapies, Dresden, Germany Injury-Associated Signaling Pathways that Initiate Muscle and Spinal Cord Regeneration in Salamanders
	Roeland Nusse, Stanford University, USA Wnt Signaling, Stem Cells and Tissue Repair
	Matthew David Keefe, University of Utah, USA Short Talk: A Central Role for beta-Catenin Signaling in Growth and Regeneration of the Exocrine Pancreas
	Juan A. Larraín, P. Universidad Catolica de Chile, Chile Short Talk: Spinal Cord Regeneration in Xenopus
9:20 - 9:40 AM	Coffee Break	Foyer
11:15 AM- 1:00 PM	Poster Setup	Breckenridge Ballroom
11:15 AM-	On Own for Lunch and Recreation
1:00 - 10:00 PM	Poster Viewing	Breckenridge Ballroom
4:30 - 5:00 PM	Coffee Available	Foyer
5:00 - 7:00 PM	Clinical Applications and Challenges II Registered attendees for this meeting can view Abstracts for this session starting on 03/01/2012	Peaks 1-4
	* Anthony P. Hollander, University of Bristol, UK
	* Marc Penn, Summa Health System, USA
	Tamir Rashid, University of Cambridge, UK Reprogrammed Adult Cells for Liver Transplantation
	Michelle Leroux Williams, Osiris Therapeutics Inc., USA Therapeutic Applications of Adult Mesenchymal Stem Cells
	Lisa A. Fortier, Cornell University, USA Equine Articular Cartilage Tissue Engineering
	Pedro M. Baptista, Wake Forest Institute for Regenerative Medicine, USA Short Talk: Human Liver Bioengineering –Turning Science Fiction into Reality
Following Session is for Whole Organ Regeneration (Z4)
5:00 - 7:00 PM	Physiological Regeneration Registered attendees for this meeting can view Abstracts for this session starting on 03/01/2012	Peak 5
	* Allan C. Spradling, HHMI/Carnegie Institute, USA
	Jenny Hsieh, University of Texas Southwestern Medical Center at Dallas, USA Timing is Everything: Development of New Neurons in the Adult Brain

	Linheng Li, Stowers Institute for Medical Research, USA Using Surface Markers to Enrich Intestinal Stem Cells Under Homeostatic and Injured Conditions
	Elaine Fuchs, HHMI/Rockefeller University, USA Stem Cells in the Skin: Natural Cycles of Regeneration

	Valentina Greco, Yale School of Medicine, USA Short Talk: Live Imaging Studies of the Stem Cell Niche of the Hair Follicle
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Breckenridge Ballroom
7:30 - 10:00 PM	Poster Session 1 Registered attendees for this meeting can view Abstracts for this session starting on 03/01/2012	Breckenridge Ballroom
Tuesday, April 3
7:00 - 8:00 AM	Breakfast	Summit Gallery
8:00 - 11:15 AM	Organ Regeneration (Joint). Session Sponsored by Development Registered attendees for this meeting can view Abstracts for this session starting on 03/01/2012	Peaks 1-5
	* Elly M. Tanaka, Center for Regenerative Therapies, Dresden, Germany
	* Bruno Péault, University of California, Los Angeles, USA
	Panagiotis Tsonis, University of Dayton, USA Lens Regeneration in Newts
	Kenneth D. Poss, HHMI/Duke University Medical Center, USA Regeneration in Zebrafish
	Elke A. Ober, National Institute for Medical Research, UK Liver Organogenesis in Zebrafish
	Phillip A. Newmark, HHMI/University of Illinois at Urbana-Champaign, USA Germ Cell Development and Regeneration in Planarians
	Eric Lagasse, University of Pittsburgh, USA Short Talk: The Lymph Node as an Ectopic Transplantation Site for Multiple Epithelial Tissues
	Carolyn E. Adler, Stowers Institute for Medical Research, USA Short Talk: A Novel Transmembrane Protein is Required for Organ Regeneration in Planaria
9:20 - 9:40 AM	Coffee Break	Foyer
11:15 AM- 1:00 PM	Poster Setup	Breckenridge Ballroom
11:15 AM-	On Own for Lunch and Recreation
1:00 - 10:00 PM	Poster Viewing	Breckenridge Ballroom
4:30 - 5:00 PM	Coffee Available	Foyer
5:00 - 7:00 PM	Biomaterials, Matrices and Scaffolds I Registered attendees for this meeting can view Abstracts for this session starting on 03/01/2012	Peaks 1-4
	* David L. Kaplan, Tufts University, USA
	* Molly Stevens, Imperial College London, UK
	Farshid Guilak, Duke University Medical Center, USA Three-Dimensionally Woven Scaffold for Cell-Based Tissue Engineering
	Christine E. Schmidt, University of Texas at Austin, USA Electrically Conducting Polymers for Neural Tissue Engineering
	Samuel I. Stupp, Northwestern University, USA Ordered Filamentous Matrices and Cell-Like Objects for Regenerative Medicine
	Dan McKinnon, University of Colorado, Boulder, USA Short Talk: Dynamically Tunable Hydrogel Materials for Modeling Axon Guidance
Following Session is for Whole Organ Regeneration (Z4)
5:00 - 7:00 PM	Evolution and Regeneration Registered attendees for this meeting can view Abstracts for this session starting on 03/01/2012	Peak 5
	* Voot Yin, Mount Desert Island Biological Laboratories, USA
	Wallace Marshall, University of California, San Francisco, USA Regeneration and Pattern Formation in a Single Cell
	Alexandra E. Bely, University of Maryland at College Park, USA Evolution of Regeneration Ability: Insights from Annelids
	Ashley W. Seifert, University of Florida, USA Skin Shedding and Tissue Regeneration in African Spiny Mice (Acomys)

	Juliette C. Azimzadeh, University of California San Francisco, USA Short Talk: Centrosomes were Discarded in the Evolution of Planarians
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Breckenridge Ballroom
7:30 - 10:00 PM	Poster Session 2 Registered attendees for this meeting can view Abstracts for this session starting on 03/01/2012	Breckenridge Ballroom
Wednesday, April 4
7:00 - 8:00 AM	Breakfast	Summit Gallery
8:00 - 11:00 AM	Biomaterials, Matrices and Scaffolds II Registered attendees for this meeting can view Abstracts for this session starting on 03/01/2012	Peaks 1-4
	* Anthony Atala, Wake Forest University, USA
	* Christine E. Schmidt, University of Texas at Austin, USA
	Molly Stevens, Imperial College London, UK New Materials-Based Approaches for Tissue Regeneration
	David L. Kaplan, Tufts University, USA Silk-Tropoelastin Biomaterial Alloys
	Teruo Okano, Tokyo Women’s Medical University, Japan Cell Sheet Tissue Engineering for 3D Vascularized Tissues
	Agneta Simionescu, Clemson University, USA Short Talk: Diabetes-Related Alterations in Collagen Scaffolds used for Cardiovascular Tissue Engineering; Mitigation with Antioxidants
	Chiara Villa, University of Milan, Italy Short Talk: Thermoresponsive Material for Muscle Cell Sheet Engineering
Following Session is for Whole Organ Regeneration (Z4)
8:00 - 11:15 AM	Aging, Development and Regeneration Registered attendees for this meeting can view Abstracts for this session starting on 03/01/2012	Peak 5
	* Sean J. Morrison, HHMI/UT Southwestern Medical Center, USA
	Anne Brunet, Stanford University, USA Regeneration in Short-Lived Fish

	Amy J. Wagers, Harvard University, USA Aging and Rejuvenation of Tissue Stem Cells
	Christoph Lepper, Carnegie Institution for Science, USA Age-Dependent Genetic Regulation of Skeletal Muscle Stem Cells

	Bernhard Kuhn, Children's Hospital, Boston, USA Short Talk: Cardiomyocyte Proliferation Contributes to Post-Natal Heart Growth in Humans
	Sandra Rieger, Mount Desert Island Biological Laboratory, USA Short Talk: Reciprocal Interactions between Wounds and Peripheral Sensory Axons Promote Zebrafish Fin Regeneration
	Ömer Hidir Yilmaz, MGH/Whitehead Institute, USA Short Talk: mTORC1 Signaling in the Paneth Cell Niche Regulates Intestinal Stem Cell Function in Response to Calorie Intake
	Feng Chen, Stanford University, USA Short Talk: The Existing Tracheal System Guides New Branch Growth by Scaffolding and Re-Expression of FGF during Drosophila Tracheal Remodeling
9:20 - 9:40 AM	Coffee Break	Foyer
11:15 AM-	On Own for Lunch and Recreation
4:30 - 5:00 PM	Coffee Available	Foyer
5:00 - 7:00 PM	Cells and Biological Mechanisms I Registered attendees for this meeting can view Abstracts for this session starting on 03/01/2012	Peaks 1-4
	* Farshid Guilak, Duke University Medical Center, USA
	* Michelle Leroux Williams, Osiris Therapeutics Inc., USA
	Rocky S. Tuan, University of Pittsburgh School of Medicine, USA Adult Stem Cells and Nanomaterials in Skeletal Tissue Engineering and Regeneration
	Helen M. Blau, Stanford University, USA Bioengineered Niches to Control Stem Cell Fate and Function
	Kevin C. Eggan, Harvard University, USA Using Stem Cells and Transcription Factors to Produce Functional Motor Neurons
	Kelly R. Stevens, Massachusetts Institute of Technology, Harvard, USA Short Talk: Multi-Cellular Architecture Regulates Physiologic Function of 3D Engineered Liver Tissue in vitro and after Implantation
Following Session is for Whole Organ Regeneration (Z4)
5:00 - 7:00 PM	Regenerative Biology and Regenerative Medicine Registered attendees for this meeting can view Abstracts for this session starting on 03/01/2012	Peak 5
	* Elaine Fuchs, HHMI/Rockefeller University, USA
	András Simon, Karolinska Institute, Sweden Reversible Suppression of Neurogenesis in the Adult Vertebrate Brain


	Michele De Luca, University of Modena and Reggio Emilia, Italy Limbal Stem-Cell Therapy and Long-Term Corneal Regeneration
	Olov Andersson, University of California, San Francisco, USA Short Talk: A Chemical Screen in Zebrafish Identifies Adenosine Signaling as a Promoter of Pancreatic Beta-Cell Regeneration
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Breckenridge Ballroom
Thursday, April 5
7:00 - 8:00 AM	Breakfast	Summit Gallery
8:00 - 11:15 AM	Cells and Biological Mechanisms II Registered attendees for this meeting can view Abstracts for this session starting on 03/01/2012	Peaks 1-4
	* Rocky S. Tuan, University of Pittsburgh School of Medicine, USA
	* Helen M. Blau, Stanford University, USA
	Bruno Péault, University of California, Los Angeles, USA Prospective Identification of Multi-Lineage Stem Cells Present in Human Adult Organs and Tissues
	Jeffrey M. Gimble, Pennington Biomedical Research Center, USA Immunogenicity and Immunoregulatory Activities of Adipose Tissue-Derived Cells
	Marc Penn, Summa Health System, USA Mechanisms of Stem Cell-Based Repair of the Heart
	Robert Deans, Athersys, Inc., USA Adult Stem Cells for Treatment of Graft Versus Host Disease
	Taymour Marwan Hammoudi, Georgia Institute of Technology and Emory School of Medicine, USA Short Talk: Novel 3D in vitro Co- and Tri-Culture Platform to Investigate Effects of Paracrine Signaling in Bone Marrow Niche Cells
	Praveen R. Arany, Harvard University, USA Short Talk: Laser Directs Stem Cells Differentiation via TGF-beta1 Activation
Following Session is for Whole Organ Regeneration (Z4)
8:00 - 11:15 AM	Stem Cells and Regeneration Registered attendees for this meeting can view Abstracts for this session starting on 03/01/2012	Peak 5
	* Panagiotis Tsonis, University of Dayton, USA
	Kenneth D. Birnbaum, New York University, USA What is the Origin of Plant Cell Plasticity?

	Jing-Wei Xiong, Peking University, China Zebrafish Heart Regeneration
	Sean J. Morrison, HHMI/UT Southwestern Medical Center, USA Stem Cell Self-Renewal in Regenerating Tissues
	Voot Yin, Mount Desert Island Biological Laboratories, USA miRNAs and Regeneration
	Arnout Schepers, Hubrecht Institute, Netherlands Short Talk: Direct Demonstration of Lgr5 Stem Cell Activity within Apc-Mutant Intestinal Adenomas
	Gufa Lin, University of Minnesota, USA Short Talk: Imparting Regenerative Capacity to Frog Limbs by Cell Transplantation
9:00 - 9:20 AM	Coffee Break	Foyer
11:15 AM-	On Own for Lunch and Recreation
2:30 - 4:30 PM	Panel: Crosscutting Topics in Regenerative Medicine: “Stone Soup” for Organ Regeneration NOTE: A cross-disciplinary panel discussion to identify specific areas of biology and bioengineering that can best benefit from each other in advancing the science and clinical translation of regenerative medicine.	Breckenridge Ballroom
	* Nadya L. Lumelsky, NIDCR, National Institutes of Health, USA
	* Fei Wang, NIAMS, National Institutes of Health, USA
	* Rosemarie Hunziker, National Institute of Biomedical Imaging and Bioengineering, USA
	Roeland Nusse, Stanford University, USA
	Linheng Li, Stowers Institute for Medical Research, USA
	Farshid Guilak, Duke University Medical Center, USA
	Christine E. Schmidt, University of Texas at Austin, USA
	Samuel I. Stupp, Northwestern University, USA
	Amy J. Wagers, Harvard University, USA
	Rocky S. Tuan, University of Pittsburgh School of Medicine, USA
	Jeffrey M. Gimble, Pennington Biomedical Research Center, USA
	Sean J. Morrison, HHMI/UT Southwestern Medical Center, USA
	Kenneth R. Chien, Massachusetts General Hospital, USA
	Ophir Klein†, University of California, San Francisco, USA
4:30 - 5:00 PM	Coffee Available	Foyer
5:00 - 6:15 PM	New Vistas in Tissue Regeneration and Engineering (Joint) Registered attendees for this meeting can view Abstracts for this session starting on 03/01/2012	Breckenridge Ballroom
	* Kenneth D. Poss, HHMI/Duke University Medical Center, USA
	* Alejandro Sánchez Alvarado, HHMI/Stowers Institute for Medical Research, USA
	Jeremy Brockes, University College London, UK Tumor Suppressor Genes and Limb Regeneration
	Kenneth R. Chien, Massachusetts General Hospital, USA Driving Heart Progenitor Cell Fate and Regeneration in vivo via Chemically Modified mRNA
6:15 - 7:15 PM	Keynote Address (Joint) Registered attendees for this meeting can view Abstracts for this session starting on 03/01/2012	Breckenridge Ballroom
	* Rocky S. Tuan, University of Pittsburgh School of Medicine, USA
	* Alejandro Sánchez Alvarado, HHMI/Stowers Institute for Medical Research, USA
	Susan J. Fisher, University of California, San Francisco, USA Embryonic Stem Cells Related to Regenerative Medicine
7:15 - 8:15 PM	Social Hour w/ Lite Bites	Breckenridge Ballroom
8:00 - 11:00 PM	Entertainment	Breckenridge Ballroom
Friday, April 6
	Departure
*=Session Chair †=Speaker invited, not yet responded.

We gratefully acknowledge support for this conference from:

Athersys Inc.

Osiris Therapeutics, Inc.

The Directors' Fund

These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.

We gratefully acknowledge the generous grants for this conference provided by:

National Institutes of Health
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
National Institute on Aging (NIA)
Grant No. 1R13EB014683-01

The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

We gratefully acknowledge the organizations that provide Keystone Symposia with additional support, such as marketing and advertising...

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Tissue engineering and regenerative medicine is a dynamic, translational research field that amalgamates life sciences, engineering and clinical medicine for the purpose of restoring structure and function to diseased, damaged or injured tissues and organs. Current efforts focus on the application of stem and progenitor cells, bioactive factors and biomaterial scaffolds in transplantation procedures to affect regenerative therapies. Breakthroughs in bladder and tracheal reconstruction and highly promising approaches for solid organ regeneration as well as musculoskeletal and nerve repair have been achieved. Effective cell sourcing, optimal assembly and fabrication of tissue-derived and synthetic biomaterial scaffolds, and targeted regulation of therapeutic and immunomodulatory functions of stem cells represent some of the current challenges in this field. In this Keystone Symposia meeting on Regenerative Tissue Engineering and Transplantation, exciting technological and intellectual advances in the field will be synthesized by expert scientists, engineers and clinicians to assess and expand the landscape in regenerative engineering and transplantation. Opportunities for interdisciplinary interactions will be significantly enhanced by the concurrent meeting on Mechanisms of Whole Organ Regeneration, which will share an opening and closing keynote address as well as two plenary sessions with this meeting. More specifically, the pairing of these two meetings represents a highly unusual opportunity for cross-talk between the more applications-driven field of tissue engineering and regenerative medicine, and the very basic research being explored in the field of whole organ regeneration.

Regenerative Tissue Engineering and Transplantation (Z3)