| Friday, March 12 |
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3:00 - 7:30 PM
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Registration
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BC Foyer
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6:30 - 7:30 PM
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Refreshments
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BC Foyer
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7:30 - 9:30 PM
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Keynote Session (Joint)
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British/Columbia Ballroom
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*
Eileen P. White,
Rutgers University
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Joan S. Brugge,
Harvard Medical School
Diversity of Cell Death Pathways in Organogenesis and Oncogenesis
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Lewis C. Cantley,
Harvard Medical School
PI 3-Kinase and Cancer Cell Metabolism
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| Saturday, March 13 |
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7:00 - 8:00 AM
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Breakfast
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Pacific Ballroom
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8:00 - 11:15 AM
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Apoptosis Pathways
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British Ballroom
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*
Anthony G. Letai,
Dana-Farber Cancer Institute
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Suzanne Cory,
Walter and Eliza Hall Institute of Medical Research
The Bcl-2 Family in Cancer Development and Cancer Treatment
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Loren D. Walensky,
Dana-Farber Cancer Institute
Dissecting the Activation Pathway of Pro-Apoptotic BAX: Mechanistic Insights and Pharmacologic Opportunities
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Xin Niu,
McMaster University
Short Talk: Identification and Mechanistic Characterization of Novel Bax Inihibitors
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Vishva M. Dixit,
Genentech, Inc.
Identification of a Stabilizing Deubiquitinase for Mcl-1 that is Over-Expressed in Tumors
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David W. Andrews,
McMaster University
Mechanisms of Mitochondrial Membrane Permeabilization by Pro-Apoptotic Bcl-2 Family Proteins
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Ingrid E. Wertz,
Genentech, Inc.
Short Talk: Resistance to Anti-tubulin Chemotherapeutics is Regulated by Mcl–1 and FBW7
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9:20 - 9:40 AM
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Coffee Break
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BC Foyer
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11:15 AM -
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On Own for Lunch and Recreation
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11:15 AM - 1:00 PM
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Poster Setup
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Pacific Ballroom
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1:00 - 10:00 PM
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Poster Viewing
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Pacific Ballroom
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2:30 - 4:30 PM
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Workshop 1: Methods for the Detection of Non-Apoptotic Cell Death
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British Ballroom
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*
Douglas R. Green,
St. Jude Children's Research Hospital
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Vassiliki Karantza,
Cancer Institute of New Jersey
Autophagy Regulates keratin 8 Homeostasis in Mammary Epithelial Cells and in Breast Tumors
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Brandon White,
San Jose State University
Flavonoids Kill Breast Cancer Cells While Inhibiting Caspase Activity: Is this Apoptosis?
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Katharina Simon,
Institute of Molecular Medicine
Detection of Autophagic Flux in Clinical Samples
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Suzanne Hibbs,
Sigma-Aldrich Research Biotech
An Application of Zinc Finger Nuclease Technology to Create Knockout Cancer Lines
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Jayanta Debnath,
University of California, San Francisco
ATG12 Conjugation to ATG3 Restricts The Expansion of Mitochondrial Mass and Promotes Cell Death
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Haymanti Bhanot,
University of Toledo, College of Medicine
Mechanisms Underlying Methuosis in Human Glioblastoma Cells
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4:30 - 5:00 PM
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Coffee Available
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BC Foyer
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5:00 - 7:00 PM
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Non-Apoptotic Pathways in Model Organisms
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British Ballroom
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*
Daniel J. Klionsky,
University of Michigan
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Frank Madeo,
University of Graz
Programmed Cell Death in Yeast: Subroutines, Mechanisms and Purposes
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Vladimir I. Titorenko,
Concordia University
Short Talk: Novel Anti-Aging Compounds Greatly Extend Yeast Life Span by Targeting a Programmed Necrotic Cell Death Pathway Triggered by the Age-Related Buildup of Free Fatty Acids
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Thomas P. Neufeld,
University of Minnesota
Autophagic Pathways in Drosophila: Good or Evil?
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John M. Abrams,
University of Texas Southwestern Medical Center
Cell Death Regulatory Networks in Drosophila
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7:00 - 8:00 PM
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Social Hour w/ Lite Bites
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Pacific Ballroom
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7:30 - 10:00 PM
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Poster Session 1
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Pacific Ballroom
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| Sunday, March 14 |
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7:00 - 8:00 AM
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Breakfast
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Pacific Ballroom
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8:00 - 11:00 AM
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Metabolic Adaptation in Cancer (Joint)
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British/Columbia Ballroom
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*
Marja Jäättelä,
Danish Cancer Society
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Eileen P. White,
Rutgers University
Role of Autophagy in Cancer and Therapy
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Guido Kroemer,
INSERM, U848, Institut Gustave Roussy
Autophagy in Stress Adaptation, Avoidance of Cell Death and Longevity
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Karen H. Vousden,
Beatson Institute for Cancer Research
Control of Metabolism by p53
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Rob Cairns,
University Health Network
Short Talk: Cancer-Associated Metabolite 2-Hydroxyglutarate Accumulates in AML with IDH1/2 Mutations
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Joshua L. Andersen,
Duke University
Short Talk: Metabolic Regulation of Caspase-2
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9:20 - 9:40 AM
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Coffee Break
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BC Foyer
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11:15 AM -
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On Own for Lunch and Recreation
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11:15 AM - 1:00 PM
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Poster Setup
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Pacific Ballroom
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1:00 - 10:00 PM
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Poster Viewing
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Pacific Ballroom
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4:30 - 5:00 PM
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Coffee Available
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BC Foyer
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5:00 - 7:00 PM
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Autophagic Pathways
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British Ballroom
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*
Noboru Mizushima,
Tokyo Medical and Dental University
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Daniel J. Klionsky,
University of Michigan
The Regulation of Macroautophagy
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Francesco Cecconi,
Dulbecco Telethon Institute, University of Rome
Short Talk: Ambra1 Regulates Autophagosome Formation and Plays a Role in Controlling Cell Proliferation
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Ana Maria Cuervo,
Albert Einstein College of Medicine
Chaperone-Mediated Autophagy in Organismal Aging
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Vojo Deretic,
University of New Mexico
Autophagy in Immunity: Microbes, Mitochondria and Cell Survival vs Cell Death
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7:00 - 8:00 PM
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Social Hour w/ Lite Bites
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Pacific Ballroom
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7:30 - 10:00 PM
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Poster Session 2
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Pacific Ballroom
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| Monday, March 15 |
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7:00 - 11:00 AM
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Poster Setup
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Pacific Ballroom
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7:00 - 8:00 AM
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Breakfast
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Pacific Ballroom
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8:00 - 11:15 AM
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Survival and Death in Development and Disease (Joint)
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British/Columbia Ballroom
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*
Karen H. Vousden,
Beatson Institute for Cancer Research
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Noboru Mizushima,
Tokyo Medical and Dental University
Lessons from Autophagy Deficient Mouse Models
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Marja Jäättelä,
Danish Cancer Society
Lysosomal Sphingolipid Metabolism as a Target for Cancer Therapy
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Douglas R. Green,
St. Jude Children's Research Hospital
The Mitochondrion: The Weapon Employed in Apoptopic Suicide
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Gerard I. Evan,
University of California, San Francisco
Inhibiting Oncogenes for Cancer Therapy
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Joan Boren,
Cambridge Research Institute, CRUK
Short Talk: Changes in Cell Lipid Content during Induction of Apoptosis
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Rebecca Lock,
University of California, San Francisco
Short Talk: Autophagy Inhibition Alters Glucose Metabolism and Promotes Epithelial Differentiation During Ras-Mediated Oncogenic Transformation
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9:20 - 9:40 AM
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Coffee Break
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BC Foyer
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11:30 AM - 12:30 PM
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Lunch
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Pacific Ballroom
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12:30 - 2:30 PM
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Poster Session 3
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Pacific Ballroom
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2:30 - 4:30 PM
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Workshop 2: Pathological Implications of Non-Apoptotic Cell Death
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British Ballroom
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*
Junying Yuan,
Harvard Medical School
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Nelson Cesar Di Paolo,
University of Washington
Necrosis and Autophagy, but not Apoptosis, are Induced in Macrophages in vivo upon Interaction with Adenovirus
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Sam McNeal,
Rhode Island Hospital
Divergent Roles of RIP1 in Septic Liver Injury
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Cristina Muñoz-Pinedo,
Institut d'Investigació Biomèdica de Bellvitge
Glucose Deprivation Induces an Atypical Form of Apoptosis Mediated by Caspase-8 in Bax, Bak Deficient Cells
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Andrey A. Parkhitko,
Brigham and Women's Hospital Harvard Medical School
Role of Autophagy in the Pathogenesis of Tuberous Sclerosis Complex
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Poonam Sansanwal,
Stanford University
Mitochondrial Autophagy: A Novel Mechanism for Cellular Injury in Nephropathic Cystinosis
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Andrew M. Leidal,
Dalhousie University
Autophagy Contributes to KSHV v-cyclin-induced Senescence
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4:30 - 5:00 PM
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Coffee Available
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BC Foyer
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5:00 - 7:00 PM
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Cell Death Induction for Cancer Therapy
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British Ballroom
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*
John A. Hickman,
Servier
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Anthony G. Letai,
Dana-Farber Cancer Institute
Why Chemotherapy Works – Chemosensitive Cancer Cells are more Primed for Apoptosis
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Jerry M. Adams,
Walter and Eliza Hall Institute of Medical Research
Short Talk: Puma-Mediated Leukocyte Apoptosis is Critical for gamma-Irradiation-Induced Thymic Lymphoma Development
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Saul H. Rosenberg,
Abbott Laboratories
Bcl-2 Family Inhibitors for the Treatment of Cancer
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Leigh S. Zawel,
Novartis Institutes for BioMedical Research
Therapeutic Targeting of Inhibitor of Apoptosis Proteins
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7:00 PM -
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On Own for Dinner
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| Tuesday, March 16 |
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7:00 - 8:00 AM
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Breakfast
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Pacific Ballroom
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8:00 - 11:15 AM
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Non-Conventional Cell Death Pathways
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British Ballroom
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*
Frank Madeo,
University of Graz
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Junying Yuan,
Harvard Medical School
Mechanisms of Programmed Cell Death: From Apoptosis to Necroptosis
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Michael B. Yaffe,
Massachusetts Institute of Technology
Mitotic Catastrophe: Mechanisms and Therapeutic Induction for Cancer Treatment
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Paul R. Clarke,
University of Dundee
Short Talk: Controlling Apoptosis in Mitosis and during Mitotic Arrest
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Peter Vandenabeele,
VIB, Ghent University
TNF-Induced Necrosis, Multiple Regulation of RIP1 Kinase Activity
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Oliver Florey,
Memorial Sloan Kettering Cancer Centre
Short Talk: A Case for Murder: Entosis is a Cell Killing Mechanism Requiring Autophagy Proteins
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Dale E. Bredesen,
Buck Institute for Age Research
Role of Cell Death Signaling in Alzheimer's Disease
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9:20 - 9:40 AM
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Coffee Break
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BC Foyer
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11:15 AM -
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On Own for Lunch and Recreation
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3:30 - 4:30 PM
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Special Lecture (Joint)
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British/Columbia Ballroom
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Craig B. Thompson,
Abramson Family Cancer Center and Research Institute, University of Pennsylvania
Therapeutic Exploitation of Metabolic Differences between Normal and Cancer Cells
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4:30 - 5:00 PM
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Coffee Available
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BC Foyer
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5:00 - 7:00 PM
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Immunologic Cell Death
|
British Ballroom
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*
Guido Kroemer,
INSERM, U848, Institut Gustave Roussy
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Polly Matzinger,
NIAID, National Institutes of Health
Conversations between Tissues and T Cells
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Matthew L. Albert,
Institut Pasteur
The Immunogenicity of Distinct Cell Death Modalities
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Seung Hyun Han,
Seoul National University
Short Talk: Functional and Phenotypic Changes in Dendritic Cells Loaded with Irradiation-Induced Apoptotic Cancer Cells
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Michel F. Gilliet,
University of Texas MD Anderson Cancer Center
Breaking Innate Immune Tolerance to Self-Nucleic Acids Released by Dying Cells
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7:00 - 8:00 PM
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Social Hour w/ Lite Bites
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Pacific Ballroom
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8:00 - 11:00 PM
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Entertainment
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Pacific Ballroom
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| Wednesday, March 17 |
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Departure
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