Keystone Symposia | Scientific Conferences on Biomedical and Life Science Topics

Alzheimer's Disease Beyond Abeta (A4)

Organizer(s): JoAnne McLaurin and Tony Wyss-Coray
January 10 - 15, 2010
Copper Mountain Resort · Copper Mountain, Colorado
Abstract Deadline: September 15, 2009
Late Abstract Deadline: October 13, 2009
Scholarship Deadline: September 15, 2009
Early Registration Deadline: November 10, 2009

Sponsored by Takeda Pharmaceutical Company Limited

This meeting took place in the 2010 season.

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Summary of Meeting
By 2010 many of the clinical trials presently underway targeting Abeta will have been completed or far enough along the pathway that we will have a better understanding of the benefit and limitations of this approach. This leads us to consider what are the next targets that will need to be addressed to fully treat and prevent Alzheimer’s disease. The objective of this meeting is therefore to stimulate and promote a discussion beyond Abeta as a key factor and therapeutic target in Alzheimer's Disease. This objective will be equally important whether therapeutic approaches targeting Abeta are successful or not, to either complement and expand successful Abeta therapies or to initiate a paradigm shift. In particular, we would like to discuss the generation of alternative models to study Alzheimer's Disease, and highlight several exciting areas of research including the role of synaptic dysfunction, neuronal regeneration, the immune system, and protein degradation in Alzheimer's Disease.

Sunday, January 10
3:00 - 7:30 PM	Registration	Kokopelli's
6:30 - 7:30 PM	Refreshments	Kokopelli's
7:30 - 8:30 PM	Keynote Address I	Big Horn B
	* JoAnne McLaurin, University of Toronto
	Dora Games, Elan Pharmaceuticals Issues and Advances in the Development of Immunotherapeutic Approaches for Alzheimer's Disease
8:30 - 9:30 PM	Keynote Address II	Big Horn B
	* Tony Wyss-Coray, Stanford University School of Medicine
	Lennart Mucke, University of California, San Francisco Strategies to Block Alzheimer's Disease-Associated Neuronal Dysfunction
Monday, January 11
7:00 - 8:00 AM	Breakfast	Kokopelli's
8:00 - 11:00 AM	Remodeling Alzheimer's Disease: An Academic Perspective Many treatment strategies have been developed for Alzheimer’s disease in animal models without adequate translation to humans. Where are the deficiencies in our models? What can be changed/enhanced for more direct translation to humans?	Big Horn B
	* Lennart Mucke, University of California, San Francisco
	Todd Eliot Golde, Mayo Clinic Jacksonville Preclincial Studies of Alzheimer's Disease and the Treatment versus Prevention Paradox

	Bart De Strooper, Center for Human Genetics Dysregulation of the microRNA network in sporadic Alzheimer's disease
	Roxana Octavia Carare, University of Southampton Perivascular Drainage of Abeta and the Pathology of CAA
	William J. Jagust, University of California, Berkeley Structural and Neurochemical Changes within the CNS during Aging and AD in Aging and AD

9:20 - 9:40 AM	Coffee Break	Kokopelli's
11:00 AM - 1:00 PM	Poster Setup	Big Horn C
11:00 AM -	On Own for Lunch and Recreation
1:00 - 10:00 PM	Poster Viewing	Big Horn C
4:30 - 5:00 PM	Coffee Available	Kokopelli's
5:00 - 7:00 PM	Remodeling Alzheimer's Disease II: An Industry Perspective Which neurotransmitter systems are disturbed in Alzheimer's Disease early on. How does their disruption contribute to disease and are they potential therapeutic targets.	Big Horn B
	* Dora Games, Elan Pharmaceuticals

	Marc Tessier-Lavigne, Genentech, Inc. APP-DR6 Signaling in Axon Development, Regeneration, and Degeneration

	Menelas N. Pangalos, AstraZeneca Beyond Abeta Based Therapies: Developing Novel Modulators of Neurotransmission


	Amie L. Phinney, Solvay Pharmaceuticals Short Talk: The Impact of Biomarkers on Alzheimer’s Disease Drug Discovery
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Kokopelli's
7:30 - 10:00 PM	Poster Session 1	Big Horn C
Tuesday, January 12
7:00 - 8:00 AM	Breakfast	Kokopelli's
8:00 - 11:00 AM	Alzheimer's and Synaptic/Neuronal Disfunction How are synapses affected in Alzheimer's Disease, do entire neurons disappear or individual synapses, or are synapses simply misfunctioning and still present.	Big Horn B
	* William E. Van Nostrand, Stony Brook University

	Sheena Josselyn, Hospital for Sick Children Cognitive Deficits in a Mouse Model of Alzheimer's Disease: The Role of CREB


	Ottavio Arancio, Columbia University Medical Center Amyloid-beta: From Physiology to Pathology
	Steffany A.L. Bennett, University of Ottawa Phospholipid Mediators of Synaptic Dysfunction
	Guojun Bu, Washington University School of Medicine ApoE and its Receptor in Brain Lipid Metabolism in AD
	Cynthia A. Massaad, Baylor College of Medicine Short Talk: Mitochondrial Free Radicals Play a Critical Role in Alzheimer’s Disease-Related Blood Flow and Axonal Transport Deficits Pathology
9:20 - 9:40 AM	Coffee Break	Kokopelli's
11:00 AM -	On Own for Lunch and Recreation
11:00 AM - 1:00 PM	Poster Setup	Big Horn C
1:00 - 10:00 PM	Poster Viewing	Big Horn C
4:30 - 5:00 PM	Coffee Available	Kokopelli's
5:00 - 7:00 PM	Alzheimer's Disease and Neuronal Regeneration Compounds are presently being developed that target neurons for enhancement of function and/or regeneration. What is the role of stem cells, neurogenesis and repair mechanisms to improvement of cognitive function in Alzheimer's Disease?	Big Horn B
	* Bruce T. Lamb, Cleveland Clinic Foundation
	Frank Longo, Stanford School of Medicine Small Molecule p75 Receptor Ligands Inhibit Abeta-Induced Degeneration, Synaptic Dysfunction and Cognitive Loss

	Daniel A. Peterson, Rosalind Franklin University, Chicago Medical School The Contribution of Neurogenesis in Repairing the Aging Brain

	Stephen M. Strittmatter, Yale University Beyond (Downstream of) Abeta: NgR and PrP
	Patrick A. Lewis, Institute of Neurology Short Talk: Investigating Lewy Body Disease with Human Neuronal Cells
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Kokopelli's
7:30 - 10:00 PM	Poster Session 2	Big Horn C
Wednesday, January 13
7:00 - 8:00 AM	Breakfast	Kokopelli's
8:00 - 11:00 AM	Alzheimer's and the Immune System What is the role of the immune system in Alzheimer's Disease? Are immune processes overactivated (inflammation) or are they deficient? Are peripheral cells recruited to the CNS and if so, what are they doing? Are peripheral immune responses changed in Alzheimer's Disease and what is their role in the disease? What is the role of microglia and what subsets of this cell type are in the brain (dendritic type CD11c, newly recruited cells, perivascular macrophages). Autoantibodies against Abeta.	Big Horn B
	* Andrea J. Tenner, University of California, Irvine
	Richard M. Ransohoff, Cleveland Clinic Microglia, Monocytes and Macrophages
	Terrence Town, Cedars-Sinai Medical Center Inflammation and Innate Immunity in Alzheimer's Disease
	Josef Priller, Charité – Universitätsmedizin Berlin Bone Marrow-Derived Cells in Models of Alzheimer's Disease
	Joseph El Khoury, Massachusetts General Hospital Chemokines and Mononuclear Phagocytes recruited in AD
	Marie E. Benoit, University of California, Irvine regents Short Talk: Neuroprotective Pathways Stimulated by the Complement Protein C1q in Neurons
9:20 - 9:40 AM	Coffee Break	Kokopelli's
11:00 AM - 1:00 PM	Poster Setup	Big Horn C
11:00 AM -	On Own for Lunch and Recreation
1:00 - 10:00 PM	Poster Viewing	Big Horn C
4:30 - 5:00 PM	Coffee Available	Kokopelli's
5:00 - 7:00 PM	Alzheimer's and Protein Degradation What is the role of the lysosomal system, are changes early or late in disease? How do lysosomal abnormalities relate to autophagy? Proteasomal dysfunction and neurodegeneration. How does this all affect Abeta generation and tau accumulation?	Big Horn B
	* Terrence Town, Cedars-Sinai Medical Center
	Jeffery W. Kelly, The Scripps Research Institute Proteostasis

	Kent Matlack, Whitehead Institute for Biomedical Research Using Simple Cells to Model Complex Diseases
	Zhenyu Yue, Mount Sinai School of Medicine Autophagy: Cell Self-Eating in Alzheimer's Disease
	Gizem Donmez, Massachusetss Institute of Technology Short Talk: SIRT1 Suppresses Alzheimer´s Disease by Activating the Alpha Secretase Gene ADAM10 in APPswe, PSEN1dE9 Mouse Model
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Kokopelli's
7:30 - 10:00 PM	Poster Session 3	Big Horn C
Thursday, January 14
7:00 - 8:00 AM	Breakfast	Kokopelli's
8:00 - 11:00 AM	Alzheimer's Disease and Diagnostics Are we imaging the appropriate targets in Alzheimer's Disease? How can the techniques be improved? What is the meaning of brain volume changes in response to treatment paradigms and cognition in general? Can biomarkers lead us to novel imaging targets?	Big Horn B

	Daniel M. Skovronsky, Avid Radiopharmaceuticals, Inc. PET Radiopharmaceuticals for Diagnosis of Dementias
	Holly Soares, Pfizer Global Research and Development Multiplex Panels as Diagnostic Tools in Alzheimer’s Disease


	Neill Graff-Radford, Mayo Clinic What have we learned from plasma Abeta?
	* Tony Wyss-Coray, Stanford University School of Medicine The Plasma Communicome of Normal Aging and Dementia
	Alice M. Wyrwicz, Northwestern University Short Talk: Diffusion Tensor Imaging as a Potential Biomarker of Dendritic Alterations in Mouse Models of AD
9:20 - 9:40 AM	Coffee Break	Kokopelli's
11:00 AM -	On Own for Lunch and Recreation
4:30 - 5:00 PM	Coffee Available	Kokopelli's
5:00 - 7:00 PM	Alzheimer's Disease and Therapeutics If anti-amyloid/tau therapies work or don’t, what are the lead-on areas that will need to be addressed to deal with cognitive function in Alzheimer's Disease. Novel targets or approaches. What role does CAA play in both development and delivery drugs?	Big Horn B
	Kullervo Hynynen, Sunnybrook Health Sciences Centre MRI Guided Ultrasound Delivery of Drugs to the CNS

	Valerie Cullen, Link Medicine Corp A New Therapeutic Strategy for Neurodegeneration
	* JoAnne McLaurin, University of Toronto Small Molecule Therapy for Alzheimer's Disease
	Linda J. Van Eldik, Northwestern University Medical School Short Talk: Targeting Glia-Neuron Interactions that Result in Synaptic Dysfunction as a Drug Discovery Strategy for Alzheimer’s Disease
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Kokopelli's
8:00 - 11:00 PM	Entertainment	Big Horn C
Friday, January 15
	Departure

*Session Chair †Speaker invited, not yet responded.