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New Insights into Healthspan and Diseases of Aging: From Molecular to Functional Senescence (B2)

Organizer(s): Sean M. Oldham, David A. Sinclair, Jan Vijg and Heidi Scrable
January 31 - February 5, 2010
Granlibakken Resort  ·  Tahoe City, California
Abstract Deadline: September 24, 2009
Late Abstract Deadline: October 30, 2009
Scholarship Deadline: September 24, 2009
Early Registration Deadline: November 30, 2009


Supported by The Directors' Fund



This meeting took place in the 2010 season.

For a complete list of the meetings for the upcoming/current season,
see our meeting list, or search for a meeting.
Summary of Meeting
Aging can be defined as the gradual loss of the ability of the organism to maintain homeostasis. Our aim will be to focus on the molecular and cellular mechanisms by which tissue and organ function deteriorate and homeostasis fails rather than on longevity itself, which has been the theme of previous Keystone Symposia meetings on aging. Work from a variety of models is recognizing that organisms, especially humans, are complicated systems in which interventions that extend lifespan might not necessarily block the aging and loss of function in specific organs or tissues and vice versa. Continuing this approach will help us gain an understanding and appreciation of the complexity that underlies aging in humans. The aim of this meeting is to reveal the integration and communication between pathways and systems during functional aging and their relationship with longevity. This meeting will highlight important questions to address in future research. Most importantly, what are the common and disparate causes underlying the cellular and physiological mechanisms responsible for human senescent phenotypes?

Sunday, January 31
3:00 - 7:30 PM Registration Pre Function
6:30 - 7:30 PM Welcome and Buffet Dinner Granhall
7:30 - 8:30 PM Keynote Address Mountain/Lake
Andrzej Bartke, Southern Illinois University School of Medicine
Growth Hormone: Elixir of Youth or Dangerous Snake Oil?
Monday, February 1
7:00 - 8:00 AM Breakfast Granhall
8:00 - 11:15 AM Aging Pathways I Mountain/Lake
* Marc Tatar, Brown University
Cynthia Kenyon, University of California, San Francisco
Insulin and Aging
Leonard P. Guarente, Massachusetts Institute of Technology
Sirtuins Aging and Disease
Daniel E.L. Promislow, University of Georgia
Networks and the Evolution of Aging
Anne Brunet, Stanford University
The plasticity of aging describing the role of FoxO3 in maintaining neuronal stem cell pool
William Mair, The Salk Institute
Short Talk: AMPK and Calcineurin extend lifespan via the CREB Regulated Transcription Co-activator (CRTC-1)
Maaike C. W. van den Berg, University Medical Center Utrecht
Short Talk: Regulation of FOXO4 through ROS Regulated Ral-JIP1-JNK Complex Assembly
9:20 - 9:40 AM Coffee Break Pre Function
11:15 AM - On Own for Lunch and Recreation
11:15 AM - 1:00 PM Poster Setup Bay
1:00 - 10:00 PM Poster Viewing Bay
4:30 - 5:00 PM Coffee Available Pre Function
5:00 - 7:00 PM Aging Pathways II Mountain/Lake
* Rolf Bodmer, Burnham Institute for Medical Research
Jennifer Cermak, Sirtris, a GSK Company
Targeting Sirtuins: Drug Development for Diseases of Aging
Robert S. Garofalo,
Insulin Resistane: Insights from high resolution transcriptional profiling
Sean M. Oldham, Burnham Institute for Medical Research
Role of Nutrient Sensing TOR Pathway in Obesity and Aging
Matthew D. McGee, Buck Institute for Age Research
Short Talk: 3D Digital Atlas of Aging in C. elegans
7:00 - 8:00 PM Dinner Granhall
8:00 - 10:00 PM Poster Session 1 Bay
8:00 - 9:00 PM Social Hour Bay
Tuesday, February 2
7:00 - 8:00 AM Breakfast Granhall
8:00 - 11:15 AM Molecules and Aging I Mountain/Lake
* David A. Sinclair, Harvard Medical School
Jan Vijg, Albert Einstein College of Medicine
Genomic Instability, Transcriptional Deregulation and Aging
Judith Campisi, Buck Institute for Age Research
The Double Edged Sword of Cellular Senescence
George M. Martin, University of Washington
Human diseases of Ageing and their evolutionary substrates
Norman E. Sharpless, University of North Carolina School of Medicine
Cell Cycle Control and Mammalian Aging
Raul Mostoslavsky, Massachusetts General Hospital, Harvard Medical School
Short Talk: The Histone Deacetylase SIRT6 Functions as a Master Regulator of Glucose Homeostasis
Eduardo Nunes Chini, Mayo Clinic
Short Talk: CD38 and DBC1: regulators of the non-oxidative functions of NAD; role of inhibitors of the longevity related enzyme SIRT1
9:20 - 9:40 AM Coffee Break Pre Function
11:15 AM - On Own for Lunch and Recreation
11:15 AM - 1:00 PM Poster Setup Bay
1:00 - 10:00 PM Poster Viewing Bay
4:30 - 5:00 PM Coffee Available Pre Function
5:00 - 7:00 PM Molecules and Aging II Mountain/Lake
* Jan Vijg, Albert Einstein College of Medicine
Heidi Scrable, Mayo Clinic
p53 and Aging
David A. Sinclair, Harvard Medical School
A tale of two Sirts
Rafael de Cabo, National Institute on Aging, NIH
From Molecules to Nutritional Interventions for Healthy Aging
* Philipp Oberdoerffer, National Cancer Institute, NIH
Short Talk: A Mechanistic Link between DNA Damage, Chromatin and Aging
7:00 - 8:00 PM Dinner Granhall
8:00 - 10:00 PM Poster Session 2 Bay
8:00 - 9:00 PM Social Hour Bay
Wednesday, February 3
7:00 - 8:00 AM Breakfast Granhall
8:00 - 11:15 AM Cells and Organelles Aging Mountain/Lake
* Heidi Scrable, Mayo Clinic
Thomas A. Rando, Stanford University School of Medicine
Stem cell aging, DNA damage and asymmetric cell division
Leanne Jones, The Salk Institute for Biological Studies
Stem Cell-Niche Cell Interactions during Aging
Amy J. Wagers, Harvard University
Reversing Dysfunction of Aged Tissue Stem Cells
* Sean J. Morrison, HHMI/University of Michigan
Stem Cell Renewal and changes in stem cell function during aging
Pier Lorenzo Puri, Sanford/Burnham Medical Research Institute
Short Talk: DNA Damage Signaling to MyoD and the Control of the Genomic Stability of Skeletal Muscles during Development and Aging
Giana Angelo, Fred Hutchinson Cancer Research Center
Short Talk: Adult Worms Protect Germline Stem Cells and Extend their Reproductive Span in Response to Starvation
9:20 - 9:40 AM Coffee Break Pre Function
11:15 AM - On Own for Lunch and Recreation
11:15 AM - 1:00 PM Poster Setup Bay
1:00 - 10:00 PM Poster Viewing Bay
2:30 - 4:30 PM Workshop: Stress, Mitochondria, and Aging Mountain/Lake
Nicholas Day, Buck Institute for Age Research
A Novel Inducible Mouse Model of Endogenous Mitochondrial Oxidative Stress Causes Heart Disease
Hadise Kabil, University of Michigan
Activity of the Transsulfuration Pathway Determines Lifespan Extension in Response to Dietary Restriction in Drosophila
* Pankaj Kapahi, Buck Institute for Age Research
4E-BP Extends Lifespan upon Dietary Restriction by Enhancing Mitochondrial Activity in Drosophila
David B. Lombard, University of Michigan
Mitochondrial Protein Acetylation in Calorie Restriction and Aging
Iain Scott, NHLBI, National Institutes of Health
The Functional Characterization of SIRT3 Modulation of Complex V of the Electron Transfer Chain
Cristiano Simone, Consorzio Mario Negri Sud
FoxO3A Localizes to Mitochondria and Regulates the Expression of the Mitochondrial Genome in Response to Nutrient Deprivation
Michael C. Velarde, Buck Institute for Age Research
Superoxide Dismutase 2 Deficiency Promotes Cellular Senescence and Excessive Differentiation in Mouse Epidermis
4:30 - 5:00 PM Coffee Available Pre Function
5:00 - 7:00 PM Cells and Organelles Aging II Mountain/Lake
* Sean M. Oldham, Burnham Institute for Medical Research
Ana Maria Cuervo, Albert Einstein College of Medicine
Autophagy and Aging
Andrew G. Dillin, The Salk Institute for Biological Studies
Aging as an Event of Proteostasis Decline
Michael S. Grotewiel, Virginia Commonwealth University
Age-Related Locomotor Impairment in Drosophila
Theodore W. Peters, Buck Institute for Age Research
Short Talk: Age-Dependent Accumulation of Insoluble Proteins is Conserved Across Taxa
7:00 - 8:00 PM Dinner Granhall
8:00 - 10:00 PM Poster Session 3 Bay
8:00 - 9:00 PM Social Hour Bay
Thursday, February 4
7:00 - 8:00 AM Breakfast Granhall
8:00 - 11:15 AM Physiological Systems, Aging and Disease I
Session is Sponsored by The Ellison Medical Foundation
Mountain/Lake
* Amy J. Wagers, Harvard University
Paul Joseph Shaw, Washington University
Sleep Aging
Michael O. Thorner, University of Virginia
Potential Role of Ghrelin Mimetics in Preventing Frailty and Partially Reversing Sarcopenia of Aging
Marc Tatar, Brown University
Drosophila as a Model for Analysis of Innate Immune Aging
Rolf Bodmer, Burnham Institute for Medical Research
Cardiac Aging
Matthew Gill, Buck Institute for Age Research
Short Talk: Endocannabinoid signaling and aging in C. elegans
Richard A. Kerber, University of Louisville
Short Talk: Association of Gene Expression Patterns in Lymphoblastoid Cell Lines with Familial Longevity and Survival
9:20 - 9:40 AM Coffee Break Pre Function
11:15 AM - On Own for Lunch and Recreation
4:30 - 5:00 PM Coffee Available Pre Function
5:00 - 7:00 PM Physiological Systems, Aging and Disease II
Session is Sponsored by The Ellison Medical Foundation
Mountain/Lake
* Anne Brunet, Stanford University
Monica Driscoll, Rutgers University
Genetic and Pharmacological Extension of Healthspan in a Simple Animal Model
Richard A. Miller, University of Michigan
Cell Stress and Aging
Bradley J. Willcox, Pacific Health Research Institute
Pathophysiological and Sociopsychological Evidence for Active and Resilient Centenarian
Floyd (Ski) Chilton, Wake Forest University School of Medicine
Short Talk: Impact of the Varying Frequencies at Common Genetic Variants in the FADS Gene Cluster on Circulating Levels of Inflammatory Fatty Acids in African Americans and Caucasians
7:00 - 8:00 PM Social Hour Alumni
8:00 - 9:00 PM Dinner Granhall
8:00 - 11:00 PM Entertainment Granhall
Friday, February 5
Departure
*Session Chair   †Speaker invited, not yet responded.



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