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Malaria: New Approaches to Understanding Host-Parasite Interactions (F1)

Organizer(s): Patrick E. Duffy and Jean Langhorne
April 11 - 16, 2010
Copper Mountain Resort  ·  Copper Mountain, Colorado
Abstract Deadline: December 11, 2009
Late Abstract Deadline: January 6, 2010
Scholarship Deadline: December 11, 2009
Early Registration Deadline: February 11, 2010


Part of the Keystone Symposia Global Health Series, Supported by the Bill & Melinda Gates Foundation. Sponsored by GlaxoSmithKline.

Joint meeting: Molecular Targets for Control of Vector-Borne Diseases: Bridging Lab and Field Research (F2)
NOTE: Registration for meeting allows attendance at joint meeting (pending space availability).



This meeting took place in the 2010 season.

For a complete list of the meetings for the upcoming/current season,
see our meeting list, or search for a meeting.
Summary of Meeting
Malaria has entered a new era—a partially effective vaccine may be licensed in the not too distant future, and the genomes of host, parasite and vector are now widely available. Major advances have been made in understanding basic parasite cell biology and fundamental immunology, using rapidly evolving molecular genetic technologies for both host and parasite. Systems biology approaches also offer a new paradigm for interrogating complex host responses to a complex pathogen. Future progress will require greater integration of these technologies to elucidate parasite cell biology, host-parasite interactions, and the specific mechanisms that confer protection in our model systems and in nature. This symposium will bring together these new fields to examine those aspects of host and Plasmodium biology important for understanding immunity and pathogenesis.

Sunday, April 11
3:00 - 7:30 PM Registration Kokopelli's
6:30 - 7:30 PM Refreshments Kokopelli's
7:30 - 9:30 PM Keynote Address (Joint) Big Horn Ballroom
Michael F. Good, Queensland Institute of Medical Research
Malaria Vaccines: Lessons from Immune Escape Instruct New Strategies
Anthony A. James, University of California, Irvine
Transgenic Strategies for Pathogen Transmission Control
Monday, April 12
7:00 - 8:00 AM Breakfast Kokopelli's/Ptarmigan B-C
8:00 - 11:15 AM Parasite Interactions with the Immune System Big Horn B
* Kate A. Fitzgerald, University of Massachusetts Medical School
Paolo Arese, University of Torino Medical School
Effects of Hemozoin and Hemozoin-Generated Molecules on Immune and Non-Immune Host Cells
James Brewer, University of Glasgow
Imaging Infection and Immune Responses in vivo
Jean Langhorne, National Institute for Medical Research
Kinetics of the Immune Response in Mice: Relevance for Human Malaria?
Takafumi Tsuboi, Ehime University
Sexual Stage Parasites and Transmission-Blocking Antibodies
Renée M. Tsolis, University of California, Davis
Short Talk: Malaria Parasite Infection Suppresses Mucosal Responses to Salmonella in the Intestine
9:20 - 9:40 AM Coffee Break Kokopelli's
11:15 AM - 1:00 PM Poster Setup Big Horn Ballroom
11:15 AM - On Own for Lunch and Recreation
1:00 - 10:00 PM Poster Viewing Big Horn Ballroom
4:30 - 5:00 PM Coffee Available Kokopelli's
5:00 - 7:00 PM Recognizing Protective Immunity Big Horn B
* John T. Harty, University of Iowa
Robert Sauerwein, Radboud University
Complete Immunity after Limited Exposure to P. falciparum in a Controlled Setting
Eleanor M. Riley, London School of Hygiene and Tropical Medicine
Cross-Talk between Innate and Adaptive Immune Cells: Relevance for Assessing Effector Cell Responses to Malaria Vaccines
Laurent Renia, Singapore Immunology Network
Mechanisms of Acquired Immunity against Malaria Liver Stage Immunity
Nathan W. Schmidt, University of Iowa
Short Talk: Plasmodium Species and Host Background Genes Profoundly Influence the Threshold of Memory CD8 T Cells Required for Protective Immunity
7:00 - 8:00 PM Social Hour w/ Lite Bites Kokopelli's
7:30 - 10:00 PM Poster Session 1 Big Horn Ballroom
Tuesday, April 13
7:00 - 8:00 AM Breakfast Kokopelli's/Ptarmigan B-C
8:00 - 11:15 AM Local Milieu for Host-Parasite Interactions Big Horn B
* Gareth Turner, Oxford University
Ute Frevert, New York University School of Medicine
Imaging the Immunobiology of Plasmodium in the Liver
Fidel P. Zavala, Johns Hopkins Bloomberg School of Public Health
Development of Memory CD8+ T Cells Against Malaria Liver Stages
Nick Crispe, Seattle Biomedical Research Institute
Immune Responses in the Liver
Pierre Buffet, Pitie-Salpetriere Hospital
Erythrocytes Squeezing across Splenic Slits and the Pathogenesis of Plasmodium falciparum Infection
Sandra March, Massachusetts Institute of Technology
Short Talk: Establishment of the Liver Stages of Plasmodium falciparum in a Microscale Human Liver Platform
Anne-Marie Zeeman, Biomedical Primate Research Centre
Short Talk: An Efficient in vitro Culture System to Study Malaria Dormant Liver Stages
9:20 - 9:40 AM Coffee Break Kokopelli's
11:15 AM - 1:00 PM Poster Setup Big Horn Ballroom
11:15 AM - On Own for Lunch and Recreation
1:00 - 10:00 PM Poster Viewing Big Horn Ballroom
4:30 - 5:00 PM Coffee Available Kokopelli's
5:00 - 7:00 PM Parasite Invasion and Arrest Big Horn B
* Robert Sauerwein, Radboud University
Maria M. Mota, Instituto de Medicina Molecular
Blood Stage /Plasmodium/ Parasites Suppress Co-Infection in the Liver
Urszula Krzych, Walter Reed Army Institute of Research
Memory CD8+ T Cells in Experimental Models of Protective Immunity Induced by Attenuated Plasmodia Sporozoites
Richard J. Pleass, University of Nottingham
Engineering Antibodies for Novel Malaria Vaccines
Audrey Gego, INSERM UMR S 945
Short Talk: Identification of New Hepatocyte Factors Involved in Malaria Liver Stage Infection by Large Scale RNAi Screening
7:00 - 8:00 PM Social Hour w/ Lite Bites Kokopelli's
7:30 - 10:00 PM Poster Session 2 Big Horn Ballroom
Wednesday, April 14
7:00 - 8:00 AM Breakfast Kokopelli's/Ptarmigan B-C
8:00 - 11:15 AM Malarial Disease: Contribution of Host Response Big Horn B
* Maria M. Mota, Instituto de Medicina Molecular
Gareth Turner, Oxford University
The Pathology of Human Malaria
Kate A. Fitzgerald, University of Massachusetts Medical School
The Innate Immune Response to Malaria
Patrick E. Duffy, National Institute of Allergy and Infectious Diseases
Malarial Disease and the Placenta
Nick M. Anstey, Menzies School of Health Research
Disease Caused by Plasmodium vivax
Andrew E. Armitage, Weatherall Institute of Molecular Medicine
Short Talk: Plasmodium falciparum Infected Erythrocytes Induce Hepcidin (HAMP) mRNA Synthesis by Peripheral Blood Mononuclear Cells
Ana Paula Freitas do Rosario, National Institute for Medical Research
Short Talk: TH1 CD4+ T Cells are the Main Source of Protective IL-10 Against Immune-Mediated Pathology during Plasmodium chabaudi AS Infection
9:20 - 9:40 AM Coffee Break Kokopelli's
11:15 AM - 1:00 PM Poster Setup Big Horn Ballroom
11:15 AM - On Own for Lunch and Recreation
1:00 - 10:00 PM Poster Viewing Big Horn Ballroom
2:30 - 4:30 PM Workshop Big Horn B
* Patrick E. Duffy, National Institute of Allergy and Infectious Diseases
Angela A. Aggrey, University of Rochester Medical Center
The Role of Platelets in Experimental Cerebral Malaria
Noah S. Butler, University of Iowa
Key Immune-Effector Molecules Differentially Regulate Memory CD8 T Cell-Mediated Immunity Against Liver Stage P. berghei versus P. yoelii Infection
Aubrey Cunnington, London School of Hygiene and Tropical Medicine
Impairment of Host Defence during Malaria: A Possible Consequence of Heme Oxygenase-1 Induction
Lei Shong Lau, University of Melbourne
The Generation of a Blood-stage Plasmodium berghei-specific CD8+ T Cell Receptor Transgenic Mouse Model
Jenni C. Lawton, National Institute for Medical Research
The cir Multi-Gene Family of Plasmodium chabaudi
Demba Sarr, University of Georgia
Differential Pregnancy Outcomes of Plasmodium chabaudi AS-Infected A/J and C57BL/6 Mice
4:30 - 5:00 PM Coffee Available Kokopelli's
5:00 - 7:00 PM Systems Biology of the Immune Response Big Horn B
* Dyann F. Wirth, Harvard University
Bali Pulendran, Emory University
Predicting Protective Immune Responses to Vaccines
Peter D. Crompton, National Institutes of Health
Using Protein Microarrays to Probe the Human Antibody Response to Plasmodium falciparum
Johanna P. Daily, Albert Einstein College of Medicine
Parasite Transcriptional Respones to Physiologic Conditions
Erica M. Pasini, Biomedical Primate Research Centre
Short Talk: Identification of a Small Exported Protein Strongly Associated with Sequestration through Proteomics of the Membranes of P. berghei Infected Erythrocytes (iRBCs)
7:00 - 8:00 PM Social Hour w/ Lite Bites Kokopelli's
7:30 - 10:00 PM Poster Session 3 Big Horn Ballroom
Thursday, April 15
7:00 - 8:00 AM Breakfast Kokopelli's/Ptarmigan B-C
8:00 - 11:15 AM Multigene Families: Role in Immunity and Pathology Big Horn B
* Jean Langhorne, National Institute for Medical Research
Dyann F. Wirth, Harvard University
Genetic Diversity in Plasmodia
Joseph D. Smith, Seattle Biomedical Research Institute
Structure-Function of DBL Domains and Vaccine Design
Peter R. Preiser, Nanyang Technological University
Understanding the Biological Role of Small Variant Antigens in Plasmodium
Lars Hviid, University of Copenhagen
The Naturally Acquired Human Antibody Response to Plasmodium falciparum Variant Surface Antigens
Benoit Gamain, Pasteur Institute
Short Talk: Full-Length Extracellular Region of the var2CSA Variant of PfEMP1 is Required for Specific, High-Affinity Binding to CSA
Marissa G. Vignali, Seattle Biomedical Research Institute
Short Talk: Differential Gene Expression in P. falciparum Field Samples of Variable Disease Severity
9:20 - 9:40 AM Coffee Break Kokopelli's
11:15 AM - On Own for Lunch and Recreation
4:30 - 5:00 PM Coffee Available Kokopelli's
5:00 - 7:00 PM Inducing Optimal Protective Responses with Vaccines Big Horn B
* Michael F. Good, Queensland Institute of Medical Research
John T. Harty, University of Iowa
Quantifying CD8 T Cell Mediated Anti-Plasmodium Immunity and Protective Immunity after Attenuated Parasite Immunization
Joanna Kubler Kielb, National Institutes of Health
A Bicomponent Pre-Erythrocytic Investigational Malaria Vaccine
Philip Bejon, University of Oxford
Immunity Induced by a Partially Protective Vaccine
Julie Healer, Walter and Eliza Hall Institute of Medical Research
Short Talk: Preclinical Development of a Combined Vaccine Against Bloodstage P. falciparum Malaria
7:00 - 8:00 PM Social Hour w/ Lite Bites Jack's
8:00 - 11:00 PM Entertainment Jack's
Friday, April 16
Departure
*Session Chair   †Speaker invited, not yet responded.



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