Keystone Symposia | Scientific Conferences on Biomedical and Life Science Topics

Towards Identifying the Pathophysiology of Autistic Syndromes (C2)

Organizer(s): Joseph Piven and Pat Levitt
February 24 - 28, 2008
Hilton Santa Fe/Historic Plaza · Santa Fe, New Mexico
Abstract Deadline: October 24, 2007
Late Abstract Deadline: November 26, 2007
Scholarship Deadline: October 24, 2007
Early Registration Deadline: December 26, 2007

Supported by the Director's Fund

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This meeting took place in the 2008 season.

Listed below are current meetings that are similar to this meeting in nature/content:

Epigenetic Basis of Neurodevelopmental Disorders (X2)
March 6 - 10, 2009

For a complete list of the meetings for the upcoming/current season,
see our meeting list, or search for a meeting.

Summary of Meeting
Autism is a common and highly heritable, neurodevelopmental disorder defined by the co-occurrence of three characteristic, behavioral features: (1) deficits in social interactions, (2) abnormalities in verbal and non-verbal communication, and (3) highly restricted interests and repetitive behaviors. The developmental etiology and specific pathogenetic mechanisms underlying autism are unknown, but the pathophysiology that underlies a small subset of etiologically-defined, rarer neurodevelopmental disorders, thought to be associated with autism and autistic behaviors—e.g., Fragile X Syndrome, tuberous sclerosis, Smith-Lemli-Opitz Syndrome and Rett Syndrome—have been well-described, yet there is disproportionately little research on these conditions as models for understanding autism. Accumulating data suggest that an underlying pathophysiology in the development of brain connectivity may be the point of convergence across all of these disorders. This conference brings together a unique group of clinical and basic scientists to examine what is known about the genetic and neurobiological underpinnings of this subset of disorders as a starting point for identifying the pathophysiological basis of autism.

Sunday, February 24
3:00 - 7:30 PM	Registration	Promenade
6:30 - 7:30 PM	Refreshments	Promenade
7:30 - 8:30 PM	Keynote Address	Mesa A-B
	Patrick Bolton, King's College, London Overview of the Medical Condition Associated with the Autistic Phenotype (Rett, FXS, SLO, TSC)
Monday, February 25
7:00 - 8:00 AM	Breakfast	Chamisa
8:00 - 11:00 AM	Autism Overview	Mesa A-B
	Pat Levitt, Vanderbilt Kennedy Center
	Geraldine Dawson, Autism Speaks The Syndrome of Autism: Early Patterns of Behavioral Symptoms, Brain Dysfunction, and Clinical Course
	Daniel H. Geschwind, University of California, Los Angeles Tackling Genetic Complexity in Autism
	David Amaral, University of California, Davis Neurobiological Studies in Autism
	Mark H. Lewis, University of Florida The Pathophysiology of Repetitive Behavior
	Joseph Piven, University of North Carolina at Chapel Hill Brain-Behavior Relationships in Early Development of Autism
9:20 - 9:40 AM	Coffee Break	Promenade
11:00 AM - 1:00 PM	Poster Setup	Ortiz
1:00 - 10:00 PM	Poster Viewing	Ortiz
4:30 - 5:00 PM	Coffee Available	Promenade
5:00 - 7:00 PM	Neurocutaneous Disorders	Mesa A-B
	* Daniel H. Geschwind, University of California, Los Angeles
	Alcino J. Silva, University of California, Los Angeles Memory and How it Fails: Unraveling Mechanisms and Finding Cures for Cognitive Disorders

	Kevin Ess, Vanderbilt University Neurobiology of Tuberous Sclerosis Complex
	Luis F. Parada, University of Texas Southwestern Medical Center The P13 Kinase Pathway and Mouse Models of Autism
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Ortiz
7:30 - 10:00 PM	Poster Session 1	Ortiz
Tuesday, February 26
7:00 - 8:00 AM	Breakfast	Chamisa
8:00 - 11:00 AM	Fragile X Syndrome	Mesa A-B
	Joseph Piven, University of North Carolina at Chapel Hill

	Declan G. Murphy, King's College London An Overview of Brain and Behavioral Phenotypes in FXS

	David L. Nelson, Baylor College of Medicine Modeling Modifiers in Fragile X Syndrome
	William T. Greenough, University of Illinois at Urbana-Champaign Neurobiology of FXS

	Gul Dolen, Picower Institute, Massachusetts Institute of Technology Correction of Fragile X in Mice

	Jacqueline J. Blundell, University of Texas Southwestern Medical Center Short Talk: A Potential Mouse Model of Non-syndromic Autism: Disease-Linked Point Mutation in Neuroligin-3 Produces Autism-Like Behavior in Mice
9:20 - 9:40 AM	Coffee Break	Promenade
11:00 AM - 1:00 PM	Poster Setup	Ortiz
1:00 - 10:00 PM	Poster Viewing	Ortiz
2:30 - 4:30 PM	Workshop: Epigenetics	Mesa A-B
	* David L. Nelson, Baylor College of Medicine


	Yi Eve Sun, University of California, Los Angeles Title to be Determined

	Arthur L. Beaudet, Baylor College of Medicine Distinct Genetic and Epigenetic Approaches to the Etiology of Autism Independent of Genetic Linkage and Association
	Jonathan Sebat, Cold Spring Harbor Laboratory Analysis of Genome Copy Number Variation in Autism Spectrum Disorders
	Marylyn D. Ritchie, Vanderbilt University Epistasis Modeling
4:30 - 5:00 PM	Coffee Available	Promenade
5:00 - 5:50 PM	Rett Syndrome	Mesa A-B
	* Declan G. Murphy, King's College London
	Huda Y. Zoghbi, Howard Hughes Medical Institute, Baylor College of Medicine Deciphering the Neurobiology of Rett Syndrome
	Sarika U. Peters, Baylor College of Medicine Short Talk: An Emerging Behavioral Phenotype in Female Carriers with MECP2 Duplications: Implications for the Broad Autism Phenotype
5:50 - 7:00 PM	Smith Lemli Opitz Syndrome	Mesa A-B
	Forbes D. Porter, National Institutes of Health and Human Development Smith-Lemli-Opitz Syndrome: Mouse Models, Pathophysiology, and Treatment
	Elaine Tierney, Kennedy Krieger Institute Smith-Lemli-Opitz Syndrome: Clinical Trials, Autism Interface

7:00 - 8:00 PM	Social Hour w/ Lite Bites	Ortiz
7:30 - 10:00 PM	Poster Session 2	Ortiz
Wednesday, February 27
7:00 - 8:00 AM	Breakfast	Chamisa
8:00 - 11:00 AM	Signaling Systems	Mesa A-B
	* Michael E. Greenberg, Harvard Medical School
	Randy D. Blakely, Vanderbilt University School of Medicine Rare Opportunities for Progress in Autism: Serotonin and Serotonin Transporters from Mouse to Man
	Pat Levitt, Vanderbilt Kennedy Center Convergent Evidence of C-Met Tyrosine Kinase Receptor Involvement In Forebrain Development and Autism Spectrum Disorder
	Takao K. Hensch, Harvard University Excitatory-Inhibitory Balance in Neuronal Circuit Development
	Lisa M. Boulanger, University of California, San Diego Regulation of Glutamatergic Synaptic Transmission and Synaptic Plasticity by MHC Class I
	Toru Takumi, Osaka Bioscience Institute Short Talk: The Mouse Model for Human 15q11-13 Duplication Displays Autistic Behaviour
9:20 - 9:40 AM	Coffee Break	Promenade
4:30 - 5:00 PM	Coffee Available	Promenade
5:00 - 6:15 PM	Mechanism of Synapse Development	Mesa A-B
	* Takao K. Hensch, Harvard University
	Michael E. Greenberg, Harvard Medical School Activity-Dependent Synapse Formation and Elimination, Role of MEF2

	Beth Stevens, Stanford University How are CNS Synapses Eliminated?
6:15 - 7:00 PM	Discussion Panel: Toward Identifying the Pathophysiology of Autism	Mesa A-B
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Ortiz
8:00 - 11:00 PM	Entertainment	Ortiz
Thursday, February 28
	Departure

*Session Chair †Speaker invited, not yet responded.