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BILE ACID RECEPTORS AS SIGNAL INTEGRATORS IN LIVER AND METABOLISM

Scientific Organizers:
Luciano Adorini, Kristina Schoonjans
and Scott L. Friedman

Date Dates:
March 3–7, 2017

Location Location:
Monterey, California, USA
Apply for a scholarship and save on the abstract submission fee by November 1, 2016.

Submit abstracts for short talk consideration no later than December 5, 2016.
SUBMIT ABSTRACT
APPLY FOR SCHOLARSHIP

In the last decade, bile acids have enjoyed a real renaissance, sparked by the identification at the turn of the millennium of their dedicated receptors, FXR and TGR5. This has been instrumental
in revealing the key role bile acids play in regulating liver and metabolic homeostasis, transforming them from detergents facilitating the intestinal absorption of nutrients into
versatile hormones.

Signaling through FXR and TGR5 indeed modulates several metabolic pathways, regulating not only bile acid synthesis and enterohepatic recirculation, but also lipid, glucose and energy homeostasis. In addition, FXR and TGR5 agonists display anti-inflammatory and anti-fibrotic properties, making these agents interesting candidates for the treatment of several liver and metabolic diseases, including nonalcoholic steatohepatitis (NASH). With hepatitis C virus infection nearly solved, NASH is already a medical problem of epidemic proportions poised to become by 2020 the leading indication for liver transplantation in the US.

This conference will review the genetics, structure and functions of bile acid receptors and will explore the intricate interactions among gut microbiota, bile acids and liver disease, as well as the multiple bidirectional signals along the gut-liver axis. Intriguingly, FXR agonists, like the bile acid derivative obeticholic acid, could have a beneficial role in the treatment of NASH by decreasing hepatic lipogenesis, steatosis and insulin resistance, while also inhibiting inflammatory and fibrogenic responses able to promote liver cirrhosis and hepatocellular carcinoma.

The conference therefore aims at integrating basic, translational and clinical aspects of bile acid receptors, bringing together an interdisciplinary group of scientists to discuss the state of the art
and propose new avenues of investigation in this active and
dynamic field.

In summary, this conference will:

  • Review the genetics, structure and functions of bile acid receptors, followed by a detailed analysis of the interactions among gut microbiota, bile acids and liver disease, as well as the multiple bidirectional signals along the gut-liver axis;
  • Cover strategies targeting bile acid receptors to treat liver and metabolic diseases including nonalcoholic steatohepatitis (NASH) and liver cancer;
  • Bring together an interdisciplinary group of basic, translational and clinical scientists to discuss the state of the art and propose new avenues of investigation in this active and dynamic field.

The four-day conference will consist of sessions focused on the following topics:

  • FXR and TGR5: Dedicated Bile Acid Sensors
  • Workshop 1: Bile Acid Receptors in Health and Disease
  • Genetics of and Epigenetics of Bile Acid Receptors
  • Interplay Between Bile Acids and the Gut Microbiome
  • Gut-Liver Metabolic Axis
  • Pathways to NASH, Liver Cirrhosis and HCC
  • Metabolic Inflammation and NASH
  • Targeting Bile Acid Receptors in Liver and Metabolic Diseases
  • Workshop 2: Approaches to NASH Treatment
  • NASH Therapeutics

The conference it will be of value to those working in the fields of:

Biochemistry • Gastroentrology • Endocrinology • Hepatology • Immunology • Liver Disease • Metabolic Disease • Molecular Biology • Signaling

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Keystone Symposia conferences offer:

  • A retreat-like atmosphere
  • An intimate environment
  • Interactive poster sessions
  • Exchange of ideas and experiences
  • Access to experts during and after talks
  • Short talk slots for breakthroughs and up-and-coming/junior investigators
  • Free time for recreation and collaboration-building
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Confirmed Speakers
(as of Oct 20, 2016)

Luciano Adorini, Intercept Pharmaceuticals, Inc., Italy
Johan Auwerx*, École Polytechnique Fédérale de Lausanne – EPFL, Switzerland
Fredrik Bäckhed, University of Gothenburg, Sweden
Ronald M. Evans, Howard Hughes Medical Institute, Salk Institute, USA
Richard A. Flavell, HHMI/Yale University School of Medicine, USA
Scott L. Friedman, Icahn School of Medicine at Mount Sinai, USA
Frank J. Gonzalez, National Institutes of Health, USA
Yujin Hoshida, Division of Liver Diseases, Icahn School of Medicine at Mount Sinai, USA
Gökhan S. Hotamisligil, Harvard University, USA
Verena Simone Keitel, University Hospital Duesseldorf, Germany
Kim Jongsook Kemper, University of Illinois at Urbana–Champaign, USA
Steven A. Kliewer, University of Texas Southwestern Medical Center, USA
Claus M. Kremoser, PheneX Pharma AG, Germany
David J. Mangelsdorf, HHMI/University of Texas Southwestern Medical Center, USA
Jelena Mann, Newcastle University, UK
David D. Moore, Baylor College of Medicine, USA
Antonio Moschetta, Clinica Medica Frugoni, University of Bari, Italy
Catherine Postic, Institut Cochin, France
Vlad Ratziu, Hôpital Pitié Salpêtriére, France
Frank Reimann, University of Cambridge, UK
Arun Sanyal, Virginia Commonwealth University Medical Center, USA
Kristina Schoonjans, École Polytechnique Fédérale de Lausanne – EPFL, Switzerland
Elizabeth K. Speliotes, University of Michigan, USA
Bart Staels, Institut Pasteur de Lille, Université Lille 2, France
Gyongyi Szabo, University of Massachusetts Medical School, USA
Michael Trauner, Medical University of Vienna, Austria
Li Wang, University of Connecticut, USA
Gary D. Wu, University of Pennsylvania School of Medicine, USA

*Keynote speaker


For the most up-to-date list of speakers and talks, click here:

VIEW PROGRAM


How to Register

keystonesymposia.org/17C1

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Conference Deadlines

Scholarship Deadline:
Nov 1, 2016

Discounted Abstract Deadline: Nov 1, 2016

Abstract Deadline:
Dec 5, 2016

Discounted Registration Deadline: Jan 9, 2017

Additional Information

  • Deadlines are at midnight US Mountain Time.
  • Discounted abstract submission and discounted registration save 50 USD and 150 USD, respectively, on later fees. Short talk speakers will be chosen from abstracts received by the "Abstract Deadline" for the meeting.
  • Scholarships are for graduate students and postdoctoral fellows; the application requires submission of an abstract by the "Scholarship/Discounted Abstract Deadline" for the meeting.
  • Please note that the first advertised meeting date is the date of arrival and registration, and the last date that of the last organized sessions.

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