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This meeting took place in 2018



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Cell Death, Inflammation and Adaptation to Tissue Stress (A6)


Organizer(s) Pascal Meier, Eric H. Baehrecke and Kim Newton
January 21—25, 2018
Beaver Run Resort • Breckenridge, Colorado USA
Discounted Abstract Deadline: Sep 27, 2017
Abstract Deadline: Oct 25, 2017
Scholarship Deadline: Sep 27, 2017
Discounted Registration Deadline: Nov 28, 2017

Sponsored by Akebia Therapeutics, Amgen Inc., Boehringer Ingelheim Pharmaceuticals, Inc., Cancer Research UK, Genentech, Inc. and Roche

Summary of Meeting:
Cell death and inflammation are ancient processes of fundamental biological importance in both normal physiology and human disease pathologies. The recent observation that cell death regulatory components have dual roles in cell death and inflammation suggests that these proteins function not primarily to kill, but to coordinate tissue repair and adaptation to tissue stress. This perspective unifies cell death components as positive regulators of tissue repair that replace malfunctioning or damaged tissues and enhances the resilience of epithelia to insult. It is now recognized that cells that die do not do so silently, but release a variety of paracrine signals to communicate with their cellular environment to ensure tissue regeneration and wound healing. Moreover, inflammatory signaling pathways, such as those emanating from the TNF-receptor or Toll-related receptors, take part in cell competition to eliminate developmentally aberrant clones. Understanding how dead and dying cells initiate and escalate inflammation has important implications for the development of novel treatment strategies for diseases associated with aging, such as chronic inflammation and cancer. This conference explores the complex relationship between cell death and inflammation, and how this cross-talk impacts on adaptation to tissue stress, inflammatory diseases, tumor formation and drug resistance. Overall, the goals of the conference are to: 1) Explore the gaps in our current understanding of how dead and dying cells influence inflammatory responses in tissue repair and disease settings; 2) Foster communication and collaborations between scientists focusing on different areas of biology (cell death, innate immunity, adaptive immunity, cancer and model organisms); 3) Pinpoint nodes of intersection linking all research fields; 4) Define key-regulatory paradigms at these intersections, and discuss molecular mechanisms that control these processes; 5) Share information on possible consequences of deregulation; 6) Discuss translational aspects and potential drug targets, e.g. in pre-clinical models of malignant disease.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


The meeting will begin on Sunday, January 21 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, January 25 with a closing plenary session and keynote address from 17:00 to 19:15, followed by a social hour and entertainment. We recommend return travel on Friday, January 26 in order to fully experience the meeting.

SUNDAY, JANUARY 21

16:00—20:00
Arrival and Registration

Foyer
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Foyer

MONDAY, JANUARY 22

07:00—08:00
Breakfast

Summit Gallery
08:00—09:00
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online.

Peaks 4 & 5
* Pascal Meier, Institute of Cancer Research, UK

Douglas R. Green, St. Jude Children's Research Hospital, USA
Programmed Necrosis in Inflammation: Toward Identification of the Effector Molecules

09:00—11:30
RIP Kinases and the Regulation of Tissue Homeostasis
Meeting has ended...abstracts no longer viewable online.

Peaks 4 & 5
* Kevin M. Ryan, Beatson Institute for Cancer Research, UK

Manolis Pasparakis, University of Cologne, Germany
Epithelial Cell Death in Tissue Homeostasis and Inflammation

Coffee Break

John Silke, Walter and Eliza Hall Institute of Medical Research, Australia
Primed to Die - The in vivo Consequences of Activating Mutations in the Necroptotic Cell Death Pathway

Igor E. Brodsky, University of Pennsylvania, USA
Short Talk: RIPK1-Dependent Apoptosis Mediates Effector-Triggered Immunity in Response to Pathogen Blockade of Innate Immune Signaling

Alessandro Barbarulo, University College London, UK
Short Talk: RIPK1 Regulates Mature Thymocyte Death and Survival in vivo in Response to TNF Independently of NF-κB

Vishva M. Dixit, Genentech, Inc., USA
Inflammasomes and their Roles in Health and Disease

11:30—17:00
On Own for Lunch

11:30—13:00
Poster Setup

Peaks 1-3
13:00—22:00
Poster Viewing

Peaks 1-3
16:30—17:00
Coffee Available

Foyer
17:00—19:00
Autophagy, Cell Health and Death
Meeting has ended...abstracts no longer viewable online.

Peaks 4 & 5
* Kate A. Fitzgerald, University of Massachusetts Medical School, USA

Eric H. Baehrecke, University of Massachusetts Medical School, USA
Autophagy and Cell Death

Kevin M. Ryan, Beatson Institute for Cancer Research, UK
The Role of Autophagy in Cellular Stress Responses and Tumor Development

Kim McCall, Boston University, USA
Short Talk: Lysosomal Machinery Promotes Extracellular Acidification to Direct Non-Apoptotic Programmed Cell Death

Ivan Dikic, Goethe University Medical School, Germany
Catalysis and Inhibition of Phosphoribosyl-Dependent Ubiquitination

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Peaks 1-3
19:30—22:00
Poster Session 1

Peaks 1-3

TUESDAY, JANUARY 23

07:00—08:00
Breakfast

Summit Gallery
08:00—11:15
Inflammatory Cell Death
Meeting has ended...abstracts no longer viewable online.

Peaks 4 & 5
* John Silke, Walter and Eliza Hall Institute of Medical Research, Australia

* Manolis Pasparakis, University of Cologne, Germany

Hao Wu, Harvard Medical School, Boston Children's Hospital, USA
Cell Death by Inflammasomes

Kate A. Fitzgerald, University of Massachusetts Medical School, USA
Regulation of Inflammatory Responses

Coffee Break

Feng Shao, National Institute of Biological Sciences, China
Pyroptosis: From Innate Immunity to Cancer

Swarna Lekha Vijayaraj, University of Melbourne, Australia
Short Talk: Post-Translational Regulation of Interleukin-1β

Moritz Gaidt, Ludwig Maximilians University, Germany
Short Talk: The DNA Inflammasome in Human Myeloid Cells Is Initiated by a STING-Cell Death Program Upstream of NLRP3

Kim Newton, Genentech, Inc., USA
Exploring the Pro-Survival Functions of Caspase-8 and RIPK1

11:15—17:00
On Own for Lunch

11:15—13:00
Poster Setup

Peaks 1-3
13:00—22:00
Poster Viewing

Peaks 1-3
16:30—17:00
Coffee Available

Foyer
17:00—19:00
Cancer as a Systemic Disease
Meeting has ended...abstracts no longer viewable online.

Peaks 4 & 5
* Andreas E. Strasser, Walter and Eliza Hall Institute of Medical Research, Australia

Laura D. Attardi, Stanford University School of Medicine, USA
Deciphering p53 Transcriptional Networks in Tumor Suppression

Scott W. Lowe, Memorial Sloan Kettering Cancer Center, USA
Constructing and Deconstructing Cancer Using Mouse Models

Mads Daugaard, University of British Columbia, Canada
Short Talk: Targeting Cancer Using Malaria Host Cell-Anchor Proteins

Guillermina Lozano, University of Texas MD Anderson Cancer Center, USA
Somatic p53 Mutations Drive Development of Triple-Negative Breast Cancer with Evolutionarily Distinct Metastases

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Peaks 1-3
19:30—22:00
Poster Session 2

Peaks 1-3

WEDNESDAY, JANUARY 24

07:00—08:00
Breakfast

Summit Gallery
08:00—11:15
Adaptive Responses to Tissue Stress
Meeting has ended...abstracts no longer viewable online.

Peaks 4 & 5
* John Silke, Walter and Eliza Hall Institute of Medical Research, Australia

Pascal Meier, Institute of Cancer Research, UK
RIPK1 and the Maintenance of Tissue Homeostasis

Andrew Oberst, University of Washington, USA
The RIP Kinases as Modulators of Inflammation and Immunity

Coffee Break

Mathieu JM Bertrand, VIB / Ghent University, Belgium
Cell Death Checkpoints in TNF Signaling

Henning Walczak, University College London, Cancer Institute, UK
Deficiency in LUBAC Components: A Surprise in Three Acts

Andreas Villunger, Medical University Innsbruck, Austria
The Resurrection of the PIDDosome

11:15—17:00
On Own for Lunch

14:30—16:30
Workshop: Signaling in Cell Death and Inflammation

Peaks 4 & 5
* Pascal Meier, Institute of Cancer Research, UK

Aditya Murthy, Genentech, Inc., USA
Selective Autophagy of the Innate Adaptor TRIF Regulates Inflammatory Signaling

Piya Ghose, Rockefeller University, USA
The Fusogen EFF-1 Drives Phagosome Sealing during Dismantling of Morphologically Complex Cells

Mausita Karmakar, Case Western Reserve University, USA
An Alternate Role for Neutrophil GasderminD (GSDMD) in Mediating Caspase-1 Activation and IL-1 Release in the Absence of Pyroptosis

Huibing Wang, Harvard Medical School, USA
PELI1 Functions as a Dual Modulator of Necroptosis and Apoptosis by Mediating Ubiquitination of RIPK1 and Regulating the mRNA Levels of c-FLIP

Justin Shaun Arnold Perry, University of Virginia, USA
A Chloride Sensing Pathway Regulates Phagocyte Volume Homeostasis and the Inflammatory Switch

Andrew J. Davidson, University of Bristol, UK
An Irrepressible Appetite: Gnawing Away at the Robustness Underlying Macrophage Phagocytosis

Michael Alan Davis, University of Washington, USA
Pyroptotic Cell Swelling: A New Model of Inflammation Initiation Independent of Osmotic Lysis

16:30—17:00
Coffee Available

Foyer
17:00—19:00
Death-Induced Tissue Remodeling
Meeting has ended...abstracts no longer viewable online.

Peaks 4 & 5
* Mary A. Logan, Oregon Health & Science University, USA

Andreas Bergmann, University of Massachusetts Medical School, USA
Non-apoptotic Roles of Caspases for Proliferation and Cancer in Drosophila

Laura A. Johnston, Columbia University, USA
Spatially Restricted Signal Activation during Myc-induced Super-Competition

Shruti Singla, University of Cambridge, UK
Short Talk: Elimination of Aneuploid Cells in the Early Mammalian Embryo

Michael Overholtzer, Memorial Sloan Kettering Cancer Center, USA
LC3 Lipidation in LAP-Related Processes

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Peaks 1-3

THURSDAY, JANUARY 25

07:00—08:00
Breakfast

Summit Gallery
08:00—11:15
Resolution and Healing
Meeting has ended...abstracts no longer viewable online.

Peaks 4 & 5
* Eric H. Baehrecke, University of Massachusetts Medical School, USA

* Will Wood, University of Bristol, UK
Detecting Death and Damage; Understanding Macrophage Migration in Drosophila

Mary A. Logan, Oregon Health & Science University, USA
Genetic Regulation of Glial Cell Migration following Nerve Injury in Drosophila

Coffee Break

Christopher D. Gregory, University of Edinburgh, UK
Sinister Self-Sacrifice: Contributions of Apoptosis to Malignant Disease

Jennifer Martinez, NIEHS, National Institutes of Health, USA
Short Talk: Non-Canonical Autophagy Mediates Immunosuppression during Challenge

Danielle Sliter, NINDS, National Institutes of Health, USA
Short Talk: Parkin, PINK1 and Inflammation

Kodi S. Ravichandran, University of Virginia, USA
Eating a Good Apoptotic Meal: Implications for Health and Disease

11:15—17:00
On Own for Lunch

16:30—17:00
Coffee Available

Foyer
17:00—18:15
Immune Response Against Dying Tumor Cells
Meeting has ended...abstracts no longer viewable online.

Peaks 4 & 5
* Kim Newton, Genentech, Inc., USA

Matthew L. Albert, Genentech, Inc., USA
Apoptotic Cell-Mediated Antigen Presentation

Scott Cameron, Novartis Institutes for BioMedical Research, USA
Clinical Experience with an IAP Antagonist, LCL161

Marcus Conrad, Helmholtz Zentrum München, Germany
Short Talk: Mechanisms Controlling Ferroptotic Cell Death

18:15—19:00
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Peaks 4 & 5
* Pascal Meier, Institute of Cancer Research, UK

* Eric H. Baehrecke, University of Massachusetts Medical School, USA

Andreas E. Strasser, Walter and Eliza Hall Institute of Medical Research, Australia
Towards Targeting MCL-1 for Cancer Therapy

19:00—19:15
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Meeting has ended...abstracts no longer viewable online.

Peaks 4 & 5
19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Peaks 1-3
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Peaks 1-3

FRIDAY, JANUARY 26

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



Keystone Symposia thanks our Sponsors for generously supporting this meeting:

Akebia Therapeutics Amgen Inc.
Boehringer Ingelheim Pharmaceuticals, Inc. Cancer Research UK
Genentech, Inc. Roche

We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1 R13 AI136036-01

Funding for this conference was made possible (in part) by 1 R13 AI136036-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Genentech, Inc.


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

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If you are interested in becoming an advertising/marketing in-kind partner, please contact:
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Phone:+1 970-262-2676