Adaptive ROS Signaling in Physiology and Disease
joint with Mitochondrial Biochemistry in Health and Disease
Scientific Organizers: Michael Ristow, Navdeep S. Chandel, Marcia C. Haigis and Yvonne M. Janssen-Heininger
Date: May 17 - 21, 2020
Location: Whistler Conference Centre, Whistler, BC, Canada
Reactive oxygen species (ROS) are widely considered unwanted by-products of mitochondrial metabolism and physiology, which can damage proteins, lipids and DNA. Accordingly, and for many decades, ROS have been linked to the initiation and progression of cancer, diabetes, neurodegeneration, systemic aging, and others. Emerging evidence suggests that ROS at physiological levels may rather act as short-lived signaling molecules linking mitochondrial activity to nuclear transcription and subsequently cellular homeostasis, a process called retrograde response. The meeting will provide a forum for new and paradigm-shifting ideas and an opportunity for new investigators to enter the field. These include ROS-sensitive transcriptional effects in the nucleus, conformational changes following cysteine oxidation within signaling molecules, ROS-mediated host-pathogen interactions, limitations of cancer growth by ROS, ROS-induced autophagy, mitophagy and proteostasis, as well as ROS-mediated effects of forkhead, NRF2 and sirtuin-signaling. Lastly and with a clinical/epidemiological perspective, the role of ROS in human disease and ROS-inducing compounds will be addressed. Given the recently established roles of ROS in diverse research areas like aging, cancer biology, immunity, metabolism, and mitochondria, this meeting will provide a forum for an unprecedented convergence of highly interdisciplinary scientific interests from both academia and industry.
Scholarship Deadline: January 21 2020 details
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