Emerging Cell Therapies: Realizing the Vision of NextGen Cell Therapeutics
Scientific Organizers: Kole T. Roybal, Alex Marson and Yvonne Y. Chen
Date: January 24 - 28, 2021
Location: Keystone Resort, Keystone, CO, USA
Cellular therapeutics are poised to be a next pillar of medicine along with small molecules and biologics. These living drugs have a unique capacity for more complex decision-making and therapeutic responses potentially alleviating the need for chronic treatment. Next-generation cell therapies will need to adapt and respond to disease progression essentially functioning as microscopic “physicians” capable of sensing, diagnosing, and eradicating disease via a multifaceted mechanism that is difficult to resist, similar to our natural immune system. Recently, the first engineered T cell therapeutics have been FDA approved, and they are transforming how we treat cancers that have few therapeutic options. While there have been unprecedented complete responses in a subset of hematological malignancies, the current therapies can show significant toxicity and on the other hand show a lack of efficacy in solid tumors. Beyond cancer, engineered cell therapies could have significant impact in the treatment of autoimmunity and in regenerative medicine. This conference will cover next-generation cellular engineering approaches important to tackle issues with refractory diseases such as solid tumors and the higher safety requirements for disease beyond late-stage metastatic cancers. We are bringing together clinically-minded cell therapists, synthetic biologists, genome and protein engineers, systems biologists, and Immunologists as these expertise are required to establish cells as a safe and effective therapeutic strategy across a range of diseases. Smart cellular therapeutics of the future must be easily customizable, have intrinsic control systems to prevent toxicity, and be able to overcome rapidly evolving mechanisms preventing disease resolution.
Registration opens in January 2020