Mitochondrial Dysfunction: From Ultra-Rare Diseases to Aging

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Mitochondrial Dysfunction: From Ultra-Rare Diseases to Aging - RESCHEDULING IN PROGRESS
Scientific Organizers: Vamsi K. Mootha and Dan Gottschling
Date: February 19 - 23, 2021
Location: Beaver Run Resort, Breckenridge, CO, USA
Supported by the Directors' Fund
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Summary of Meeting:
Mitochondrial dysfunction accompanies a spectrum of conditions, ranging from severe, inborn errors of metabolism to the very aging process itself. Inherited mitochondrial diseases are individually rare and tend to be associated with severe defects in the organelle, while aging and age-associated degeneration is universal and tend to be associated with a more subtle, quantitative decline in mitochondrial function. What are the underlying mechanisms of mitochondrial pathogenesis? Are they shared across this disease spectrum? Might therapies for orphan diseases be useful for age associated disorders, or vice versa? This Keystone Symposia conference will explore mechanisms of mitochondrial dysfunction across this continuum by bringing together established and emerging leaders both in rare mitochondrial disorders and in aging. The ensuing cross-fertilization is expected to result in the synthesis of new testable hypotheses that will help to drive the entire field forward.
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