Cancer Stem Cells: Advances in Biology and Clinical Translation

Web Desc
MEETING CHANGE TO VIRTUAL: Cancer Stem Cells: Advances in Biology and Clinical Translation
Organizer(s): Irene Oi Lin Ng, Xin Wei Wang and Dean G. Tang
Date: May 18 - 21, 2021
Location: Virtual at your computer. Recorded presentation content is available On Demand.
Organized in collaboration with Volkswagen Foundation
Summary of Meeting:
For more information on the virtual eSymposia program Click here

Preponderant experimental and clinical evidence has demonstrated that pervasive cancer cell heterogeneity in both phenotypic presentations and functional properties exists, such that a population of cancer cells with cardinal stem cell properties (i.e., cancer stem cells) pre-exists in untreated tumors and spatiotemporally evolves during tumor progression and therapeutic interventions. Recent studies have also revealed significant phenotypic and functional plasticity in cancer cells, regulated by both genetic networks and epigenetic mechanisms. Both cancer cell heterogeneity and plasticity constitute major barriers to effective and durable clinical treatments. Ever since the revival of the cancer stem cell research field in the last two decades, we have made great strides in identifying and elucidating the biology of cancer stem cells in virtually all tumor systems. Significant progress has also been made in understanding how cancer stem cells interact with the cellular constituents and soluble factors in the proinflammatory and immune-suppressive tumor microenvironment. Facilitated by an explosion of technical advances in recent years, especially single-cell RNA-seq, we are achieving an unprecedented appreciation of the complexity of the cellular heterogeneity of human tumors. Significantly, novel therapeutic strategies that target cancer stem cells and cancer cell heterogeneity and plasticity are rapidly progressing to the clinical arena. This conference is organized to recapitulate these recent advances in our understanding of cancer stem cell biology and, importantly, the clinical translation of targeting cancer stem cells.
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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

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