Heart Failure: Mechanisms and Therapies joint with Mitochondria, Metabolism and Heart Scientific Organizers: David A. Kass and Saptarsi M. Haldar Date: January 14 - 18, 2021
Location: Eldorado Hotel & Spa, Santa Fe, NM, USA Heart failure is a leading global cause of morbidity and mortality. Moreover, it prevalence is increasing exponentially as individuals live longer to experience the collusive effects of accumulated disease, genetic propensities, environmental stressors, and behavioral factors. The underpinnings of HF are multifactorial, providing a broad array of relevant biochemical therapeutic targets that could impact clinical symptoms and outcome. The impacts of aging, and epidemic of obesity and associated disorders such as diabetes are having a major impact on heart failure pathophysiology. This meeting will particularly highlight the roles of altered metabolism, mitochondrial dysfunction, protein quality control, inflammation, and fibrosis. The recent explosion of methods to assess subpopulations at the single-cell level, and studies of epigenetic controls on disease and heart development/regeneration are presented. Lastly, we are at the dawn of a new age for manipulating contractility of the heart, and recent advances in HF treatment including clinical testing will be presented. We are holding the meeting jointly with a Keystone Symposium on Mitochondrial Function – also with a cardiac emphasis. Two joint sessions will focus on mitochondrial function and metabolism, respectively. The meeting emphasizes cutting edge basic research, emphasizing rapidly advancing areas paving new opportunities. Many of the speakers will be leaders in highly relevant fields yet often not those one would hear at the typical heart failure meeting. In this sense, we aim to encourage new dialog and interdisciplinary collaborations between fields that all have prominent roles in the failing heart. Registration opens in January 2020 |