Proteomics in Cell Biology and Disease

Web Desc
MEETING CHANGE TO VIRTUAL: Proteomics in Cell Biology and Disease
Scientific Organizers: Jennie R. Lill, Forest M. White and Kathryn S. Lilley
Date: September 20 - 23, 2020
Location: Virtual at your computer
Supported by the Directors' Fund
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Summary of Meeting:
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Proteomics provides critical biological information about the activation state of enzymes, pathways, and signaling networks that drive all biological processes. However, the power of this approach is currently limited by the capabilities of proteomics technologies and methods. Although single dimensional proteomics analysis is now routine on abundant samples, challenges remain in analyzing limited samples collected from in vivo studies and in examining dynamic cellular processes. This meeting aims to address these challenges, focusing on the latest advances and innovations in sample preparation, instrumentation, and bioinformatic/computational analysis, to push the boundaries of proteomics to enable more powerful analytics for translational research. Specifically, the program will cover: (1) cutting edge sample preparation methods that enable increased sensitivity and functional analysis of proteins; (2) approaches to tackle single cell proteomics analysis, in parallel with genomics and transcriptomics advances; (3) advancing multiplex capabilities beyond 2-10 plex experimentation to for more meaningful clinical analysis; and (4) integration of various “omics” data sets with proteomics to provide a more global view of the dynamic cellular environment. A critical focus of this meeting will be on new technologies needed to further improve the feasibility of looking at multicellular dimensions & multiplexed analyses in proteomics. The program features diverse content on current biological applications and needs, highlighting the application of high sensitivity proteomics to real-world translational questions. Attendees will learn what instrumentation, data acquisition methods, and informatic pipelines allow researchers to answer critical yet challenging questions, while also learning what is not yet feasible. By bringing together a multidisciplinary team of experts across a broad range of fields, this meeting aims to stimulate a collaborative environment and cross-pollination of ideas to drive the next wave of innovation in proteomics approaches and technologies. We will also discuss how we can better work together as a community to disseminate these methods and analytical tools, similar to recent movements in the open source computational programming world. Ultimately our goal is to help build a proteomics community that is ready to tackle even the most complex biological problems.
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