Hepatobiliary Cancers: Pathobiology and Translational Advances
joint with Fatty Liver Disease and Multi-System Complications
Scientific Organizers: Alphonse E. Sirica, Gregory J. Gores and Lopa Mishra
Date: March 21 - 24, 2021
Location: Fairmont Hotel Vancouver, Vancouver, BC, Canada
Hepatobiliary cancers [hepatocellular carcinomas (HCC) and intrahepatic cholangiocarcinomas (iCCA)] represent a major global health burden that continues to be biologically and clinically challenging. Hepatobiliary cancers are now ranked 2nd or 3rd as the most common cause of annual worldwide cancer deaths, with over 840,000 new cases worldwide in 2018. This first of its kind Keystone Symposium will provide a distinctive and clinically relevant view of current and emerging basic and translational research aimed at furthering our understanding of the pathobiology of both HCC and iCCA, as well as advancing mechanism-based targeted strategies for hepatobiliary cancer therapy and/or prevention. Challenging topics that will be explored will include (1) changing trends in the etiologies of hepatobiliary cancers, with a focus on mechanisms linked to cell injury, inflammation, and fibrogenesis, (2) what roles do the microbiome and tumor microenvironment play in affecting HCC and iCCA progression, therapeutic resistance, and immunosurveillance, (3) identifying novel and more effective biomarker signatures for monitoring HCC and iCCA prognosis and treatments, (4) challenges of inter-and intra-tumoral heterogeneity, (5) advances in “omics” for personalizing HCC and iCCA therapies, and (6) current and emerging trends in molecular and immune targeting, together with future perspectives. Moreover, pairing this uniquely programmed conference with one on fatty liver disease is a perfect fit in lieu of the fact that non-alcoholic steatohepatitis is now considered to be an important risk factor for hepatobiliary cancer. It is also very much anticipated that this conference will foster new and productive research collaborations and training opportunities.
Registration opens in January 2020