Lipidomics of Health and Disease
joint with Resolution of Inflammation
Scientific Organizers: Michael J.O. Wakelam, Steffany A.L. Bennett and Jean E. Schaffer
Date: March 22 - 25, 2021
Location: Fairmont Chateau Whistler, Whistler, BC, Canada
Lipid metabolism provides essential building blocks for cell growth and replication, molecules that can initiate and propagate signaling inside and outside of cells, and fuel for cell function and division. As the ability to detect and accurately quantify lipid species has advanced, there is a growing appreciation of the critical contributions of these molecular species to a wide range of human diseases. This meeting aims to integrate the information being generated through lipidomics studies, particularly identifying changes in particular molecular species with genetic and proteomic data to identify the importance of changes in lipid metabolism and signaling and the regulatory enzymes for neurodegeneration, metabolic disorders, cancer and inflammation and immune responses. This meeting covers the importance of lipids in health and disease. We aim to integrate lipidomics approaches into talks that will present biological and clinical importance rather than placing methodologies at the center. This will allow us to focus, in particular, upon the mechanistic importance of lipids in neurodegeneration and other neurological disorders, cancer, inflammation and metabolic disorders. Through identifying the enzymes that regulate the lipidomics changes, there is potential to identify novel therapeutic targets. The paradigm for this approach is PI3kinase where the basic biochemistry has led to the development of effective inhibitors, we intend that identifying other targets will meet the need for other lipid enzyme therapeutics. We aim to move away from a focus upon lipidomics methodologies per se and instead bring together those working on lipid analysis and those on the biological and medical importance of lipid regulatory pathways to discuss how we can use lipidomic profiling to get to the heart of new understanding (and treatment) of different diseases. This approach is distinct from the majority of other lipid-related meetings. We also believe that PI3kinase should be reintegrated into meetings addressing lipid-related disease since it is an example of successfully adopting this approach and, whilst its own meeting is no longer attracting sufficient attendees, it remains an important scientific area for discussion. A particular gap this meeting will seek to address is the importance of particular lipid molecular species rather than lipid classes. The existence of more than 20,000 potential lipid species in a cell has been highlighted by modern lipidomic methodologies. The biological and medical importance of this diversity is demonstrated by particular species regulating enzyme activities and by distinct species regulating membrane properties and thus functions such as signaling and cell migration. Recognizing this importance, the meeting will include a workshop, led by members of LIPID MAPS, upon lipidomics methodologies, data handling and storage.
Registration for this meeting is not open yet, it will open later in January 2020