Inter Organ Crosstalk in Non-Alcoholic Steatohepatitis (NASH)
joint with Adipose Tissue and Metabolic Health
Scientific Organizers: Greg Steinberg, Camilla Charlotte Schéele and Saswata Talukdar
Date: February 06 - 09, 2022
Location: Keystone Resort, Keystone, CO, USA
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The epidemics of obesity and type 2 diabetes are driving the development of non-alcoholic steatohepatitis (NASH) which is rapidly accelerating rates of liver cirrhosis and hepatocellar carcinoma (HCC). NASH is characterized by complex crosstalk between different cell types and organ systems that leads to statosis, inflammation and fibrosis. This intracellular communication involves multiple cells types within the microenvironment (e.g. stellate cells, macrophages, t-cells and hepatocytes) but also includes interactions with multiple organ systems (e.g. gut microbiome, brown/beige/white adipose tissue and muscle). With the development of many new technological advances (e.g. proteomics, single cell RNAseq, organoids) our understanding of these intricate signaling pathways is rapidly expanding. The primary aim of this meeting is to bring scientists across different disciplines together to provide a forum for sharing rapidly emerging methodological advances in order to understand the mechanisms by which cells and organ systems communicate, in order to develop new paradigms and therapeutic strategies for the treatment of NASH. Given the importance of adipose tissue as a critical storage depot, an endocrine organ, and a regulator of energy expenditure, hosting this meeting with one focused on adipose tissue function will expand opportunities for interdisciplinary interactions.
Scholarship Deadline: October 21 2021 details
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Registered attendees of one meeting in a joint pair may participate in sessions of the other, pending space availability.