GPCRs: An Odyssey from Structure, Signaling and Regulation to Therapeutics
joint with Micropeptides: Biogenesis and Function
Scientific Organizers: Brian Kobilka, Mark von Zastrow and Aylin Hanyaloglu
Date: April 06 - 09, 2022
Location: Snowbird Resort, Snowbird, UT, USA
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The superfamily of G protein-coupled receptors (GPCRs) act as molecular sensors central to all cellular and physiological systems. Coupled with their ability to respond to a highly diverse range of chemical stimuli, they represent the therapeutic targets for many existing drugs. While GPCRs are considered a well-established field, recent technological advances to dissect the molecular mechanisms of GPCR function has revealed new paradigms with increasingly complex models of receptor activation and signaling. In turn, this complexity raises further fundamental questions and challenges in the study of GPCR action in multiple systems, but also offers exciting opportunities in the translational development of these findings to generate safe and effective precision therapies. The goal of this meeting is to bring together a highly interdisciplinary group of scientists to exchange new experimental data, technologies and ideas in the following areas: 1. Spatial-temporal signaling of GPCRs and physiological functions; 2. GPCRs as environmental sensors; 3. The structural basis for GPCR activation of down-stream signaling and regulatory proteins; and 4. New approaches to GPCR drug discovery. This timely meeting will not only provide an inclusive forum for communication, but also a platform for generating new collaborative opportunities and discuss new enabling technologies in order to leverage the recent advances in the field towards new discoveries and solutions in GPCR drug discovery.
Scholarship Deadline: December 15 2021 details
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Registered attendees of one meeting in a joint pair may participate in sessions of the other, pending space availability.