Web Desc
JAKs and STATs: Activation and Biologic Impact
Organizer(s): George R. Stark, Ian M. Kerr and James E. Darnell, Jr.
Date: January 13 - 18, 2002
Location: Snowbird Resort, Snowbird, UT, USA
Sponsored in part by The Director's Sponsor Fund
For important information on the coronavirus, please click here
Summary of Meeting:
The JAK tyrosine kinases and STAT transcription factors are now appreciated to be essential for the function of many pathways that regulate gene expression and biological function. Exciting current research has revealed, for example, family members in slime molds and insects, both positive and negative regulation of gene expression, cross-responses to pathways that use serine phosphorylation, and that Stat3 is an oncogene and Stat1 a tumor suppressor. Future issues: determine more protein structures, mechanisms and significance of serine phosphorylation, details of pivotal protein-protein interactions, basis of ligand-specific signals. Meeting goals: to cross-fertilize a very large range of research projects in an exciting and rapidly evolving field.
Discounted Abstract Deadline: October 1 2001
Discounted Registration Deadline: November 13 2001
We gratefully acknowledge the generous grant for this conference provided by:

National Cancer Institute (NCI)
Grant No. 1 R13 CA30714-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

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Program

Sunday, January 13 | 4:00PM - 7:00PM
Registration
Room: Ballroom Lobby


Sunday, January 13 | 6:15PM - 7:15PM
Welcome
Room: Ballroom Lobby


Sunday, January 13 | 7:15PM - 7:30PM
Orientation
Room: Ballroom 3


Sunday, January 13 | 7:30PM - 8:30PM
Keynote Address
Room: Ballroom 3

Speaker 1 of 1
C. David Allis, Rockefeller University, USA
The Histone Modification Circus: Balancing Acts Fundamental to Human Biology and Disease

Monday, January 14 | 7:00AM - 8:00AM
Breakfast
Room: Golden Cliff


Monday, January 14 | 8:00AM - 12:00PM
Receptor/JAK Complexes, Receptor Cross-Talk, Modular Signali
ng/STATs

Room: Ballroom 3

Speaker 1 of 6
* Ian M. Kerr, Cancer Research UK, UK
JAK/STAT Signaling

Monday, January 14 | 8:00AM - 12:00PM
Receptor/JAK Complexes, Receptor Cross-Talk, Modular Signali
ng/STATs

Room: Ballroom 3

Speaker 2 of 6
Pipsa I. Saharinen, Haartman Institute, University of Helsinki, Finland
Short Talk: The Pseudokinase Domain in the Regulation of JAK2 and JAK3 Tyrosine Kinases

Monday, January 14 | 8:00AM - 12:00PM
Receptor/JAK Complexes, Receptor Cross-Talk, Modular Signali
ng/STATs

Room: Ballroom 3

Speaker 3 of 6
K. Christopher Garcia, Stanford University School of Medicine, USA
Short Talk: The Interaction between gp130 and Viral Interleukin-6: A Paradigm for the Architecture of gp130-Cytokine Signaling Assemblies

Monday, January 14 | 8:00AM - 12:00PM
Receptor/JAK Complexes, Receptor Cross-Talk, Modular Signali
ng/STATs

Room: Ballroom 3

Speaker 4 of 6
Nicholas K. Tonks, Cold Spring Harbor Laboratory, USA

Monday, January 14 | 8:00AM - 12:00PM
Receptor/JAK Complexes, Receptor Cross-Talk, Modular Signali
ng/STATs

Room: Ballroom 3

Speaker 5 of 6
Tadatsugu Taniguchi, University of Tokyo, Japan
STATs and IRFs in the Regulation of Immunity and Bone Remodeling

Monday, January 14 | 8:00AM - 12:00PM
Receptor/JAK Complexes, Receptor Cross-Talk, Modular Signali
ng/STATs

Room: Ballroom 3

Speaker 6 of 6
Stephen Brown, University of Cambridge, UK
Short Talk: Characterisation of Domeless, the Drosophila JAK/STAT Receptor

Monday, January 14 | 9:20AM - 9:40AM
Coffee Break
Room: Ballroom Lobby


Monday, January 14 | 12:00PM - 1:00PM
Poster Setup
Room: Ballroom 2


Monday, January 14 | 1:00PM - 9:30PM
Poster Viewing
Room: Ballroom 2


Monday, January 14 | 2:00PM - 4:00PM
Workshop 1
Room: Ballroom 3

Speaker 1 of 6
Athanasia D. Panopoulos, University of Texas MD Anderson Cancer Center, USA
Cytokine-Inducible Expression of the Myeloid-Specific Integrin alphaMbeta2 (CD11b/CD18) is Regulated by STAT3-Dependent Activation of PU.1

Monday, January 14 | 2:00PM - 4:00PM
Workshop 1
Room: Ballroom 3

Speaker 2 of 6
* Nancy C. Reich, Stony Brook University, USA
Regulated Cellular Localization of STATs and Influence of Small GTPases

Monday, January 14 | 2:00PM - 4:00PM
Workshop 1
Room: Ballroom 3

Speaker 3 of 6
Pravin B. Sehgal, New York Medical College, USA
STATs in Membrane Rafts

Monday, January 14 | 2:00PM - 4:00PM
Workshop 1
Room: Ballroom 3

Speaker 4 of 6
Erika A. Bach, New York University School of Medicine, USA
A Genetic Screen to Identify New Components of the Drosophila JAK-STAT Pathway

Monday, January 14 | 2:00PM - 4:00PM
Workshop 1
Room: Ballroom 3

Speaker 5 of 6
Antonis E. Koromilas, Lady Davis Institute, McGill University, Canada
The Interferon-Inducible Protein Kinase PKR is a Mediator of JAK-STAT Activation and Translational Control

Monday, January 14 | 2:00PM - 4:00PM
Workshop 1
Room: Ballroom 3

Speaker 6 of 6
Joe F. Lau, Mount Sinai School of Medicine, USA
A Hybrid IRF9-STAT2 Transcription Factor Recapitulates Gene Expression and Biological Responses

Monday, January 14 | 4:00PM - 4:30PM
Coffee & Snacks Available
Room: Ballroom Lobby


Monday, January 14 | 4:30PM - 6:30PM
Transcription Mechanisms 1
Room: Ballroom 3

Speaker 1 of 5
* James E. Darnell, Rockefeller University, USA
Transcriptional Activation by STATs and Biologic Impact

Monday, January 14 | 4:30PM - 6:30PM
Transcription Mechanisms 1
Room: Ballroom 3

Speaker 2 of 5
Joo-Yeon Yoo, Postech, South Korea
Short Talk: Specific Ablation of STAT3beta Distorts the Pattern of STAT3-Responsive Gene Expression and Impairs Recovery from Endotoxic Shock

Monday, January 14 | 4:30PM - 6:30PM
Transcription Mechanisms 1
Room: Ballroom 3

Speaker 3 of 5
J. Jillian Zhang, Cornell Medical School, USA
Short Talk: Analysis of Trancription Co-Activators of STAT1 in IFN-gamma Signaling

Monday, January 14 | 4:30PM - 6:30PM
Transcription Mechanisms 1
Room: Ballroom 3

Speaker 4 of 5
Jan H. Tavernier, Ghent University, Belgium
Short Talk: Design and Application of a Cytokine Receptor-Based Interaction Trap

Monday, January 14 | 4:30PM - 6:30PM
Transcription Mechanisms 1
Room: Ballroom 3

Speaker 5 of 5
Carmen Herrero, Hospital for Special Surgery, USA
Short Talk: Modulation of IL-10 Activity and Signaling during Macrophage Activation

Monday, January 14 | 6:30PM - 7:30PM
Welcome Mixer
Room: Ballroom Lobby


Monday, January 14 | 7:30PM - 9:30PM
Poster Session 1
Room: Ballroom 2


Monday, January 14 | 7:30PM - 8:30PM
Cash Bar
Room: Ballroom Lobby


Tuesday, January 15 | 7:00AM - 8:00AM
Breakfast
Room: Golden Cliff


Tuesday, January 15 | 8:00AM - 12:00PM
Negative Regulation
Room: Ballroom 3

Speaker 1 of 7
* Douglas J. Hilton, Walter and Eliza Hall Institute of Medical Research, Australia
SOCS Proteins - Negative Regulations of Cytokine Signal Transduction

Tuesday, January 15 | 8:00AM - 12:00PM
Negative Regulation
Room: Ballroom 3

Speaker 2 of 7
Ann L. Cornish, University of Melbourne, Australia
Short Talk: SOCS-1 is Important in the Negative Regulation of T Cell Activation

Tuesday, January 15 | 8:00AM - 12:00PM
Negative Regulation
Room: Ballroom 3

Speaker 3 of 7
Alexander H. Dalpke, University Heidelberg, Germany
Short Talk: Toll-Like Receptor-Dependent Microbial Stimuli Modulate Cytokine Responses in Antigen Presenting Cells by Inducing Suppressors of Cytokine Signaling

Tuesday, January 15 | 8:00AM - 12:00PM
Negative Regulation
Room: Ballroom 3

Speaker 4 of 7
Thomas A.F. Decker, Vienna Biocenter, University of Vienna, Austria
Short Talk: The STAT1 Binding Motif of the IFN-gamma Receptor is Sufficient to Mediate STAT5 Activation and Its Repression by SOCS3

Tuesday, January 15 | 8:00AM - 12:00PM
Negative Regulation
Room: Ballroom 3

Speaker 5 of 7
Christin Carter-Su, University of Michigan Medical School, USA
Regulation of JAK Activity and Cytokine Signaling by Members of the SH2-B Family of Adapter Proteins

Tuesday, January 15 | 8:00AM - 12:00PM
Negative Regulation
Room: Ballroom 3

Speaker 6 of 7
Ke Shuai, University of California, Los Angeles, USA
Inactivation of STAT Signaling in the Nucleus

Tuesday, January 15 | 8:00AM - 12:00PM
Negative Regulation
Room: Ballroom 3

Speaker 7 of 7
Yi Eve Sun, University of California, Los Angeles, USA
Short Talk: Neurogenin1 Inhibits the JAK-STAT Pathway Via Multiple Routes

Tuesday, January 15 | 9:20AM - 9:40AM
Coffee Break
Room: Ballroom Lobby


Tuesday, January 15 | 12:00PM - 1:00PM
Poster Setup
Room: Ballroom 2


Tuesday, January 15 | 1:00PM - 9:30PM
Poster Viewing
Room: Ballroom 2


Tuesday, January 15 | 4:00PM - 4:30PM
Coffee & Snacks Available
Room: Ballroom Lobby


Tuesday, January 15 | 4:30PM - 6:30PM
Transcription Mechanisms 2
Room: Ballroom 3

Speaker 1 of 5
* Christin Carter-Su, University of Michigan Medical School, USA

Tuesday, January 15 | 4:30PM - 6:30PM
Transcription Mechanisms 2
Room: Ballroom 3

Speaker 2 of 5
Peter C. Heinrich, Universitätsklinikum Aachen, Germany
Modulation of IL-6-Type Cytokine Signaling

Tuesday, January 15 | 4:30PM - 6:30PM
Transcription Mechanisms 2
Room: Ballroom 3

Speaker 3 of 5
Heather A. Bruns, Indiana University School of Medicine, USA
Short Talk: A Constitutively Active STAT6 is not Sufficient to Alter B Cell Gene Expression and Function in the Absence of IL-4

Tuesday, January 15 | 4:30PM - 6:30PM
Transcription Mechanisms 2
Room: Ballroom 3

Speaker 4 of 5
Edith B. Pfitzner, Institute for Biomedical Research, Germany
Short Talk: Transciptional Activation by STAT6 Requires the Direct Interaction with NCoA-1

Tuesday, January 15 | 4:30PM - 6:30PM
Transcription Mechanisms 2
Room: Ballroom 3

Speaker 5 of 5
Curt M. Horvath, Northwestern University, USA
Analysis of STAT Transcription Mechanisms

Tuesday, January 15 | 6:30PM - 7:30PM
Welcome Mixer
Room: Ballroom Lobby


Tuesday, January 15 | 7:30PM - 9:30PM
Poster Session 2
Room: Ballroom 2


Tuesday, January 15 | 7:30PM - 8:30PM
Cash Bar
Room: Ballroom Lobby


Wednesday, January 16 | 7:00AM - 8:00AM
Breakfast
Room: Golden Cliff


Wednesday, January 16 | 8:00AM - 12:00PM
Oncogenesis, Immune Regulation, Tissue-Specific Effects 1
Room: Ballroom 3

Speaker 1 of 5
John J. O'Shea, NIAMS, National Institutes of Health, USA
Cytokine Signaling and Lymphoid Development, Differentiation and Immunoregulation

Wednesday, January 16 | 8:00AM - 12:00PM
Oncogenesis, Immune Regulation, Tissue-Specific Effects 1
Room: Ballroom 3

Speaker 2 of 5
Kenneth M. Murphy, HHMI/Washington University School of Medicine, USA
Mechanisms of STAT4 in Th1 Development

Wednesday, January 16 | 8:00AM - 12:00PM
Oncogenesis, Immune Regulation, Tissue-Specific Effects 1
Room: Ballroom 3

Speaker 3 of 5
* Robert D. Schreiber, Washington University School of Medicine, USA
STAT1 and Lymphocytes: Tumor Suppression and Tumor Editing

Wednesday, January 16 | 8:00AM - 12:00PM
Oncogenesis, Immune Regulation, Tissue-Specific Effects 1
Room: Ballroom 3

Speaker 4 of 5
David E. Levy, New York University School of Medicine, USA
STAT Transcriptional Mechanisms in Host Defense and Cancer

Wednesday, January 16 | 8:00AM - 12:00PM
Oncogenesis, Immune Regulation, Tissue-Specific Effects 1
Room: Ballroom 3

Speaker 5 of 5
George R. Stark, Case Western Reserve University, USA
Stat1-Independent Responses to IFNgamma and Stat 1,3-Dependent Transcription Without Tyrosine Phosphorylation

Wednesday, January 16 | 9:20AM - 9:40AM
Coffee Break
Room: Ballroom Lobby


Wednesday, January 16 | 1:00PM - 9:30PM
Poster Viewing
Room: Ballroom 2


Wednesday, January 16 | 2:00PM - 4:00PM
Workshop 2
Room: Ballroom 3

Speaker 1 of 8
* Peter C. Heinrich, Universitätsklinikum Aachen, Germany

Wednesday, January 16 | 2:00PM - 4:00PM
Workshop 2
Room: Ballroom 3

Speaker 2 of 8
Markus H. Heim, University Hospital Basel, Switzerland
Inhibition of Interferon Alpha Signaling Through the JAK-STAT Pathway in HVC Transgenic Mice

Wednesday, January 16 | 2:00PM - 4:00PM
Workshop 2
Room: Ballroom 3

Speaker 3 of 8
Simone Radtke, Medical School RWTH Aachen, Germany
Short Talk: Novel Role of Janus Kinase 1 in the Regulation of Oncostatin M Receptor Surface Expression

Wednesday, January 16 | 2:00PM - 4:00PM
Workshop 2
Room: Ballroom 3

Speaker 4 of 8
Lily Huang, University of Texas Southwestern Medical Center at Dallas, USA
Short Talk: The N-Terminal Domain of Janus Kinase 2 is Required for Golgi Processing and Cell Surface Expression of Erythropoietin Receptor

Wednesday, January 16 | 2:00PM - 4:00PM
Workshop 2
Room: Ballroom 3

Speaker 5 of 8
Jennifer Rubin Grandis, University of Pittsburgh Eye & Ear Institute, USA
STATs in Head and Neck Cancer

Wednesday, January 16 | 2:00PM - 4:00PM
Workshop 2
Room: Ballroom 3

Speaker 6 of 8
June H. Lee, University of California, San Francisco, USA
IL-13 and IL-4 Induce Differential Gene Expression in Bronchial Smooth Muscle Cells and Lung Fibroblasts

Wednesday, January 16 | 2:00PM - 4:00PM
Workshop 2
Room: Ballroom 3

Speaker 7 of 8
Thomas Kay, St. Vincent's Institute of Medical Research, Australia
Hypersensitivity to TNF-alpha-Induced Cell Death in Pancreatic beta Cells with SOCS-1 Deficiency

Wednesday, January 16 | 2:00PM - 4:00PM
Workshop 2
Room: Ballroom 3

Speaker 8 of 8
Bao Q. Vuong, City College of New York, CUNY, USA
Pim Serine/Theronine Kinases Regulate the Stability of SOCS-1 Protein

Wednesday, January 16 | 4:00PM - 4:30PM
Coffee & Snacks Available
Room: Ballroom Lobby


Wednesday, January 16 | 4:30PM - 6:30PM
Oncogenesis, Immune Regulation, Tissue-Specific Effects 2
Room: Ballroom 3

Speaker 1 of 4
* George R. Stark, Case Western Reserve University, USA

Wednesday, January 16 | 4:30PM - 6:30PM
Oncogenesis, Immune Regulation, Tissue-Specific Effects 2
Room: Ballroom 3

Speaker 2 of 4
Merav Socolovsky, University of Massachusetts Medical School, USA
The Roles of EpoR and STAT5 in Red Cell Formation

Wednesday, January 16 | 4:30PM - 6:30PM
Oncogenesis, Immune Regulation, Tissue-Specific Effects 2
Room: Ballroom 3

Speaker 3 of 4
James N. Ihle, St. Jude Children's Research Hospital, USA
JAKs and STATs in Cytokine Signaling

Wednesday, January 16 | 4:30PM - 6:30PM
Oncogenesis, Immune Regulation, Tissue-Specific Effects 2
Room: Ballroom 3

Speaker 4 of 4
M. A.Q. Siddiqui, Downstate Medical Center, State University of New York, USA
JAK/STAT Signaling Mediates Myocardial Dysfunction during Hypertrophy and Ischemia

Wednesday, January 16 | 6:30PM - 7:30PM
Welcome Mixer
Room: Ballroom Lobby


Wednesday, January 16 | 7:30PM - 9:30PM
Poster Sessions 1 & 2
Room: Ballroom 2


Wednesday, January 16 | 7:30PM - 8:30PM
Cash Bar
Room: Ballroom Lobby


Thursday, January 17 | 7:00AM - 8:00AM
Breakfast
Room: Golden Cliff


Thursday, January 17 | 8:00AM - 12:00PM
Growth Regulation, Constitutive Gene Expression, Alternate P
athways, Apoptosis

Room: Ballroom 3

Speaker 1 of 9
* David E. Levy, New York University School of Medicine, USA

Thursday, January 17 | 8:00AM - 12:00PM
Growth Regulation, Constitutive Gene Expression, Alternate P
athways, Apoptosis

Room: Ballroom 3

Speaker 2 of 9
Norbert Perrimon, Harvard Medical School, USA
Studies on the Drosophila JAK/STAT Pathway

Thursday, January 17 | 8:00AM - 12:00PM
Growth Regulation, Constitutive Gene Expression, Alternate P
athways, Apoptosis

Room: Ballroom 3

Speaker 3 of 9
Jacqueline F. Bromberg, Memorial Sloan Kettering Cancer Center, USA
Short Talk: The Role of STAT3 in Breast Cancer Tumorigenesis

Thursday, January 17 | 8:00AM - 12:00PM
Growth Regulation, Constitutive Gene Expression, Alternate P
athways, Apoptosis

Room: Ballroom 3

Speaker 4 of 9
Keith Syson Chan, Stem Cells and Regenerative Medicine, USA
Short Talk: Activation of STAT3 during Multistage Skin Tumorigenesis

Thursday, January 17 | 8:00AM - 12:00PM
Growth Regulation, Constitutive Gene Expression, Alternate P
athways, Apoptosis

Room: Ballroom 3

Speaker 5 of 9
Mariusz A. Wasik, University of Pennsylvania, USA
Short Talk: Multilevel Dysregulation of STAT3 Activation in T-Cell Lymphomas Expressing Anaplastic Lymphoma Kinase (ALK)

Thursday, January 17 | 8:00AM - 12:00PM
Growth Regulation, Constitutive Gene Expression, Alternate P
athways, Apoptosis

Room: Ballroom 3

Speaker 6 of 9
James L. Watson, McMaster University, Canada
Short Talk: (-)-Epigallocatechin Gallate (EGCG) Inhibits IFNgamma-Induced STAT1 Activation in Human T84 Epithelia: Implications for the Regulation of Intestinal Barrier Function

Thursday, January 17 | 8:00AM - 12:00PM
Growth Regulation, Constitutive Gene Expression, Alternate P
athways, Apoptosis

Room: Ballroom 3

Speaker 7 of 9
Leonidas C. Platanias, University of Illinois at Chicago, USA
Role of Map Kinases in Interferon Signaling

Thursday, January 17 | 8:00AM - 12:00PM
Growth Regulation, Constitutive Gene Expression, Alternate P
athways, Apoptosis

Room: Ballroom 3

Speaker 8 of 9
Anna I. Dimberg, Uppsala University Hospital, Sweden
Short Talk: Serine-727 Phosphorylated STAT1 is Required for ATRA-Induced G0/G1 Arrest of U-937 Cells and the Associated Regulation of Cyclins and p27Kip1

Thursday, January 17 | 8:00AM - 12:00PM
Growth Regulation, Constitutive Gene Expression, Alternate P
athways, Apoptosis

Room: Ballroom 3

Speaker 9 of 9
Tania C. Benatar, Sunnybrook Research Institute, Canada
Short Talk: ES Cell Fate is Determined Through a Complex Balance of Intracellular Signaling Pathways

Thursday, January 17 | 9:20AM - 9:40AM
Coffee Break
Room: Ballroom Lobby


Thursday, January 17 | 4:00PM - 4:30PM
Coffee & Snacks Available
Room: Ballroom Lobby


Thursday, January 17 | 4:30PM - 6:30PM
Slime Molds to Zebrafish
Room: Ballroom 3

Speaker 1 of 3
* Jeffrey G. Williams, University of Dundee, School of Biological Sciences, UK
Regulation of the Nuclear Import and Export of Dictyostelium STAT Proteins: Pointers from Ancestral STATs?

Thursday, January 17 | 4:30PM - 6:30PM
Slime Molds to Zebrafish
Room: Ballroom 3

Speaker 2 of 3
Leanne Jones, University of California, Los Angeles, USA
Short Talk: Stem Cell Self-Renewal Specified by JAK-STAT Activation in Response to a Support Cell Cue

Thursday, January 17 | 4:30PM - 6:30PM
Slime Molds to Zebrafish
Room: Ballroom 3

Speaker 3 of 3
Toshio Hirano, Osaka University Graduate School of Medicine, Japan
Roles of JAK/STAT Signaling in Gastrulation

Thursday, January 17 | 6:30PM - 7:30PM
Welcome Mixer
Room: Ballroom 2/Lobby


Thursday, January 17 | 7:30PM - 10:30PM
Entertainment
Room: Ballroom 2


Thursday, January 17 | 7:30PM - 10:30PM
Cash Bar
Room: Ballroom 2


Friday, January 18 | 10:21AM - 10:21AM
Departure


*Session Chair
†Invited, not yet responded.