Past Meeting | Keystone Symposia

This meeting took place in the past. Here is a list of meetings that are related:
Jaks, Stats and Immunity (2007A1)
Jaks and Stats: Development to Disease (2004E2)

Web Desc
JAKs and STATs: Activation and Biologic Impact Organizer(s): George R. Stark, Ian M. Kerr and James E. Darnell, Jr. Date: January 13 - 18, 2002 Location: Snowbird Resort, Snowbird, UT, USA Sponsored in part by The Director's Sponsor Fund For important information on the coronavirus, please click here Summary of Meeting: The JAK tyrosine kinases and STAT transcription factors are now appreciated to be essential for the function of many pathways that regulate gene expression and biological function. Exciting current research has revealed, for example, family members in slime molds and insects, both positive and negative regulation of gene expression, cross-responses to pathways that use serine phosphorylation, and that Stat3 is an oncogene and Stat1 a tumor suppressor. Future issues: determine more protein structures, mechanisms and significance of serine phosphorylation, details of pivotal protein-protein interactions, basis of ligand-specific signals. Meeting goals: to cross-fertilize a very large range of research projects in an exciting and rapidly evolving field. Discounted Abstract Deadline: October 1 2001 Discounted Registration Deadline: November 13 2001 We gratefully acknowledge the generous grant for this conference provided by: National Cancer Institute (NCI) Grant No. 1 R13 CA30714-01 We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising: Click here to view more of these organizations Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds: Click here to view more of these organizations

Web Desc

JAKs and STATs: Activation and Biologic Impact

Organizer(s): George R. Stark, Ian M. Kerr and James E. Darnell, Jr.

Date: January 13 - 18, 2002
Location: Snowbird Resort, Snowbird, UT, USA

Sponsored in part by The Director's Sponsor Fund

For important information on the coronavirus, please click here

Summary of Meeting:

The JAK tyrosine kinases and STAT transcription factors are now appreciated to be essential for the function of many pathways that regulate gene expression and biological function. Exciting current research has revealed, for example, family members in slime molds and insects, both positive and negative regulation of gene expression, cross-responses to pathways that use serine phosphorylation, and that Stat3 is an oncogene and Stat1 a tumor suppressor. Future issues: determine more protein structures, mechanisms and significance of serine phosphorylation, details of pivotal protein-protein interactions, basis of ligand-specific signals. Meeting goals: to cross-fertilize a very large range of research projects in an exciting and rapidly evolving field.

Discounted Abstract Deadline: October 1 2001

Discounted Registration Deadline: November 13 2001

We gratefully acknowledge the generous grant for this conference provided by:

National Cancer Institute (NCI)
Grant No. 1 R13 CA30714-01

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program


Sunday, January 13 \| 4:00PM - 7:00PM Registration Room: Ballroom Lobby
Sunday, January 13 \| 6:15PM - 7:15PM Welcome Room: Ballroom Lobby
Sunday, January 13 \| 7:15PM - 7:30PM Orientation Room: Ballroom 3
Sunday, January 13 \| 7:30PM - 8:30PM Keynote Address Room: Ballroom 3 Speaker 1 of 1 C. David Allis, Rockefeller University, USA The Histone Modification Circus: Balancing Acts Fundamental to Human Biology and Disease
Monday, January 14 \| 7:00AM - 8:00AM Breakfast Room: Golden Cliff
Monday, January 14 \| 8:00AM - 12:00PM Receptor/JAK Complexes, Receptor Cross-Talk, Modular Signali ng/STATs Room: Ballroom 3 Speaker 1 of 6 * Ian M. Kerr, Cancer Research UK, UK JAK/STAT Signaling
Monday, January 14 \| 8:00AM - 12:00PM Receptor/JAK Complexes, Receptor Cross-Talk, Modular Signali ng/STATs Room: Ballroom 3 Speaker 2 of 6 Pipsa I. Saharinen, Haartman Institute, University of Helsinki, Finland Short Talk: The Pseudokinase Domain in the Regulation of JAK2 and JAK3 Tyrosine Kinases
Monday, January 14 \| 8:00AM - 12:00PM Receptor/JAK Complexes, Receptor Cross-Talk, Modular Signali ng/STATs Room: Ballroom 3 Speaker 3 of 6 K. Christopher Garcia, Stanford University School of Medicine, USA Short Talk: The Interaction between gp130 and Viral Interleukin-6: A Paradigm for the Architecture of gp130-Cytokine Signaling Assemblies
Monday, January 14 \| 8:00AM - 12:00PM Receptor/JAK Complexes, Receptor Cross-Talk, Modular Signali ng/STATs Room: Ballroom 3 Speaker 4 of 6 Nicholas K. Tonks, Cold Spring Harbor Laboratory, USA
Monday, January 14 \| 8:00AM - 12:00PM Receptor/JAK Complexes, Receptor Cross-Talk, Modular Signali ng/STATs Room: Ballroom 3 Speaker 5 of 6 Tadatsugu Taniguchi, University of Tokyo, Japan STATs and IRFs in the Regulation of Immunity and Bone Remodeling
Monday, January 14 \| 8:00AM - 12:00PM Receptor/JAK Complexes, Receptor Cross-Talk, Modular Signali ng/STATs Room: Ballroom 3 Speaker 6 of 6 Stephen Brown, University of Cambridge, UK Short Talk: Characterisation of Domeless, the Drosophila JAK/STAT Receptor
Monday, January 14 \| 9:20AM - 9:40AM Coffee Break Room: Ballroom Lobby
Monday, January 14 \| 12:00PM - 1:00PM Poster Setup Room: Ballroom 2
Monday, January 14 \| 1:00PM - 9:30PM Poster Viewing Room: Ballroom 2
Monday, January 14 \| 2:00PM - 4:00PM Workshop 1 Room: Ballroom 3 Speaker 1 of 6 Athanasia D. Panopoulos, University of Texas MD Anderson Cancer Center, USA Cytokine-Inducible Expression of the Myeloid-Specific Integrin alphaMbeta2 (CD11b/CD18) is Regulated by STAT3-Dependent Activation of PU.1
Monday, January 14 \| 2:00PM - 4:00PM Workshop 1 Room: Ballroom 3 Speaker 2 of 6 * Nancy C. Reich, Stony Brook University, USA Regulated Cellular Localization of STATs and Influence of Small GTPases
Monday, January 14 \| 2:00PM - 4:00PM Workshop 1 Room: Ballroom 3 Speaker 3 of 6 Pravin B. Sehgal, New York Medical College, USA STATs in Membrane Rafts
Monday, January 14 \| 2:00PM - 4:00PM Workshop 1 Room: Ballroom 3 Speaker 4 of 6 Erika A. Bach, New York University School of Medicine, USA A Genetic Screen to Identify New Components of the Drosophila JAK-STAT Pathway
Monday, January 14 \| 2:00PM - 4:00PM Workshop 1 Room: Ballroom 3 Speaker 5 of 6 Antonis E. Koromilas, Lady Davis Institute, McGill University, Canada The Interferon-Inducible Protein Kinase PKR is a Mediator of JAK-STAT Activation and Translational Control
Monday, January 14 \| 2:00PM - 4:00PM Workshop 1 Room: Ballroom 3 Speaker 6 of 6 Joe F. Lau, Mount Sinai School of Medicine, USA A Hybrid IRF9-STAT2 Transcription Factor Recapitulates Gene Expression and Biological Responses
Monday, January 14 \| 4:00PM - 4:30PM Coffee & Snacks Available Room: Ballroom Lobby
Monday, January 14 \| 4:30PM - 6:30PM Transcription Mechanisms 1 Room: Ballroom 3 Speaker 1 of 5 * James E. Darnell, Rockefeller University, USA Transcriptional Activation by STATs and Biologic Impact
Monday, January 14 \| 4:30PM - 6:30PM Transcription Mechanisms 1 Room: Ballroom 3 Speaker 2 of 5 Joo-Yeon Yoo, Postech, South Korea Short Talk: Specific Ablation of STAT3beta Distorts the Pattern of STAT3-Responsive Gene Expression and Impairs Recovery from Endotoxic Shock
Monday, January 14 \| 4:30PM - 6:30PM Transcription Mechanisms 1 Room: Ballroom 3 Speaker 3 of 5 J. Jillian Zhang, Cornell Medical School, USA Short Talk: Analysis of Trancription Co-Activators of STAT1 in IFN-gamma Signaling
Monday, January 14 \| 4:30PM - 6:30PM Transcription Mechanisms 1 Room: Ballroom 3 Speaker 4 of 5 Jan H. Tavernier, Ghent University, Belgium Short Talk: Design and Application of a Cytokine Receptor-Based Interaction Trap
Monday, January 14 \| 4:30PM - 6:30PM Transcription Mechanisms 1 Room: Ballroom 3 Speaker 5 of 5 Carmen Herrero, Hospital for Special Surgery, USA Short Talk: Modulation of IL-10 Activity and Signaling during Macrophage Activation
Monday, January 14 \| 6:30PM - 7:30PM Welcome Mixer Room: Ballroom Lobby
Monday, January 14 \| 7:30PM - 9:30PM Poster Session 1 Room: Ballroom 2
Monday, January 14 \| 7:30PM - 8:30PM Cash Bar Room: Ballroom Lobby
Tuesday, January 15 \| 7:00AM - 8:00AM Breakfast Room: Golden Cliff
Tuesday, January 15 \| 8:00AM - 12:00PM Negative Regulation Room: Ballroom 3 Speaker 1 of 7 * Douglas J. Hilton, Walter and Eliza Hall Institute of Medical Research, Australia SOCS Proteins - Negative Regulations of Cytokine Signal Transduction
Tuesday, January 15 \| 8:00AM - 12:00PM Negative Regulation Room: Ballroom 3 Speaker 2 of 7 Ann L. Cornish, University of Melbourne, Australia Short Talk: SOCS-1 is Important in the Negative Regulation of T Cell Activation
Tuesday, January 15 \| 8:00AM - 12:00PM Negative Regulation Room: Ballroom 3 Speaker 3 of 7 Alexander H. Dalpke, University Heidelberg, Germany Short Talk: Toll-Like Receptor-Dependent Microbial Stimuli Modulate Cytokine Responses in Antigen Presenting Cells by Inducing Suppressors of Cytokine Signaling
Tuesday, January 15 \| 8:00AM - 12:00PM Negative Regulation Room: Ballroom 3 Speaker 4 of 7 Thomas A.F. Decker, Vienna Biocenter, University of Vienna, Austria Short Talk: The STAT1 Binding Motif of the IFN-gamma Receptor is Sufficient to Mediate STAT5 Activation and Its Repression by SOCS3
Tuesday, January 15 \| 8:00AM - 12:00PM Negative Regulation Room: Ballroom 3 Speaker 5 of 7 Christin Carter-Su, University of Michigan Medical School, USA Regulation of JAK Activity and Cytokine Signaling by Members of the SH2-B Family of Adapter Proteins
Tuesday, January 15 \| 8:00AM - 12:00PM Negative Regulation Room: Ballroom 3 Speaker 6 of 7 Ke Shuai, University of California, Los Angeles, USA Inactivation of STAT Signaling in the Nucleus
Tuesday, January 15 \| 8:00AM - 12:00PM Negative Regulation Room: Ballroom 3 Speaker 7 of 7 Yi Eve Sun, University of California, Los Angeles, USA Short Talk: Neurogenin1 Inhibits the JAK-STAT Pathway Via Multiple Routes
Tuesday, January 15 \| 9:20AM - 9:40AM Coffee Break Room: Ballroom Lobby
Tuesday, January 15 \| 12:00PM - 1:00PM Poster Setup Room: Ballroom 2
Tuesday, January 15 \| 1:00PM - 9:30PM Poster Viewing Room: Ballroom 2
Tuesday, January 15 \| 4:00PM - 4:30PM Coffee & Snacks Available Room: Ballroom Lobby
Tuesday, January 15 \| 4:30PM - 6:30PM Transcription Mechanisms 2 Room: Ballroom 3 Speaker 1 of 5 * Christin Carter-Su, University of Michigan Medical School, USA
Tuesday, January 15 \| 4:30PM - 6:30PM Transcription Mechanisms 2 Room: Ballroom 3 Speaker 2 of 5 Peter C. Heinrich, Universitätsklinikum Aachen, Germany Modulation of IL-6-Type Cytokine Signaling
Tuesday, January 15 \| 4:30PM - 6:30PM Transcription Mechanisms 2 Room: Ballroom 3 Speaker 3 of 5 Heather A. Bruns, Indiana University School of Medicine, USA Short Talk: A Constitutively Active STAT6 is not Sufficient to Alter B Cell Gene Expression and Function in the Absence of IL-4
Tuesday, January 15 \| 4:30PM - 6:30PM Transcription Mechanisms 2 Room: Ballroom 3 Speaker 4 of 5 Edith B. Pfitzner, Institute for Biomedical Research, Germany Short Talk: Transciptional Activation by STAT6 Requires the Direct Interaction with NCoA-1
Tuesday, January 15 \| 4:30PM - 6:30PM Transcription Mechanisms 2 Room: Ballroom 3 Speaker 5 of 5 Curt M. Horvath, Northwestern University, USA Analysis of STAT Transcription Mechanisms
Tuesday, January 15 \| 6:30PM - 7:30PM Welcome Mixer Room: Ballroom Lobby
Tuesday, January 15 \| 7:30PM - 9:30PM Poster Session 2 Room: Ballroom 2
Tuesday, January 15 \| 7:30PM - 8:30PM Cash Bar Room: Ballroom Lobby
Wednesday, January 16 \| 7:00AM - 8:00AM Breakfast Room: Golden Cliff
Wednesday, January 16 \| 8:00AM - 12:00PM Oncogenesis, Immune Regulation, Tissue-Specific Effects 1 Room: Ballroom 3 Speaker 1 of 5 John J. O'Shea, NIAMS, National Institutes of Health, USA Cytokine Signaling and Lymphoid Development, Differentiation and Immunoregulation
Wednesday, January 16 \| 8:00AM - 12:00PM Oncogenesis, Immune Regulation, Tissue-Specific Effects 1 Room: Ballroom 3 Speaker 2 of 5 Kenneth M. Murphy, HHMI/Washington University School of Medicine, USA Mechanisms of STAT4 in Th1 Development
Wednesday, January 16 \| 8:00AM - 12:00PM Oncogenesis, Immune Regulation, Tissue-Specific Effects 1 Room: Ballroom 3 Speaker 3 of 5 * Robert D. Schreiber, Washington University School of Medicine, USA STAT1 and Lymphocytes: Tumor Suppression and Tumor Editing
Wednesday, January 16 \| 8:00AM - 12:00PM Oncogenesis, Immune Regulation, Tissue-Specific Effects 1 Room: Ballroom 3 Speaker 4 of 5 David E. Levy, New York University School of Medicine, USA STAT Transcriptional Mechanisms in Host Defense and Cancer
Wednesday, January 16 \| 8:00AM - 12:00PM Oncogenesis, Immune Regulation, Tissue-Specific Effects 1 Room: Ballroom 3 Speaker 5 of 5 George R. Stark, Case Western Reserve University, USA Stat1-Independent Responses to IFNgamma and Stat 1,3-Dependent Transcription Without Tyrosine Phosphorylation
Wednesday, January 16 \| 9:20AM - 9:40AM Coffee Break Room: Ballroom Lobby
Wednesday, January 16 \| 1:00PM - 9:30PM Poster Viewing Room: Ballroom 2
Wednesday, January 16 \| 2:00PM - 4:00PM Workshop 2 Room: Ballroom 3 Speaker 1 of 8 * Peter C. Heinrich, Universitätsklinikum Aachen, Germany
Wednesday, January 16 \| 2:00PM - 4:00PM Workshop 2 Room: Ballroom 3 Speaker 2 of 8 Markus H. Heim, University Hospital Basel, Switzerland Inhibition of Interferon Alpha Signaling Through the JAK-STAT Pathway in HVC Transgenic Mice
Wednesday, January 16 \| 2:00PM - 4:00PM Workshop 2 Room: Ballroom 3 Speaker 3 of 8 Simone Radtke, Medical School RWTH Aachen, Germany Short Talk: Novel Role of Janus Kinase 1 in the Regulation of Oncostatin M Receptor Surface Expression
Wednesday, January 16 \| 2:00PM - 4:00PM Workshop 2 Room: Ballroom 3 Speaker 4 of 8 Lily Huang, University of Texas Southwestern Medical Center at Dallas, USA Short Talk: The N-Terminal Domain of Janus Kinase 2 is Required for Golgi Processing and Cell Surface Expression of Erythropoietin Receptor
Wednesday, January 16 \| 2:00PM - 4:00PM Workshop 2 Room: Ballroom 3 Speaker 5 of 8 Jennifer Rubin Grandis, University of Pittsburgh Eye & Ear Institute, USA STATs in Head and Neck Cancer
Wednesday, January 16 \| 2:00PM - 4:00PM Workshop 2 Room: Ballroom 3 Speaker 6 of 8 June H. Lee, University of California, San Francisco, USA IL-13 and IL-4 Induce Differential Gene Expression in Bronchial Smooth Muscle Cells and Lung Fibroblasts
Wednesday, January 16 \| 2:00PM - 4:00PM Workshop 2 Room: Ballroom 3 Speaker 7 of 8 Thomas Kay, St. Vincent's Institute of Medical Research, Australia Hypersensitivity to TNF-alpha-Induced Cell Death in Pancreatic beta Cells with SOCS-1 Deficiency
Wednesday, January 16 \| 2:00PM - 4:00PM Workshop 2 Room: Ballroom 3 Speaker 8 of 8 Bao Q. Vuong, City College of New York, CUNY, USA Pim Serine/Theronine Kinases Regulate the Stability of SOCS-1 Protein
Wednesday, January 16 \| 4:00PM - 4:30PM Coffee & Snacks Available Room: Ballroom Lobby
Wednesday, January 16 \| 4:30PM - 6:30PM Oncogenesis, Immune Regulation, Tissue-Specific Effects 2 Room: Ballroom 3 Speaker 1 of 4 * George R. Stark, Case Western Reserve University, USA
Wednesday, January 16 \| 4:30PM - 6:30PM Oncogenesis, Immune Regulation, Tissue-Specific Effects 2 Room: Ballroom 3 Speaker 2 of 4 Merav Socolovsky, University of Massachusetts Medical School, USA The Roles of EpoR and STAT5 in Red Cell Formation
Wednesday, January 16 \| 4:30PM - 6:30PM Oncogenesis, Immune Regulation, Tissue-Specific Effects 2 Room: Ballroom 3 Speaker 3 of 4 James N. Ihle, St. Jude Children's Research Hospital, USA JAKs and STATs in Cytokine Signaling
Wednesday, January 16 \| 4:30PM - 6:30PM Oncogenesis, Immune Regulation, Tissue-Specific Effects 2 Room: Ballroom 3 Speaker 4 of 4 M. A.Q. Siddiqui, Downstate Medical Center, State University of New York, USA JAK/STAT Signaling Mediates Myocardial Dysfunction during Hypertrophy and Ischemia
Wednesday, January 16 \| 6:30PM - 7:30PM Welcome Mixer Room: Ballroom Lobby
Wednesday, January 16 \| 7:30PM - 9:30PM Poster Sessions 1 & 2 Room: Ballroom 2
Wednesday, January 16 \| 7:30PM - 8:30PM Cash Bar Room: Ballroom Lobby
Thursday, January 17 \| 7:00AM - 8:00AM Breakfast Room: Golden Cliff
Thursday, January 17 \| 8:00AM - 12:00PM Growth Regulation, Constitutive Gene Expression, Alternate P athways, Apoptosis Room: Ballroom 3 Speaker 1 of 9 * David E. Levy, New York University School of Medicine, USA
Thursday, January 17 \| 8:00AM - 12:00PM Growth Regulation, Constitutive Gene Expression, Alternate P athways, Apoptosis Room: Ballroom 3 Speaker 2 of 9 Norbert Perrimon, Harvard Medical School, USA Studies on the Drosophila JAK/STAT Pathway
Thursday, January 17 \| 8:00AM - 12:00PM Growth Regulation, Constitutive Gene Expression, Alternate P athways, Apoptosis Room: Ballroom 3 Speaker 3 of 9 Jacqueline F. Bromberg, Memorial Sloan Kettering Cancer Center, USA Short Talk: The Role of STAT3 in Breast Cancer Tumorigenesis
Thursday, January 17 \| 8:00AM - 12:00PM Growth Regulation, Constitutive Gene Expression, Alternate P athways, Apoptosis Room: Ballroom 3 Speaker 4 of 9 Keith Syson Chan, Stem Cells and Regenerative Medicine, USA Short Talk: Activation of STAT3 during Multistage Skin Tumorigenesis
Thursday, January 17 \| 8:00AM - 12:00PM Growth Regulation, Constitutive Gene Expression, Alternate P athways, Apoptosis Room: Ballroom 3 Speaker 5 of 9 Mariusz A. Wasik, University of Pennsylvania, USA Short Talk: Multilevel Dysregulation of STAT3 Activation in T-Cell Lymphomas Expressing Anaplastic Lymphoma Kinase (ALK)
Thursday, January 17 \| 8:00AM - 12:00PM Growth Regulation, Constitutive Gene Expression, Alternate P athways, Apoptosis Room: Ballroom 3 Speaker 6 of 9 James L. Watson, McMaster University, Canada Short Talk: (-)-Epigallocatechin Gallate (EGCG) Inhibits IFNgamma-Induced STAT1 Activation in Human T84 Epithelia: Implications for the Regulation of Intestinal Barrier Function
Thursday, January 17 \| 8:00AM - 12:00PM Growth Regulation, Constitutive Gene Expression, Alternate P athways, Apoptosis Room: Ballroom 3 Speaker 7 of 9 Leonidas C. Platanias, University of Illinois at Chicago, USA Role of Map Kinases in Interferon Signaling
Thursday, January 17 \| 8:00AM - 12:00PM Growth Regulation, Constitutive Gene Expression, Alternate P athways, Apoptosis Room: Ballroom 3 Speaker 8 of 9 Anna I. Dimberg, Uppsala University Hospital, Sweden Short Talk: Serine-727 Phosphorylated STAT1 is Required for ATRA-Induced G0/G1 Arrest of U-937 Cells and the Associated Regulation of Cyclins and p27Kip1
Thursday, January 17 \| 8:00AM - 12:00PM Growth Regulation, Constitutive Gene Expression, Alternate P athways, Apoptosis Room: Ballroom 3 Speaker 9 of 9 Tania C. Benatar, Sunnybrook Research Institute, Canada Short Talk: ES Cell Fate is Determined Through a Complex Balance of Intracellular Signaling Pathways
Thursday, January 17 \| 9:20AM - 9:40AM Coffee Break Room: Ballroom Lobby
Thursday, January 17 \| 4:00PM - 4:30PM Coffee & Snacks Available Room: Ballroom Lobby
Thursday, January 17 \| 4:30PM - 6:30PM Slime Molds to Zebrafish Room: Ballroom 3 Speaker 1 of 3 * Jeffrey G. Williams, University of Dundee, School of Biological Sciences, UK Regulation of the Nuclear Import and Export of Dictyostelium STAT Proteins: Pointers from Ancestral STATs?
Thursday, January 17 \| 4:30PM - 6:30PM Slime Molds to Zebrafish Room: Ballroom 3 Speaker 2 of 3 Leanne Jones, University of California, Los Angeles, USA Short Talk: Stem Cell Self-Renewal Specified by JAK-STAT Activation in Response to a Support Cell Cue
Thursday, January 17 \| 4:30PM - 6:30PM Slime Molds to Zebrafish Room: Ballroom 3 Speaker 3 of 3 Toshio Hirano, Osaka University Graduate School of Medicine, Japan Roles of JAK/STAT Signaling in Gastrulation
Thursday, January 17 \| 6:30PM - 7:30PM Welcome Mixer Room: Ballroom 2/Lobby
Thursday, January 17 \| 7:30PM - 10:30PM Entertainment Room: Ballroom 2
Thursday, January 17 \| 7:30PM - 10:30PM Cash Bar Room: Ballroom 2
Friday, January 18 \| 10:21AM - 10:21AM Departure *Session Chair †Invited, not yet responded.