Web Desc
Strategies for the Identification and Development of Novel Antimicrobial Agents
Organizer(s): Steven J. Projan, Karen Bush and Richard J. Whitley
Date: January 31 - February 05, 2002
Location: Hilton Santa Fe Historic Plaza Hotel, Santa Fe, NM, USA
Sponsored by GlaxoSmithKline
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Summary of Meeting:
In many ways we are entering the golden age of anti-infective research. Many of the major pathogenic bacteria have been completely sequenced and complete sequence information is also available for most all clinically important viruses and some pathogenic fungi. While the roles of many bacterial and viral genes have yet to be elucidated, a variety of methods including proteomics, transcriptional profiling, in vivo expression technology and tightly regulable, in vivo gene expression are giving us new insights into the physiology of infections at the level of both the pathogen and the host. As multitudes of potential targets have emerged from these and other studies, an increasing array of methods for finding substances that interact with these novel (and not so novel) targets have also been developed and are being improved upon daily. These technologies are making increasingly effective uses of automated approaches to screening and chemical syntheses, structural biology approaches to rational drug design and ever-sophisticated animal models of human disease. Perhaps our greatest difficulty is being able to effectively utilize the vast amount of biological data being generated in the drug discovery process. The goal of this conference will be to interface our new understanding of molecular pathogenesis with our enhanced ability to define targets and screen for novel molecules that interact with those targets. While there are many levels at which one can affect the course of infection from prevention through therapy, this conference will focus on developing treatments for infected patients. However we will also try and focus not only on direct interference with bacterial or viral replication but also on strategies to boost host defenses as a means of therapy, clearly an under-appreciated subject. Tempering this enthusiasm is the understanding that resistance to anti-infective agents is the direct consequence of their use, but our ever improving understanding of both pathogenesis and resistance may allow for counter-strategies to prevent or at least ameliorate, the acquisition and spread of resistant pathogens. While it is becoming increasingly uncommon to combine anti-viral and anti-bacterial drug discovery symposia, the fact is that the rapid development of resistance to both antibacterial and antiviral agents, the molecular nature of the targets, and the approaches to find molecules that interact with them are actually converging. This meeting will provide an excellent opportunity for cross-fertilization.
Discounted Abstract Deadline: October 8 2001
Discounted Registration Deadline: November 30 2001
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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

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Program

Thursday, January 31 | 4:00PM - 7:00PM
Registration
Room: Promenade


Thursday, January 31 | 6:15PM - 7:15PM
Welcome
Room: Promenade


Thursday, January 31 | 7:15PM - 7:30PM
Orientation
Room: Mesa Ballroom A-B


Thursday, January 31 | 7:30PM - 8:30PM
Keynote Address
Room: Mesa Ballroom A-B

Speaker 1 of 2
* Richard J. Whitley, Children's Hospital, USA

Thursday, January 31 | 7:30PM - 8:30PM
Keynote Address
Room: Mesa Ballroom A-B

Speaker 2 of 2
Barbara E. Murray, University of Texas-Houston Medical School, USA
New Anti-Infective Drugs - What Do We Need and When are We Going to Need Them?

Friday, February 01 | 7:00AM - 8:00AM
Breakfast
Room: Chamisa


Friday, February 01 | 8:00AM - 11:00AM
Platform Technologies - Give Us a Robot, a Place to Stand, a
nd We Can Screen a World of Compounds, but Will We Find Anything? Session Sponsored by Infection Discovery - AstraZeneca R&D, Boston.

Room: Mesa Ballroom A-B

Speaker 1 of 5
* Karen Bush, Indiana University, USA

Friday, February 01 | 8:00AM - 11:00AM
Platform Technologies - Give Us a Robot, a Place to Stand, a
nd We Can Screen a World of Compounds, but Will We Find Anything? Session Sponsored by Infection Discovery - AstraZeneca R&D, Boston.

Room: Mesa Ballroom A-B

Speaker 2 of 5
Chaitan Khosla, Stanford University, USA
Challenges and Opportunities in Developing Natural Product Antimicrobial Agents

Friday, February 01 | 8:00AM - 11:00AM
Platform Technologies - Give Us a Robot, a Place to Stand, a
nd We Can Screen a World of Compounds, but Will We Find Anything? Session Sponsored by Infection Discovery - AstraZeneca R&D, Boston.

Room: Mesa Ballroom A-B

Speaker 3 of 5
Richard J. White, Versicor Inc., USA
Using Combinatorial Chemistry to Find New Drugs, New Targets or Pump Life into Old Ones

Friday, February 01 | 8:00AM - 11:00AM
Platform Technologies - Give Us a Robot, a Place to Stand, a
nd We Can Screen a World of Compounds, but Will We Find Anything? Session Sponsored by Infection Discovery - AstraZeneca R&D, Boston.

Room: Mesa Ballroom A-B

Speaker 4 of 5
Manuel A. Navia, eXlthera Pharmaceuticals, USA
The First Wave of Drugs from Structure-Based Drug Design

Friday, February 01 | 8:00AM - 11:00AM
Platform Technologies - Give Us a Robot, a Place to Stand, a
nd We Can Screen a World of Compounds, but Will We Find Anything? Session Sponsored by Infection Discovery - AstraZeneca R&D, Boston.

Room: Mesa Ballroom A-B

Speaker 5 of 5
David Knowles, RiboTargets, UK
Virtual Screening, Better than the Real Thing? Lessons from the Bacterial Ribosome

Friday, February 01 | 9:20AM - 9:40AM
Coffee Break
Room: Promenade


Friday, February 01 | 11:00AM - 1:00PM
Poster Setup
Room: Mesa Ballroom C


Friday, February 01 | 1:00PM - 10:00PM
Poster Viewing
Room: Mesa Ballroom C


Friday, February 01 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Promenade


Friday, February 01 | 5:00PM - 7:00PM
Genomics & Bioinformatics: A Promise Fulfilled or an Expensi
ve Hobby?

Room: Mesa Ballroom A-B

Speaker 1 of 4
* Steven J. Projan, MedImmune, USA

Friday, February 01 | 5:00PM - 7:00PM
Genomics & Bioinformatics: A Promise Fulfilled or an Expensi
ve Hobby?

Room: Mesa Ballroom A-B

Speaker 2 of 4
George M. Weinstock, The Jackson Laboratory, USA
Microbial Genomics: Fact and Fancy

Friday, February 01 | 5:00PM - 7:00PM
Genomics & Bioinformatics: A Promise Fulfilled or an Expensi
ve Hobby?

Room: Mesa Ballroom A-B

Speaker 3 of 4
Karen Joy Shaw, Johnson & Johnson Pharmaceutical Research & Development, LLC, USA
Antibacterial Drug Discovery and DNA Microarrays

Friday, February 01 | 5:00PM - 7:00PM
Genomics & Bioinformatics: A Promise Fulfilled or an Expensi
ve Hobby?

Room: Mesa Ballroom A-B

Speaker 4 of 4
Klaus Früh, Oregon Health & Science University, USA
Uncovering Novel Targets for Antiviral Therapy by Functional Genomics

Friday, February 01 | 7:00PM - 8:00PM
Welcome Mixer
Room: Promenade


Friday, February 01 | 8:00PM - 10:00PM
Poster Session 1
Room: Mesa Ballroom C


Friday, February 01 | 8:00PM - 9:00PM
Cash Bar
Room: Promenade


Saturday, February 02 | 7:00AM - 8:00AM
Breakfast
Room: Chamisa


Saturday, February 02 | 8:00AM - 11:00AM
Novel and Not So Novel Targets - Can't Anybody Here Shoot St
raight?

Room: Mesa Ballroom A-B

Speaker 1 of 5
* Karen Bush, Indiana University, USA

Saturday, February 02 | 8:00AM - 11:00AM
Novel and Not So Novel Targets - Can't Anybody Here Shoot St
raight?

Room: Mesa Ballroom A-B

Speaker 2 of 5
Jeffrey W. Jacobs, Ardelyx, USA
Targeting Protein-Protein Interactions - A Fragment Assembly Approach

Saturday, February 02 | 8:00AM - 11:00AM
Novel and Not So Novel Targets - Can't Anybody Here Shoot St
raight?

Room: Mesa Ballroom A-B

Speaker 3 of 5
Scott Hultgren, Washington University School of Medicine, USA
Pilicides

Saturday, February 02 | 8:00AM - 11:00AM
Novel and Not So Novel Targets - Can't Anybody Here Shoot St
raight?

Room: Mesa Ballroom A-B

Speaker 4 of 5
Clayton C. Huntley, National Institutes of Health, USA
In Vitro Analysis of Resistance to RFI-641, a Novel RSV Fusion Inhibitor

Saturday, February 02 | 8:00AM - 11:00AM
Novel and Not So Novel Targets - Can't Anybody Here Shoot St
raight?

Room: Mesa Ballroom A-B

Speaker 5 of 5
Philip J. Youngman, Elitra Pharmaceuticals, USA
Novel Targets vs. Novel Ways to Exploit Well-Validated Target Pathways

Saturday, February 02 | 9:20AM - 9:40AM
Coffee Break
Room: Promenade


Saturday, February 02 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Promenade


Saturday, February 02 | 5:00PM - 7:00PM
Taking on Resistance: A Losing Battle or a Winning Strategem
?

Room: Mesa Ballroom A-B

Speaker 1 of 4
* Richard J. Whitley, Children's Hospital, USA

Saturday, February 02 | 5:00PM - 7:00PM
Taking on Resistance: A Losing Battle or a Winning Strategem
?

Room: Mesa Ballroom A-B

Speaker 2 of 4
Karen Bush, Indiana University, USA
Beta-Lactamase Inhibitors: The Bacteria Strike Back. How Should We Respond?

Saturday, February 02 | 5:00PM - 7:00PM
Taking on Resistance: A Losing Battle or a Winning Strategem
?

Room: Mesa Ballroom A-B

Speaker 3 of 4
Olga Lomovskaya, Medicine Company, USA
So Many Pumps, So Few Drugs

Saturday, February 02 | 5:00PM - 7:00PM
Taking on Resistance: A Losing Battle or a Winning Strategem
?

Room: Mesa Ballroom A-B

Speaker 4 of 4
David C. Hooper, Massachusetts General Hospital, USA
Are Drug-Resistant Organisms Less Virulent?

Saturday, February 02 | 7:00PM - 8:00PM
Welcome Mixer
Room: Promenade


Sunday, February 03 | 7:00AM - 8:00AM
Breakfast
Room: Chamisa


Sunday, February 03 | 8:00AM - 11:00AM
Antiviral Chemotherapeutics - The Good, the Bad and the Ugly
. Session Sponsored by Eli Lilly and Company, Lilly Research Laboratories.

Room: Mesa Ballroom A-B

Speaker 1 of 5
* Richard J. Whitley, Children's Hospital, USA

Sunday, February 03 | 8:00AM - 11:00AM
Antiviral Chemotherapeutics - The Good, the Bad and the Ugly
. Session Sponsored by Eli Lilly and Company, Lilly Research Laboratories.

Room: Mesa Ballroom A-B

Speaker 2 of 5
Bernard Roizman, University of Chicago, USA
Novel Targets for Anti Herpes Simplex Virus Therapy

Sunday, February 03 | 8:00AM - 11:00AM
Antiviral Chemotherapeutics - The Good, the Bad and the Ugly
. Session Sponsored by Eli Lilly and Company, Lilly Research Laboratories.

Room: Mesa Ballroom A-B

Speaker 3 of 5
Marc S. Collett, Viropharma, Inc., USA
Do We Need a Rhinovirus Inhibitor? Is There Such a Thing? If So, Does it Work?

Sunday, February 03 | 8:00AM - 11:00AM
Antiviral Chemotherapeutics - The Good, the Bad and the Ugly
. Session Sponsored by Eli Lilly and Company, Lilly Research Laboratories.

Room: Mesa Ballroom A-B

Speaker 4 of 5
Charles M. Rice, Rockefeller University, USA
Hepatitis C - How can a Virus that Replicates so Poorly Make so Many People Sick?

Sunday, February 03 | 8:00AM - 11:00AM
Antiviral Chemotherapeutics - The Good, the Bad and the Ugly
. Session Sponsored by Eli Lilly and Company, Lilly Research Laboratories.

Room: Mesa Ballroom A-B

Speaker 5 of 5
Richard P. Novick, New York University, USA
Targeting the Regulation of Staphylococcal Virulence. Can this Work for Other Organisms?

Sunday, February 03 | 9:20AM - 9:40AM
Coffee Break
Room: Promenade


Sunday, February 03 | 11:00AM - 1:00PM
Poster Setup
Room: Mesa Ballroom C


Sunday, February 03 | 1:00PM - 10:00PM
Poster Viewing
Room: Mesa Ballroom C


Sunday, February 03 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Promenade


Sunday, February 03 | 5:00PM - 7:00PM
Virulence, Regulation and the Molecular Physiology of Infect
ion: Is There Hope Amid the Hype?

Room: Mesa Ballroom A-B

Speaker 1 of 4
* Steven J. Projan, MedImmune, USA

Sunday, February 03 | 5:00PM - 7:00PM
Virulence, Regulation and the Molecular Physiology of Infect
ion: Is There Hope Amid the Hype?

Room: Mesa Ballroom A-B

Speaker 2 of 4
Peter M. Palese, Icahn School of Medicine at Mount Sinai, USA
Toward a Better Understanding of the Intracellular Trafficking of Influenza Virus Components: Novel Antiviral Targets?

Sunday, February 03 | 5:00PM - 7:00PM
Virulence, Regulation and the Molecular Physiology of Infect
ion: Is There Hope Amid the Hype?

Room: Mesa Ballroom A-B

Speaker 3 of 4
James A. Hoch, The Scripps Research Institute, USA
Virulence- and Antibiotic Resistance-Associated Two-Component Signal Transduction Systems as Targets for Antimicrobial Therapy

Sunday, February 03 | 5:00PM - 7:00PM
Virulence, Regulation and the Molecular Physiology of Infect
ion: Is There Hope Amid the Hype?

Room: Mesa Ballroom A-B

Speaker 4 of 4
Thomas E. Shenk, Princeton University, USA
Human Cytomegalovirus Blocks the Induction of a Set of Cellular Anti-Viral Genes

Sunday, February 03 | 7:00PM - 8:00PM
Welcome Mixer
Room: Promenade


Sunday, February 03 | 8:00PM - 10:00PM
Poster Session 2
Room: Mesa Ballroom C


Sunday, February 03 | 8:00PM - 9:00PM
Cash Bar
Room: Promenade


Monday, February 04 | 7:00AM - 8:00AM
Breakfast
Room: Chamisa


Monday, February 04 | 8:00AM - 11:00AM
Lessons from Immunology?
Room: Mesa Ballroom A-B

Speaker 1 of 5
* Steven J. Projan, MedImmune, USA

Monday, February 04 | 8:00AM - 11:00AM
Lessons from Immunology?
Room: Mesa Ballroom A-B

Speaker 2 of 5
Arturo Casadevall, Albert Einstein College of Medicine, USA
New Insights into Antibody-Structure Function

Monday, February 04 | 8:00AM - 11:00AM
Lessons from Immunology?
Room: Mesa Ballroom A-B

Speaker 3 of 5
Ferric C. Fang, University of Washington School of Medicine, USA
Can We Treat Infectious Diseases by Modulating Host Defenses?

Monday, February 04 | 8:00AM - 11:00AM
Lessons from Immunology?
Room: Mesa Ballroom A-B

Speaker 4 of 5
Michael R. Yeaman, University of California, Los Angeles, USA
Code Among Chaos: Lessons from Host Defense Proteins

Monday, February 04 | 8:00AM - 11:00AM
Lessons from Immunology?
Room: Mesa Ballroom A-B

Speaker 5 of 5
Zimra R. Israel, Wyeth Pharmaceuticals, USA
Immunotherapeutic Vaccines for HIV

Monday, February 04 | 9:20AM - 9:40AM
Coffee Break
Room: Promenade


Monday, February 04 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Promenade


Monday, February 04 | 5:00PM - 7:00PM
General Strategies/Specific Solutions
Room: Mesa Ballroom A-B

Speaker 1 of 4
* Karen Bush, Indiana University, USA

Monday, February 04 | 5:00PM - 7:00PM
General Strategies/Specific Solutions
Room: Mesa Ballroom A-B

Speaker 2 of 4
Trevor J. Trust, AstraZeneca R&D Boston, USA
Broad Spectrum vs. Pathogen Specific Antimicrobials - The Case for Helicobacter pylori Inhibitors

Monday, February 04 | 5:00PM - 7:00PM
General Strategies/Specific Solutions
Room: Mesa Ballroom A-B

Speaker 3 of 4
Lynn L. Silver, LL Silver Consulting, USA
Choose Your Weapons: Pathway Screening vs. Identification of Single Enzyme Inhibitors

Monday, February 04 | 5:00PM - 7:00PM
General Strategies/Specific Solutions
Room: Mesa Ballroom A-B

Speaker 4 of 4
Jianshi Tao, Novartis, USA
Blocking Target Function with Inducibly Expressed Peptides: Application to Antibacterial Drug Discovery

Monday, February 04 | 7:00PM - 8:00PM
Welcome Mixer
Room: Promenade/Mesa C


Monday, February 04 | 8:00PM - 11:00PM
Entertainment
Room: Mesa C


Monday, February 04 | 8:00PM - 11:00PM
Cash Bar
Room: Promenade/Mesa C


Tuesday, February 05 | 10:21AM - 10:21AM
Departure


*Session Chair
†Invited, not yet responded.