Web Desc
Rethinking the Pathogenesis of Asthma
Organizer(s): Daniel Rotrosen, Jeffrey M. Drazen and Stephen T. Holgate
Date: February 08 - 13, 2002
Location: Hilton Santa Fe Historic Plaza Hotel, Santa Fe, NM, USA
Sponsored by Aventis Pharmaceuticals, Inc. and Inflazyme Pharmaceuticals, Ltd.
For important information on the coronavirus, please click here
Summary of Meeting:
Asthma is a major cause of illness and disability worldwide. During the past 2-3 decades, the prevalence of asthma and morbidity due to asthma have increased substantially. Since previous models of asthma pathogenesis cannot explain this trend, this conference will bring together basic and clinical scientists representing a wide range of scientific disciplines to reexamine the pathogenesis of asthma from the perspective of new insights into human immune system development and biology and an expanding awareness of the role of environmental factors. Examples include advances in gene discovery and receptor-mediated signaling, an appreciation of the importance of early life events in molding the allergic diathesis, and an understanding of the role of the innate immune system in the establishment and maintenance of airway inflammation and hyperreactivity. This conference will highlight current research and future directions in areas that hold promise for the development of new therapeutic agents and preventive approaches.
Discounted Abstract Deadline: October 8 2001
Discounted Registration Deadline: December 7 2001
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1 R13 AI50897-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Friday, February 08 | 4:00PM - 7:00PM
Registration
Room: Promenade


Friday, February 08 | 6:15PM - 7:15PM
Welcome
Room: Promenade


Friday, February 08 | 7:15PM - 7:30PM
Orientation
Room: Mesa A-B


Friday, February 08 | 7:30PM - 8:30PM
Keynote Address. Sponsored in part by OSI Pharmaceuticals,
Inc.
Room: Mesa A-B

Speaker 1 of 1
Andrew Saxon, University of California, Los Angeles, USA
Environment, the Immune System and Asthma

Saturday, February 09 | 7:00AM - 8:00AM
Breakfast
Room: Chamisa


Saturday, February 09 | 8:00AM - 11:00AM
Developmental Immunobiology and Immunologic Origins of Asthm
a

Room: Mesa A-B

Speaker 1 of 5
* Fernando D. Martinez, University of Arizona, USA

Saturday, February 09 | 8:00AM - 11:00AM
Developmental Immunobiology and Immunologic Origins of Asthm
a

Room: Mesa A-B

Speaker 2 of 5
Denis J. Reen, Our Lady's Hospital for Sick Children, Ireland
T-Cell Function at Birth in Humans

Saturday, February 09 | 8:00AM - 11:00AM
Developmental Immunobiology and Immunologic Origins of Asthm
a

Room: Mesa A-B

Speaker 3 of 5
Patrick G. Holt, University of Western Australia, Australia
Fetal and Neonatal Immunity in Asthma and Allergy

Saturday, February 09 | 8:00AM - 11:00AM
Developmental Immunobiology and Immunologic Origins of Asthm
a

Room: Mesa A-B

Speaker 4 of 5
Becky Adkins, University of Miami Medical School, USA
Development of Murine Neonatal Th1/Th2 Function


Saturday, February 09 | 8:00AM - 11:00AM
Developmental Immunobiology and Immunologic Origins of Asthm
a

Room: Mesa A-B

Speaker 5 of 5
Erika von Mutius, University Children's Hospital, Munich, Germany
The Hygiene Hypothesis

Saturday, February 09 | 9:20AM - 9:40AM
Coffee Break
Room: Promenade


Saturday, February 09 | 11:00AM - 1:00PM
Poster Setup
Room: Mesa C


Saturday, February 09 | 1:00PM - 10:00PM
Poster Viewing
Room: Mesa C


Saturday, February 09 | 2:30PM - 4:30PM
Workshop 1
Room: Mesa A-B

Speaker 1 of 9
* K. Frank Austen, Harvard Medical School, USA

Saturday, February 09 | 2:30PM - 4:30PM
Workshop 1
Room: Mesa A-B

Speaker 2 of 9
Talal A. Chatila, University of California, Los Angeles, USA
Function of the I4R Motif in IL-4Ra Signaling

Saturday, February 09 | 2:30PM - 4:30PM
Workshop 1
Room: Mesa A-B

Speaker 3 of 9
Udo Herz, Philipps-Universität, Germany
Influence of Maternal Allergic Sensitization on the Development of Atopy in the Offspring

Saturday, February 09 | 2:30PM - 4:30PM
Workshop 1
Room: Mesa A-B

Speaker 4 of 9
Edith M. Hessel, Dynavax Technologies, USA
A Restricted Subset of Dendritic Cells Captures Airborne Allergens and Retains the Capacity to Activate Antigen-Specific T Cells Long after the Last Exposure

Saturday, February 09 | 2:30PM - 4:30PM
Workshop 1
Room: Mesa A-B

Speaker 5 of 9
Ann E. Welch, American Red Cross/Holland Lab, USA
Contribution of the IL-4Ra to Inflammatory Responses in the Lung

Saturday, February 09 | 2:30PM - 4:30PM
Workshop 1
Room: Mesa A-B

Speaker 6 of 9
David J. Klinke, Entelos, Inc., USA
Contributions of Th2 Cytokines to Airway Hyperresponsiveness in Asthma

Saturday, February 09 | 2:30PM - 4:30PM
Workshop 1
Room: Mesa A-B

Speaker 7 of 9
Douglas A. Kuperman, Northwestern University, USA
Direct Effects of IL-13 on Epithelial Cells Cause Airway Hyperreactivity and Mucus Production in the Absence of Inflammation

Saturday, February 09 | 2:30PM - 4:30PM
Workshop 1
Room: Mesa A-B

Speaker 8 of 9
Claudia Zuany-Amorim, Pfizer Global Research & Development, France
Suppression of Airway Eosinophilia by Allergen Specific, IL-10-Producing Regulatory CD4+ T Cells from Heat-Killed Mycobacterium vaccae-Treated Mice

Saturday, February 09 | 2:30PM - 4:30PM
Workshop 1
Room: Mesa A-B

Speaker 9 of 9
Joel Tocker, Janssen R&D, USA
Comparative Effects of Blocking either IL-4 or IL-4R in a Mouse Model of Asthma

Saturday, February 09 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Promenade


Saturday, February 09 | 5:00PM - 7:00PM
Immune Mechanisms in Asthma (Session I). Session Sponsored
by AstraZeneca R&D, Lund.

Room: Mesa A-B

Speaker 1 of 4
* Robert L. Coffman, Dynavax Technologies, USA

Saturday, February 09 | 5:00PM - 7:00PM
Immune Mechanisms in Asthma (Session I). Session Sponsored
by AstraZeneca R&D, Lund.

Room: Mesa A-B

Speaker 2 of 4
Stefanie N. Vogel, University of Maryland, USA
New Insights into Differential Gene Expression Induced by Toll-Like Receptors (TLRs) TLR2 vs. TLR4

Saturday, February 09 | 5:00PM - 7:00PM
Immune Mechanisms in Asthma (Session I). Session Sponsored
by AstraZeneca R&D, Lund.

Room: Mesa A-B

Speaker 3 of 4
Bali Pulendran, Stanford University School of Medicine, USA
Sensing Pathogens and Tuning Immune Responses with Dendritic Cells

Saturday, February 09 | 5:00PM - 7:00PM
Immune Mechanisms in Asthma (Session I). Session Sponsored
by AstraZeneca R&D, Lund.

Room: Mesa A-B

Speaker 4 of 4
Muriel Moser, Université Libre de Bruxelles, Belgium
Dendritic Cell Regulation of Th1/Th2 Development

Saturday, February 09 | 7:00PM - 8:00PM
Welcome Mixer
Room: Promenade


Saturday, February 09 | 8:00PM - 10:00PM
Poster Session 1: Immunologic Origins of Asthma/Immune Mecha
nisms in Asthma
Room: Mesa C


Saturday, February 09 | 8:00PM - 9:00PM
Cash Bar
Room: Promenade


Sunday, February 10 | 7:00AM - 8:00AM
Breakfast
Room: Chamisa


Sunday, February 10 | 8:00AM - 11:30AM
Immune Mechanisms in Asthma (Session II) Session Sponsored
by AstraZeneca R&D, Lund

Room: Mesa A-B

Speaker 1 of 6
* A. Barry Kay, National Heart and Lung Institute, UK

Sunday, February 10 | 8:00AM - 11:30AM
Immune Mechanisms in Asthma (Session II) Session Sponsored
by AstraZeneca R&D, Lund

Room: Mesa A-B

Speaker 2 of 6
K. Frank Austen, Harvard Medical School, USA
Mast Cell Effector Mechanisms

Sunday, February 10 | 8:00AM - 11:30AM
Immune Mechanisms in Asthma (Session II) Session Sponsored
by AstraZeneca R&D, Lund

Room: Mesa A-B

Speaker 3 of 6
Soman N. Abraham, Duke University Medical Center, USA
Caveolae Mediated Uptake of Particulate Allergens and Bacteria by
Mast Cells


Sunday, February 10 | 8:00AM - 11:30AM
Immune Mechanisms in Asthma (Session II) Session Sponsored
by AstraZeneca R&D, Lund

Room: Mesa A-B

Speaker 4 of 6
Donald W. MacGlashan, Johns Hopkins University, USA
IgE and its Receptor

Sunday, February 10 | 8:00AM - 11:30AM
Immune Mechanisms in Asthma (Session II) Session Sponsored
by AstraZeneca R&D, Lund

Room: Mesa A-B

Speaker 5 of 6
Achsah D. Keegan, University of Maryland School of Medicine, USA
Signaling by the IL-4Ralpha

Sunday, February 10 | 8:00AM - 11:30AM
Immune Mechanisms in Asthma (Session II) Session Sponsored
by AstraZeneca R&D, Lund

Room: Mesa A-B

Speaker 6 of 6
Craig Gerard, Children's Hospital Harvard University, USA
Complement in Asthma

Sunday, February 10 | 9:20AM - 9:40AM
Coffee Break
Room: Promenade


Sunday, February 10 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Promenade


Sunday, February 10 | 5:00PM - 7:00PM
Environmental Factors and Epidemiology of Asthma (Session I)
Room: Mesa A-B

Speaker 1 of 4
* Jeffrey M. Drazen, New England Journal of Medicine, USA

Sunday, February 10 | 5:00PM - 7:00PM
Environmental Factors and Epidemiology of Asthma (Session I)
Room: Mesa A-B

Speaker 2 of 4
Jonathan M. Samet, Johns Hopkins University, USA
The Changing Epidemiology of Asthma: What is the Environment's Role?

Sunday, February 10 | 5:00PM - 7:00PM
Environmental Factors and Epidemiology of Asthma (Session I)
Room: Mesa A-B

Speaker 3 of 4
Stephen T. Holgate, Southampton General Hospital, UK
Airway Epithelium and Responses to Environmental Factors

Sunday, February 10 | 5:00PM - 7:00PM
Environmental Factors and Epidemiology of Asthma (Session I)
Room: Mesa A-B

Speaker 4 of 4
Thomas A.E. Platts-Mills, University of Virginia, USA
The Modified Th2 Response (IgG/IgG4) as a Mechanism of Tolerance to Inhaled Allergens

Sunday, February 10 | 7:00PM - 8:00PM
Welcome Mixer
Room: Promenade


Monday, February 11 | 7:00AM - 8:00AM
Breakfast
Room: Chamisa


Monday, February 11 | 8:00AM - 11:00AM
Environmental Factors and Epidemiology of Asthma (Session II
)

Room: Mesa A-B

Speaker 1 of 5
* Erika von Mutius, University Children's Hospital, Munich, Germany

Monday, February 11 | 8:00AM - 11:00AM
Environmental Factors and Epidemiology of Asthma (Session II
)

Room: Mesa A-B

Speaker 2 of 5
Scott T. Weiss, Brigham and Women's Hospital, USA
The Natural History of Asthma: Early Childhood Events and Asthma in Later Life: The Obesity/Growth Story

Monday, February 11 | 8:00AM - 11:00AM
Environmental Factors and Epidemiology of Asthma (Session II
)

Room: Mesa A-B

Speaker 3 of 5
Fernando D. Martinez, University of Arizona, USA
Gene-Environment Interactions

Monday, February 11 | 8:00AM - 11:00AM
Environmental Factors and Epidemiology of Asthma (Session II
)

Room: Mesa A-B

Speaker 4 of 5
Diane R. Gold, Brigham and Women's Hospital, USA
Environment, The Early Childhood Immune Response, and Asthma

Monday, February 11 | 8:00AM - 11:00AM
Environmental Factors and Epidemiology of Asthma (Session II
)

Room: Mesa A-B

Speaker 5 of 5
Charles G. Plopper, University of California, Davis, USA
Allergen-Ozone Interactions in Non-Human Primates

Monday, February 11 | 9:20AM - 9:40AM
Coffee Break
Room: Promenade


Monday, February 11 | 11:00AM - 1:00PM
Poster Setup
Room: Mesa C


Monday, February 11 | 1:00PM - 10:00PM
Poster Viewing
Room: Mesa C


Monday, February 11 | 2:30PM - 4:30PM
Workshop 2
Room: Mesa A-B

Speaker 1 of 9
* Thomas A.E. Platts-Mills, University of Virginia, USA

Monday, February 11 | 2:30PM - 4:30PM
Workshop 2
Room: Mesa A-B

Speaker 2 of 9
Susan J. Wilson, University of Southampton, UK
Advanced Glycation End-Products in the Pathogenesis of Airway Remodeling in Asthma

Monday, February 11 | 2:30PM - 4:30PM
Workshop 2
Room: Mesa A-B

Speaker 3 of 9
Kenji Izuhara, Saga Medical School, Japan
Analysis of Novel Disease-Related Genes in Bronchial Asthma

Monday, February 11 | 2:30PM - 4:30PM
Workshop 2
Room: Mesa A-B

Speaker 4 of 9
Philip J. Cooper, St George's, University of London, UK
Reduced Risk of Atopy Among School Age Children Infected with Geohelminth Parasites in a Rural Area of the Tropics

Monday, February 11 | 2:30PM - 4:30PM
Workshop 2
Room: Mesa A-B

Speaker 5 of 9
Michael J. Evans, University of California, Davis, USA
Perlecan and Fibroblast Growth Factor-2 Immunoreactivity During Postnatal Development and Remodeling of the Basement Membrane Zone of Rhesus Monkeys Exposed to Allergen and Ozone

Monday, February 11 | 2:30PM - 4:30PM
Workshop 2
Room: Mesa A-B

Speaker 6 of 9
Miriam F. Moffatt, University of Oxford, UK
Epigenetic Effects on Association of Atopic Disease to the SPINK5 Gene

Monday, February 11 | 2:30PM - 4:30PM
Workshop 2
Room: Mesa A-B

Speaker 7 of 9
Benjamin J. Marsland, Monash University, Australia
Influenza A Induced Memory CD8+ T Cells Inhibit Allergen-induced CD4+ T Cell Migration and Effector Function

Monday, February 11 | 2:30PM - 4:30PM
Workshop 2
Room: Mesa A-B

Speaker 8 of 9
Andrea Keane-Myers, National Institutes of Health, USA
Alterations in Allergic Inflammation Following Ascaris Infection

Monday, February 11 | 2:30PM - 4:30PM
Workshop 2
Room: Mesa A-B

Speaker 9 of 9
Peter D. Sly, TVWT Telethon Institute for Child Health, Australia
Measurement of Airway Tone in vivo to Assess Post-Viral Wheeze Mechanisms

Monday, February 11 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Promenade


Monday, February 11 | 5:00PM - 7:00PM
Genetics of Asthma
Room: Mesa A-B

Speaker 1 of 4
* Stephen T. Holgate, Southampton General Hospital, UK

Monday, February 11 | 5:00PM - 7:00PM
Genetics of Asthma
Room: Mesa A-B

Speaker 2 of 4
William O.C. Cookson, Wellcome Trust Centre for Human Genetics, UK
Genetics of Asthma: Recent Advances

Monday, February 11 | 5:00PM - 7:00PM
Genetics of Asthma
Room: Mesa A-B

Speaker 3 of 4
Carole Ober, University of Chicago, USA
Gene-Gene and Gene-Environment Interactions and the Genetics of Asthma

Monday, February 11 | 5:00PM - 7:00PM
Genetics of Asthma
Room: Mesa A-B

Speaker 4 of 4
Jeffrey M. Drazen, New England Journal of Medicine, USA
Pharmacogenetics of Asthma

Monday, February 11 | 7:00PM - 8:00PM
Welcome Mixer
Room: Promenade


Monday, February 11 | 8:00PM - 10:00PM
Poster Session 2: Environmental Factors and Epidemiology of
Asthma/Genetics and Therapeutics of Asthma
Room: Mesa C


Monday, February 11 | 8:00PM - 9:00PM
Cash Bar
Room: Promenade


Tuesday, February 12 | 7:00AM - 8:00AM
Breakfast
Room: Chamisa


Tuesday, February 12 | 8:00AM - 10:45AM
Novel Therapeutic Approaches (Session I). Session Sponsored
by Merck & Co., Inc.

Room: Mesa A-B

Speaker 1 of 4
* Achsah D. Keegan, University of Maryland School of Medicine, USA

Tuesday, February 12 | 8:00AM - 10:45AM
Novel Therapeutic Approaches (Session I). Session Sponsored
by Merck & Co., Inc.

Room: Mesa A-B

Speaker 2 of 4
Lars Jacobsen, ALK-Abello A/S, Denmark
Immunotherapy to Prevent Asthma in Children

Tuesday, February 12 | 8:00AM - 10:45AM
Novel Therapeutic Approaches (Session I). Session Sponsored
by Merck & Co., Inc.

Room: Mesa A-B

Speaker 3 of 4
Arthur M. Krieg, Checkmate Pharmaceuticals, USA
Shifting from Th2 to Th1 with Immune Stimulatory CpG DNA


Tuesday, February 12 | 8:00AM - 10:45AM
Novel Therapeutic Approaches (Session I). Session Sponsored
by Merck & Co., Inc.

Room: Mesa A-B

Speaker 4 of 4
A. Barry Kay, National Heart and Lung Institute, UK
Tolerance Induction by T Cell Peptide Immunotherapy

Tuesday, February 12 | 9:20AM - 9:40AM
Coffee Break
Room: Promenade


Tuesday, February 12 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Promenade


Tuesday, February 12 | 5:00PM - 7:00PM
Novel Therapeutic Approaches (Session II). Session Sponsore
d by Merck & Co., Inc.

Room: Mesa A-B

Speaker 1 of 4
* Arthur M. Krieg, Checkmate Pharmaceuticals, USA

Tuesday, February 12 | 5:00PM - 7:00PM
Novel Therapeutic Approaches (Session II). Session Sponsore
d by Merck & Co., Inc.

Room: Mesa A-B

Speaker 2 of 4
Robert W. Egan, Schering-Plough Research Institute, USA
Eosinophils in Asthma

Tuesday, February 12 | 5:00PM - 7:00PM
Novel Therapeutic Approaches (Session II). Session Sponsore
d by Merck & Co., Inc.

Room: Mesa A-B

Speaker 3 of 4
Larry Borish, University of Virginia Medical Center, USA
Interleukin-4 Antagonism in the Treatment of Asthma

Tuesday, February 12 | 5:00PM - 7:00PM
Novel Therapeutic Approaches (Session II). Session Sponsore
d by Merck & Co., Inc.

Room: Mesa A-B

Speaker 4 of 4
Robert L. Coffman, Dynavax Technologies, USA
Modulating Th2 Responses in Asthma with Immunostimulatory DNA

Tuesday, February 12 | 7:00PM - 8:00PM
Welcome Mixer
Room: Promenade


Tuesday, February 12 | 8:00PM - 11:00PM
Entertainment
Room: Mesa Ballroom


Tuesday, February 12 | 8:00PM - 11:00PM
Cash Bar
Room: Mesa Ballroom


Wednesday, February 13 | 10:21AM - 10:21AM
Departure


*Session Chair
†Invited, not yet responded.