Web Desc
Innate Immunity: Evolution and Link to Adaptive Immunity
Organizer(s): R. Alan B. Ezekowitz, Jules A. Hoffmann and Fotis C. Kafatos
Date: February 12 - 17, 2002
Location: Sagebrush Inn & Suites, Taos, NM, USA
Sponsored in part by The Director's Sponsor Fund
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Summary of Meeting:
Recent exciting information has determined that the templates that are laid down in primitive life forms, like flowering plants and insects, form the basic principles of first line host defense that are conserved in mammalian systems. The next frontier in the field is to understand the dynamic adaptive changes that occur as a result of the interplay between host defenses and infectious agents. One emerging theme is that microorganisms are constantly seeking ways to co-opt host defenses. On the other hand, host defense to infection is mediated by the coordinate action pattern recognition molecules and receptors that, in mammals, are important and probably necessary antecedents to the development of an adaptive immune response. This conference aims to explore the intersection between host pathogen interactions across an evolutionary spectrum that will inform our understanding of the dynamic interplay between infectious agents and host defense in man
Discounted Abstract Deadline: October 12 2001
Discounted Registration Deadline: December 12 2001
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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

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Program

Tuesday, February 12 | 4:00PM - 7:00PM
Registration
Room: Chamisa Lobby


Tuesday, February 12 | 6:15PM - 7:15PM
Welcome
Room: Chamisa Lobby


Tuesday, February 12 | 7:15PM - 7:30PM
Orientation
Room: Chamisa Ballroom 2


Tuesday, February 12 | 7:30PM - 8:30PM
Keynote Address
Room: Chamisa Ballroom 2

Speaker 1 of 1
Charles A. Janeway Jr., Yale University School of Medicine, USA
Is Innate Immunity an Absolute Requirement to Generate an Adaptive Immune Response?

Wednesday, February 13 | 7:00AM - 8:00AM
Breakfast
Room: Los Vaqueros


Wednesday, February 13 | 8:00AM - 11:00AM
Dynamic Interaction Between Microbes and Macrophages
Room: Chamisa Ballroom 2

Speaker 1 of 4
Pascale Cossart, Institut Pasteur, France
Molecular and Cellular Basis of Listeria Monocytogenes: From in vitro data to in vivo Models

Wednesday, February 13 | 8:00AM - 11:00AM
Dynamic Interaction Between Microbes and Macrophages
Room: Chamisa Ballroom 2

Speaker 2 of 4
* Gerald R. Fink, Whitehead Institute for Biomedical Research, USA
Relationship between Metabolism and Pathogenics

Wednesday, February 13 | 8:00AM - 11:00AM
Dynamic Interaction Between Microbes and Macrophages
Room: Chamisa Ballroom 2

Speaker 3 of 4
Samuel I. Miller, University of Washington, USA
Salmonella Evasion of Macrophage Killing

Wednesday, February 13 | 8:00AM - 11:00AM
Dynamic Interaction Between Microbes and Macrophages
Room: Chamisa Ballroom 2

Speaker 4 of 4
Catharina Svanborg, A*STAR, Singapore
Toll-Like Receptor Signaling, Chemokine Receptor Expression and the Severity of Urinary Tract Infection

Wednesday, February 13 | 9:20AM - 9:40AM
Coffee Break
Room: Chamisa Lobby


Wednesday, February 13 | 11:00AM - 1:00PM
Poster Setup
Room: Chamisa Ballroom 1


Wednesday, February 13 | 1:00PM - 10:00PM
Poster Viewing
Room: Chamisa Ballroom 1


Wednesday, February 13 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Chamisa Lobby


Wednesday, February 13 | 5:00PM - 7:00PM
Primitive Immunity
Room: Chamisa Ballroom 2

Speaker 1 of 4
Charles J. Hackett, NIAID, National Institutes of Health, USA

Wednesday, February 13 | 5:00PM - 7:00PM
Primitive Immunity
Room: Chamisa Ballroom 2

Speaker 2 of 4
Jules A. Hoffmann, Institute of Cellular and Molecular Biology, France
Innate Immunity in Drosophila

Wednesday, February 13 | 5:00PM - 7:00PM
Primitive Immunity
Room: Chamisa Ballroom 2

Speaker 3 of 4
* Fotis C. Kafatos, Imperial College London, UK
Mosquitos and Immunity to Malaria

Wednesday, February 13 | 5:00PM - 7:00PM
Primitive Immunity
Room: Chamisa Ballroom 2

Speaker 4 of 4
Jeffery L. Dangl, University of North Carolina at Chapel Hill, USA
Recognition and Signaling in the Plant Innate Immune System

Wednesday, February 13 | 7:00PM - 8:00PM
Welcome Mixer
Room: Chamisa Ballroom 1


Wednesday, February 13 | 8:00PM - 10:00PM
Poster Session 1: Dynamic Interaction Between Microbes and M
acrophages/Primitive Immunity
Room: Chamisa Ballroom 1


Wednesday, February 13 | 8:00PM - 9:00PM
Cash Bar
Room: Chamisa Ballroom 1


Thursday, February 14 | 7:00AM - 8:00AM
Breakfast
Room: Los Vaqueros


Thursday, February 14 | 8:00AM - 11:00AM
Interactions Between Innate and Adaptive Immunity
Room: Chamisa Ballroom 2

Speaker 1 of 4
* Alan Ezekowitz, Abide Therapeutics, USA
The Role of Pattern Recognition Molecules in Innate Immunity

Thursday, February 14 | 8:00AM - 11:00AM
Interactions Between Innate and Adaptive Immunity
Room: Chamisa Ballroom 2

Speaker 2 of 4
Peter M. Henson, National Jewish Health Center and University of Colorado Denver, USA
Collectins in Innate Immunity Regulation of Inflammation and Apoptotic Cell Clearence

Thursday, February 14 | 8:00AM - 11:00AM
Interactions Between Innate and Adaptive Immunity
Room: Chamisa Ballroom 2

Speaker 3 of 4
Marco Colonna, Washington University School of Medicine, USA
TREM-1 Mediates Neutrophil Survival in vivo

Thursday, February 14 | 8:00AM - 11:00AM
Interactions Between Innate and Adaptive Immunity
Room: Chamisa Ballroom 2

Speaker 4 of 4
John F. Kearney, University of Alabama, Birmingham, USA
Natural Antibodies: A Bridge between Innate and Acquired Immunity

Thursday, February 14 | 9:20AM - 9:40AM
Coffee Break
Room: Chamisa Lobby


Thursday, February 14 | 11:00AM - 1:00PM
Poster Setup
Room: Chamisa Ballroom 1


Thursday, February 14 | 1:00PM - 10:00PM
Poster Viewing
Room: Chamisa Ballroom 1


Thursday, February 14 | 2:30PM - 4:30PM
Workshop: Humoral Factors and Innate Immunity
Room: Chamisa Ballroom 2

Speaker 1 of 1
* John F. Kearney, University of Alabama, Birmingham, USA

Thursday, February 14 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Chamisa Lobby


Thursday, February 14 | 5:00PM - 7:00PM
Apoptotic Cell Recognition
Room: Chamisa Ballroom 2

Speaker 1 of 4
* † Jules A. Hoffmann, Institute of Cellular and Molecular Biology, France

Thursday, February 14 | 5:00PM - 7:00PM
Apoptotic Cell Recognition
Room: Chamisa Ballroom 2

Speaker 2 of 4
Kodi S. Ravichandran, University of Virginia, USA
Evolutionarily Conserved Pathways for Engulfment of Apoptotic Cells

Thursday, February 14 | 5:00PM - 7:00PM
Apoptotic Cell Recognition
Room: Chamisa Ballroom 2

Speaker 3 of 4
Valerie A. Fadok, National Jewish Medical and Research Center, USA
Phosphatidylserine and its Receptor(s) as a Molecular Switch: How Apoptotic Cells Block Acquired Immunity

Thursday, February 14 | 5:00PM - 7:00PM
Apoptotic Cell Recognition
Room: Chamisa Ballroom 2

Speaker 4 of 4
Shun-ichiro Kawabata, Kyushu University, Japan
Common Origin of Innate Immunity and Blood Coagulation System: The Horseshoe Crab Acetyl Group-Recognized Lectin

Thursday, February 14 | 7:00PM - 8:00PM
Welcome Mixer
Room: Chamisa Ballroom 1


Thursday, February 14 | 8:00PM - 10:00PM
Poster Session 2: Interactions Between Innate and Adaptive I
mmunity/Apoptotic Cell Recognition
Room: Chamisa Ballroom 1


Thursday, February 14 | 8:00PM - 9:00PM
Cash Bar
Room: Chamisa Ballroom 1


Friday, February 15 | 7:00AM - 8:00AM
Breakfast
Room: Los Vaqueros


Friday, February 15 | 8:00AM - 11:00AM
First Line Cellular Responses to Infectious Challenge
Room: Chamisa Ballroom 2

Speaker 1 of 4
* Siamon Gordon, Chang Gung University / University of Oxford, UK
Macrophage Recognition of Pathogens: Scavenger Receptor A and beta Glucan Receptor

Friday, February 15 | 8:00AM - 11:00AM
First Line Cellular Responses to Infectious Challenge
Room: Chamisa Ballroom 2

Speaker 2 of 4
K. Frank Austen, Harvard Medical School, USA
Mast Cell Responses

Friday, February 15 | 8:00AM - 11:00AM
First Line Cellular Responses to Infectious Challenge
Room: Chamisa Ballroom 2

Speaker 3 of 4
Emil R. Unanue, Washington University School of Medicine, USA
Intracellular Fate of Listeria Monocytogenes

Friday, February 15 | 8:00AM - 11:00AM
First Line Cellular Responses to Infectious Challenge
Room: Chamisa Ballroom 2

Speaker 4 of 4
Wayne M. Yokoyama, Washington University School of Medicine, USA
Innate Natural Killer Cell Responses to Viral Infections

Friday, February 15 | 9:20AM - 9:40AM
Coffee Break
Room: Chamisa Lobby


Friday, February 15 | 11:00AM - 1:00PM
Poster Setup
Room: Chamisa Ballroom 1


Friday, February 15 | 1:00PM - 10:00PM
Poster Viewing
Room: Chamisa Ballroom 1


Friday, February 15 | 2:30PM - 4:30PM
Workshop: Genes that Confer Resistance/Susceptibility to Inf
ection
Room: Chamisa Ballroom 2

Speaker 1 of 1
* Bruce A. Beutler, University of Texas Southwestern Medical Center, USA

Friday, February 15 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Chamisa Lobby


Friday, February 15 | 5:00PM - 7:00PM
Toll-Like Receptors
Room: Chamisa Ballroom 2

Speaker 1 of 3
Ruslan Medzhitov, HHMI/Yale University School of Medicine, USA
The Role of Toll-Like Receptors in Immune Recognition

Friday, February 15 | 5:00PM - 7:00PM
Toll-Like Receptors
Room: Chamisa Ballroom 2

Speaker 2 of 3
Bruce A. Beutler, University of Texas Southwestern Medical Center, USA
Mutational Dissection of the Innate Immune Response

Friday, February 15 | 5:00PM - 7:00PM
Toll-Like Receptors
Room: Chamisa Ballroom 2

Speaker 3 of 3
* Alan Aderem, Center for Infectious Disease Research, USA
Macrophage Phagocytes and Toll Receptors in the Innate Immune Response

Friday, February 15 | 7:00PM - 8:00PM
Welcome Mixer
Room: Chamisa Ballroom 1


Friday, February 15 | 8:00PM - 10:00PM
Poster Session 3: First Line Cellular Responses to Infectiou
s Challenge/Toll-Like Receptors/Host Pathogen Interactions/Molecules Involved in Innate Host Defense
Room: Chamisa Ballroom 1


Friday, February 15 | 8:00PM - 9:00PM
Cash Bar
Room: Chamisa Ballroom 1


Saturday, February 16 | 7:00AM - 8:00AM
Breakfast
Room: Los Vaqueros


Saturday, February 16 | 8:00AM - 11:00AM
Host Pathogen Interactions
Room: Chamisa Ballroom 2

Speaker 1 of 3
Michel Desjardins, University of Montreal, Canada
A Proteomic Approach to Study Host-Pathogen Interaction

Saturday, February 16 | 8:00AM - 11:00AM
Host Pathogen Interactions
Room: Chamisa Ballroom 2

Speaker 2 of 3
* Albert S. Bendelac, University of Chicago, USA
CD-1 Mediated Presentation of Lipid Antigens

Saturday, February 16 | 8:00AM - 11:00AM
Host Pathogen Interactions
Room: Chamisa Ballroom 2

Speaker 3 of 3
Elena A. Levashina, Max Planck Institute for Infection Biology, Germany
Thioester-Containing Proteins: From Insects to Mammals

Saturday, February 16 | 9:20AM - 9:40AM
Coffee Break
Room: Chamisa Lobby


Saturday, February 16 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Chamisa Lobby


Saturday, February 16 | 5:00PM - 7:00PM
Molecules Involved in Innate Host Defense
Room: Chamisa Ballroom 2

Speaker 1 of 3
Antonio Lanzavecchia, Institute for Research in Biomedicine, Switzerland
The Instructive Role of Dendritic Cells in T Cell Responses

Saturday, February 16 | 5:00PM - 7:00PM
Molecules Involved in Innate Host Defense
Room: Chamisa Ballroom 2

Speaker 2 of 3
* Jeffrey V. Ravetch, Rockefeller University, USA
Fc Receptors: A Paradigm of Activation and Inhibitory Receptor Pairing

Saturday, February 16 | 5:00PM - 7:00PM
Molecules Involved in Innate Host Defense
Room: Chamisa Ballroom 2

Speaker 3 of 3
Michael C. Carroll, Boston Children's Hospital, Harvard Medical School, USA
Linkage of Innate and Adaptive Immunity by Complement

Saturday, February 16 | 7:00PM - 8:00PM
Welcome Mixer
Room: Chamisa Ballroom 1


Saturday, February 16 | 8:00PM - 11:00PM
Entertainment
Room: Chamisa Ballroom 1


Saturday, February 16 | 8:00PM - 11:00PM
Cash Bar
Room: Chamisa Ballroom 1


Sunday, February 17 | 10:21AM - 10:21AM
Departure


*Session Chair
†Invited, not yet responded.