Web Desc
Molecular Biology of the Heart
Organizer(s): Leslie A. Leinwand and Mark C. Fishman
Date: February 13 - 18, 2002
Location: Keystone Resort, Keystone, CO, USA
Summary of Meeting:
The focus of this symposium will be on the use of molecular and genetic tools to understand cardiovascular development, function and disease. It is a very exciting time in this field and we will take advantage of the veritable explosion in information that has resulted from the genome projects of multiple organisms. Gene discovery by the time of this meeting will undoubtedly be quite advanced and we should have information about changes in gene expression that accompany cardiovascular disease in mice and men. Another exciting 'hot' area of investigation is the potential for stem cells in the heart. We will devote a session to the promise and practice of cardiac stem cells. The use of model organisms has made it possible to develop paradigms for early heart formation and we will use examples of these studies to explore vertebrate and invertebrate heart development. Single gene disorders have contributed a great deal of information about congenital and adult cardiac disease ranging from valve and septal disorders to sudden death in young athletes. We will explore single gene disorders, but also approaches leading to the understanding of complex genetic disorders such as hypertension and predisposition for heart disease. Another emerging area of research is our ability to understand the molecular mechanisms leading to cardiac failure, the most prevalent disease and cause of death in North America. Sessions will be developed that are the essence of 'bench-to-bedside' dealing with cardiac failure and how to develop treatment paradigms based on basic research findings. This symposium will bring together people from industry, clinicians and basic scientists in a way that serves the mission of the Keystone symposium. It will be a multidisciplinary meeting that should bring together people who are beginning to have regular dialogues but whose traditions have been somewhat separate.
Discounted Abstract Deadline: October 12 2001
Discounted Registration Deadline: December 13 2001
We gratefully acknowledge the generous grant for this conference provided by:

National Heart, Lung, and Blood Institute (NHLBI)
Grant No. 1 R13 HL69887-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Wednesday, February 13 | 4:00PM - 7:00PM
Registration
Room: Shavano Peak Foyer


Wednesday, February 13 | 6:15PM - 7:15PM
Welcome
Room: Shavano Peak Foyer


Wednesday, February 13 | 7:15PM - 7:30PM
Orientation
Room: Shavano Peak


Wednesday, February 13 | 7:30PM - 8:30PM
Keynote Address
Room: Shavano Peak

Speaker 1 of 1
James A. Spudich, Stanford University, USA
Single Molecule Mechanics and the Myosin Family of Molecular Motors

Thursday, February 14 | 7:00AM - 8:00AM
Breakfast
Room: Red Cloud


Thursday, February 14 | 8:00AM - 11:00AM
Genetics of Heart Formation and Function (1)
Room: Shavano Peak

Speaker 1 of 4
* Mark C. Fishman, Novartis Institutes for BioMedical Research, USA
Preparing for the First Heartbeat

Thursday, February 14 | 8:00AM - 11:00AM
Genetics of Heart Formation and Function (1)
Room: Shavano Peak

Speaker 2 of 4
Rolf Bodmer, Sanford-Burnham Medical Research Institute, USA
Genetics of Cardiac Positioning and Cell-Type Specification

Thursday, February 14 | 8:00AM - 11:00AM
Genetics of Heart Formation and Function (1)
Room: Shavano Peak

Speaker 3 of 4
Glenn I. Fishman, New York University School of Medicine, USA
Murine Cardiac Conduction: Molecular and Functional Characterization

Thursday, February 14 | 8:00AM - 11:00AM
Genetics of Heart Formation and Function (1)
Room: Shavano Peak

Speaker 4 of 4
Mark T. Keating, Novartis Institutes for BioMedical Research, USA
Channelopathies and Heart Disease

Thursday, February 14 | 9:20AM - 9:40AM
Coffee Break
Room: Shavano Peak Foyer


Thursday, February 14 | 11:00AM - 1:00PM
Poster Setup
Room: Torreys Peak 1-4


Thursday, February 14 | 1:00PM - 10:00PM
Poster Viewing
Room: Torreys Peak 1-4


Thursday, February 14 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Shavano Peak Foyer


Thursday, February 14 | 5:00PM - 7:00PM
Genetics of Heart Formation and Function (2)
Room: Shavano Peak

Speaker 1 of 5
* Nadia A. Rosenthal, The Jackson Laboratory, USA

Thursday, February 14 | 5:00PM - 7:00PM
Genetics of Heart Formation and Function (2)
Room: Shavano Peak

Speaker 2 of 5
Kenneth R. Chien, Karolinska Institutet, Sweden
Molecular Interventions into Hypertrophic Pathways

Thursday, February 14 | 5:00PM - 7:00PM
Genetics of Heart Formation and Function (2)
Room: Shavano Peak

Speaker 3 of 5
Jonathan A. Epstein, University of Pennsylvania, USA
Neural Crest and Cardiac Development

Thursday, February 14 | 5:00PM - 7:00PM
Genetics of Heart Formation and Function (2)
Room: Shavano Peak

Speaker 4 of 5
Martina Brueckner, Yale University School of Medicine, USA
Cilia, Dynein and the Development of Left-Right Asymmetry

Thursday, February 14 | 5:00PM - 7:00PM
Genetics of Heart Formation and Function (2)
Room: Shavano Peak

Speaker 5 of 5
Didier Stainier, Max Planck Institute for Heart and Lung Research, Germany
Cardiac Valve Formation

Thursday, February 14 | 7:00PM - 8:00PM
Welcome Mixer
Room: Torreys Peak 1-4


Thursday, February 14 | 7:00PM - 9:00PM
Cash Bar
Room: Torreys Peak 1-4


Thursday, February 14 | 8:00PM - 10:00PM
Poster Session 1: Genetics of Heart Formation and Function
Room: Torreys Peak 1-4


Friday, February 15 | 7:00AM - 8:00AM
Breakfast
Room: Red Cloud


Friday, February 15 | 8:00AM - 11:00AM
Stem Cells Hopes
Room: Shavano Peak

Speaker 1 of 4
Fabio M.V. Rossi, University of British Columbia, Canada
From Blood to Brain and Brawn

Friday, February 15 | 8:00AM - 11:00AM
Stem Cells Hopes
Room: Shavano Peak

Speaker 2 of 4
* Charles E. Murry, University of Washington, USA
Cellular Therapy for Cardiac Injury

Friday, February 15 | 8:00AM - 11:00AM
Stem Cells Hopes
Room: Shavano Peak

Speaker 3 of 4
Giulio Cossu, Stem Cell Research Institute, Italy
Pluripotent Progenitors Associated with Fetal Vasculature

Friday, February 15 | 8:00AM - 11:00AM
Stem Cells Hopes
Room: Shavano Peak

Speaker 4 of 4
Piero Anversa, Brigham and Women's Hospital, USA
Myocardial Damage and Repair

Friday, February 15 | 9:20AM - 9:40AM
Coffee Break
Room: Shavano Peak Foyer


Friday, February 15 | 11:00AM - 1:00PM
Poster Setup
Room: Torreys Peak 1-4


Friday, February 15 | 1:00PM - 10:00PM
Poster Viewing
Room: Torreys Peak 1-4


Friday, February 15 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Shavano Peak Foyer


Friday, February 15 | 5:00PM - 7:00PM
Genetics of Cardiomyopathy
Room: Shavano Peak

Speaker 1 of 3
* Jonathan G. Seidman, Harvard Medical School, USA
Genetics of Hypertrophic and Dilated Cardiomyopathy in Mouse and Man

Friday, February 15 | 5:00PM - 7:00PM
Genetics of Cardiomyopathy
Room: Shavano Peak

Speaker 2 of 3
Elizabeth M. McNally, Northwestern University, USA
Genetics of Cardiomyopathy and Muscle Disease

Friday, February 15 | 5:00PM - 7:00PM
Genetics of Cardiomyopathy
Room: Shavano Peak

Speaker 3 of 3
Neal D. Epstein, National Institutes of Health, USA
The Overall Pattern of Cardiac Contraction Depends on a Spatial Gradient of Myosin Regulatory Light Chain Phosphorylation

Friday, February 15 | 7:00PM - 8:00PM
Welcome Mixer
Room: Torreys Peak 1-4


Friday, February 15 | 7:00PM - 9:00PM
Cash Bar
Room: Torreys Peak 1-4


Friday, February 15 | 8:00PM - 10:00PM
Poster Session 2: Stem Cells Hopes/Genetics of Cardiomyopath
y
Room: Torreys Peak 1-4


Saturday, February 16 | 7:00AM - 8:00AM
Breakfast
Room: Red Cloud


Saturday, February 16 | 8:00AM - 11:00AM
Molecular Mechanisms of Cardiac Function and Failure (1)
Room: Shavano Peak

Speaker 1 of 4
* Leslie A. Leinwand, University of Colorado Boulder, USA
Molecular Mechanisms of Cardiac Failure

Saturday, February 16 | 8:00AM - 11:00AM
Molecular Mechanisms of Cardiac Function and Failure (1)
Room: Shavano Peak

Speaker 2 of 4
Eric N. Olson, University of Texas Southwestern Medical Center, USA
The Role of HDACs and Transcriptional Pathways of Hypertrophy

Saturday, February 16 | 8:00AM - 11:00AM
Molecular Mechanisms of Cardiac Function and Failure (1)
Room: Shavano Peak

Speaker 3 of 4
* Nadia A. Rosenthal, The Jackson Laboratory, USA
How to Become a Muscle Cell

Saturday, February 16 | 8:00AM - 11:00AM
Molecular Mechanisms of Cardiac Function and Failure (1)
Room: Shavano Peak

Speaker 4 of 4
Julie R. McMullen, Baker Heart and Diabetes Institute, Australia
Signal Transduction in Cardiac Hypertrophy in vivo

Saturday, February 16 | 9:20AM - 9:40AM
Coffee Break
Room: Shavano Peak Foyer


Saturday, February 16 | 11:00AM - 1:00PM
Poster Setup
Room: Torreys Peak 1-4


Saturday, February 16 | 1:00PM - 10:00PM
Poster Viewing
Room: Torreys Peak 1-4


Saturday, February 16 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Shavano Peak Foyer


Saturday, February 16 | 5:00PM - 7:00PM
Molecular Mechanisms of Cardiac Function and Failure (2)
Room: Shavano Peak

Speaker 1 of 5
* Stephen C. Mockrin, NHLBI, National Institutes of Health, USA

Saturday, February 16 | 5:00PM - 7:00PM
Molecular Mechanisms of Cardiac Function and Failure (2)
Room: Shavano Peak

Speaker 2 of 5
Paul Rosenberg, Duke University, USA
Calcium Signals that Regulate Calcineurin/NFAT Signaling in Muscle

Saturday, February 16 | 5:00PM - 7:00PM
Molecular Mechanisms of Cardiac Function and Failure (2)
Room: Shavano Peak

Speaker 3 of 5
Andrew R. Marks, Columbia University College of Physicians and Surgeons, USA
Defective Calcium Signaling in Failing Hearts: Why Beta Blockers Work

Saturday, February 16 | 5:00PM - 7:00PM
Molecular Mechanisms of Cardiac Function and Failure (2)
Room: Shavano Peak

Speaker 4 of 5
Michael R. Bristow, University of Colorado Anschutz Medical Campus, USA
Adrenergic Mechanisms in Human Myocardial Failure

Saturday, February 16 | 5:00PM - 7:00PM
Molecular Mechanisms of Cardiac Function and Failure (2)
Room: Shavano Peak

Speaker 5 of 5
Michael D. Schneider, Imperial College London, UK
Genetic Dissection of Cardiac Growth Cascades

Saturday, February 16 | 7:00PM - 8:00PM
Welcome Mixer
Room: Torreys Peak 1-4


Saturday, February 16 | 7:00PM - 9:00PM
Cash Bar
Room: Torreys Peak 1-4


Saturday, February 16 | 8:00PM - 10:00PM
Poster Session 3: Molecular Mechanisms of Cardiac Function a
nd Failure/Large Scale Genomics/Proteomics/Late Breaking Science
Room: Torreys Peak 1-4


Sunday, February 17 | 7:00AM - 8:00AM
Breakfast
Room: Red Cloud


Sunday, February 17 | 8:00AM - 11:00AM
Large Scale Genomics/Proteomics
Room: Shavano Peak

Speaker 1 of 4
* Susan E. Old, NHLBI, National Institutes of Health, USA

Sunday, February 17 | 8:00AM - 11:00AM
Large Scale Genomics/Proteomics
Room: Shavano Peak

Speaker 2 of 4
Edward M. Rubin, Lawrence Berkeley National Laboratory, USA
Comparative Analysis to Identify Functional Mouse Sequences

Sunday, February 17 | 8:00AM - 11:00AM
Large Scale Genomics/Proteomics
Room: Shavano Peak

Speaker 3 of 4
Larry Gold, SomaLogic Inc., USA
Proteomics and Heart Disease

Sunday, February 17 | 8:00AM - 11:00AM
Large Scale Genomics/Proteomics
Room: Shavano Peak

Speaker 4 of 4
James D. Bristow, University of California, San Francisco, USA
Expression Profiling of Cardiac Hypertrophy

Sunday, February 17 | 9:20AM - 9:40AM
Coffee Break
Room: Shavano Peak Foyer


Sunday, February 17 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Shavano Peak Foyer


Sunday, February 17 | 5:00PM - 7:00PM
Late Breaking Science
Room: Shavano Peak

Speaker 1 of 3
* Robert J. Schwartz, Texas A&M University, USA
Molecular Induced Specification of Early Cardiovascular Lineages

Sunday, February 17 | 5:00PM - 7:00PM
Late Breaking Science
Room: Shavano Peak

Speaker 2 of 3
Robert A. Schulz, University of Texas MD Anderson Cancer Center, USA
Cardioblast Specification and Diversification During Heart Development

Sunday, February 17 | 5:00PM - 7:00PM
Late Breaking Science
Room: Shavano Peak

Speaker 3 of 3
Bernardo Nadal-Ginard, New York Medical College, USA
Stem Cells in Myocardial Maintenance and Regeneration. Clinical
Implications


Sunday, February 17 | 7:00PM - 8:00PM
Welcome Mixer
Room: Torreys Peak 1-4


Sunday, February 17 | 8:00PM - 11:00PM
Entertainment
Room: Torreys Peak 1-4


Sunday, February 17 | 8:00PM - 11:00PM
Cash Bar
Room: Torreys Peak 1-4


Monday, February 18 | 10:26AM - 10:26AM
Departure


*Session Chair.