Web Desc
NF-kappaB: Bench to Bedside
Organizer(s): Inder M. Verma and David Baltimore
Date: February 25 - March 03, 2002
Location: Keystone Resort, Keystone, CO, USA
Sponsored by Aventis Pharmaceuticals, Inc. and The Director's Sponsor Fund
For important information on the coronavirus, please click here
Summary of Meeting:
NF-kappaB (NF-kB) is a transcription factor which is involved in the transcription of many genes involved in growth differentiation and development. In addition, the transcription of many lymphokines and cytokines involved in inflammation, rheumatoid arthritis, cancer, and other metabolic diseases is also regulated by NF-kB. NF-kB resides in the cytoplasm, and following induction with a wide variety of agents, is translocated to the nucleus. The translocation to the nucleus, however, is dependent on the degradation of IkB which is associated with NF-kB in the cytoplasm. There is a very complex machinery which leads to the phosphorylation, ubiquitination, and degradation of IkB. This meeting is designed for graduate students, postdoctoral fellows, and scientists working in the field, to understand the molecular mechanisms of activation of NF-kB. There is extensive emphasis on the mechanisms by which NF-kB proteins play a role in disease and identification of therapeutic molecules that may intervene in the biological activity of NF-kB.
Discounted Abstract Deadline: October 25 2001
Discounted Registration Deadline: December 27 2001
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

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Program

Monday, February 25 | 4:00PM - 7:00PM
Registration
Room: Longs Peak Foyer


Monday, February 25 | 6:15PM - 7:15PM
Welcome
Room: Longs Peak Foyer


Monday, February 25 | 7:15PM - 7:30PM
Orientation
Room: Quandry 1-3


Monday, February 25 | 7:30PM - 8:30PM
Keynote Address
Room: Quandry 1-3

Speaker 1 of 1
Charles A. Dinarello, University of Colorado Health Sciences Center, USA
Anti-Cytokine Therapy Works

Tuesday, February 26 | 7:00AM - 8:00AM
Breakfast
Room: Longs Peak


Tuesday, February 26 | 8:00AM - 11:00AM
NF-kappaB: Biochemistry and Structure
Room: Quandry 1-3

Speaker 1 of 5
* Ulrich K. Siebenlist, NIAID, National Institutes of Health, USA

Tuesday, February 26 | 8:00AM - 11:00AM
NF-kappaB: Biochemistry and Structure
Room: Quandry 1-3

Speaker 2 of 5
Stephen C. Harrison, Harvard Medical School, USA
Structural Studies of the NF-kappaB Pathway

Tuesday, February 26 | 8:00AM - 11:00AM
NF-kappaB: Biochemistry and Structure
Room: Quandry 1-3

Speaker 3 of 5
Gourisankar Ghosh, University of California, San Diego, USA
NF-kappaB regulation by IkappaBalpha and IkappaBbeta

Tuesday, February 26 | 8:00AM - 11:00AM
NF-kappaB: Biochemistry and Structure
Room: Quandry 1-3

Speaker 4 of 5
Yinon M. Ben-Neriah, Hebrew University, Hadassah Medical School, Israel
Regulation of IkappaBalpha Ubiquitination

Tuesday, February 26 | 8:00AM - 11:00AM
NF-kappaB: Biochemistry and Structure
Room: Quandry 1-3

Speaker 5 of 5
Warner Craig Greene, Gladstone Institute of Virology and Immunology, USA
Reversible Acetylation and the Regulation of NF-kappaB Action

Tuesday, February 26 | 9:20AM - 9:40AM
Coffee Break
Room: Quandry Peak Foyer


Tuesday, February 26 | 11:00AM - 1:00PM
Poster Setup
Room: Longs Peak


Tuesday, February 26 | 1:00PM - 10:00PM
Poster Viewing
Room: Long Peak


Tuesday, February 26 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Quandry Peak Foyer


Tuesday, February 26 | 5:00PM - 7:00PM
NF-kappaB: Signaling I
Room: Quandry 1-3

Speaker 1 of 4
* Yinon M. Ben-Neriah, Hebrew University, Hadassah Medical School, Israel

Tuesday, February 26 | 5:00PM - 7:00PM
NF-kappaB: Signaling I
Room: Quandry 1-3

Speaker 2 of 4
Sankar Ghosh, Columbia University, USA
Phosphorylation Events in the Activation of NF-kappaB

Tuesday, February 26 | 5:00PM - 7:00PM
NF-kappaB: Signaling I
Room: Quandry 1-3

Speaker 3 of 4
Guoqing Chen, Amgen Inc., USA
Short Talk: TNF Signaling: New Insights into the Composition and Activation of the IKK Complex

Tuesday, February 26 | 5:00PM - 7:00PM
NF-kappaB: Signaling I
Room: Quandry 1-3

Speaker 4 of 4
David Baltimore, California Institute of Technology, USA
Genetic Analysis of NF-kappaB Function

Tuesday, February 26 | 7:00PM - 8:00PM
Welcome Mixer
Room: Longs Peak


Tuesday, February 26 | 7:00PM - 9:00PM
Cash Bar
Room: Longs Peak


Tuesday, February 26 | 8:00PM - 10:00PM
Poster Session 1
Room: Longs Peak


Wednesday, February 27 | 7:00AM - 8:00AM
Breakfast
Room: Longs Peak


Wednesday, February 27 | 8:00AM - 11:00AM
NF-kappaB: Signaling II
Room: Quandry 1-3

Speaker 1 of 5
* Gerald R. Crabtree, Stanford University, USA

Wednesday, February 27 | 8:00AM - 11:00AM
NF-kappaB: Signaling II
Room: Quandry 1-3

Speaker 2 of 5
Michael Karin, University of California, San Diego, USA
IKK - A Master Regulator of Innate and Adaptive Immune Responses

Wednesday, February 27 | 8:00AM - 11:00AM
NF-kappaB: Signaling II
Room: Quandry 1-3

Speaker 3 of 5
Ulrich K. Siebenlist, NIAID, National Institutes of Health, USA
Biologic Functions and Modes of Activation of NF-kappaB

Wednesday, February 27 | 8:00AM - 11:00AM
NF-kappaB: Signaling II
Room: Quandry 1-3

Speaker 4 of 5
Jun-Ichiro Inoue, University of Tokyo, Japan
Regulation of Cytokine Signalings Mediated by TNF Receptor-Associated Factor 6 (TRAF6)

Wednesday, February 27 | 8:00AM - 11:00AM
NF-kappaB: Signaling II
Room: Quandry 1-3

Speaker 5 of 5
Zhijian 'James' Chen, University of Texas Southwestern Medical Center, USA
Short Talk: Ubiquitin-Mediated Activation of IKK by TRAF6

Wednesday, February 27 | 9:20AM - 9:40AM
Coffee Break
Room: Quandry Peak Foyer


Wednesday, February 27 | 11:00AM - 1:00PM
Poster Setup
Room: Longs Peak


Wednesday, February 27 | 1:00PM - 10:00PM
Poster Viewing
Room: Longs Peak


Wednesday, February 27 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Quandry Peak Foyer


Wednesday, February 27 | 5:00PM - 7:00PM
Workshop 1. NF-kappaB: Function in Whole Animals
Room: Quandry 1-3

Speaker 1 of 5
* David Baltimore, California Institute of Technology, USA

Wednesday, February 27 | 5:00PM - 7:00PM
Workshop 1. NF-kappaB: Function in Whole Animals
Room: Quandry 1-3

Speaker 2 of 5
Manolis Pasparakis, University of Cologne, Germany
In vivo Analysis of NF-kappaB Function by Conditional Mutagenesis

Wednesday, February 27 | 5:00PM - 7:00PM
Workshop 1. NF-kappaB: Function in Whole Animals
Room: Quandry 1-3

Speaker 3 of 5
Tak W. Mak, Campbell Family Institute for Breast Cancer, Canada
Genetic Dissection of the NF-kappaB Pathways

Wednesday, February 27 | 5:00PM - 7:00PM
Workshop 1. NF-kappaB: Function in Whole Animals
Room: Quandry 1-3

Speaker 4 of 5
Inder M. Verma, The Salk Institute, USA
Regulation of NF-kappaB Functions

Wednesday, February 27 | 5:00PM - 7:00PM
Workshop 1. NF-kappaB: Function in Whole Animals
Room: Quandry 1-3

Speaker 5 of 5
Steve D. Gerondakis, Monash University, Australia
The Roles of Rel/NF-kappaB in Cell Growth and Embryonic Development

Wednesday, February 27 | 7:00PM - 8:00PM
Welcome Mixer
Room: Longs Peak


Wednesday, February 27 | 7:00PM - 9:00PM
Cash Bar
Room: Longs Peak


Wednesday, February 27 | 8:00PM - 10:00PM
Poster Session 2
Room: Longs Peak


Thursday, February 28 | 7:00AM - 8:00AM
Breakfast
Room: Longs Peak


Thursday, February 28 | 8:00AM - 11:00AM
NF-kappaB: Cell Growth and Cell Death
Room: Quandry 1-3

Speaker 1 of 6
* Michael Karin, University of California, San Diego, USA

Thursday, February 28 | 8:00AM - 11:00AM
NF-kappaB: Cell Growth and Cell Death
Room: Quandry 1-3

Speaker 2 of 6
Albert S. Baldwin Jr., University of North Carolina School of Medicine, USA
Roles for NF-kappaB in Controlling Cell Growth, Differentiation, and Cell Death


Thursday, February 28 | 8:00AM - 11:00AM
NF-kappaB: Cell Growth and Cell Death
Room: Quandry 1-3

Speaker 3 of 6
Shigeki Miyamoto, University of Wisconsin, Madison, USA
NF-kappaB Activation in Biological Responses to DNA Damage

Thursday, February 28 | 8:00AM - 11:00AM
NF-kappaB: Cell Growth and Cell Death
Room: Quandry 1-3

Speaker 4 of 6
Douglas R. Green, St. Jude Children's Research Hospital, USA
NF-kappaB and the Mitochondrial Regulation of Apoptosis

Thursday, February 28 | 8:00AM - 11:00AM
NF-kappaB: Cell Growth and Cell Death
Room: Quandry 1-3

Speaker 5 of 6
Shyamala Maheswaran, Massachusetts General Hospital, USA
Short Talk: Müllerian Inhibiting Substance Regulates NF-kappaB Signaling and Growth of Mammary Epithelial Cells

Thursday, February 28 | 8:00AM - 11:00AM
NF-kappaB: Cell Growth and Cell Death
Room: Quandry 1-3

Speaker 6 of 6
Mark S. Kindy, Medical University of South Carolina, USA
Short Talk: NF-kappaB and Cerebral Ischemic Injury

Thursday, February 28 | 9:20AM - 9:40AM
Coffee Break
Room: Quandry Peak Foyer


Thursday, February 28 | 11:00AM - 1:00PM
Poster Setup
Room: Longs Peak


Thursday, February 28 | 1:00PM - 10:00PM
Poster Viewing
Room: Longs Peak


Thursday, February 28 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Quandry Peak Foyer


Thursday, February 28 | 5:00PM - 7:00PM
Workshop 2. NF-kappaB in Viruses
Room: Quandry 1-3

Speaker 1 of 5
* Céline Gélinas, Center for Advanced Biotechnology and Medicine, USA

Thursday, February 28 | 5:00PM - 7:00PM
Workshop 2. NF-kappaB in Viruses
Room: Quandry 1-3

Speaker 2 of 5
Thomas D. Gilmore, Boston University, USA
Malignant Transformation of Cells by Rel Proteins

Thursday, February 28 | 5:00PM - 7:00PM
Workshop 2. NF-kappaB in Viruses
Room: Quandry 1-3

Speaker 3 of 5
Elliott D. Kieff, Harvard University, USA
NF-kappaB in Lymphocyte Transcription and Survival

Thursday, February 28 | 5:00PM - 7:00PM
Workshop 2. NF-kappaB in Viruses
Room: Quandry 1-3

Speaker 4 of 5
Claus Scheidereit, Max Delbrück Center for Molecular Medicine, Germany
NF-kappaB Activation in Tumorigenesis and Epidermal Organogenesis

Thursday, February 28 | 5:00PM - 7:00PM
Workshop 2. NF-kappaB in Viruses
Room: Quandry 1-3

Speaker 5 of 5
Amer A. Beg, Moffitt Cancer Center, USA
Short Talk: Regulation of Dendritic Cell Development and Survival by Distinct NF-kappaB Complexes

Thursday, February 28 | 7:00PM - 8:00PM
Welcome Mixer
Room: Longs Peak


Thursday, February 28 | 7:00PM - 9:00PM
Cash Bar
Room: Longs Peak


Thursday, February 28 | 8:00PM - 10:00PM
Poster Session 3
Room: Longs Peak


Friday, March 01 | 7:00AM - 8:00AM
Breakfast
Room: Longs Peak


Friday, March 01 | 8:00AM - 11:00AM
NF-kappaB and Immunology
Room: Quandry 1-3

Speaker 1 of 5
* Klaus Rajewsky, Max Delbrück Center for Molecular Medicine, Germany

Friday, March 01 | 8:00AM - 11:00AM
NF-kappaB and Immunology
Room: Quandry 1-3

Speaker 2 of 5
Gerald R. Crabtree, Stanford University, USA
NF-AT Signaling: Choreographing the Social Lives of Cells

Friday, March 01 | 8:00AM - 11:00AM
NF-kappaB and Immunology
Room: Quandry 1-3

Speaker 3 of 5
Anjana Rao, La Jolla Institute for Allergy and Immunology, USA
NFAT Transcription Factors: Siblings of NFkappaB/Rel Proteins

Friday, March 01 | 8:00AM - 11:00AM
NF-kappaB and Immunology
Room: Quandry 1-3

Speaker 4 of 5
Tadatsugu Taniguchi, University of Tokyo, Japan
Gene Regulation by NF-kappaB, IRFs and STATs: Immunity and Bone Remodeling

Friday, March 01 | 8:00AM - 11:00AM
NF-kappaB and Immunology
Room: Quandry 1-3

Speaker 5 of 5
Dan R. Littman, HHMI/New York University School of Medicine, USA
Dissection of TCR Signaling Pathways in T Cells

Friday, March 01 | 9:20AM - 9:40AM
Coffee Break
Room: Quandry Peak Foyer


Friday, March 01 | 11:00AM - 1:00PM
Poster Setup
Room: Longs Peak


Friday, March 01 | 1:00PM - 10:00PM
Poster Viewing
Room: Longs Peak


Friday, March 01 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Quandry Peak Foyer


Friday, March 01 | 5:00PM - 7:00PM
NF-kappaB: Model Organisms
Room: Quandry 1-3

Speaker 1 of 4
* Steve D. Gerondakis, Monash University, Australia

Friday, March 01 | 5:00PM - 7:00PM
NF-kappaB: Model Organisms
Room: Quandry 1-3

Speaker 2 of 4
Guy Haegeman, Ghent University, Belgium
Short Talk

Friday, March 01 | 5:00PM - 7:00PM
NF-kappaB: Model Organisms
Room: Quandry 1-3

Speaker 3 of 4
Dan Hultmark, Umea University, Sweden
Immune Responses in the Fruit Fly

Friday, March 01 | 5:00PM - 7:00PM
NF-kappaB: Model Organisms
Room: Quandry 1-3

Speaker 4 of 4
Ruth Steward, Rutgers University, USA
NF-kappaB/Rel Pathways in Drosophila

Friday, March 01 | 7:00PM - 8:00PM
Welcome Mixer
Room: Longs Peak


Friday, March 01 | 7:00PM - 9:00PM
Cash Bar
Room: Longs Peak


Friday, March 01 | 8:00PM - 10:00PM
Poster Session 4
Room: Longs Peak


Saturday, March 02 | 7:00AM - 8:00AM
Breakfast
Room: Longs Peak


Saturday, March 02 | 8:00AM - 11:00AM
NF-kappaB: To the Clinic I. Session Sponsored by Serono In
ternational S.A.

Room: Quandry 1-3

Speaker 1 of 7
* Albert S. Baldwin Jr., University of North Carolina School of Medicine, USA

Saturday, March 02 | 8:00AM - 11:00AM
NF-kappaB: To the Clinic I. Session Sponsored by Serono In
ternational S.A.

Room: Quandry 1-3

Speaker 2 of 7
Julian Adams, Vedantra Pharmaceuticals, Inc., USA
NF-kappaB Inhibition with the Proteasome Inhibitors PS-341

Saturday, March 02 | 8:00AM - 11:00AM
NF-kappaB: To the Clinic I. Session Sponsored by Serono In
ternational S.A.

Room: Quandry 1-3

Speaker 3 of 7
Bharat B. Aggarwal, University of Texas MD Anderson Cancer Center, USA
Transcription Factor NF-kappaB as Potential Target for Chemoprevention and Chemosensitization

Saturday, March 02 | 8:00AM - 11:00AM
NF-kappaB: To the Clinic I. Session Sponsored by Serono In
ternational S.A.

Room: Quandry 1-3

Speaker 4 of 7
James C. Cusack, Massachusetts General Hospital, USA
Short Talk: Ingibition of Nf-kappa B as an Adjuvant Approach for Chemotherapy

Saturday, March 02 | 8:00AM - 11:00AM
NF-kappaB: To the Clinic I. Session Sponsored by Serono In
ternational S.A.

Room: Quandry 1-3

Speaker 5 of 7
Carter Van Waes, NIDCD, National Institutes of Health, USA
Short Talk: Nf-kappaB and Proteasome Inhibition in Therapy of Head and Neck Squamos Cell Carcinoma

Saturday, March 02 | 8:00AM - 11:00AM
NF-kappaB: To the Clinic I. Session Sponsored by Serono In
ternational S.A.

Room: Quandry 1-3

Speaker 6 of 7
Xiao-Hong Sun, Oklahoma Medical Research Foundation, USA
Short Talk: Helix-Loop-Helix Proteins Regulate Pre-TCR and TCR Signaling Through Modulation of Rel/NF-kappaB Activities

Saturday, March 02 | 8:00AM - 11:00AM
NF-kappaB: To the Clinic I. Session Sponsored by Serono In
ternational S.A.

Room: Quandry 1-3

Speaker 7 of 7
Lin Chen, University of Southern California, USA
Short Talk: Structural Connections Between the NFAT and NF-kappaB Families of Transcription Factors

Saturday, March 02 | 9:20AM - 9:40AM
Coffee Break
Room: Quandry Peak Foyer


Saturday, March 02 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Quandry Peak Foyer


Saturday, March 02 | 5:00PM - 7:00PM
NF-kappaB: To the Clinic II
Room: Quandry 1-3

Speaker 1 of 4
* Inder M. Verma, The Salk Institute, USA

Saturday, March 02 | 5:00PM - 7:00PM
NF-kappaB: To the Clinic II
Room: Quandry 1-3

Speaker 2 of 4
Louis M. Staudt, NCI, National Institutes of Health, USA
Validation of NF-kappaB as a Molecular Target in Non-Hodgkin's Lymphoma

Saturday, March 02 | 5:00PM - 7:00PM
NF-kappaB: To the Clinic II
Room: Quandry 1-3

Speaker 3 of 4
Steven E. Shoelson, Harvard Medical School, Joslin Diabetes Center, USA
Relationships Between Inflammation, IKKb, and Insulin Resistance in Type 2 Diabetes

Saturday, March 02 | 5:00PM - 7:00PM
NF-kappaB: To the Clinic II
Room: Quandry 1-3

Speaker 4 of 4
Frank Mercurio, BioTheryX, Inc., USA
NF-kappaB: A Rich Source of Therapeutic Targets in Cancer and Inflammation

Saturday, March 02 | 7:00PM - 8:00PM
Welcome Mixer
Room: Longs Peak


Saturday, March 02 | 8:00PM - 11:00PM
Entertainment
Room: Longs Peak


Saturday, March 02 | 8:00PM - 11:00PM
Cash Bar
Room: Longs Peak


Sunday, March 03 | 10:21AM - 10:21AM
Departure


*Session Chair
†Invited, not yet responded.