Web Desc
DNA Helicases, Cancer and Aging
Organizer(s): Ian D. Hickson and Judith Campisi
Date: March 12 - 17, 2002
Location: Granlibakken Tahoe, Tahoe City, CA, USA
Summary of Meeting:
Cancer and aging are frequently considered distinct disorders, although both are associated with genomic instability and are phenotypic consequences of the interplay between genes and the environment. The totally unexpected finding that defects in DNA helicases are responsible for several cancer-prone and/or premature aging syndromes in humans, indicates a need to integrate studies of the basic biology of helicases with studies of cancer and longevity. This conference will provide a unique opportunity to bring together world leaders in aging and cancer biology, with experts on the structure and function of DNA helicases. Sessions will cover structural and functional characterization of DNA helicases from humans and model organisms, and their roles in cancer predisposition or premature aging disorders. By bringing together scientists from the fields of structural biology, biochemistry, cell and molecular biology, cancer and aging research, the conference will facilitate the application of fundamental studies in biology to improvements in human health.
Discounted Abstract Deadline: November 12 2001
Discounted Registration Deadline: January 11 2002
We gratefully acknowledge the generous grant for this conference provided by:

National Cancer Institute (NCI)
Grant No. 1 R13 CA94351-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Tuesday, March 12 | 4:00PM - 7:00PM
Registration
Room: Lobby


Tuesday, March 12 | 5:00PM - 6:00PM
Cocktail Social


Tuesday, March 12 | 7:15PM - 7:30PM
Orientation
Room: Granhall


Tuesday, March 12 | 7:30PM - 8:30PM
Keynote Address
Room: Granhall

Speaker 1 of 1
George M. Martin, University of Washington, USA
Classes of Gene Action that Escape the Force of Natural Selection and Thus Modulate Cancer and Senescence

Wednesday, March 13 | 7:00AM - 8:00AM
Breakfast
Room: Granhall


Wednesday, March 13 | 8:00AM - 11:00AM
DNA Helicases: Structure and Function I
Room: Mountain/Lake Room

Speaker 1 of 4
Dale B. Wigley, Institute of Cancer Research, UK
Relating Structure to Mechanism in Helicases

Wednesday, March 13 | 8:00AM - 11:00AM
DNA Helicases: Structure and Function I
Room: Mountain/Lake Room

Speaker 2 of 4
Timothy M. Lohman, Washington University School of Medicine, USA
DNA Unwinding by the E. coli SF-1 Helicases, Rep and UvrD

Wednesday, March 13 | 8:00AM - 11:00AM
DNA Helicases: Structure and Function I
Room: Mountain/Lake Room

Speaker 3 of 4
* Steven W. Matson, University of North Carolina at Chapel Hill, USA
Biochemical and Genetic Studies of DNA Helicases I and II from E. coli


Wednesday, March 13 | 8:00AM - 11:00AM
DNA Helicases: Structure and Function I
Room: Mountain/Lake Room

Speaker 4 of 4
Edward H. Egelman, University of Virginia, USA
Structural Analysis of Oligomeric Helicases Using Electron Microscopy

Wednesday, March 13 | 9:20AM - 9:40AM
Coffee Break
Room: Prefunction


Wednesday, March 13 | 11:00AM - 1:00PM
Poster Setup
Room: Lake


Wednesday, March 13 | 1:00PM - 10:00PM
Poster Viewing
Room: Lake


Wednesday, March 13 | 2:30PM - 4:30PM
Workshop 1
Room: Mountain/Lake Room

Speaker 1 of 7
* Dale B. Wigley, Institute of Cancer Research, UK

Wednesday, March 13 | 2:30PM - 4:30PM
Workshop 1
Room: Mountain/Lake Room

Speaker 2 of 7
Jennifer A. Cobb, University of Calgary, Canada
Evidence for Interaction Between Sgs1 and Rad53 in the S- Phase Checkpoint Response to HU

Wednesday, March 13 | 2:30PM - 4:30PM
Workshop 1
Room: Mountain/Lake Room

Speaker 3 of 7
Matthew R. Redinbo, University of North Carolina at Chapel Hill, USA
WRN Exonuclease Forms a Hexamer on DNA and Possesses Both 3'-5' Exonuclease and 5'-Protruding Strand Endonuclease Activities

Wednesday, March 13 | 2:30PM - 4:30PM
Workshop 1
Room: Mountain/Lake Room

Speaker 4 of 7
Moreshwar Bhanudas Vaze, Cequent Pharmaceuticals, USA
The SRS2 Helicase is Required for Cells to Recover from Checkpoint-Mediated Arrest that Precedes Repair of a Double-Strand Break

Wednesday, March 13 | 2:30PM - 4:30PM
Workshop 1
Room: Mountain/Lake Room

Speaker 5 of 7
Lars Eide, National Hospital of Norway, Norway
Characterization of a Novel DNA Glycosylase / AP Lyase Activity that Removes Premutagenic Lesions from Mouse Mitochondrial DNA

Wednesday, March 13 | 2:30PM - 4:30PM
Workshop 1
Room: Mountain/Lake Room

Speaker 6 of 7
Maria Spies, University of California, Davis, USA
Definition of the RecA Loading Domain of the RecBCD Helicase/Nuclease

Wednesday, March 13 | 2:30PM - 4:30PM
Workshop 1
Room: Mountain/Lake Room

Speaker 7 of 7
Zeynep Ayse Ozsoy, University of North Carolina at Chapel Hill, USA
Biochemical Characterization of Small and Large Isoforms of Drosophila RecQ5

Wednesday, March 13 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Promenade


Wednesday, March 13 | 5:00PM - 7:00PM
DNA Helicases: Structure and Function II
Room: Mountain/Lake Room

Speaker 1 of 3
Stephen C. West, Francis Crick Institute, UK
Strand Transfer and DNA Helicase Activities in the Recombinational Repair of DNA Breaks

Wednesday, March 13 | 5:00PM - 7:00PM
DNA Helicases: Structure and Function II
Room: Mountain/Lake Room

Speaker 2 of 3
* Kenneth J. Marians, Memorial Sloan Kettering Cancer Center, USA
DNA Helicases and Replication Fork Restart

Wednesday, March 13 | 5:00PM - 7:00PM
DNA Helicases: Structure and Function II
Room: Mountain/Lake Room

Speaker 3 of 3
Fyodor D. Urnov, University of California, Berkeley, USA
Mechanisms of Chromatin Remodeling

Wednesday, March 13 | 7:00PM - 8:00PM
Dinner
Room: Granhall


Wednesday, March 13 | 8:00PM - 10:00PM
Poster Session 1: DNA Helicases: Structure and Function
Room: Lake


Wednesday, March 13 | 8:00PM - 9:00PM
Welcome Mixer
Room: Lake


Thursday, March 14 | 7:00AM - 8:00AM
Breakfast
Room: Granhall


Thursday, March 14 | 8:00AM - 11:00AM
Biochemistry and Genetics of DNA Helicases I
Room: Mountain/Lake Room

Speaker 1 of 4
Philip C. Hanawalt, Stanford University, USA
Discovery of Rec Q: Role of the Rec Q Helicase in E. coli

Thursday, March 14 | 8:00AM - 11:00AM
Biochemistry and Genetics of DNA Helicases I
Room: Mountain/Lake Room

Speaker 2 of 4
Clare H. McGowan, The Scripps Research Institute, USA
Human Mus81 Associated Endonuclease Cleaves Holliday Junctions in vitro

Thursday, March 14 | 8:00AM - 11:00AM
Biochemistry and Genetics of DNA Helicases I
Room: Mountain/Lake Room

Speaker 3 of 4
Jean-Marc Egly, Institut de Genetique et de Biologie Moleculaire Cellulaire, France
Transcription Defects Associated with Xeroderma pigmentosum and Cockayne Syndromes

Thursday, March 14 | 8:00AM - 11:00AM
Biochemistry and Genetics of DNA Helicases I
Room: Mountain/Lake Room

Speaker 4 of 4
* Rodney J. Rothstein, Columbia University Medical Center, USA
Genetic Analysis of the Sgs1/Top3 Complex of Saccharomyces cerevisiae

Thursday, March 14 | 9:20AM - 9:40AM
Coffee Break
Room: Prefunction


Thursday, March 14 | 11:00AM - 1:00PM
Poster Setup
Room: Lake


Thursday, March 14 | 1:00PM - 10:00PM
Poster Viewing
Room: Lake


Thursday, March 14 | 2:30PM - 4:30PM
Workshop 2
Room: Mountain/Lake Room

Speaker 1 of 7
* Nathan A. Ellis, University of Illinois, Chicago, USA

Thursday, March 14 | 2:30PM - 4:30PM
Workshop 2
Room: Mountain/Lake Room

Speaker 2 of 7
Hong Yan, Fox Chase Cancer Center, USA
Distinct Roles of Werner Syndrome Protein and Bloom Syndrome Protein in DNA Replication and Double-strand Break Repair

Thursday, March 14 | 2:30PM - 4:30PM
Workshop 2
Room: Mountain/Lake Room

Speaker 3 of 7
Giordano Liberi, F.I.R.C. Institute of Molecular Oncology Foundation, Italy
DNA Replication Fork Progression and Processing in sgs1 snd srs2 Mutant Cells Experiencing Intra-S DNA Damage

Thursday, March 14 | 2:30PM - 4:30PM
Workshop 2
Room: Mountain/Lake Room

Speaker 4 of 7
Steven M. Yannone, Lawrence Berkeley National Laboratory, USA
Werner Syndrome Protein is Regulated and Phosphorylated by DNA-Dependent Protein Kinase

Thursday, March 14 | 2:30PM - 4:30PM
Workshop 2
Room: Mountain/Lake Room

Speaker 5 of 7
Sharon B. Cantor, University of Massachusetts Medical School, USA
BACH1, a DNA Helicase that Binds Directly to BRCA1

Thursday, March 14 | 2:30PM - 4:30PM
Workshop 2
Room: Mountain/Lake Room

Speaker 6 of 7
Feyruz V. Rassool, Rayne Institute, UK
Increased Constitutive Replication-Associated DNA Damage in Bloom's Syndrome (BS) is Associated with Increased Infidelity of Non Homologous End-Joining (NHEJ): Implication for Chromosomal Instability in BS?

Thursday, March 14 | 2:30PM - 4:30PM
Workshop 2
Room: Mountain/Lake Room

Speaker 7 of 7
Hyeon-Sook Koo, Yonsei University, South Korea
The Functions of RecQ Family DNA Helicases in Caenorhabditis elegans

Thursday, March 14 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Promenade


Thursday, March 14 | 5:00PM - 7:00PM
Biochemistry and Genetics of DNA Helicases II
Room: Mountain/Lake Room

Speaker 1 of 4
* Stephen C. Kowalczykowski, University of California, Davis, USA
Mechanism of RecQ Helicase and Topoisomerase III Function

Thursday, March 14 | 5:00PM - 7:00PM
Biochemistry and Genetics of DNA Helicases II
Room: Mountain/Lake Room

Speaker 2 of 4
Virginia A. Zakian, Princeton University, USA
The Pif1-Subfamily of DNA Helicases: Functional Consequences of Sequence Similarity?

Thursday, March 14 | 5:00PM - 7:00PM
Biochemistry and Genetics of DNA Helicases II
Room: Mountain/Lake Room

Speaker 3 of 4
James E. Haber, Brandeis University, USA
Role of S. cerevisiae Sgs1 and Srs2 in Recombination and Checkpoint Control

Thursday, March 14 | 5:00PM - 7:00PM
Biochemistry and Genetics of DNA Helicases II
Room: Mountain/Lake Room

Speaker 4 of 4
John Bradsher, National Cancer Institute, National Institutes of Health, USA
Short Talk: Novel Roles for 3 Helicases in RNA pol I Transcription

Thursday, March 14 | 7:00PM - 8:00PM
Dinner
Room: Granhall


Thursday, March 14 | 8:00PM - 10:00PM
Poster Session 2: Biochemistry and Genetics of DNA Helicases
Room: Lake


Thursday, March 14 | 8:00PM - 9:00PM
Welcome Mixer
Room: Lake


Thursday, March 14 | 9:00PM - 10:00PM
Cash Bar
Room: Alumni Room


Friday, March 15 | 7:00AM - 8:00AM
Breakfast
Room: Granhall


Friday, March 15 | 8:00AM - 11:00AM
Helicases and Cancer I
Room: Mountain/Lake Room

Speaker 1 of 4
Ian D. Hickson, University of Copenhagen, Denmark
Molecular Pathways to Genome Instability and Cancer: Analysis of the Bloom's Syndrome Helicase

Friday, March 15 | 8:00AM - 11:00AM
Helicases and Cancer I
Room: Mountain/Lake Room

Speaker 2 of 4
* Errol C. Friedberg, University of Texas Southwestern Medical Center, USA
Error-Prone DNA Polymerases, Mutagenesis and Cancer

Friday, March 15 | 8:00AM - 11:00AM
Helicases and Cancer I
Room: Mountain/Lake Room

Speaker 3 of 4
Wim Vermeulen, Erasmus University, Netherlands
DNA Repair and Transcription Defects in the Human Population

Friday, March 15 | 8:00AM - 11:00AM
Helicases and Cancer I
Room: Mountain/Lake Room

Speaker 4 of 4
Nathan A. Ellis, University of Illinois, Chicago, USA
Bloom's Syndrome: Genomic Instability, Nuclear Bodies, and the BLM Helicase

Friday, March 15 | 9:20AM - 9:40AM
Coffee Break
Room: Prefunction


Friday, March 15 | 11:00AM - 1:00PM
Poster Setup
Room: Lake


Friday, March 15 | 1:00PM - 10:00PM
Poster Viewing
Room: Lake


Friday, March 15 | 2:30PM - 4:30PM
Workshop 3
Room: Mountain/Lake Room

Speaker 1 of 6
* Edward J. Louis, University of Nottingham, UK

Friday, March 15 | 2:30PM - 4:30PM
Workshop 3
Room: Mountain/Lake Room

Speaker 2 of 6
Narendra Tuteja, International Center Genetic Engineering & Biotechnology, India
A Pea Homologue of Human DNA Helicase I is Upregulated by Phosphorylation and is Localised Within the Nucleolus

Friday, March 15 | 2:30PM - 4:30PM
Workshop 3
Room: Mountain/Lake Room

Speaker 3 of 6
Lucio Comai, University of Southern California, USA
The Werner Syndrome Protein and DNA Damage

Friday, March 15 | 2:30PM - 4:30PM
Workshop 3
Room: Mountain/Lake Room

Speaker 4 of 6
Brad Brad Johnson, University of Pennsylvania, USA
Testing the Function of the Werner and Bloom Syndrome Genes in Mice Lacking Telomerase

Friday, March 15 | 2:30PM - 4:30PM
Workshop 3
Room: Mountain/Lake Room

Speaker 5 of 6
Lisa L. Wang, Baylor College of Medicine, USA
Deleterious Mutations in RecQL4 are Associated with Osteosarcoma Risk in Rothmund-Thomson Syndrome

Friday, March 15 | 2:30PM - 4:30PM
Workshop 3
Room: Mountain/Lake Room

Speaker 6 of 6
Robert Michael Brosh Jr., NIA, National Institutes of Health, USA
Dual Functions of Werner Syndrome Protein as a DNA Helicase and Activator of Flap Endonuclease 1

Friday, March 15 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Promenade


Friday, March 15 | 5:00PM - 7:00PM
Helicases and Cancer II
Room: Mountain/Lake Room

Speaker 1 of 3
* Curtis C. Harris, NCI, National Institutes of Health, USA
p53-Mediated Apoptosis and Genomic Instability Syndromes

Friday, March 15 | 5:00PM - 7:00PM
Helicases and Cancer II
Room: Mountain/Lake Room

Speaker 2 of 3
Joanna L. Groden, Ohio State University, USA
Mouse Models for Studying Cancer Predisposition

Friday, March 15 | 5:00PM - 7:00PM
Helicases and Cancer II
Room: Mountain/Lake Room

Speaker 3 of 3
Hans Spelbrink, University of Tampere, Finland
Human Mitochondrial DNA Instability Caused By Mutations in Twinkle, a Helicase with Similarity to Phage T7 gp4

Friday, March 15 | 7:00PM - 8:00PM
Dinner
Room: Granhall


Friday, March 15 | 8:00PM - 10:00PM
Poster Session 3: Helicases and Cancer/Helicases and Aging
Room: Lake


Friday, March 15 | 8:00PM - 9:00PM
Welcome Mixer
Room: Lake


Friday, March 15 | 9:00PM - 10:00PM
Cash Bar
Room: Alumni Room


Saturday, March 16 | 7:00AM - 8:00AM
Breakfast
Room: Granhall


Saturday, March 16 | 8:00AM - 11:00AM
Helicases and Aging I
Room: Mountain/Lake Room

Speaker 1 of 4
Judith Campisi, Buck Institute for Research on Aging, USA
Mammalian RECQ-Like Helicases and Cellular Senescence

Saturday, March 16 | 8:00AM - 11:00AM
Helicases and Aging I
Room: Mountain/Lake Room

Speaker 2 of 4
Edward J. Louis, University of Nottingham, UK
Helicases, Telomere Maintenance and Genome Stability

Saturday, March 16 | 8:00AM - 11:00AM
Helicases and Aging I
Room: Mountain/Lake Room

Speaker 3 of 4
* Vilhelm A. Bohr, NIA, National Institutes of Health, USA
Werner Protein Function, Interactions and Pathways

Saturday, March 16 | 8:00AM - 11:00AM
Helicases and Aging I
Room: Mountain/Lake Room

Speaker 4 of 4
Junko Oshima, University of Washington, USA
Role of the WRN Gene in Maintenance of Genome Stability and Aging

Saturday, March 16 | 9:00AM - 12:00PM
Entertainment
Room: Granhall


Saturday, March 16 | 9:00AM - 12:00PM
Cash Bar
Room: Granhall


Saturday, March 16 | 9:20AM - 9:40AM
Coffee Break
Room: Prefunction


Saturday, March 16 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Prefunction


Saturday, March 16 | 5:00PM - 7:00PM
Helicases and Aging II
Room: Mountain/Lake Room

Speaker 1 of 3
* Raymond J. Monnat Jr., University of Washington, USA
Genome Instability and Cancer Pathogenesis in the Human RecQ Helicase Deficiencies

Saturday, March 16 | 5:00PM - 7:00PM
Helicases and Aging II
Room: Mountain/Lake Room

Speaker 2 of 3
Yasuhiro Furuichi, GeneCare Research Institute Co., Ltd., Japan
Upregulation of Human RecQ Helicases in Transformed and Cancer Cells

Saturday, March 16 | 5:00PM - 7:00PM
Helicases and Aging II
Room: Mountain/Lake Room

Speaker 3 of 3
Jan Vijg, Albert Einstein College of Medicine, USA
Genomic Instability in Mouse Models of Aging and Cancer

Saturday, March 16 | 7:00PM - 8:00PM
Welcome Mixer
Room: Granhall


Saturday, March 16 | 8:00PM - 9:00PM
Dinner
Room: Granhall


Sunday, March 17 | 7:00AM - 8:00AM
Breakfast
Room: Granhall


Sunday, March 17 | 10:26AM - 10:26AM
Departure


*Session Chair.