Molecular and Cellular Biology of Leukocyte Regulatory Receptors

Organizer(s): John R. Ortaldo and Lewis L. Lanier

Sponsored by DNAX Research, Inc. and The Director's Sponsor Fund

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Summary of Meeting:

The goal of this conference is to highlight progress in both molecular and cellular biology for a novel class of Leukocyte Regulatory Receptors (LRR) that are involved in positive and negative regulation of immune cell function. LRR contain either ITIM- or ITAM-sequences in the cytoplasmic domains and include membrane receptors of the Ig- and C-type lectin superfamily. Their expression is broad since family members are found on a variety of leukocytes (LAIR), including natural killer and T cells (KIR, Ly-49, CD94, gp49, NKG2), B (PIR) cells, mast cells (gp49, MAFA) and monocyte-macrophage-dendritic cells (ILT, LIR, PIR). This meeting will bring together leaders whose studies include expression, structure, signal transduction and biological functions of LRR, and their interactions with ligands, including tumor cells, viral and bacterial pathogens.

Discounted Abstract Deadline: November 16 2001

Discounted Registration Deadline: January 17 2002

We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1 R13 AI51933-01

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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

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