Web Desc
Mechanisms and Applications of Immune Tolerance
Organizer(s): Jeffrey A. Bluestone, Abul K. Abbas and Christopher C. Goodnow
Date: April 03 - 09, 2002
Location: Sheraton Steamboat Resort, Steamboat Springs, CO, USA
Sponsored by The Director's Sponsor Fund
Summary of Meeting:
The idea of reprogramming immune cells in a way that would eliminate pathogenic responses while preserving normal immune function is a concept that has tantalized immunologists for decades. Current immunotherapeutic drugs have met with a degree of clinical success, however, such therapies require lifelong usage and non-specifically suppress the entire immune system. Recent conceptual advances in our understanding of the mechanisms operative in the induction of tolerance and restoration of self-tolerance provide unprecedented insights into the development of new tolerogenic strategies. However, major challenges remain. What are the biochemical and molecular events that lead to tolerance? How do the central and peripheral mechanisms of tolerance interact? This meeting will bring together researchers to present recent breakthroughs in the study of the processes that regulate tolerance: clonal deletion; clonal inactivation; immune deviation and suppression. The topics will include: T and B cell receptor signaling; co-stimulation; accessory cell function; cell survival; and the intracellular signaling events that control immune tolerance. Finally, specific talks in immunotherapy of autoimmunity, transplantation, cancer and infectious disease will be included.
Discounted Abstract Deadline: December 3 2001
Discounted Registration Deadline: February 4 2002
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1 R13 AI51294-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Wednesday, April 03 | 4:00PM - 7:00PM
Registration
Room: Foyer


Wednesday, April 03 | 6:15PM - 7:15PM
Welcome
Room: Foyer


Wednesday, April 03 | 7:15PM - 7:30PM
Orientation
Room: Sunshine/Mt. Werner


Wednesday, April 03 | 7:30PM - 8:30PM
Keynote Address
Room: Sunshine/Mt. Werner

Speaker 1 of 1
Hugh O. McDevitt, Stanford University, USA
Tolerance and Autoimmunity

Thursday, April 04 | 7:00AM - 8:00AM
Breakfast
Room: 3 Saddles/Sevens


Thursday, April 04 | 8:00AM - 11:00AM
Central T Cell Tolerance
Room: Sunshine/Mt. Werner

Speaker 1 of 4
Jonathan Sprent, Garvan Institute, Australia
Requirements for Negative Selection of Thymocytes

Thursday, April 04 | 8:00AM - 11:00AM
Central T Cell Tolerance
Room: Sunshine/Mt. Werner

Speaker 2 of 4
Bruno A. Kyewski, German Cancer Research Center, Germany
'Promiscuous' Gene Expression and Immunological Self Tolerance: An Intricate Interface

Thursday, April 04 | 8:00AM - 11:00AM
Central T Cell Tolerance
Room: Sunshine/Mt. Werner

Speaker 3 of 4
Kristin A. Hogquist, University of Minnesota, USA
The Thymocyte Response to Self Peptide Ligands

Thursday, April 04 | 8:00AM - 11:00AM
Central T Cell Tolerance
Room: Sunshine/Mt. Werner

Speaker 4 of 4
* Ronald N. Germain, NIAID, National Institutes of Health, USA
Molecular Mechanisms Underlying Ligand-Selective Signaling in Immature and Mature T Cells

Thursday, April 04 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Thursday, April 04 | 11:00AM - 1:00PM
Poster Setup
Room: Storm Pk/Twilight/Rainbow


Thursday, April 04 | 1:00PM - 10:00PM
Poster Viewing
Room: Storm Pk/Twilight/Rainbow


Thursday, April 04 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Foyer


Thursday, April 04 | 5:00PM - 7:00PM
B Cell Tolerance - 1
Room: Sunshine/Mt. Werner

Speaker 1 of 3
Mark J. Shlomchik, University of Pittsburgh School of Medicine, USA
Loss of B Cell Tolerance in Systemic Autoimmunity

Thursday, April 04 | 5:00PM - 7:00PM
B Cell Tolerance - 1
Room: Sunshine/Mt. Werner

Speaker 2 of 3
* Anthony L. DeFranco, University of California, San Francisco, USA
Autoimmunity and B Cell Tolerance Defects in Lyn-Deficient Mice

Thursday, April 04 | 5:00PM - 7:00PM
B Cell Tolerance - 1
Room: Sunshine/Mt. Werner

Speaker 3 of 3
Richard A. Flavell, HHMI/Yale University School of Medicine, USA
Genetic Manipulation of Tolerance

Thursday, April 04 | 7:00PM - 8:00PM
Welcome Mixer
Room: Foyer


Thursday, April 04 | 7:00PM - 9:00PM
Cash Bar
Room: Foyer


Thursday, April 04 | 8:00PM - 10:00PM
Poster Session 1: Central T Cell Tolerance/B Cell Tolerance
- 1
Room: Storm Pk/Twilight/Rainbow


Friday, April 05 | 7:00AM - 8:00AM
Breakfast
Room: 3 Saddles/Sevens


Friday, April 05 | 8:00AM - 11:00AM
B Cell Tolerance - 2
Room: Sunshine/Mt. Werner

Speaker 1 of 4
Jan S. Erikson, Wistar Institute, USA
Regulation of Autoreactive B Cells in Healthy and Autoimmune Mice

Friday, April 05 | 8:00AM - 11:00AM
B Cell Tolerance - 2
Room: Sunshine/Mt. Werner

Speaker 2 of 4
Timothy W. Behrens, Genentech, Inc., USA
Regulation of Receptor Editing and Allelic Exclusion in Immature B Cells

Friday, April 05 | 8:00AM - 11:00AM
B Cell Tolerance - 2
Room: Sunshine/Mt. Werner

Speaker 3 of 4
* Christopher C. Goodnow, Garvan Institute of Medical Research, Australia
Failure to Censor Forbidden Clones of CD4 T Cells in Autoimmune Diabetes

Friday, April 05 | 8:00AM - 11:00AM
B Cell Tolerance - 2
Room: Sunshine/Mt. Werner

Speaker 4 of 4
Ann Marshak-Rothstein, University of Massachusetts Medical School, USA
Short Talk: Activation of Autoreactive B Cells by BCR/TLR Dual Engagement

Friday, April 05 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Friday, April 05 | 11:00AM - 1:00PM
Poster Setup
Room: Storm Pk/Twilight/Rainbow


Friday, April 05 | 1:00PM - 10:00PM
Poster Viewing
Room: Storm Pk/Twilight/Rainbow


Friday, April 05 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Foyer


Friday, April 05 | 5:00PM - 7:00PM
Anergy and Apoptosis in Peripheral T Cell Tolerance
Room: Sunshine/Mt. Werner

Speaker 1 of 3
* Abul K. Abbas, University of California, San Francisco, USA
Anergy and Apoptosis in Peripheral T Cell Tolerance

Friday, April 05 | 5:00PM - 7:00PM
Anergy and Apoptosis in Peripheral T Cell Tolerance
Room: Sunshine/Mt. Werner

Speaker 2 of 3
Andreas E. Strasser, Walter and Eliza Hall Institute of Medical Research, Australia
BH3-Only Members of the Bcl-2 Family Are Critical Inducers of Apoptosis and Preclude Autoimmunity

Friday, April 05 | 5:00PM - 7:00PM
Anergy and Apoptosis in Peripheral T Cell Tolerance
Room: Sunshine/Mt. Werner

Speaker 3 of 3
Luk Van Parijs, Massachusetts Institute of Technology, USA
Short Talk: Regulation of Regulatory T Cell Development and Function by IL-2

Friday, April 05 | 7:00PM - 8:00PM
Welcome Mixer
Room: Foyer


Friday, April 05 | 7:00PM - 9:00PM
Cash Bar
Room: Storm Peak


Friday, April 05 | 8:00PM - 10:00PM
Poster Session 2: B Cell Tolerance - 2/Anergy and Apoptosis
in Peripheral T Cell Tolerance
Room: Storm Pk/Twilight/Rainbow


Saturday, April 06 | 7:00AM - 8:00AM
Breakfast
Room: 3 Saddles/Sevens


Saturday, April 06 | 8:00AM - 11:00AM
Immune Suppression
Room: Sunshine/Mt. Werner

Speaker 1 of 5
Jean François Bach, American Autoimmune Related Diseases Association, Inc., USA
CD4+ Regulatory Cells

Saturday, April 06 | 8:00AM - 11:00AM
Immune Suppression
Room: Sunshine/Mt. Werner

Speaker 2 of 5
* Jeffrey A. Bluestone, University of California, San Francisco, USA
Regulation of Autoimmunity in Ongoing Responses

Saturday, April 06 | 8:00AM - 11:00AM
Immune Suppression
Room: Sunshine/Mt. Werner

Speaker 3 of 5
Ethan M. Shevach, NIAID, National Institutes of Health, USA
Control of Autoimmunity by Regulatory T Cells88

Saturday, April 06 | 8:00AM - 11:00AM
Immune Suppression
Room: Sunshine/Mt. Werner

Speaker 4 of 5
Fred J. Ramsdell, Parker Institute for Cancer Immunotherapy, USA
Short Talk: A Novel Transcription Factor Involved in CD4+25+ T Cell Function

Saturday, April 06 | 8:00AM - 11:00AM
Immune Suppression
Room: Sunshine/Mt. Werner

Speaker 5 of 5
Yang-Xin Fu, University of Texas Southwestern Medical Center, USA
Short Talk: The Regulation of T Cell Homeostasis and Autoimmunity by T Cell Derived LIGHT

Saturday, April 06 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Saturday, April 06 | 11:00AM - 1:00PM
Poster Setup
Room: Storm Pk/Twilight/Rainbow


Saturday, April 06 | 1:00PM - 10:00PM
Poster Viewing
Room: Storm Pk/Twilight/Rainbow


Saturday, April 06 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Foyer


Saturday, April 06 | 5:00PM - 7:00PM
APCs and Peripheral Activation vs. Tolerance
Room: Sunshine/Mt. Werner

Speaker 1 of 4
Marc K. Jenkins, University of Minnesota Medical School, USA
Mechanisms of CD4 T Cell Tolerance Induced by Peptide Antigen in the Absence of Inflammation

Saturday, April 06 | 5:00PM - 7:00PM
APCs and Peripheral Activation vs. Tolerance
Room: Sunshine/Mt. Werner

Speaker 2 of 4
Ralph M. Steinman, Rockefeller University, USA
Dendritic Cells and the Induction of Peripheral T Cell Tolerance

Saturday, April 06 | 5:00PM - 7:00PM
APCs and Peripheral Activation vs. Tolerance
Room: Sunshine/Mt. Werner

Speaker 3 of 4
* Linda A. Sherman, The Scripps Research Institute, USA
Life, Death, and the Pursuit of Immortality by CD8 T Lymphocytes.

Saturday, April 06 | 5:00PM - 7:00PM
APCs and Peripheral Activation vs. Tolerance
Room: Sunshine/Mt. Werner

Speaker 4 of 4
Gordon Freeman, Dana Farber Cancer Institute, USA
Short Talk: Blockade of PD-1 Ligands on Dendritic Cells and Tumors Enhances T Cell Activation and Cytokine Production

Saturday, April 06 | 7:00PM - 8:00PM
Welcome Mixer
Room: Foyer


Saturday, April 06 | 7:00PM - 9:00PM
Cash Bar
Room: Foyer


Saturday, April 06 | 8:00PM - 10:00PM
Poster Session 3: Immune Suppression/APCs and Peripheral Act
ivation vs. Tolerance
Room: Storm Pk/Twilight/Rainbow


Sunday, April 07 | 7:00AM - 8:00AM
Breakfast
Room: 3 Saddles/Sevens


Sunday, April 07 | 8:00AM - 11:00AM
Signaling in Activation vs. Tolerance. Session Sponsored in
part by SangStat

Room: Sunshine/Mt. Werner

Speaker 1 of 4
Arthur Weiss, University of California, San Francisco, USA
CD45 Turns T Cells On and Off

Sunday, April 07 | 8:00AM - 11:00AM
Signaling in Activation vs. Tolerance. Session Sponsored in
part by SangStat

Room: Sunshine/Mt. Werner

Speaker 2 of 4
* Ed Palmer, University of Basel Hospital, Switzerland
T Cell Receptor Regulation of T Cell Biology

Sunday, April 07 | 8:00AM - 11:00AM
Signaling in Activation vs. Tolerance. Session Sponsored in
part by SangStat

Room: Sunshine/Mt. Werner

Speaker 3 of 4
Daniel L. Mueller, University of Minnesota Medical School, USA
Transcriptional Regulation by B7 and CD28 Costimulatory Signals

Sunday, April 07 | 8:00AM - 11:00AM
Signaling in Activation vs. Tolerance. Session Sponsored in
part by SangStat

Room: Sunshine/Mt. Werner

Speaker 4 of 4
Michael L. Dustin, University of Oxford, UK
The Immunological Synapse

Sunday, April 07 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Sunday, April 07 | 11:00AM - 1:00PM
Poster Setup
Room: Storm Pk/Twilight/Rainbow


Sunday, April 07 | 1:00PM - 10:00PM
Poster Viewing
Room: Storm Pk/Twilight/Rainbow


Sunday, April 07 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Foyer


Sunday, April 07 | 5:00PM - 7:00PM
Tolerance in Cancer and Transplantation
Room: Sunshine/Mt. Werner

Speaker 1 of 4
James P. Allison, University of Texas MD Anderson Cancer Center, USA
More is Less: New Insights into The Mechanisms of Negative
Costimulation by CTLA-4 and its Manipulation in Tumor Immunotherapy


Sunday, April 07 | 5:00PM - 7:00PM
Tolerance in Cancer and Transplantation
Room: Sunshine/Mt. Werner

Speaker 2 of 4
Hyam I. Levitsky, Century Therapeutics, USA
Tumor Specific CD4+ T Cell Tolerance- Concomitant Immunity Revisited.


Sunday, April 07 | 5:00PM - 7:00PM
Tolerance in Cancer and Transplantation
Room: Sunshine/Mt. Werner

Speaker 3 of 4
* Laurence A. Turka, Rheos Medicines, USA
Clonal Size Restriction and Tolerance

Sunday, April 07 | 5:00PM - 7:00PM
Tolerance in Cancer and Transplantation
Room: Sunshine/Mt. Werner

Speaker 4 of 4
Kathryn J. Wood, University of Oxford, UK
Tolerance in Transplantation: Epitope Spreading and Immune Tolerance

Sunday, April 07 | 7:00PM - 8:00PM
Welcome Mixer
Room: Foyer


Sunday, April 07 | 7:00PM - 9:00PM
Cash Bar
Room: Foyer


Sunday, April 07 | 8:00PM - 10:00PM
Poster Session 4: Signaling in Activation vs. Tolerance/Tole
rance in Cancer and Transplantation/Tolerance in Infectious Disease and Autoimmunity/Therapeutic Approaches
Room: Storm Pk/Twilight/Rainbow


Monday, April 08 | 7:00AM - 8:00AM
Breakfast
Room: 3 Saddles/Sevens


Monday, April 08 | 8:00AM - 11:00AM
Tolerance in Infectious Disease and Autoimmunity
Room: Sunshine/Mt. Werner

Speaker 1 of 4
* Stephen D. Miller, Northwestern University Medical School, USA
Mechanisms of Intrinsic and Induced Regulation of Relapsing-Remitting Experimental Autoimmune Encephalomyelitis

Monday, April 08 | 8:00AM - 11:00AM
Tolerance in Infectious Disease and Autoimmunity
Room: Sunshine/Mt. Werner

Speaker 2 of 4
Matthias G. von Herrath, Novo Nordisk and La Jolla Institute for Allergy and Immunology, USA
Autoreactive CD4+ Cells, Bystander Suppression and Virus Infections

Monday, April 08 | 8:00AM - 11:00AM
Tolerance in Infectious Disease and Autoimmunity
Room: Sunshine/Mt. Werner

Speaker 3 of 4
Maria Grazia Roncarolo, Stanford University School of Medicine, USA
Critical Cytokines in the Generation and Function of T Regulatory Cells

Monday, April 08 | 8:00AM - 11:00AM
Tolerance in Infectious Disease and Autoimmunity
Room: Sunshine/Mt. Werner

Speaker 4 of 4
Nora E. Sarvetnick, University of Nebraska Medical Center, USA
Regulation of Autoimmunity

Monday, April 08 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Monday, April 08 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Foyer


Monday, April 08 | 5:00PM - 7:00PM
Therapeutic Approaches
Room: Sunshine/Mt. Werner

Speaker 1 of 3
* C. Garrison Fathman, Stanford University, USA
Adoptive Cellular Gene Therapy

Monday, April 08 | 5:00PM - 7:00PM
Therapeutic Approaches
Room: Sunshine/Mt. Werner

Speaker 2 of 3
Kevan C. Herold, Yale University, USA
Preservation of Insulin Production in Type 1 Diabetes with a FcR Non-Binding Anti-CD3 mAb (hOKT3gamma1(Ala-Ala))

Monday, April 08 | 5:00PM - 7:00PM
Therapeutic Approaches
Room: Sunshine/Mt. Werner

Speaker 3 of 3
Terry B. Strom, Beth Israel Deaconess Medical Center, USA
Harnessing Apoptosis to Promote Transplantation Tolerance

Monday, April 08 | 7:00PM - 8:00PM
Welcome Mixer
Room: Foyer


Monday, April 08 | 7:00PM - 11:00PM
Cash Bar
Room: Foyer


Monday, April 08 | 8:00PM - 11:00PM
Entertainment
Room: Sunshine/Mt. Werner


Tuesday, April 09 | 10:26AM - 10:26AM
Departure


*Session Chair.