Web Desc
Mitochondria and Pathogenesis
Organizer(s): John J. Lemasters and Anna-Liisa Nieminen
Date: April 06 - 11, 2002
Location: Copper Mountain Resort, Copper Mountain, Colorado, USA
Sponsored by MitoKor
For important information on the coronavirus, please click here
Summary of Meeting:
Current research is showing involvement of mitochondria in a variety of pathological situations. Inherited mitochondrial diseases show a unique maternal inheritance characterized by partial penetrance and heteroplasmy among the tissues. Mitochondrial DNA mutations may accumulate with age due to inadequate repair and turnover. In several instances of necrotic cell death caused by hypoxia/ischemia or chemical toxicity, opening of high conductance permeability transition pores in the mitochondrial inner membrane has been shown to lead to mitochondrial depolarization, release of ions, uncoupling of oxidative phosphorylation, permeation of solutes and, ultimately, cell killing. Onset of this mitochondrial permeability transition also activates the machinery for apoptosis. Release of cytochrome c after onset of the mitochondrial permeability transition activates proteases and endonucleases of the apoptotic program. The anti-apoptotic gene, Bcl-2, encodes a protein that localizes to mitochondria and prevents onset of the mitochondrial permeability transition. Inherited and acquired defects of the mitochondrial genome are linked to impaired mitochondrial energy production, increased mitochondrial free radical generation and cell death in aging, neurodegenerative diseases and maternally inherited mitochondrial disorders. These examples illustrate how mitochondrial dysfunction underlies a wide spectrum of disease. Understanding of the basic mechanisms underlying mitochondrial dysfunction can lead to a better understanding of pathophysiologic processes and new strategies for prevention and treatment. The purpose of this conference is to bring together leading researchers studying mitochondrial dysfunction in many different disease settings to share ideas and recent research findings.
Discounted Abstract Deadline: December 6 2001
Discounted Registration Deadline: February 6 2002
We gratefully acknowledge the generous grant for this conference provided by:

National Institution on Alcohol Abuse and Alcoholism (NIAAA)
Grant No. 1 R13 AA13453-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Saturday, April 06 | 4:00PM - 7:00PM
Registration
Room: Kokopelli's


Saturday, April 06 | 6:15PM - 7:15PM
Welcome
Room: Kokopelli's


Saturday, April 06 | 7:15PM - 7:30PM
Orientation
Room: Bighorn B


Saturday, April 06 | 7:30PM - 8:30PM
Keynote Address
Room: Bighorn B

Speaker 1 of 1
Paolo Bernardi, University of Padova Medical School, Italy
Mitochondria and Cell Death: A Pore Man's View

Sunday, April 07 | 7:00AM - 8:00AM
Breakfast
Room: Jack's


Sunday, April 07 | 8:00AM - 11:00AM
Mitochondrial DNA Turnover, Repair and Biogenesis
Room: Bighorn B

Speaker 1 of 7
* Phillip Nagley, Monash University, Australia

Sunday, April 07 | 8:00AM - 11:00AM
Mitochondrial DNA Turnover, Repair and Biogenesis
Room: Bighorn B

Speaker 2 of 7
Eric A. Shoubridge, McGill University, Canada
Nuclear Control of mtDNA Segregation

Sunday, April 07 | 8:00AM - 11:00AM
Mitochondrial DNA Turnover, Repair and Biogenesis
Room: Bighorn B

Speaker 3 of 7
Vilhelm A. Bohr, NIA, National Institutes of Health, USA
Mitochondrial DNA Repair

Sunday, April 07 | 8:00AM - 11:00AM
Mitochondrial DNA Turnover, Repair and Biogenesis
Room: Bighorn B

Speaker 4 of 7
Walter Neupert, Universität Muenchen, Germany
Protein Import into Mitochondria

Sunday, April 07 | 8:00AM - 11:00AM
Mitochondrial DNA Turnover, Repair and Biogenesis
Room: Bighorn B

Speaker 5 of 7
William Lewis, Emory University, USA
Mitochondrial Toxicity of Antiviral Agents

Sunday, April 07 | 8:00AM - 11:00AM
Mitochondrial DNA Turnover, Repair and Biogenesis
Room: Bighorn B

Speaker 6 of 7
Carl A. Pinkert, Auburn University, USA
Short Talk: Development of Transmitochondrial Mice Using Mitochondrial Injection and ES Cell Cybrid Technologies

Sunday, April 07 | 8:00AM - 11:00AM
Mitochondrial DNA Turnover, Repair and Biogenesis
Room: Bighorn B

Speaker 7 of 7
Keshav K. Singh, Johns Hopkins School of Medicine, USA
Short Talk: Genetics of DNA Repair in Yeast Mitochondria

Sunday, April 07 | 9:20AM - 9:40AM
Coffee Break
Room: Kokopelli's


Sunday, April 07 | 11:00AM - 1:00PM
Poster Setup
Room: Bighorn C


Sunday, April 07 | 1:00PM - 10:00PM
Poster Viewing
Room: Bighorn C


Sunday, April 07 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Kokopelli's


Sunday, April 07 | 5:00PM - 7:00PM
Inherited and Acquired Mitochondrial Mutations
Room: Bighorn B

Speaker 1 of 6
* Eric A. Shoubridge, McGill University, Canada

Sunday, April 07 | 5:00PM - 7:00PM
Inherited and Acquired Mitochondrial Mutations
Room: Bighorn B

Speaker 2 of 6
Neil Howell, Migenix, USA
Evolution and Divergence of the Human Mitochondrial Genome

Sunday, April 07 | 5:00PM - 7:00PM
Inherited and Acquired Mitochondrial Mutations
Room: Bighorn B

Speaker 3 of 6
Phillip Nagley, Monash University, Australia
Mitochondria in Aging, Cancer and Cell Death

Sunday, April 07 | 5:00PM - 7:00PM
Inherited and Acquired Mitochondrial Mutations
Room: Bighorn B

Speaker 4 of 6
William C. Copeland, NIEHS, National Institutes of Health, USA
Short Talk: DNA Mutations Produced by Mitochondrial DNA Replication

Sunday, April 07 | 5:00PM - 7:00PM
Inherited and Acquired Mitochondrial Mutations
Room: Bighorn B

Speaker 5 of 6
Siu Sylvia Sylvia Lee, Cornell University, USA
Short Talk: A Critical Role for Mitochondria in C. elegans Lifespan Regulation

Sunday, April 07 | 5:00PM - 7:00PM
Inherited and Acquired Mitochondrial Mutations
Room: Bighorn B

Speaker 6 of 6
Justin Lee Mott, Mayo Clinic College of Medicine, USA
Short Talk: The Mitochondrial Permeability Transition Pore may Initiate Disease Caused by MtDNA Mutations

Sunday, April 07 | 7:00PM - 8:00PM
Welcome Mixer
Room: Bighorn C/Kokopelli's


Sunday, April 07 | 7:00PM - 9:00PM
Cash Bar
Room: Bighorn C/Kokopelli's


Sunday, April 07 | 8:00PM - 10:00PM
Poster Session 1: Mitochondrial DNA Turnover, Repair, Biogen
esis and Mutations
Room: Bighorn C


Monday, April 08 | 7:00AM - 8:00AM
Breakfast
Room: Jack's


Monday, April 08 | 8:00AM - 11:00AM
Oxidative Stress
Room: Bighorn B

Speaker 1 of 7
* Donald A. Fox, University of Houston, USA

Monday, April 08 | 8:00AM - 11:00AM
Oxidative Stress
Room: Bighorn B

Speaker 2 of 7
Enrique Cadenas, University of Southern California, USA
Oxyradical Production by Mitochondria: Regulation by Nitric Oxide


Monday, April 08 | 8:00AM - 11:00AM
Oxidative Stress
Room: Bighorn B

Speaker 3 of 7
Simon Melov, Buck Institute for Research on Aging, USA
Mitochondrial Oxidative Stress and Neurodegeneration

Monday, April 08 | 8:00AM - 11:00AM
Oxidative Stress
Room: Bighorn B

Speaker 4 of 7
Jose C. Fernandez-Checa, Instituto Investigaciones Biomedicas Barcelona, CSIC, Spain
Mitochondria, Glutathione and Cell Death

Monday, April 08 | 8:00AM - 11:00AM
Oxidative Stress
Room: Bighorn B

Speaker 5 of 7
Sten Orrenius, Karolinska Institutet, Sweden
Role of Calcium and Oxidative Stress in Mitochondrial Regulation of Cell Death

Monday, April 08 | 8:00AM - 11:00AM
Oxidative Stress
Room: Bighorn B

Speaker 6 of 7
Guy C. Brown, University of Cambridge, UK
Short Talk: The Role of Mitochondria in Nitric Oxide-Induced Cell Death

Monday, April 08 | 8:00AM - 11:00AM
Oxidative Stress
Room: Bighorn B

Speaker 7 of 7
Giorgio Lenaz, University of Bologna, Italy
Short Talk: Factors Affecting Superoxide Radical Production by Complex 1 of the Mitochondrial Respiratory Chain

Monday, April 08 | 9:20AM - 9:40AM
Coffee Break
Room: Kokopelli's


Monday, April 08 | 11:00AM - 1:00PM
Poster Setup
Room: Bighorn C


Monday, April 08 | 1:00PM - 10:00PM
Poster Viewing
Room: Bighorn C


Monday, April 08 | 2:30PM - 4:30PM
Workshop 1: Mechanisms of Mitochondria Membrane Permeabiliza
tion
Room: Bighorn B

Speaker 1 of 6
* Paolo Bernardi, University of Padova Medical School, Italy

Monday, April 08 | 2:30PM - 4:30PM
Workshop 1: Mechanisms of Mitochondria Membrane Permeabiliza
tion
Room: Bighorn B

Speaker 2 of 6
Andrew P. Halestrap, University of Bristol, UK
Molecular Mechanisms and Pathophysiological Implications of the Permeability Transition Pore

Monday, April 08 | 2:30PM - 4:30PM
Workshop 1: Mechanisms of Mitochondria Membrane Permeabiliza
tion
Room: Bighorn B

Speaker 3 of 6
Kathleen W. Kinnally, New York University College of Dentistry, USA
Characterization of the Mitochondrial Apoptosis-induced Channel, MAC.

Monday, April 08 | 2:30PM - 4:30PM
Workshop 1: Mechanisms of Mitochondria Membrane Permeabiliza
tion
Room: Bighorn B

Speaker 4 of 6
Marco Colombini, University of Maryland, USA
Ceramide Channels in the Mitochondrial Outer Membrane are Conduits for Protein Flux

Monday, April 08 | 2:30PM - 4:30PM
Workshop 1: Mechanisms of Mitochondria Membrane Permeabiliza
tion
Room: Bighorn B

Speaker 5 of 6
Paul H. Schlesinger, Washington University School of Medicine, USA
Mechanism of Pore Formation by Bcl-2 Family Proteins in Phospholipid Bilayer Membranes

Monday, April 08 | 2:30PM - 4:30PM
Workshop 1: Mechanisms of Mitochondria Membrane Permeabiliza
tion
Room: Bighorn B

Speaker 6 of 6
Donald A. Fox, University of Houston, USA
Bcl-XL Overexpression Blocks Apoptosis and Contact Site Formation in Retinas of Lead-Exposed Mice

Monday, April 08 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Kokopelli's


Monday, April 08 | 5:00PM - 7:00PM
Imaging Mitochondrial Physiology and Pathophysiology in Livi
ng Cells

Room: Bighorn B

Speaker 1 of 5
* György Hajnóczky, Thomas Jefferson University, USA

Monday, April 08 | 5:00PM - 7:00PM
Imaging Mitochondrial Physiology and Pathophysiology in Livi
ng Cells

Room: Bighorn B

Speaker 2 of 5
Rosario Rizzuto, University of Padua, Italy
Mitochondrial Ca2+ Signalling: Molecular Determinants and Physiological Role

Monday, April 08 | 5:00PM - 7:00PM
Imaging Mitochondrial Physiology and Pathophysiology in Livi
ng Cells

Room: Bighorn B

Speaker 3 of 5
Francois Ichas, INSERM, European Institute of Chemistry and Biology, France
Regulation of the Permeability Transition Pore in situ

Monday, April 08 | 5:00PM - 7:00PM
Imaging Mitochondrial Physiology and Pathophysiology in Livi
ng Cells

Room: Bighorn B

Speaker 4 of 5
John J. Lemasters, Medical University of South Carolina, USA
Mitochondrial Inner Membrane Permeabilization in Cell Life and Death


Monday, April 08 | 5:00PM - 7:00PM
Imaging Mitochondrial Physiology and Pathophysiology in Livi
ng Cells

Room: Bighorn B

Speaker 5 of 5
Shana Katzman, Marine Biological Laboratory, USA
Short Talk: Monitoring Mitochondrial Membrane Potential Reveals a Distinguished Functional Architecture in Intact Langerhans Islets of Psammomys obesus: A Rodent Model for Type II Diabetes

Monday, April 08 | 7:00PM - 8:00PM
Welcome Mixer
Room: Bighorn C/Kokopelli's


Monday, April 08 | 7:00PM - 9:00PM
Cash Bar
Room: Bighorn C/Kokopelli's


Monday, April 08 | 8:00PM - 10:00PM
Poster Session 2: Oxidative Stress and Pathophysiology
Room: Bighorn C


Tuesday, April 09 | 7:00AM - 8:00AM
Breakfast
Room: Jack's


Tuesday, April 09 | 8:00AM - 11:00AM
Mitochondrial Permeabilization in Apoptosis
Room: Bighorn B

Speaker 1 of 7
* John J. Lemasters, Medical University of South Carolina, USA

Tuesday, April 09 | 8:00AM - 11:00AM
Mitochondrial Permeabilization in Apoptosis
Room: Bighorn B

Speaker 2 of 7
Stanley J. Korsmeyer, Harvard University, USA
The Mitochondrial Gateway to Apoptosis

Tuesday, April 09 | 8:00AM - 11:00AM
Mitochondrial Permeabilization in Apoptosis
Room: Bighorn B

Speaker 3 of 7
Douglas R. Green, St. Jude Children's Research Hospital, USA
Cytochrome c Release during Apoptosis

Tuesday, April 09 | 8:00AM - 11:00AM
Mitochondrial Permeabilization in Apoptosis
Room: Bighorn B

Speaker 4 of 7
Richard J. Youle, NINDS, National Institutes of Health, USA
Consequences of Bax Translocation to Mitochondria

Tuesday, April 09 | 8:00AM - 11:00AM
Mitochondrial Permeabilization in Apoptosis
Room: Bighorn B

Speaker 5 of 7
Guido Kroemer, Cordeliers Research Center, France
Mechanisms of Mitochondrial Membrane Permeabilization during Apoptosis

Tuesday, April 09 | 8:00AM - 11:00AM
Mitochondrial Permeabilization in Apoptosis
Room: Bighorn B

Speaker 6 of 7
Anne Chomyn, California Institute of Technology, USA
Short Talk: Early Decrease in Respiration, Independent of Cytochrome c Release, in Apoptotic 143B Osteosarcoma Cells

Tuesday, April 09 | 8:00AM - 11:00AM
Mitochondrial Permeabilization in Apoptosis
Room: Bighorn B

Speaker 7 of 7
Anatoly A. Starkov, University of Maryland, USA
Short Talk: Bax-Mediated Cytochrome C Release From Brain Mitochondria Stimulates Production of Reactive Oxygen Species

Tuesday, April 09 | 9:20AM - 9:40AM
Coffee Break
Room: Kokopelli's


Tuesday, April 09 | 11:00AM - 1:00PM
Poster Setup
Room: Bighorn C


Tuesday, April 09 | 1:00PM - 10:00PM
Poster Viewing
Room: Bighorn C


Tuesday, April 09 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Kokopelli's


Tuesday, April 09 | 5:00PM - 7:00PM
Mitochondrial Regulation of Cell Signaling and Cytotoxicity
Room: Bighorn B

Speaker 1 of 5
* David G. Nicholls, Sweden

Tuesday, April 09 | 5:00PM - 7:00PM
Mitochondrial Regulation of Cell Signaling and Cytotoxicity
Room: Bighorn B

Speaker 2 of 5
Pierre Maechler, University of Geneva Medical Center, Switzerland
Mitochondrial Signals in Metabolism Secretion Coupling in the Pancreatic Beta Cell

Tuesday, April 09 | 5:00PM - 7:00PM
Mitochondrial Regulation of Cell Signaling and Cytotoxicity
Room: Bighorn B

Speaker 3 of 5
Anna-Liisa Nieminen, Case Western Reserve University, USA
Mitochondria in Apoptosis Induced by Photodynamic and Hypoxic Stress

Tuesday, April 09 | 5:00PM - 7:00PM
Mitochondrial Regulation of Cell Signaling and Cytotoxicity
Room: Bighorn B

Speaker 4 of 5
Jan B. Hoek, Thomas Jefferson University, USA
Mitochondrial Dysfunction and Alcoholic Liver Damage

Tuesday, April 09 | 5:00PM - 7:00PM
Mitochondrial Regulation of Cell Signaling and Cytotoxicity
Room: Bighorn B

Speaker 5 of 5
Frederic Bouillaud, Centre National de la Recherche Scientifique, France
Short Talk: Uncoupling Protein 2(UCP2): Translational Control of Expression, and Studies with Mitochondria of Ucp2 Knock-Out Mice

Tuesday, April 09 | 7:00PM - 8:00PM
Welcome Mixer
Room: Bighorn C/Kokopelli's


Tuesday, April 09 | 7:00PM - 9:00PM
Cash Bar
Room: Bighorn C/Kokopelli's


Tuesday, April 09 | 8:00PM - 10:00PM
Poster Session 3: Mitochondria in Apoptosis, Neurodegenerati
on and Ischemia/Reperfusion
Room: Bighorn C


Wednesday, April 10 | 7:00AM - 8:00AM
Breakfast
Room: Jack's


Wednesday, April 10 | 8:00AM - 11:00AM
Mitochondria in Acute and Chronic Neurodegeneration
Room: Bighorn B

Speaker 1 of 7
* Simon Melov, Buck Institute for Research on Aging, USA

Wednesday, April 10 | 8:00AM - 11:00AM
Mitochondria in Acute and Chronic Neurodegeneration
Room: Bighorn B

Speaker 2 of 7
David G. Nicholls, Sweden
Mitochondrial Control of Glutamate Excitotoxicity

Wednesday, April 10 | 8:00AM - 11:00AM
Mitochondria in Acute and Chronic Neurodegeneration
Room: Bighorn B

Speaker 3 of 7
M. Flint Beal, Weill Medical College of Cornell University, USA
Bioenergetics in Neurodegenerative Diseases

Wednesday, April 10 | 8:00AM - 11:00AM
Mitochondria in Acute and Chronic Neurodegeneration
Room: Bighorn B

Speaker 4 of 7
Eric A. Schon, Columbia University, USA
Mitochondrial Deficiencies and Mutations in Human Disease

Wednesday, April 10 | 8:00AM - 11:00AM
Mitochondria in Acute and Chronic Neurodegeneration
Room: Bighorn B

Speaker 5 of 7
Mohanish Deshmukh, University of North Carolina at Chapel Hill, USA
Development of Competence for Cytochrome c Mediated Apoptosis in Sympathetic Neurons

Wednesday, April 10 | 8:00AM - 11:00AM
Mitochondria in Acute and Chronic Neurodegeneration
Room: Bighorn B

Speaker 6 of 7
Alexander V. Panov, Emory University School of Medicine, USA
Short Talk: Early Mitochondrial Calcium Defects in Huntington's Disease Transgenic Mice

Wednesday, April 10 | 8:00AM - 11:00AM
Mitochondria in Acute and Chronic Neurodegeneration
Room: Bighorn B

Speaker 7 of 7
Zhenhai Yao, University of North Carolina at Chapel Hill, USA
Short Talk: Role of Mitochondria and Nitric Oxide in Signaling Opioid Preconditioning

Wednesday, April 10 | 9:20AM - 9:40AM
Coffee Break
Room: Kokopelli's


Wednesday, April 10 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Kokopelli's


Wednesday, April 10 | 5:00PM - 6:45PM
Ischemia/Reperfusion and Preconditioning
Room: Bighorn B

Speaker 1 of 4
* Andrew P. Halestrap, University of Bristol, UK

Wednesday, April 10 | 5:00PM - 6:45PM
Ischemia/Reperfusion and Preconditioning
Room: Bighorn B

Speaker 2 of 4
Tadeusz W. Wieloch, Lund University, Sweden
Mitochondrial Involvement in Acute Neurodegeneration and Preconditioning

Wednesday, April 10 | 5:00PM - 6:45PM
Ischemia/Reperfusion and Preconditioning
Room: Bighorn B

Speaker 3 of 4
Eduardo Marban, Cedars-Sinai Medical Center, USA
Role of Mitochondria in Ischemic Preconditioning

Wednesday, April 10 | 5:00PM - 6:45PM
Ischemia/Reperfusion and Preconditioning
Room: Bighorn B

Speaker 4 of 4
György Hajnóczky, Thomas Jefferson University, USA
Mitochondrial Calcium Signaling and Cardiac Apoptosis

Wednesday, April 10 | 6:45PM - 7:00PM
Closing Remarks
Room: Bighorn B


Wednesday, April 10 | 7:00PM - 8:00PM
Welcome Mixer
Room: Bighorn C/Kokopelli's


Wednesday, April 10 | 7:00PM - 11:00PM
Cash Bar
Room: Bighorn C/Kokopelli's


Wednesday, April 10 | 8:00PM - 11:00PM
Entertainment
Room: Bighorn C


Thursday, April 11 | 10:21AM - 10:21AM
Departure


*Session Chair
†Invited, not yet responded.