Web Desc
Malaria's Challenge: From Infants to Genomics to Vaccines
joint with Drugs Against Tropical Protozoan Parasites: Target Selection, Structural Biology, and Rational Medicinal Chemistry
Organizer(s): Stephen L. Hoffman and Carole A. Long
Date: March 03 - 08, 2002
Location: Keystone Resort, Keystone, CO, USA
For important information on the coronavirus, please click here
Summary of Meeting:
The malaria and human genome projects, and recent advances in epidemiology, immunology, and vaccinology provide unique opportunities for developing methods to control malaria, a disease that kills more children annually, and has influenced the human genome more than any other infectious disease. Despite a century of research, the 2 major drugs for severe malaria were introduced by ancient Chinese (artemesinin) and Amerindian (quinine) healers, and no subunit vaccine has ever been produced against a complex, multi-stage, variant parasite like P. falciparum. The goal of this meeting is for scientists to examine host-parasite interactions in model systems and in endemic areas that provide the foundation for malaria vaccine development; review recent results from clinical trials of malaria vaccines; and discuss how these data and that from the malaria and human genome projects, computational biology, quantitative epidemiology, molecular immunology; and new vaccine technologies are being used to develop vaccines to control this ancient scourge.
Discounted Abstract Deadline: November 16 2001
Discounted Registration Deadline: January 3 2002
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

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Program

Sunday, March 03 | 4:00PM - 7:00PM
Registration
Room: Shavano Peak Foyer


Sunday, March 03 | 6:15PM - 7:15PM
Welcome
Room: Shavano Peak Foyer


Sunday, March 03 | 7:15PM - 7:30PM
Orientation
Room: Torreys Peak 1-2


Sunday, March 03 | 7:30PM - 8:30PM
Keynote Address
Room: Torreys Peak 1-2

Speaker 1 of 1
Jeff Sachs, Earth Institute at Columbia University, USA
The Economics of a Malaria Vaccine: Costs, Benefits and Incentives

Monday, March 04 | 7:00AM - 8:00AM
Breakfast
Room: Red Cloud


Monday, March 04 | 8:00AM - 11:00AM
Defining the Malaria Problem and the Human Models Indicating
Developing Vaccines is Feasible

Room: Torreys Peak1-2

Speaker 1 of 5
* Louis H. Miller, National Institutes of Health, USA

Monday, March 04 | 8:00AM - 11:00AM
Defining the Malaria Problem and the Human Models Indicating
Developing Vaccines is Feasible

Room: Torreys Peak1-2

Speaker 2 of 5
Kevin Marsh, University of Oxford, Kenya
Malaria Vaccination: What are We Trying to Prevent?

Monday, March 04 | 8:00AM - 11:00AM
Defining the Malaria Problem and the Human Models Indicating
Developing Vaccines is Feasible

Room: Torreys Peak1-2

Speaker 3 of 5
Stephen L. Hoffman, Sanaria, USA
Induction of Protection Against Malaria in Naïve Humans by Experimental Exposure to Whole Parasites


Monday, March 04 | 8:00AM - 11:00AM
Defining the Malaria Problem and the Human Models Indicating
Developing Vaccines is Feasible

Room: Torreys Peak1-2

Speaker 4 of 5
Andrew G. Clark, Cornell University, USA
The Role of Population Biology and Genetics in Developing Strategies for Malaria Vaccine Development

Monday, March 04 | 8:00AM - 11:00AM
Defining the Malaria Problem and the Human Models Indicating
Developing Vaccines is Feasible

Room: Torreys Peak1-2

Speaker 5 of 5
Andrew Read, Pennsylvania State University, USA
Imperfect Vaccines and the Evolution of Virulence

Monday, March 04 | 8:00AM - 11:00AM
Impact of Parasite Genomics on Drug Target Selection. Spons
ored by The Burroughs Wellcome Fund.
This session is from Drugs Against Tropical Protozo

Room: Torreys Peak 3-4

Speaker 1 of 6
* Peter J. Myler, Seattle Biomedical Research Institute, USA
Kinetoplast Genome Projects


Monday, March 04 | 8:00AM - 11:00AM
Impact of Parasite Genomics on Drug Target Selection. Spons
ored by The Burroughs Wellcome Fund.
This session is from Drugs Against Tropical Protozo

Room: Torreys Peak 3-4

Speaker 2 of 6
Daniel J. Carucci, Foundation for the National Institutes of Health, USA
Exploring the Malaria Genome for Targets of Vaccines and Drugs


Monday, March 04 | 8:00AM - 11:00AM
Impact of Parasite Genomics on Drug Target Selection. Spons
ored by The Burroughs Wellcome Fund.
This session is from Drugs Against Tropical Protozo

Room: Torreys Peak 3-4

Speaker 3 of 6
Terry Gaasterland, University of California, San Diego, USA
Computational Analysis of the Trypanosoma brucei Genome


Monday, March 04 | 8:00AM - 11:00AM
Impact of Parasite Genomics on Drug Target Selection. Spons
ored by The Burroughs Wellcome Fund.
This session is from Drugs Against Tropical Protozo

Room: Torreys Peak 3-4

Speaker 4 of 6
Stephen M. Beverley, Washington University School of Medicine, USA
Molecular Approaches to Trypanosomatid Pteridine Metabolic Pathways and Their Role(s) in Virulence and Chemotherapy


Monday, March 04 | 8:00AM - 11:00AM
Impact of Parasite Genomics on Drug Target Selection. Spons
ored by The Burroughs Wellcome Fund.
This session is from Drugs Against Tropical Protozo

Room: Torreys Peak 3-4

Speaker 5 of 6
Sebastian Ulbert, Netherlands Cancer Institute, Netherlands
Short Talk: The Significance of Base J in the DNA of Trypanosoma brucei for the Base Excision Repair


Monday, March 04 | 8:00AM - 11:00AM
Impact of Parasite Genomics on Drug Target Selection. Spons
ored by The Burroughs Wellcome Fund.
This session is from Drugs Against Tropical Protozo

Room: Torreys Peak 3-4

Speaker 6 of 6
Christian Doerig, Monash University, Australia
Short Talk: A Chemical Genetics Approach for Functional Studies and Target Validation of Plasmodium Protein Kinases


Monday, March 04 | 9:20AM - 9:40AM
Coffee Break
Room: Shavano Peak Foyer


Monday, March 04 | 11:00AM - 1:00PM
Poster Setup
Room: Shavano Peak


Monday, March 04 | 1:00PM - 10:00PM
Poster Viewing
Room: Shavano Peak


Monday, March 04 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Shavano Peak Foyer


Monday, March 04 | 5:00PM - 7:00PM
Genes, Genomics and Malaria. Session Sponsored by The Burro
ughs Wellcome Fund

Room: Torreys Peak 1-2

Speaker 1 of 4
* Victor Nussenzweig, New York University, USA

Monday, March 04 | 5:00PM - 7:00PM
Genes, Genomics and Malaria. Session Sponsored by The Burro
ughs Wellcome Fund

Room: Torreys Peak 1-2

Speaker 2 of 4
Louis H. Miller, National Institutes of Health, USA
Genes Involved in Susceptibility to Malaria

Monday, March 04 | 5:00PM - 7:00PM
Genes, Genomics and Malaria. Session Sponsored by The Burro
ughs Wellcome Fund

Room: Torreys Peak 1-2

Speaker 3 of 4
Ross L. Coppel, Monash University, Australia
How is the Malaria Genome Facilitating Studies on Malaria?

Monday, March 04 | 5:00PM - 7:00PM
Genes, Genomics and Malaria. Session Sponsored by The Burro
ughs Wellcome Fund

Room: Torreys Peak 1-2

Speaker 4 of 4
Mani Subramanian, Celera Genomics, USA
The Potential Impact of the Human Genome Project on Malaria and Other Infectious Diseases

Monday, March 04 | 5:00PM - 7:00PM
Target Selection and Drug Development-I
This session is from Drugs Against Tropical Protozo
Room: Torreys Peak 3-4

Speaker 1 of 4
* Daniel E. Goldberg, Washington University, USA
The Biochemistry of Hemoglobin Digestion in P. falciparum


Monday, March 04 | 5:00PM - 7:00PM
Target Selection and Drug Development-I
This session is from Drugs Against Tropical Protozo
Room: Torreys Peak 3-4

Speaker 2 of 4
Gary H. Posner, Johns Hopkins University, USA
Mechanism-Based Rational Design of New Antimalarial Peroxides


Monday, March 04 | 5:00PM - 7:00PM
Target Selection and Drug Development-I
This session is from Drugs Against Tropical Protozo
Room: Torreys Peak 3-4

Speaker 3 of 4
James H. McKerrow, University of California, San Diego, USA
Inhibitors of Thiol Proteases for Treating Chagas Disease


Monday, March 04 | 5:00PM - 7:00PM
Target Selection and Drug Development-I
This session is from Drugs Against Tropical Protozo
Room: Torreys Peak 3-4

Speaker 4 of 4
Akhil B. Vaidya, Drexel University College of Medicine, USA
Selective Interference with Parasite Mitochondrial Functions


Monday, March 04 | 7:00PM - 8:00PM
Welcome Mixer
Room: Shavano Peak


Monday, March 04 | 7:00PM - 9:00PM
Cash Bar
Room: Shavano Peak


Monday, March 04 | 8:00PM - 10:00PM
Poster Session 1: Defining the Malaria Problem and the Human
Models Indicating Developing Vaccines is Feasible; Genes, Genomics, and Malaria
Room: Shavano Peak


Tuesday, March 05 | 7:00AM - 8:00AM
Breakfast
Room: Red Cloud


Tuesday, March 05 | 8:00AM - 11:00AM
Immunological Mechanisms of Protective Immunity
Room: Torreys Peak 1-2

Speaker 1 of 5
* † Martha Sedegah, Naval Medical Research Center, USA

Tuesday, March 05 | 8:00AM - 11:00AM
Immunological Mechanisms of Protective Immunity
Room: Torreys Peak 1-2

Speaker 2 of 5
Eleanor M. Riley, Roslin Institute, UK
Regulation of Innate and Adaptive Immunity to Malaria in Humans

Tuesday, March 05 | 8:00AM - 11:00AM
Immunological Mechanisms of Protective Immunity
Room: Torreys Peak 1-2

Speaker 3 of 5
Denise L. Doolan, James Cook University, Australia
Immunological Mechanisms of Protective Immunity Induced by Radiation Attenuated Sporozoites

Tuesday, March 05 | 8:00AM - 11:00AM
Immunological Mechanisms of Protective Immunity
Room: Torreys Peak 1-2

Speaker 4 of 5
Allan J. Saul, National Institutes Of Health, USA
Nature and Immunologic Mechanisms of Protective Immunity Against Mosquito Stage Parasites

Tuesday, March 05 | 8:00AM - 11:00AM
Immunological Mechanisms of Protective Immunity
Room: Torreys Peak 1-2

Speaker 5 of 5
Michael F. Good, Griffith University, Australia
Short Talk: Induction of Malaria Cell Mediated Immunity and Target Antigen Identification

Tuesday, March 05 | 8:00AM - 11:00AM
Structure-Based Drug Design
This session is from Drugs Against Tropical Protozo
Room: Torreys Peak 3-4

Speaker 1 of 6
* Gerhard Klebe, Philipps University Marburg, Germany
New Leads from De Novo Design and Virtual Screening for the Treatment of Shigellosis and Malaria


Tuesday, March 05 | 8:00AM - 11:00AM
Structure-Based Drug Design
This session is from Drugs Against Tropical Protozo
Room: Torreys Peak 3-4

Speaker 2 of 6
William T. Windsor, Schering-Plough Research Institute, USA
Structure Based Design of Protein Farnesyltransferase Inhibitors


Tuesday, March 05 | 8:00AM - 11:00AM
Structure-Based Drug Design
This session is from Drugs Against Tropical Protozo
Room: Torreys Peak 3-4

Speaker 3 of 6
William N. Hunter, University of Dundee, UK
X-ray Studies of Trypanothione Reductase; The Discovery of Novel Inhibitors


Tuesday, March 05 | 8:00AM - 11:00AM
Structure-Based Drug Design
This session is from Drugs Against Tropical Protozo
Room: Torreys Peak 3-4

Speaker 4 of 6
Timothy A.J. Haystead, Duke University, USA
Discovery of a New Antimilarial Target in the Human Purine Binding Proteome


Tuesday, March 05 | 8:00AM - 11:00AM
Structure-Based Drug Design
This session is from Drugs Against Tropical Protozo
Room: Torreys Peak 3-4

Speaker 5 of 6
Vern L. Schramm, Albert Einstein College of Medicine, USA
Short Talk: Inhibition of PNP by Immucillins Induces Purine-Less Death of Plasmodium falciparum in Cultured Erythrocytes


Tuesday, March 05 | 8:00AM - 11:00AM
Structure-Based Drug Design
This session is from Drugs Against Tropical Protozo
Room: Torreys Peak 3-4

Speaker 6 of 6
Meg Phillips, University of Texas Southwestern Medical Center, USA
Short Talk: Interactions in the Dimer Interface of Trypanosoma brucei Ornithine Decarboxylase: Implications for Drug Design


Tuesday, March 05 | 9:20AM - 9:40AM
Coffee Break
Room: Shavano Peak Foyer


Tuesday, March 05 | 11:00AM - 1:00PM
Poster Setup
Room: Shavano Peak


Tuesday, March 05 | 1:00PM - 10:00PM
Poster Viewing
Room: Shavano Peak


Tuesday, March 05 | 2:30PM - 4:30PM
Open Discussion: Are We Missing Something? Why is it Taking
So Long to Develop Effective Malaria Vaccines?
Room: Torreys Peak 1-2


Tuesday, March 05 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Shavano Peak Foyer


Tuesday, March 05 | 5:00PM - 7:00PM
Identifying the Antigenic Targets (Proteins and Epitopes) of
Protective Immune Responses. Session Sponsored by Science Applications International Corp. (SAIC)

Room: Torreys Peak 1-2

Speaker 1 of 5
* † Robin Fredric Anders, La Trobe University, Australia

Tuesday, March 05 | 5:00PM - 7:00PM
Identifying the Antigenic Targets (Proteins and Epitopes) of
Protective Immune Responses. Session Sponsored by Science Applications International Corp. (SAIC)

Room: Torreys Peak 1-2

Speaker 2 of 5
Anthony A. Holder, Medical Research Council, UK
Antibodies to Merozoite Surface Proteins and Inhibition of Erythrocyte Invasion

Tuesday, March 05 | 5:00PM - 7:00PM
Identifying the Antigenic Targets (Proteins and Epitopes) of
Protective Immune Responses. Session Sponsored by Science Applications International Corp. (SAIC)

Room: Torreys Peak 1-2

Speaker 3 of 5
Alessandro Sette, La Jolla Institute for Immunology, USA
The Multi-Epitope Approach to Development of Malaria Vaccine

Tuesday, March 05 | 5:00PM - 7:00PM
Identifying the Antigenic Targets (Proteins and Epitopes) of
Protective Immune Responses. Session Sponsored by Science Applications International Corp. (SAIC)

Room: Torreys Peak 1-2

Speaker 4 of 5
Daniel J. Carucci, Foundation for the National Institutes of Health, USA
Exploring the Malaria Genome for Targets of Vaccines and Drugs

Tuesday, March 05 | 5:00PM - 7:00PM
Identifying the Antigenic Targets (Proteins and Epitopes) of
Protective Immune Responses. Session Sponsored by Science Applications International Corp. (SAIC)

Room: Torreys Peak 1-2

Speaker 5 of 5
Patrick E. Duffy, NIAID, National Institutes for Health, USA
Variant Surface Antigens on Infected Erythrocytes: Vaccine Prospects


Tuesday, March 05 | 5:00PM - 7:00PM
Target Selection and Drug Development-II
This session is from Drugs Against Tropical Protozo
Room: Torreys Peak 3-4

Speaker 1 of 4
* Richard R. Tidwell, University of North Carolina at Chapel Hill, USA
Pentamidine-Type Compounds as Antiprotozoan Agents. Contemporary Investigations of these Molecules.


Tuesday, March 05 | 5:00PM - 7:00PM
Target Selection and Drug Development-II
This session is from Drugs Against Tropical Protozo
Room: Torreys Peak 3-4

Speaker 2 of 4
Henri Vial, Universite Montpellier II, France
Peculiarities of the Phospholipid Metabolism in the Malaria-Causing Parasite Plasmodium and Pharmacological Implications


Tuesday, March 05 | 5:00PM - 7:00PM
Target Selection and Drug Development-II
This session is from Drugs Against Tropical Protozo
Room: Torreys Peak 3-4

Speaker 3 of 4
Philip J. Rosenthal, University of California, San Francisco, USA
Cysteine Protease Inhibitors to Treat Malaria


Tuesday, March 05 | 5:00PM - 7:00PM
Target Selection and Drug Development-II
This session is from Drugs Against Tropical Protozo
Room: Torreys Peak 3-4

Speaker 4 of 4
Frederick S. Buckner, University of Washington, USA
Sterol Biosynthesis and Protein Prenylation Pathways as Targets for
Anti-Protozoan Chemotherapy


Tuesday, March 05 | 7:00PM - 8:00PM
Welcome Mixer
Room: Shavano Peak


Tuesday, March 05 | 7:00PM - 9:00PM
Cash Bar
Room: Shavano Peak


Tuesday, March 05 | 8:00PM - 10:00PM
Poster Session 2: Immunological Mechanisms of Protective Imm
unity; Identifying the Antigenic Targets (Proteins and Epitopes) of Protective Immune Responses
Room: Shavano Peak


Wednesday, March 06 | 7:00AM - 8:00AM
Breakfast
Room: Red Cloud


Wednesday, March 06 | 8:00AM - 11:00AM
Pre-Clinical Research and Development
Room: Torreys Peak 1-2

Speaker 1 of 1
* Rafi Ahmed, Emory University School of Medicine, USA
Vaccines and Immune Memory

Wednesday, March 06 | 8:00AM - 11:00AM
Target Selection, Drug Resistance
This session is from Drugs Against Tropical Protozo
Room: Torreys Peak 3-4

Speaker 1 of 6
* Paul A.M. Michels, Christian de Duve Institute of Cellular Pathology, Belgium
Glycosomes of Trypanosomes as Target for Drug Design


Wednesday, March 06 | 8:00AM - 11:00AM
Target Selection, Drug Resistance
This session is from Drugs Against Tropical Protozo
Room: Torreys Peak 3-4

Speaker 2 of 6
Aloysius G.M. Tielens, University of Utrecht, Netherlands
Mitochondrial Metabolism as Possible Drug Target?


Wednesday, March 06 | 8:00AM - 11:00AM
Target Selection, Drug Resistance
This session is from Drugs Against Tropical Protozo
Room: Torreys Peak 3-4

Speaker 3 of 6
Pradipsinh K. Rathod, University of Washington, USA
Initiation of Malaria Drug Resistance Through Hypermutations


Wednesday, March 06 | 8:00AM - 11:00AM
Target Selection, Drug Resistance
This session is from Drugs Against Tropical Protozo
Room: Torreys Peak 3-4

Speaker 4 of 6
Dyann F. Wirth, Harvard School of Public Health, USA
Molecular Genetics of Leishmania and Plasmodium: Implications for Drug Discovery and Drug Resistance


Wednesday, March 06 | 8:00AM - 11:00AM
Target Selection, Drug Resistance
This session is from Drugs Against Tropical Protozo
Room: Torreys Peak 3-4

Speaker 5 of 6
David C. Warhurst, London School of Hygiene and Tropical Medicine, UK
Short Talk: Understanding Drug-Resistance of Plasmodium falciparum DHFR by Homology Modeling


Wednesday, March 06 | 8:00AM - 11:00AM
Target Selection, Drug Resistance
This session is from Drugs Against Tropical Protozo
Room: Torreys Peak 3-4

Speaker 6 of 6
Jeanne A. Geyer, Walter Reed Army Institute of Research, USA
Short Talk: Drug Treatment and Genomic Stability in Plasmodium falciparum


Wednesday, March 06 | 8:30AM - 9:30AM
Rountable: How Does One Optimize the Magnitude, Quality, and
Longevity of T Cell Responses in Humans?


Speaker 1 of 2
* Stephen L. Hoffman, Sanaria, USA

Wednesday, March 06 | 8:30AM - 9:30AM
Rountable: How Does One Optimize the Magnitude, Quality, and
Longevity of T Cell Responses in Humans?


Speaker 2 of 2
* Adrian V. S. Hill, Jenner Institute, University of Oxford, UK

Wednesday, March 06 | 9:20AM - 9:40AM
Coffee Break
Room: Shavano Peak Foyer


Wednesday, March 06 | 9:30AM - 11:00AM
Pre-Clinical Research and Development

Speaker 1 of 2
Garnett H. Kelsoe, Duke University and Medical Center, USA
Infection, Inflammation and the Induction of Peripheral V(D)J Rearrangement

Wednesday, March 06 | 9:30AM - 11:00AM
Pre-Clinical Research and Development


Speaker to be Announced
Applied Perspective: How Does One Optimize the Magnitude,
Quality, and Duration of B Cell Responses?


Wednesday, March 06 | 11:00AM - 1:00PM
Poster Setup
Room: Shavano Peak


Wednesday, March 06 | 1:00PM - 10:00PM
Poster Viewing
Room: Shavano Peak


Wednesday, March 06 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Shavano Peak Foyer


Wednesday, March 06 | 5:00PM - 7:00PM
Pre-Clinical Development and Clinical Testing
Room: Torreys Peak 1-2

Speaker 1 of 4
* † Chetan E. Chitnis, International Centre for Genetic Engineering and Biotechnology, India

Wednesday, March 06 | 5:00PM - 7:00PM
Pre-Clinical Development and Clinical Testing
Room: Torreys Peak 1-2

Speaker 2 of 4
Ruth S. Nussenzweig, New York University School of Medicine, USA
Special Lecture: From Rodents to Humans: 35 Years of Malaria Vaccine Development

Wednesday, March 06 | 5:00PM - 7:00PM
Pre-Clinical Development and Clinical Testing
Room: Torreys Peak 1-2

Speaker 3 of 4
Carole A. Long, National Institutes of Health, USA
Laboratory Correlates of in vivo Protective Responses

Wednesday, March 06 | 5:00PM - 7:00PM
Pre-Clinical Development and Clinical Testing
Room: Torreys Peak 1-2

Speaker 4 of 4
Pedro L. Alonso, World Health Organization, Switzerland
Field Trials of Malaria Vaccines

Wednesday, March 06 | 5:00PM - 7:00PM
Target Selection and Drug Development-III
This session is from Drugs Against Tropical Protozo
Room: Torreys Peak 3-4

Speaker 1 of 4
* Donald J. Krogstad, Tulane University Health Sciences Center, USA
Aminoquinoline Antimalarials Active Against Multiply-Resistant P. falciparum


Wednesday, March 06 | 5:00PM - 7:00PM
Target Selection and Drug Development-III
This session is from Drugs Against Tropical Protozo
Room: Torreys Peak 3-4

Speaker 2 of 4
Dennis M. Schmatz, Merck Research Laboratories, USA
The Drug Discovery Process: A Pharmaceutical Perspective


Wednesday, March 06 | 5:00PM - 7:00PM
Target Selection and Drug Development-III
This session is from Drugs Against Tropical Protozo
Room: Torreys Peak 3-4

Speaker 3 of 4
Buddy Ullman, Oregon Health & Science University, USA
Nucleoside Transporters of Protozoan Parasites


Wednesday, March 06 | 5:00PM - 7:00PM
Target Selection and Drug Development-III
This session is from Drugs Against Tropical Protozo
Room: Torreys Peak 3-4

Speaker 4 of 4
Wim G.J. Hol, University of Washington, USA
Medicinal Protein Crystallography and Structural Genomics for Tropical Diseases


Wednesday, March 06 | 7:00PM - 7:45PM
Roundtable: Outcome Variables for Clinical Trials
Room: Torreys Peak 1-2

Speaker 1 of 2
* Pedro L. Alonso, World Health Organization, Switzerland

Wednesday, March 06 | 7:00PM - 7:45PM
Roundtable: Outcome Variables for Clinical Trials
Room: Torreys Peak 1-2

Speaker 2 of 2
* † Kwadwo Ansah Koram, Noguchi Memorial Institute for Medical Research, Ghana

Wednesday, March 06 | 7:00PM - 8:00PM
Welcome Mixer
Room: Shavano Peak


Wednesday, March 06 | 7:00PM - 9:00PM
Cash Bar
Room: Shavano Peak


Wednesday, March 06 | 8:30PM - 10:30PM
Poster Session 3: Pre-Clinical Research and Development; Cli
nical Testing; Current Status of Efficacy Trials of Malaria Vaccines
Room: Shavano Peak


Thursday, March 07 | 7:00AM - 8:00AM
Breakfast
Room: Red Cloud


Thursday, March 07 | 8:00AM - 11:00AM
Current Status of Efficacy Trials of Malaria Vaccines. Sess
ion Sponsored by GlaxoSmithKline Biologicals S.A.

Room: Torreys Peak 1-2

Speaker 1 of 5
* † Joe D. Cohen, GlaxoSmithKline Biologicals, Belgium

Thursday, March 07 | 8:00AM - 11:00AM
Current Status of Efficacy Trials of Malaria Vaccines. Sess
ion Sponsored by GlaxoSmithKline Biologicals S.A.

Room: Torreys Peak 1-2

Speaker 2 of 5
D. Gray Heppner, Walter Reed Army Institute of Research, USA
Current Status of Clinical Trials with RTS, S and MSP-1 and AMA-1 Recombinant Protein Vaccines

Thursday, March 07 | 8:00AM - 11:00AM
Current Status of Efficacy Trials of Malaria Vaccines. Sess
ion Sponsored by GlaxoSmithKline Biologicals S.A.

Room: Torreys Peak 1-2

Speaker 3 of 5
Thomas L. Richie, Sanaria Inc., USA
Clinical Trials of Multi-Stage DNA Malaria Vaccines


Thursday, March 07 | 8:00AM - 11:00AM
Current Status of Efficacy Trials of Malaria Vaccines. Sess
ion Sponsored by GlaxoSmithKline Biologicals S.A.

Room: Torreys Peak 1-2

Speaker 4 of 5
Adrian V. S. Hill, Jenner Institute, University of Oxford, UK
Clinical Trials of Protective T Cell Inducing Vaccines

Thursday, March 07 | 8:00AM - 11:00AM
Current Status of Efficacy Trials of Malaria Vaccines. Sess
ion Sponsored by GlaxoSmithKline Biologicals S.A.

Room: Torreys Peak 1-2


Speakers to be Announced
Short Updates from Other Speakers on Their Clinical Trials

Thursday, March 07 | 8:00AM - 11:00AM
Target Selection and Drug Development-IV
This session is from Drugs Against Tropical Protozo
Room: Torreys Peak 3-4

Speaker 1 of 6
* Michael Riscoe, Oregon Health & Science University, USA
Exploitation of Parasite Heme Metabolism by Xanthones


Thursday, March 07 | 8:00AM - 11:00AM
Target Selection and Drug Development-IV
This session is from Drugs Against Tropical Protozo
Room: Torreys Peak 3-4

Speaker 2 of 6
Nicholas J. Westwood, University of St Andrews, UK
Chemical Genetic Approaches in Parasitology


Thursday, March 07 | 8:00AM - 11:00AM
Target Selection and Drug Development-IV
This session is from Drugs Against Tropical Protozo
Room: Torreys Peak 3-4

Speaker 3 of 6
Andrew D. Hamilton, Yale University, USA
Protein Farnesyltransferase as a Novel Target for the Design of Anti-Parasitic Agents


Thursday, March 07 | 8:00AM - 11:00AM
Target Selection and Drug Development-IV
This session is from Drugs Against Tropical Protozo
Room: Torreys Peak 3-4

Speaker 4 of 6
Sanjeev Krishna, St. George's Hospital Medical School, UK
The Plasmodium Falciparum Hexose Transporter is a Promising New Drug Target


Thursday, March 07 | 8:00AM - 11:00AM
Target Selection and Drug Development-IV
This session is from Drugs Against Tropical Protozo
Room: Torreys Peak 3-4

Speaker 5 of 6
Eric Oldfield, University of Illinois at Urbana-Champaign, USA
Short Talk: Prenyl Diphosphate Synthase Inhibitors as Anti-Parasitic Agents


Thursday, March 07 | 8:00AM - 11:00AM
Target Selection and Drug Development-IV
This session is from Drugs Against Tropical Protozo
Room: Torreys Peak 3-4

Speaker 6 of 6
Norman C. Waters, United States Military Academy, USA
Short Talk: Targeting the Plasmodial Cell Cycle Machinery Through Development of Novel Cyclin Dependent Protein Kinase Inhibitors


Thursday, March 07 | 9:20AM - 9:40AM
Coffee Break
Room: Shavano Peak Foyer


Thursday, March 07 | 4:00PM - 6:00PM
Target Selection and Drug Development-V
This session is from Drugs Against Tropical Protozo
Room: Torreys Peak 3-4

Speaker 1 of 4
* Julio A. Urbina, Venezuelan Institute for Science Research, USA
Isoprenoid and Sterol Biosynthesis Enzymes as Chemotherapeutic Targets in Trypanosomatid Parasites: Chemical Validation


Thursday, March 07 | 4:00PM - 6:00PM
Target Selection and Drug Development-V
This session is from Drugs Against Tropical Protozo
Room: Torreys Peak 3-4

Speaker 2 of 4
Glaucius Oliva, University of São Paulo, Brazil
Rational Design and Biodiversity in the Search of New Anti-Chagasic Drugs


Thursday, March 07 | 4:00PM - 6:00PM
Target Selection and Drug Development-V
This session is from Drugs Against Tropical Protozo
Room: Torreys Peak 3-4

Speaker 3 of 4
Ching-Chung Wang, University of California, San Francisco, USA
The Presence of an Essential Ubiquitin-Proteasome Pathway in Trypanosoma brucei


Thursday, March 07 | 4:00PM - 6:00PM
Target Selection and Drug Development-V
This session is from Drugs Against Tropical Protozo
Room: Torreys Peak 3-4

Speaker 4 of 4
Jeremy C. Mottram, University of Glasgow, UK
Unusual Cysteine Proteases as Drug Targets in Trypanosomatids


Thursday, March 07 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Shavano Peak Foyer


Thursday, March 07 | 5:00PM - 7:00PM
From Research to Deployed Malaria Vaccine
Room: Torreys Peak 1-2

Speaker 1 of 3
* † Robert Sauerwein, Radboud University, Netherlands

Thursday, March 07 | 5:00PM - 7:00PM
From Research to Deployed Malaria Vaccine
Room: Torreys Peak 1-2

Speaker 2 of 3
Regina N. Rabinovich, ISGlobal, Spain / Harvard T.H. Chan School of Public Health, USA, Spain
Is Current Investment Adequate Enough to Develop a Potential Malaria Vaccine?

Thursday, March 07 | 5:00PM - 7:00PM
From Research to Deployed Malaria Vaccine
Room: Torreys Peak 1-2


Speakers to be Announced
Discussion Group

Thursday, March 07 | 6:00PM - 7:00PM
Plenary
This session is from Drugs Against Tropical Protozo

Speaker 1 of 3
Simon L. Croft, London School of Hygiene & Tropical Medicine, UK
Short Talk: Miltefosine for the Treatment of Leishmaniasis


Thursday, March 07 | 6:00PM - 7:00PM
Plenary
This session is from Drugs Against Tropical Protozo

Speaker 2 of 3
Solomon O. Nwaka, World Health Organization, Switzerland
Short Talk: Medicines for Malaria Venture: New Paradigm for the Discovery and Development of Antimalarial Drugs


Thursday, March 07 | 6:00PM - 7:00PM
Plenary
This session is from Drugs Against Tropical Protozo

Speaker 3 of 3
Victoria G. Hale, Institute for OneWorld Health, USA
Short Talk: The Institute for One World Health: Filling the Gaps in the Development of New Drugs for Neglected Diseases


Thursday, March 07 | 7:00PM - 8:00PM
Welcome Mixer
Room: Shavano Peak


Thursday, March 07 | 8:00PM - 11:00PM
Entertainment
Room: Shavano Peak


Thursday, March 07 | 8:00PM - 11:00PM
Cash Bar
Room: Shavano Peak


Friday, March 08 | 10:21AM - 10:21AM
Departure


*Session Chair
†Invited, not yet responded.