Web Desc
Drugs Against Tropical Protozoan Parasites: Target Selection, Structural Biology, and Rational Medicinal Chemistry
joint with Malaria's Challenge: From Infants to Genomics to Vaccines
Organizer(s): Michael H. Gelb and Wim G.J. Hol
Date: March 03 - 08, 2002
Location: Keystone Resort, Keystone, CO, USA
For important information on the coronavirus, please click here
Summary of Meeting:
Diseases in humans caused by protozoa lead to suffering in hundreds of millions of people worldwide. We are approaching a time when the genomes of organisms responsible for diseases such as malaria, sleeping sickness, and leishmaniasis are fully sequenced. This provides an optimal setting for the discovery and evaluation of new drug targets, especially when combined with structural biology, combinatorial chemistry, and parasite genetics. Effective drugs are lacking for diseases including sleeping sickness and leishmaniasis, and current therapies for treating malaria are at risk due to the emergence of drug resistance. Thus, the development of new lines of anti-protozoan agents is urgently needed. Groups of talks, one or two given by the chemist/structural biologist and the other by the parasitologist, will exemplify the power of multi-disciplinary collaborations. We will also invite people outside of parasitology in an effort to stimulate their interests in tropical medicine.
Discounted Abstract Deadline: November 16 2001
Discounted Registration Deadline: January 3 2002
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1 R13 AI50962-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, March 03 | 4:00PM - 7:00PM
Registration
Room: Shavano Peak Foyer


Sunday, March 03 | 6:15PM - 7:15PM
Welcome
Room: Shavano Peak Foyer


Sunday, March 03 | 7:15PM - 7:30PM
Orientation
Room: Torreys Peak 3-4


Sunday, March 03 | 7:30PM - 8:30PM
Keynote Address
Room: Torreys Peak 3-4

Speaker 1 of 1
David S. Roos, University of Pennsylvania, USA
Designing and Mining Parasite Genome Databases

Monday, March 04 | 7:00AM - 8:00AM
Breakfast
Room: Red Cloud


Monday, March 04 | 8:00AM - 11:00AM
Impact of Parasite Genomics on Drug Target Selection. Spons
ored by The Burroughs Wellcome Fund.

Room: Torreys Peak 3-4

Speaker 1 of 6
* Peter J. Myler, Seattle Biomedical Research Institute, USA
Kinetoplast Genome Projects

Monday, March 04 | 8:00AM - 11:00AM
Impact of Parasite Genomics on Drug Target Selection. Spons
ored by The Burroughs Wellcome Fund.

Room: Torreys Peak 3-4

Speaker 2 of 6
Daniel J. Carucci, Foundation for the National Institutes of Health, USA
Exploring the Malaria Genome for Targets of Vaccines and Drugs

Monday, March 04 | 8:00AM - 11:00AM
Impact of Parasite Genomics on Drug Target Selection. Spons
ored by The Burroughs Wellcome Fund.

Room: Torreys Peak 3-4

Speaker 3 of 6
Terry Gaasterland, University of California, San Diego, USA
Computational Analysis of the Trypanosoma brucei Genome

Monday, March 04 | 8:00AM - 11:00AM
Impact of Parasite Genomics on Drug Target Selection. Spons
ored by The Burroughs Wellcome Fund.

Room: Torreys Peak 3-4

Speaker 4 of 6
Stephen M. Beverley, Washington University School of Medicine, USA
Molecular Approaches to Trypanosomatid Pteridine Metabolic Pathways and Their Role(s) in Virulence and Chemotherapy

Monday, March 04 | 8:00AM - 11:00AM
Impact of Parasite Genomics on Drug Target Selection. Spons
ored by The Burroughs Wellcome Fund.

Room: Torreys Peak 3-4

Speaker 5 of 6
Sebastian Ulbert, Netherlands Cancer Institute, Netherlands
Short Talk: The Significance of Base J in the DNA of Trypanosoma brucei for the Base Excision Repair

Monday, March 04 | 8:00AM - 11:00AM
Impact of Parasite Genomics on Drug Target Selection. Spons
ored by The Burroughs Wellcome Fund.

Room: Torreys Peak 3-4

Speaker 6 of 6
Christian Doerig, Monash University, Australia
Short Talk: A Chemical Genetics Approach for Functional Studies and Target Validation of Plasmodium Protein Kinases

Monday, March 04 | 8:00AM - 11:00AM
Defining the Malaria Problem and the Human Models Indicating
Developing Vaccines is Feasible
This session is from Malaria's Challenge

Room: Torreys Peak1-2

Speaker 1 of 5
* Louis H. Miller, National Institutes of Health, USA


Monday, March 04 | 8:00AM - 11:00AM
Defining the Malaria Problem and the Human Models Indicating
Developing Vaccines is Feasible
This session is from Malaria's Challenge

Room: Torreys Peak1-2

Speaker 2 of 5
Kevin Marsh, University of Oxford, Kenya
Malaria Vaccination: What are We Trying to Prevent?


Monday, March 04 | 8:00AM - 11:00AM
Defining the Malaria Problem and the Human Models Indicating
Developing Vaccines is Feasible
This session is from Malaria's Challenge

Room: Torreys Peak1-2

Speaker 3 of 5
Stephen L. Hoffman, Sanaria, USA
Induction of Protection Against Malaria in Naïve Humans by Experimental Exposure to Whole Parasites


Monday, March 04 | 8:00AM - 11:00AM
Defining the Malaria Problem and the Human Models Indicating
Developing Vaccines is Feasible
This session is from Malaria's Challenge

Room: Torreys Peak1-2

Speaker 4 of 5
Andrew G. Clark, Cornell University, USA
The Role of Population Biology and Genetics in Developing Strategies for Malaria Vaccine Development


Monday, March 04 | 8:00AM - 11:00AM
Defining the Malaria Problem and the Human Models Indicating
Developing Vaccines is Feasible
This session is from Malaria's Challenge

Room: Torreys Peak1-2

Speaker 5 of 5
Andrew Read, Pennsylvania State University, USA
Imperfect Vaccines and the Evolution of Virulence


Monday, March 04 | 9:20AM - 9:40AM
Coffee Break
Room: Shavano Peak Foyer


Monday, March 04 | 11:00AM - 1:00PM
Poster Setup
Room: Shavano Peak


Monday, March 04 | 1:00PM - 10:00PM
Poster Viewing
Room: Shavano Peak


Monday, March 04 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Shavano Peak Foyer


Monday, March 04 | 5:00PM - 7:00PM
Target Selection and Drug Development-I
Room: Torreys Peak 3-4

Speaker 1 of 4
* Daniel E. Goldberg, Washington University, USA
The Biochemistry of Hemoglobin Digestion in P. falciparum

Monday, March 04 | 5:00PM - 7:00PM
Target Selection and Drug Development-I
Room: Torreys Peak 3-4

Speaker 2 of 4
Gary H. Posner, Johns Hopkins University, USA
Mechanism-Based Rational Design of New Antimalarial Peroxides

Monday, March 04 | 5:00PM - 7:00PM
Target Selection and Drug Development-I
Room: Torreys Peak 3-4

Speaker 3 of 4
James H. McKerrow, University of California, San Diego, USA
Inhibitors of Thiol Proteases for Treating Chagas Disease

Monday, March 04 | 5:00PM - 7:00PM
Target Selection and Drug Development-I
Room: Torreys Peak 3-4

Speaker 4 of 4
Akhil B. Vaidya, Drexel University College of Medicine, USA
Selective Interference with Parasite Mitochondrial Functions

Monday, March 04 | 5:00PM - 7:00PM
Genes, Genomics and Malaria. Session Sponsored by The Burro
ughs Wellcome Fund
This session is from Malaria's Challenge

Room: Torreys Peak 1-2

Speaker 1 of 4
* Victor Nussenzweig, New York University, USA


Monday, March 04 | 5:00PM - 7:00PM
Genes, Genomics and Malaria. Session Sponsored by The Burro
ughs Wellcome Fund
This session is from Malaria's Challenge

Room: Torreys Peak 1-2

Speaker 2 of 4
Louis H. Miller, National Institutes of Health, USA
Genes Involved in Susceptibility to Malaria


Monday, March 04 | 5:00PM - 7:00PM
Genes, Genomics and Malaria. Session Sponsored by The Burro
ughs Wellcome Fund
This session is from Malaria's Challenge

Room: Torreys Peak 1-2

Speaker 3 of 4
Ross L. Coppel, Monash University, Australia
How is the Malaria Genome Facilitating Studies on Malaria?


Monday, March 04 | 5:00PM - 7:00PM
Genes, Genomics and Malaria. Session Sponsored by The Burro
ughs Wellcome Fund
This session is from Malaria's Challenge

Room: Torreys Peak 1-2

Speaker 4 of 4
Mani Subramanian, Celera Genomics, USA
The Potential Impact of the Human Genome Project on Malaria and Other Infectious Diseases


Monday, March 04 | 7:00PM - 8:00PM
Welcome Mixer
Room: Shavano Peak


Monday, March 04 | 7:00PM - 9:00PM
Cash Bar
Room: Shavano Peak


Monday, March 04 | 8:00PM - 10:00PM
Poster Session 1: Impact of Parasite Genomics on Drug Target
Selection/Target Selection and Drug Development
Room: Shavano Peak


Tuesday, March 05 | 7:00AM - 8:00AM
Breakfast
Room: Red Cloud


Tuesday, March 05 | 8:00AM - 11:00AM
Structure-Based Drug Design
Room: Torreys Peak 3-4

Speaker 1 of 6
* Gerhard Klebe, Philipps University Marburg, Germany
New Leads from De Novo Design and Virtual Screening for the Treatment of Shigellosis and Malaria

Tuesday, March 05 | 8:00AM - 11:00AM
Structure-Based Drug Design
Room: Torreys Peak 3-4

Speaker 2 of 6
William T. Windsor, Schering-Plough Research Institute, USA
Structure Based Design of Protein Farnesyltransferase Inhibitors

Tuesday, March 05 | 8:00AM - 11:00AM
Structure-Based Drug Design
Room: Torreys Peak 3-4

Speaker 3 of 6
William N. Hunter, University of Dundee, UK
X-ray Studies of Trypanothione Reductase; The Discovery of Novel Inhibitors

Tuesday, March 05 | 8:00AM - 11:00AM
Structure-Based Drug Design
Room: Torreys Peak 3-4

Speaker 4 of 6
Timothy A.J. Haystead, Duke University, USA
Discovery of a New Antimilarial Target in the Human Purine Binding Proteome

Tuesday, March 05 | 8:00AM - 11:00AM
Structure-Based Drug Design
Room: Torreys Peak 3-4

Speaker 5 of 6
Vern L. Schramm, Albert Einstein College of Medicine, USA
Short Talk: Inhibition of PNP by Immucillins Induces Purine-Less Death of Plasmodium falciparum in Cultured Erythrocytes


Tuesday, March 05 | 8:00AM - 11:00AM
Structure-Based Drug Design
Room: Torreys Peak 3-4

Speaker 6 of 6
Meg Phillips, University of Texas Southwestern Medical Center, USA
Short Talk: Interactions in the Dimer Interface of Trypanosoma brucei Ornithine Decarboxylase: Implications for Drug Design

Tuesday, March 05 | 8:00AM - 11:00AM
Immunological Mechanisms of Protective Immunity
This session is from Malaria's Challenge
Room: Torreys Peak 1-2

Speaker 1 of 5
* † Martha Sedegah, Naval Medical Research Center, USA


Tuesday, March 05 | 8:00AM - 11:00AM
Immunological Mechanisms of Protective Immunity
This session is from Malaria's Challenge
Room: Torreys Peak 1-2

Speaker 2 of 5
Eleanor M. Riley, Roslin Institute, UK
Regulation of Innate and Adaptive Immunity to Malaria in Humans


Tuesday, March 05 | 8:00AM - 11:00AM
Immunological Mechanisms of Protective Immunity
This session is from Malaria's Challenge
Room: Torreys Peak 1-2

Speaker 3 of 5
Denise L. Doolan, James Cook University, Australia
Immunological Mechanisms of Protective Immunity Induced by Radiation Attenuated Sporozoites


Tuesday, March 05 | 8:00AM - 11:00AM
Immunological Mechanisms of Protective Immunity
This session is from Malaria's Challenge
Room: Torreys Peak 1-2

Speaker 4 of 5
Allan J. Saul, National Institutes Of Health, USA
Nature and Immunologic Mechanisms of Protective Immunity Against Mosquito Stage Parasites


Tuesday, March 05 | 8:00AM - 11:00AM
Immunological Mechanisms of Protective Immunity
This session is from Malaria's Challenge
Room: Torreys Peak 1-2

Speaker 5 of 5
Michael F. Good, Griffith University, Australia
Short Talk: Induction of Malaria Cell Mediated Immunity and Target Antigen Identification


Tuesday, March 05 | 9:20AM - 9:40AM
Coffee Break
Room: Shavano Peak Foyer


Tuesday, March 05 | 11:00AM - 1:00PM
Poster Setup
Room: Shavano Peak


Tuesday, March 05 | 1:00PM - 10:00PM
Poster Viewing
Room: Shavano Peak


Tuesday, March 05 | 2:30PM - 4:30PM
Open Discussion: Are We Missing Something? Why is it Taking
So Long to Develop Effective Malaria Vaccines?
This session is from Malaria's Challenge
Room: Torreys Peak 1-2


Tuesday, March 05 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Shavano Peak Foyer


Tuesday, March 05 | 5:00PM - 7:00PM
Target Selection and Drug Development-II
Room: Torreys Peak 3-4

Speaker 1 of 4
* Richard R. Tidwell, University of North Carolina at Chapel Hill, USA
Pentamidine-Type Compounds as Antiprotozoan Agents. Contemporary Investigations of these Molecules.

Tuesday, March 05 | 5:00PM - 7:00PM
Target Selection and Drug Development-II
Room: Torreys Peak 3-4

Speaker 2 of 4
Henri Vial, Universite Montpellier II, France
Peculiarities of the Phospholipid Metabolism in the Malaria-Causing Parasite Plasmodium and Pharmacological Implications

Tuesday, March 05 | 5:00PM - 7:00PM
Target Selection and Drug Development-II
Room: Torreys Peak 3-4

Speaker 3 of 4
Philip J. Rosenthal, University of California, San Francisco, USA
Cysteine Protease Inhibitors to Treat Malaria

Tuesday, March 05 | 5:00PM - 7:00PM
Target Selection and Drug Development-II
Room: Torreys Peak 3-4

Speaker 4 of 4
Frederick S. Buckner, University of Washington, USA
Sterol Biosynthesis and Protein Prenylation Pathways as Targets for
Anti-Protozoan Chemotherapy


Tuesday, March 05 | 5:00PM - 7:00PM
Identifying the Antigenic Targets (Proteins and Epitopes) of
Protective Immune Responses. Session Sponsored by Science Applications International Corp. (SAIC)
This session is from Malaria's Challenge

Room: Torreys Peak 1-2

Speaker 1 of 5
* † Robin Fredric Anders, La Trobe University, Australia


Tuesday, March 05 | 5:00PM - 7:00PM
Identifying the Antigenic Targets (Proteins and Epitopes) of
Protective Immune Responses. Session Sponsored by Science Applications International Corp. (SAIC)
This session is from Malaria's Challenge

Room: Torreys Peak 1-2

Speaker 2 of 5
Anthony A. Holder, Medical Research Council, UK
Antibodies to Merozoite Surface Proteins and Inhibition of Erythrocyte Invasion


Tuesday, March 05 | 5:00PM - 7:00PM
Identifying the Antigenic Targets (Proteins and Epitopes) of
Protective Immune Responses. Session Sponsored by Science Applications International Corp. (SAIC)
This session is from Malaria's Challenge

Room: Torreys Peak 1-2

Speaker 3 of 5
Alessandro Sette, La Jolla Institute for Immunology, USA
The Multi-Epitope Approach to Development of Malaria Vaccine


Tuesday, March 05 | 5:00PM - 7:00PM
Identifying the Antigenic Targets (Proteins and Epitopes) of
Protective Immune Responses. Session Sponsored by Science Applications International Corp. (SAIC)
This session is from Malaria's Challenge

Room: Torreys Peak 1-2

Speaker 4 of 5
Daniel J. Carucci, Foundation for the National Institutes of Health, USA
Exploring the Malaria Genome for Targets of Vaccines and Drugs


Tuesday, March 05 | 5:00PM - 7:00PM
Identifying the Antigenic Targets (Proteins and Epitopes) of
Protective Immune Responses. Session Sponsored by Science Applications International Corp. (SAIC)
This session is from Malaria's Challenge

Room: Torreys Peak 1-2

Speaker 5 of 5
Patrick E. Duffy, NIAID, National Institutes for Health, USA
Variant Surface Antigens on Infected Erythrocytes: Vaccine Prospects


Tuesday, March 05 | 7:00PM - 8:00PM
Welcome Mixer
Room: Shavano Peak


Tuesday, March 05 | 7:00PM - 9:00PM
Cash Bar
Room: Shavano Peak


Tuesday, March 05 | 8:00PM - 10:00PM
Poster Session 2: Structure-Based Drug Design/Target Selecti
on and Drug Development
Room: Shavano Peak


Wednesday, March 06 | 7:00AM - 8:00AM
Breakfast
Room: Red Cloud


Wednesday, March 06 | 8:00AM - 11:00AM
Target Selection, Drug Resistance
Room: Torreys Peak 3-4

Speaker 1 of 6
* Paul A.M. Michels, Christian de Duve Institute of Cellular Pathology, Belgium
Glycosomes of Trypanosomes as Target for Drug Design

Wednesday, March 06 | 8:00AM - 11:00AM
Target Selection, Drug Resistance
Room: Torreys Peak 3-4

Speaker 2 of 6
Aloysius G.M. Tielens, University of Utrecht, Netherlands
Mitochondrial Metabolism as Possible Drug Target?

Wednesday, March 06 | 8:00AM - 11:00AM
Target Selection, Drug Resistance
Room: Torreys Peak 3-4

Speaker 3 of 6
Pradipsinh K. Rathod, University of Washington, USA
Initiation of Malaria Drug Resistance Through Hypermutations

Wednesday, March 06 | 8:00AM - 11:00AM
Target Selection, Drug Resistance
Room: Torreys Peak 3-4

Speaker 4 of 6
Dyann F. Wirth, Harvard School of Public Health, USA
Molecular Genetics of Leishmania and Plasmodium: Implications for Drug Discovery and Drug Resistance

Wednesday, March 06 | 8:00AM - 11:00AM
Target Selection, Drug Resistance
Room: Torreys Peak 3-4

Speaker 5 of 6
David C. Warhurst, London School of Hygiene and Tropical Medicine, UK
Short Talk: Understanding Drug-Resistance of Plasmodium falciparum DHFR by Homology Modeling

Wednesday, March 06 | 8:00AM - 11:00AM
Target Selection, Drug Resistance
Room: Torreys Peak 3-4

Speaker 6 of 6
Jeanne A. Geyer, Walter Reed Army Institute of Research, USA
Short Talk: Drug Treatment and Genomic Stability in Plasmodium falciparum

Wednesday, March 06 | 8:00AM - 11:00AM
Pre-Clinical Research and Development
This session is from Malaria's Challenge
Room: Torreys Peak 1-2

Speaker 1 of 1
* Rafi Ahmed, Emory University School of Medicine, USA
Vaccines and Immune Memory


Wednesday, March 06 | 8:30AM - 9:30AM
Rountable: How Does One Optimize the Magnitude, Quality, and
Longevity of T Cell Responses in Humans?
This session is from Malaria's Challenge


Speaker 1 of 2
* Stephen L. Hoffman, Sanaria, USA


Wednesday, March 06 | 8:30AM - 9:30AM
Rountable: How Does One Optimize the Magnitude, Quality, and
Longevity of T Cell Responses in Humans?
This session is from Malaria's Challenge


Speaker 2 of 2
* Adrian V. S. Hill, Jenner Institute, University of Oxford, UK


Wednesday, March 06 | 9:20AM - 9:40AM
Coffee Break
Room: Shavano Peak Foyer


Wednesday, March 06 | 9:30AM - 11:00AM
Pre-Clinical Research and Development
This session is from Malaria's Challenge

Speaker 1 of 2
Garnett H. Kelsoe, Duke University and Medical Center, USA
Infection, Inflammation and the Induction of Peripheral V(D)J Rearrangement


Wednesday, March 06 | 9:30AM - 11:00AM
Pre-Clinical Research and Development
This session is from Malaria's Challenge


Speaker to be Announced
Applied Perspective: How Does One Optimize the Magnitude,
Quality, and Duration of B Cell Responses?


Wednesday, March 06 | 11:00AM - 1:00PM
Poster Setup
Room: Shavano Peak


Wednesday, March 06 | 1:00PM - 10:00PM
Poster Viewing
Room: Shavano Peak


Wednesday, March 06 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Shavano Peak Foyer


Wednesday, March 06 | 5:00PM - 7:00PM
Target Selection and Drug Development-III
Room: Torreys Peak 3-4

Speaker 1 of 4
* Donald J. Krogstad, Tulane University Health Sciences Center, USA
Aminoquinoline Antimalarials Active Against Multiply-Resistant P. falciparum

Wednesday, March 06 | 5:00PM - 7:00PM
Target Selection and Drug Development-III
Room: Torreys Peak 3-4

Speaker 2 of 4
Dennis M. Schmatz, Merck Research Laboratories, USA
The Drug Discovery Process: A Pharmaceutical Perspective

Wednesday, March 06 | 5:00PM - 7:00PM
Target Selection and Drug Development-III
Room: Torreys Peak 3-4

Speaker 3 of 4
Buddy Ullman, Oregon Health & Science University, USA
Nucleoside Transporters of Protozoan Parasites

Wednesday, March 06 | 5:00PM - 7:00PM
Target Selection and Drug Development-III
Room: Torreys Peak 3-4

Speaker 4 of 4
Wim G.J. Hol, University of Washington, USA
Medicinal Protein Crystallography and Structural Genomics for Tropical Diseases

Wednesday, March 06 | 5:00PM - 7:00PM
Pre-Clinical Development and Clinical Testing
This session is from Malaria's Challenge
Room: Torreys Peak 1-2

Speaker 1 of 4
* † Chetan E. Chitnis, International Centre for Genetic Engineering and Biotechnology, India


Wednesday, March 06 | 5:00PM - 7:00PM
Pre-Clinical Development and Clinical Testing
This session is from Malaria's Challenge
Room: Torreys Peak 1-2

Speaker 2 of 4
Ruth S. Nussenzweig, New York University School of Medicine, USA
Special Lecture: From Rodents to Humans: 35 Years of Malaria Vaccine Development


Wednesday, March 06 | 5:00PM - 7:00PM
Pre-Clinical Development and Clinical Testing
This session is from Malaria's Challenge
Room: Torreys Peak 1-2

Speaker 3 of 4
Carole A. Long, National Institutes of Health, USA
Laboratory Correlates of in vivo Protective Responses


Wednesday, March 06 | 5:00PM - 7:00PM
Pre-Clinical Development and Clinical Testing
This session is from Malaria's Challenge
Room: Torreys Peak 1-2

Speaker 4 of 4
Pedro L. Alonso, World Health Organization, Switzerland
Field Trials of Malaria Vaccines


Wednesday, March 06 | 7:00PM - 7:45PM
Roundtable: Outcome Variables for Clinical Trials
This session is from Malaria's Challenge
Room: Torreys Peak 1-2

Speaker 1 of 2
* Pedro L. Alonso, World Health Organization, Switzerland


Wednesday, March 06 | 7:00PM - 7:45PM
Roundtable: Outcome Variables for Clinical Trials
This session is from Malaria's Challenge
Room: Torreys Peak 1-2

Speaker 2 of 2
* † Kwadwo Ansah Koram, Noguchi Memorial Institute for Medical Research, Ghana


Wednesday, March 06 | 7:00PM - 8:00PM
Welcome Mixer
Room: Shavano Peak


Wednesday, March 06 | 7:00PM - 9:00PM
Cash Bar
Room: Shavano Peak


Wednesday, March 06 | 8:00PM - 10:00PM
Poster Session 3: Target Selection, Drug Resistance/Target S
election and Drug Development
Room: Shavano Peak


Thursday, March 07 | 7:00AM - 8:00AM
Breakfast
Room: Red Cloud


Thursday, March 07 | 8:00AM - 11:00AM
Target Selection and Drug Development-IV
Room: Torreys Peak 3-4

Speaker 1 of 6
* Michael Riscoe, Oregon Health & Science University, USA
Exploitation of Parasite Heme Metabolism by Xanthones

Thursday, March 07 | 8:00AM - 11:00AM
Target Selection and Drug Development-IV
Room: Torreys Peak 3-4

Speaker 2 of 6
Nicholas J. Westwood, University of St Andrews, UK
Chemical Genetic Approaches in Parasitology

Thursday, March 07 | 8:00AM - 11:00AM
Target Selection and Drug Development-IV
Room: Torreys Peak 3-4

Speaker 3 of 6
Andrew D. Hamilton, Yale University, USA
Protein Farnesyltransferase as a Novel Target for the Design of Anti-Parasitic Agents

Thursday, March 07 | 8:00AM - 11:00AM
Target Selection and Drug Development-IV
Room: Torreys Peak 3-4

Speaker 4 of 6
Sanjeev Krishna, St. George's Hospital Medical School, UK
The Plasmodium Falciparum Hexose Transporter is a Promising New Drug Target

Thursday, March 07 | 8:00AM - 11:00AM
Target Selection and Drug Development-IV
Room: Torreys Peak 3-4

Speaker 5 of 6
Eric Oldfield, University of Illinois at Urbana-Champaign, USA
Short Talk: Prenyl Diphosphate Synthase Inhibitors as Anti-Parasitic Agents

Thursday, March 07 | 8:00AM - 11:00AM
Target Selection and Drug Development-IV
Room: Torreys Peak 3-4

Speaker 6 of 6
Norman C. Waters, United States Military Academy, USA
Short Talk: Targeting the Plasmodial Cell Cycle Machinery Through Development of Novel Cyclin Dependent Protein Kinase Inhibitors

Thursday, March 07 | 8:00AM - 11:00AM
Current Status of Efficacy Trials of Malaria Vaccines. Sess
ion Sponsored by GlaxoSmithKline Biologicals S.A.
This session is from Malaria's Challenge

Room: Torreys Peak 1-2

Speaker 1 of 5
* † Joe D. Cohen, GlaxoSmithKline Biologicals, Belgium


Thursday, March 07 | 8:00AM - 11:00AM
Current Status of Efficacy Trials of Malaria Vaccines. Sess
ion Sponsored by GlaxoSmithKline Biologicals S.A.
This session is from Malaria's Challenge

Room: Torreys Peak 1-2

Speaker 2 of 5
D. Gray Heppner, Walter Reed Army Institute of Research, USA
Current Status of Clinical Trials with RTS, S and MSP-1 and AMA-1 Recombinant Protein Vaccines


Thursday, March 07 | 8:00AM - 11:00AM
Current Status of Efficacy Trials of Malaria Vaccines. Sess
ion Sponsored by GlaxoSmithKline Biologicals S.A.
This session is from Malaria's Challenge

Room: Torreys Peak 1-2

Speaker 3 of 5
Thomas L. Richie, Sanaria Inc., USA
Clinical Trials of Multi-Stage DNA Malaria Vaccines


Thursday, March 07 | 8:00AM - 11:00AM
Current Status of Efficacy Trials of Malaria Vaccines. Sess
ion Sponsored by GlaxoSmithKline Biologicals S.A.
This session is from Malaria's Challenge

Room: Torreys Peak 1-2

Speaker 4 of 5
Adrian V. S. Hill, Jenner Institute, University of Oxford, UK
Clinical Trials of Protective T Cell Inducing Vaccines


Thursday, March 07 | 8:00AM - 11:00AM
Current Status of Efficacy Trials of Malaria Vaccines. Sess
ion Sponsored by GlaxoSmithKline Biologicals S.A.
This session is from Malaria's Challenge

Room: Torreys Peak 1-2


Speakers to be Announced
Short Updates from Other Speakers on Their Clinical Trials


Thursday, March 07 | 9:20AM - 9:40AM
Coffee Break
Room: Shavano Peak Foyer


Thursday, March 07 | 4:00PM - 5:00PM
Coffee & Snacks Available
Room: Shavano Peak Foyer


Thursday, March 07 | 4:00PM - 6:00PM
Target Selection and Drug Development-V
Room: Torreys Peak 3-4

Speaker 1 of 4
* Julio A. Urbina, Venezuelan Institute for Science Research, USA
Isoprenoid and Sterol Biosynthesis Enzymes as Chemotherapeutic Targets in Trypanosomatid Parasites: Chemical Validation

Thursday, March 07 | 4:00PM - 6:00PM
Target Selection and Drug Development-V
Room: Torreys Peak 3-4

Speaker 2 of 4
Glaucius Oliva, University of São Paulo, Brazil
Rational Design and Biodiversity in the Search of New Anti-Chagasic Drugs

Thursday, March 07 | 4:00PM - 6:00PM
Target Selection and Drug Development-V
Room: Torreys Peak 3-4

Speaker 3 of 4
Ching-Chung Wang, University of California, San Francisco, USA
The Presence of an Essential Ubiquitin-Proteasome Pathway in Trypanosoma brucei

Thursday, March 07 | 4:00PM - 6:00PM
Target Selection and Drug Development-V
Room: Torreys Peak 3-4

Speaker 4 of 4
Jeremy C. Mottram, University of Glasgow, UK
Unusual Cysteine Proteases as Drug Targets in Trypanosomatids

Thursday, March 07 | 5:00PM - 7:00PM
From Research to Deployed Malaria Vaccine
This session is from Malaria's Challenge
Room: Torreys Peak 1-2

Speaker 1 of 3
* † Robert Sauerwein, Radboud University, Netherlands


Thursday, March 07 | 5:00PM - 7:00PM
From Research to Deployed Malaria Vaccine
This session is from Malaria's Challenge
Room: Torreys Peak 1-2

Speaker 2 of 3
Regina N. Rabinovich, ISGlobal, Spain / Harvard T.H. Chan School of Public Health, USA, Spain
Is Current Investment Adequate Enough to Develop a Potential Malaria Vaccine?


Thursday, March 07 | 5:00PM - 7:00PM
From Research to Deployed Malaria Vaccine
This session is from Malaria's Challenge
Room: Torreys Peak 1-2


Speakers to be Announced
Discussion Group


Thursday, March 07 | 6:00PM - 7:00PM
Plenary

Speaker 1 of 3
Simon L. Croft, London School of Hygiene & Tropical Medicine, UK
Short Talk: Miltefosine for the Treatment of Leishmaniasis

Thursday, March 07 | 6:00PM - 7:00PM
Plenary

Speaker 2 of 3
Solomon O. Nwaka, World Health Organization, Switzerland
Short Talk: Medicines for Malaria Venture: New Paradigm for the Discovery and Development of Antimalarial Drugs

Thursday, March 07 | 6:00PM - 7:00PM
Plenary

Speaker 3 of 3
Victoria G. Hale, Institute for OneWorld Health, USA
Short Talk: The Institute for One World Health: Filling the Gaps in the Development of New Drugs for Neglected Diseases

Thursday, March 07 | 7:00PM - 8:00PM
Welcome Mixer
Room: Shavano Peak


Thursday, March 07 | 8:00PM - 11:00PM
Entertainment
Room: Shavano Peak


Thursday, March 07 | 8:00PM - 11:00PM
Cash Bar
Room: Shavano Peak


Friday, March 08 | 10:21AM - 10:21AM
Departure


*Session Chair
†Invited, not yet responded.