Web Desc
Protein Phosphorylation and Mechanisms of Cellular Regulation
joint with Wnt and Beta-Catenin Signaling in Development and Disease
Organizer(s): Natalie G. Ahn and Gary L. Johnson
Date: March 05 - 10, 2002
Location: Taos Convention Center (meeting only), Taos, New Mexico, USA
Sponsored by Amgen Inc.
For important information on the coronavirus, please click here
Summary of Meeting:
This meeting will focus on the control of signal transduction and cell cycle control by phosphorylation and posttranslational modifications, featuring pathways which are well studied and new mechanisms which are emerging. One aim is to report new concepts and discoveries on mechanisms for cellular regulation by signaling molecules, as well as creative approaches towards the design and development of highly specific inhibitors for these targets. Our goal is to provide investigators and students with a broad yet comprehesive understanding of new discoveries in this field using biochemical, structural and genetic strategies. A second aim is to promote novel experimental approaches for participants to use in their research. Plenary talks will highlight innovative strategies towards problems in signal transduction, including monitoring global cellular responses by genomics, proteomics and database mining, new strategies for protein engineering, and fluorescence based assays for monitoring signal transduction in single cells. A workshop will also be held on practical aspects of applying genomics, proteomics and bioinformatics to research problems. The meeting will be held jointly with a Keystone Symposium on 'Wnt and Beta-catenin Signaling in Development and Disease', which discusses mechanisms by which the Wnt signaling pathway is regulated, ranging from basic research to clinical applications. Participants can choose between concurrent talks in each program, and two evening sessions will be held jointly, providiing a venue to learn perspectives at the forefront of each discipline, and to establish new contacts and collaborations.
Meeting is full. Please contact info@keystonesymposia.org for questions or to be placed on a waitlist.


We gratefully acknowledge additional support for this conference from:

BD Technologies
Educational donation provided by Amgen
We gratefully acknowledge the generous grant for this conference provided by:

National Cancer Institute (NCI)
Grant No. 1 R13 CA94350-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Tuesday, March 05 | 4:00PM - 7:00PM
Registration
Room: Rio Grande D


Tuesday, March 05 | 6:15PM - 7:15PM
Welcome
Room: Rio Grande A-C


Tuesday, March 05 | 7:15PM - 7:30PM
Orientation
Room: Bataan


Tuesday, March 05 | 7:30PM - 9:30PM
Keynote Address (Joint). Address Sponsored in part by Genen
tech, Inc.
Room: Bataan

Speaker 1 of 2
Roeland Nusse, HHMI/Stanford University, USA
Signaling by Wnt Proteins

Tuesday, March 05 | 7:30PM - 9:30PM
Keynote Address (Joint). Address Sponsored in part by Genen
tech, Inc.
Room: Bataan

Speaker 2 of 2
Roger Y. Tsien, HHMI/University of California, San Diego, USA
Signal Transduction Visualized with Genetically Encoded Indicators

Wednesday, March 06 | 7:00AM - 8:00AM
Breakfast
Room: Bataan


Wednesday, March 06 | 8:00AM - 11:30AM
Cell Proliferation. Session Sponsored in part by Schering-P
lough Research Institute

Room: Rio Grande C-D

Speaker 1 of 8
* Melanie H. Cobb, University of Texas Southwestern Medical Center, USA
ERK's in Progress

Wednesday, March 06 | 8:00AM - 11:30AM
Cell Proliferation. Session Sponsored in part by Schering-P
lough Research Institute

Room: Rio Grande C-D

Speaker 2 of 8
Beverly J. Errede, University of North Carolina at Chapel Hill, USA
Regulation of MAPK Activation Module Assembly

Wednesday, March 06 | 8:00AM - 11:30AM
Cell Proliferation. Session Sponsored in part by Schering-P
lough Research Institute

Room: Rio Grande C-D

Speaker 3 of 8
Marc K. Saba-El-Leil, Institut de Recherches Cliniques de Montreal, Canada
Short Talk: Targeted Inactivation of the Erk2 MAP Kinase Gene in the Mouse

Wednesday, March 06 | 8:00AM - 11:30AM
Cell Proliferation. Session Sponsored in part by Schering-P
lough Research Institute

Room: Rio Grande C-D

Speaker 4 of 8
Carol A. Lange, University of Minnesota, USA
Short Talk: MAPK Couples Multiple Functions of Human Progesterone Receptors: Degradation, Transcription, and Nuclear Localization

Wednesday, March 06 | 8:00AM - 11:30AM
Cell Proliferation. Session Sponsored in part by Schering-P
lough Research Institute

Room: Rio Grande C-D

Speaker 5 of 8
Kun-Liang Guan, University of California, San Diego, USA
Regulation of the Raf Kinase

Wednesday, March 06 | 8:00AM - 11:30AM
Cell Proliferation. Session Sponsored in part by Schering-P
lough Research Institute

Room: Rio Grande C-D

Speaker 6 of 8
Michael A. White, University of Texas Southwestern Medical Center, USA
Short Talk: Critical Contribution of Linker Proteins to Raf Kinase Activation

Wednesday, March 06 | 8:00AM - 11:30AM
Cell Proliferation. Session Sponsored in part by Schering-P
lough Research Institute

Room: Rio Grande C-D

Speaker 7 of 8
Meera V. Sundaram, University of Pennsylvania, USA
Short Talk: C. elegans ksr-1 and ksr-2 have both Unique and Redundant Functions and are Required for MPK-1 Phosphorylation


Wednesday, March 06 | 8:00AM - 11:30AM
Cell Proliferation. Session Sponsored in part by Schering-P
lough Research Institute

Room: Rio Grande C-D

Speaker 8 of 8
Larry Feig, Tufts University School of Medicine, USA
Short Talk: A Novel Kinase-Independent Function of PDK1: Allosteric Activator of an Exchange Factor for the Ral-GTPase

Wednesday, March 06 | 8:00AM - 11:30AM
Wnt/Beta-Catenin Pathway in Model Organisms
This session is from Wnt and Beta-Catenin Signaling
Room: Rio Grande A-B

Speaker 1 of 10
* Roeland Nusse, HHMI/Stanford University, USA


Wednesday, March 06 | 8:00AM - 11:30AM
Wnt/Beta-Catenin Pathway in Model Organisms
This session is from Wnt and Beta-Catenin Signaling
Room: Rio Grande A-B

Speaker 2 of 10
Lilianna Solnica-Krezel, Vanderbilt University, USA
Short Talk: Regulation of Cell Polarity During Zebrafish Gastrulation


Wednesday, March 06 | 8:00AM - 11:30AM
Wnt/Beta-Catenin Pathway in Model Organisms
This session is from Wnt and Beta-Catenin Signaling
Room: Rio Grande A-B

Speaker 3 of 10
Yasuhiko Kawakami, The Salk Institute for Biological Studies, USA
Short Talk: Wnt Signaling Controls Limb-Type Specification in Vertebrate Embryos


Wednesday, March 06 | 8:00AM - 11:30AM
Wnt/Beta-Catenin Pathway in Model Organisms
This session is from Wnt and Beta-Catenin Signaling
Room: Rio Grande A-B

Speaker 4 of 10
Karl H. Willert, University of California, San Diego, USA
Short Talk: Purification and Biochemical Characterization of a Wnt Protein


Wednesday, March 06 | 8:00AM - 11:30AM
Wnt/Beta-Catenin Pathway in Model Organisms
This session is from Wnt and Beta-Catenin Signaling
Room: Rio Grande A-B

Speaker 5 of 10
Jianbo Wang, University of California, San Diego, USA
Short Talk: The Murine Dishevelled 2 Gene is Essential for Neural Tube Closure


Wednesday, March 06 | 8:00AM - 11:30AM
Wnt/Beta-Catenin Pathway in Model Organisms
This session is from Wnt and Beta-Catenin Signaling
Room: Rio Grande A-B

Speaker 6 of 10
Bruce A. Bowerman, University of Oregon, USA
Using Conditional Mutations and RNA Interference to Identify Genes that Interact with a Non-Canonical Wnt Pathway in the Nematode Caenorhabditis elegans


Wednesday, March 06 | 8:00AM - 11:30AM
Wnt/Beta-Catenin Pathway in Model Organisms
This session is from Wnt and Beta-Catenin Signaling
Room: Rio Grande A-B

Speaker 7 of 10
Mariann Bienz, MRC Laboratory of Molecular Biology, UK
Short Talk: A New Core Component of the Wnt Signaling Pathway


Wednesday, March 06 | 8:00AM - 11:30AM
Wnt/Beta-Catenin Pathway in Model Organisms
This session is from Wnt and Beta-Catenin Signaling
Room: Rio Grande A-B

Speaker 8 of 10
Adrian John Harwood, University College London, UK
Short Talk: A Non-Metazoan GSK-3/beta-Catenin Signaling Pathway


Wednesday, March 06 | 8:00AM - 11:30AM
Wnt/Beta-Catenin Pathway in Model Organisms
This session is from Wnt and Beta-Catenin Signaling
Room: Rio Grande A-B

Speaker 9 of 10
Janet Heasman, Cincinnati Children's Research Foundation, USA
Maternal XTcf3 Prevents the Ectopic Activation of Dorsal Zygotic Genes in the Early Xenopus Embryo


Wednesday, March 06 | 8:00AM - 11:30AM
Wnt/Beta-Catenin Pathway in Model Organisms
This session is from Wnt and Beta-Catenin Signaling
Room: Rio Grande A-B

Speaker 10 of 10
James I. Kim, Takeda, USA
Short Talk: Array Analysis of Gene Expression Profiles During Neural Induction and Organizer Formation in Xenopus.


Wednesday, March 06 | 9:20AM - 9:40AM
Coffee Break
Room: Bataan


Wednesday, March 06 | 11:30AM - 2:00PM
Poster Setup
Room: Bataan


Wednesday, March 06 | 2:00PM - 10:30PM
Poster Viewing
Room: Bataan


Wednesday, March 06 | 2:30PM - 4:30PM
Workshop: Post-Genomic Methods
Room: Rio Grande C-D

Speaker 1 of 5
* Natalie G. Ahn, University of Colorado, USA

Wednesday, March 06 | 2:30PM - 4:30PM
Workshop: Post-Genomic Methods
Room: Rio Grande C-D

Speaker 2 of 5
Mark W. Geraci, University of Colorado, USA
Expression Analysis to Study Disease Pathogenesi

Wednesday, March 06 | 2:30PM - 4:30PM
Workshop: Post-Genomic Methods
Room: Rio Grande C-D

Speaker 3 of 5
Katheryn A. Resing, University of Colorado, USA
Mapping Covalent Modifications on Proteins

Wednesday, March 06 | 2:30PM - 4:30PM
Workshop: Post-Genomic Methods
Room: Rio Grande C-D

Speaker 4 of 5
Huilin Zhou, Institute for Systems Biology, USA
Quantitative Proteomic: New Technologies and Their Applications

Wednesday, March 06 | 2:30PM - 4:30PM
Workshop: Post-Genomic Methods
Room: Rio Grande C-D

Speaker 5 of 5
Michael B. Yaffe, Massachusetts Institute of Technology, USA
Scansite: Motif-Based Profile Scanning

Wednesday, March 06 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Bataan


Wednesday, March 06 | 5:00PM - 7:30PM
Adhesion, Cell Shape and Migration
Room: Rio Grande C-D

Speaker 1 of 5
* David A. Cheresh, University of California, San Diego, USA
Signaling by Angiogenic Growth Factors

Wednesday, March 06 | 5:00PM - 7:30PM
Adhesion, Cell Shape and Migration
Room: Rio Grande C-D

Speaker 2 of 5
Morag Park, McGill University, Canada
Combinatorial Signals Involved in Epithelial Cell Dispersal and Invasion


Wednesday, March 06 | 5:00PM - 7:30PM
Adhesion, Cell Shape and Migration
Room: Rio Grande C-D

Speaker 3 of 5
Michael P. Sheetz, Mechanobiology Institute, National University of Singapore, Singapore
Force Sensing by the Cell Cytoskeleton: Roles of Tyrosine Phosphatases/Kinases

Wednesday, March 06 | 5:00PM - 7:30PM
Adhesion, Cell Shape and Migration
Room: Rio Grande C-D

Speaker 4 of 5
Kozo Kaibuchi, Nagoya University Graduate School of Medicine, Japan
Regulation of Neuronal Morphology by Rho/Rho-Kinase

Wednesday, March 06 | 5:00PM - 7:30PM
Adhesion, Cell Shape and Migration
Room: Rio Grande C-D

Speaker 5 of 5
Audrey G. Minden, Rutgers University, USA
Short Talk: Regulation of Cell Morphology by PAK5, a New Brain Specific Kinase

Wednesday, March 06 | 5:00PM - 7:30PM
Beta-Catenin Signaling and Cancer
This session is from Wnt and Beta-Catenin Signaling
Room: Rio Grande A-B

Speaker 1 of 6
* Paul G. Polakis, Genentech, Inc., USA
The Involvement of Wnt Signaling in Human Cancer


Wednesday, March 06 | 5:00PM - 7:30PM
Beta-Catenin Signaling and Cancer
This session is from Wnt and Beta-Catenin Signaling
Room: Rio Grande A-B

Speaker 2 of 6
Wendy J. Fantl, Chiron Corporation, USA
Short Talk: Beta-Catenin Regulates Vascular Endothelial Growth Factor (VEGF-A) Expression in Colon Cancer


Wednesday, March 06 | 5:00PM - 7:30PM
Beta-Catenin Signaling and Cancer
This session is from Wnt and Beta-Catenin Signaling
Room: Rio Grande A-B

Speaker 3 of 6
Hans C. Clevers, Hubrecht Institute, Netherlands
TCF Factors, Mediators of Wnt Signaling


Wednesday, March 06 | 5:00PM - 7:30PM
Beta-Catenin Signaling and Cancer
This session is from Wnt and Beta-Catenin Signaling
Room: Rio Grande A-B

Speaker 4 of 6
Alicia Collado-Hidalgo, University of California, Los Angeles, USA
Short Talk: Wnt and TGF-beta Cooperation in Mammary Tumor Progression


Wednesday, March 06 | 5:00PM - 7:30PM
Beta-Catenin Signaling and Cancer
This session is from Wnt and Beta-Catenin Signaling
Room: Rio Grande A-B

Speaker 5 of 6
David A. Jones, University of Utah, USA
Microarray Analysis of Colorectal Cancer and Signal Transduction Pathways


Wednesday, March 06 | 5:00PM - 7:30PM
Beta-Catenin Signaling and Cancer
This session is from Wnt and Beta-Catenin Signaling
Room: Rio Grande A-B

Speaker 6 of 6
Joyce A. Schroeder, Mayo Clinic-Scottsdale, USA
Short Talk: ErbB/b-Catenin Complex Formation is Specific to Both Transgenic Mammary Gland Carcinoma and Human Breast Cancer Metastases.


Wednesday, March 06 | 7:30PM - 8:30PM
Welcome Mixer
Room: Bataan


Wednesday, March 06 | 8:30PM - 10:30PM
Poster Session 1
Room: Bataan


Wednesday, March 06 | 8:30PM - 9:30PM
Cash Bar
Room: Bataan


Thursday, March 07 | 7:00AM - 8:00AM
Breakfast
Room: Bataan


Thursday, March 07 | 8:00AM - 11:30AM
Second Messengers. Session Sponsored in part by BD Bioscien
ces Pharmingen

Room: Rio Grande C-D

Speaker 1 of 7
* Susan S. Taylor, University of California, San Diego, USA
Dynamics of PKA

Thursday, March 07 | 8:00AM - 11:30AM
Second Messengers. Session Sponsored in part by BD Bioscien
ces Pharmingen

Room: Rio Grande C-D

Speaker 2 of 7
Franz Hofmann, Technische Universität München, Germany
Signaling Through NO and cGMP-Dependent Protein Kinase

Thursday, March 07 | 8:00AM - 11:30AM
Second Messengers. Session Sponsored in part by BD Bioscien
ces Pharmingen

Room: Rio Grande C-D

Speaker 3 of 7
Dario Alessi, University of Dundee, UK
Signal Transduction Downstream of PI3 Kinase

Thursday, March 07 | 8:00AM - 11:30AM
Second Messengers. Session Sponsored in part by BD Bioscien
ces Pharmingen

Room: Rio Grande C-D

Speaker 4 of 7
Tian Xu, Yale University School of Medicine, USA
Cell Growth, Proliferation, and the Control of Organ Size in Drosophila

Thursday, March 07 | 8:00AM - 11:30AM
Second Messengers. Session Sponsored in part by BD Bioscien
ces Pharmingen

Room: Rio Grande C-D

Speaker 5 of 7
John D. Scott, University of Washington, USA
Molecular Organization of Cytoskeletal Transduction Complexes

Thursday, March 07 | 8:00AM - 11:30AM
Second Messengers. Session Sponsored in part by BD Bioscien
ces Pharmingen

Room: Rio Grande C-D

Speaker 6 of 7
Mark L. Dell'Acqua, University of Colorado, USA
Short Talk: Imaging a Ternary Kinase-AKAP-Phosphatase Signaling Complex in Living Cells Using Fret Microscopy

Thursday, March 07 | 8:00AM - 11:30AM
Second Messengers. Session Sponsored in part by BD Bioscien
ces Pharmingen

Room: Rio Grande C-D

Speaker 7 of 7
Wei-Jen Tang, University of Chicago, USA
Short Talk: Activation of the Anthrax Adenylyl Cyclase Exotoxin by Calmodulin


Thursday, March 07 | 8:00AM - 11:30AM
Beta-Catenin-Independent Wnt and Frizzled Signaling
This session is from Wnt and Beta-Catenin Signaling
Room: Rio Grande A-B

Speaker 1 of 6
* Jeffrey D. Axelrod, Stanford University, USA
Asymmetry and Signal Amplification in Frizzled Mediated Planar Cell Polarity Signaling


Thursday, March 07 | 8:00AM - 11:30AM
Beta-Catenin-Independent Wnt and Frizzled Signaling
This session is from Wnt and Beta-Catenin Signaling
Room: Rio Grande A-B

Speaker 2 of 6
Maiyon Park, University of Washington, USA
Short Talk: The Planar Cell Polarity Gene Strabismus Encodes a Dishevelled-Associated Protein that Regulates Cell Behavior and Cell Fate in Vertebrate Embryos


Thursday, March 07 | 8:00AM - 11:30AM
Beta-Catenin-Independent Wnt and Frizzled Signaling
This session is from Wnt and Beta-Catenin Signaling
Room: Rio Grande A-B

Speaker 3 of 6
Malini Sen, University of California, San Diego, USA
Short Talk: Wnt Signaling in Rheumatoid Arthritis


Thursday, March 07 | 8:00AM - 11:30AM
Beta-Catenin-Independent Wnt and Frizzled Signaling
This session is from Wnt and Beta-Catenin Signaling
Room: Rio Grande A-B

Speaker 4 of 6
Cliff Tabin, Harvard Medical School, USA
Wnt-14 Plays a Pivotal Role in Inducing Synovial Joint Formation in the Developing Appendicular Skeleton


Thursday, March 07 | 8:00AM - 11:30AM
Beta-Catenin-Independent Wnt and Frizzled Signaling
This session is from Wnt and Beta-Catenin Signaling
Room: Rio Grande A-B

Speaker 5 of 6
Shoukat Dedhar, British Columbia Cancer Research Centre, Canada
Short Talk: Molecular Basis for the Regulation of Nuclear Beta-Catenin by the Tumor Suppressor PTEN


Thursday, March 07 | 8:00AM - 11:30AM
Beta-Catenin-Independent Wnt and Frizzled Signaling
This session is from Wnt and Beta-Catenin Signaling
Room: Rio Grande A-B

Speaker 6 of 6
Alan R. Kimmel, National Institutes of Health, USA
Short Talk: The Frizzled-Domain cAMP Receptors Antagonistically Regulate Differential Tyrosine Phosphorylation and Activity of GSK3 to Orchestrate Cell Fate Specification and Cell Migration.


Thursday, March 07 | 9:20AM - 9:40AM
Coffee Break
Room: Bataan


Thursday, March 07 | 11:30AM - 2:00PM
Poster Setup
Room: Rio Grande


Thursday, March 07 | 2:00PM - 10:30PM
Poster Viewing
Room: Rio Grande


Thursday, March 07 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Rio Grande


Thursday, March 07 | 5:00PM - 7:30PM
Integration of Signaling Pathways (Joint)
Room: Bataan

Speaker 1 of 4
* Joan Massagué, Memorial Sloan Kettering Cancer Center, USA
Driving and Integrating TGFbeta Signaling

Thursday, March 07 | 5:00PM - 7:30PM
Integration of Signaling Pathways (Joint)
Room: Bataan

Speaker 2 of 4
Jim Woodgett, Mount Sinai Hospital, Canada
Regulation of Glycogen Synthase Kinase-3 and Protein Kinase B

Thursday, March 07 | 5:00PM - 7:30PM
Integration of Signaling Pathways (Joint)
Room: Bataan

Speaker 3 of 4
Bart De Strooper, University College London, UK
Where Notch and Wnt Signaling Meet: The Presenilin Hub

Thursday, March 07 | 5:00PM - 7:30PM
Integration of Signaling Pathways (Joint)
Room: Bataan

Speaker 4 of 4
Michael P. Snyder, Stanford University School of Medicine, USA
Global Analysis of Yeast Proteins Using Protein Chips

Thursday, March 07 | 7:30PM - 8:30PM
Welcome Mixer
Room: Rio Grande


Thursday, March 07 | 8:30PM - 10:30PM
Poster Session 2
Room: Rio Grande


Thursday, March 07 | 8:30PM - 9:30PM
Cash Bar
Room: Rio Grande


Friday, March 08 | 7:00AM - 8:00AM
Breakfast
Room: Bataan


Friday, March 08 | 8:00AM - 11:30AM
Cell Cycle and Metabolism. Session Sponsored by Wyeth/Genet
ics Institute

Room: Rio Grande C-D

Speaker 1 of 8
* Jeremy Thorner, University of California, Berkeley, USA
Hsl7, a Negative Regulator of the Swe1 Protein Kinase, Shuttles Between the Spindle Pole Body and the Septin Ring in the Budding Yeast Saccharomyces cerevisiae.

Friday, March 08 | 8:00AM - 11:30AM
Cell Cycle and Metabolism. Session Sponsored by Wyeth/Genet
ics Institute

Room: Rio Grande C-D

Speaker 2 of 8
Eisuke Nishida, Kyoto University, Japan
Spatiotemporal Control of M Phase Regulators

Friday, March 08 | 8:00AM - 11:30AM
Cell Cycle and Metabolism. Session Sponsored by Wyeth/Genet
ics Institute

Room: Rio Grande C-D

Speaker 3 of 8
Brenda Joyce Huneycutt, University of Colorado at Boulder, USA
Short Talk: Understanding Mps1p Function Using Chemical Genetics

Friday, March 08 | 8:00AM - 11:30AM
Cell Cycle and Metabolism. Session Sponsored by Wyeth/Genet
ics Institute

Room: Rio Grande C-D

Speaker 4 of 8
Kenji Fukasawa, H Lee Moffitt Cancer Center and Research Institute, USA
Short Talk: Phosphorylation of Nucleophosmin (NPM/B23) by CDK2/Cyclin E and Its Role in Centrosome Duplication


Friday, March 08 | 8:00AM - 11:30AM
Cell Cycle and Metabolism. Session Sponsored by Wyeth/Genet
ics Institute

Room: Rio Grande C-D

Speaker 5 of 8
J. Wade Harper, Harvard Medical School, USA
Phosphorylation-Dependent Ubiquitization via the SCF Ubiquitin Ligase Pathway

Friday, March 08 | 8:00AM - 11:30AM
Cell Cycle and Metabolism. Session Sponsored by Wyeth/Genet
ics Institute

Room: Rio Grande C-D

Speaker 6 of 8
Bei B. Zhang, Pfizer Inc., USA
Discovery of Small Molecule Insulin Mimetic Agents with Anti-Obesity and Insulin Sensitizing Effects

Friday, March 08 | 8:00AM - 11:30AM
Cell Cycle and Metabolism. Session Sponsored by Wyeth/Genet
ics Institute

Room: Rio Grande C-D

Speaker 7 of 8
Rina Plattner, Duke University Medical Center, USA
Short Talk: Novel Link Between the c-Abl Nonreceptor Tyrosine Kinase and Phosphoinositide Signaling via PLC-gamma1

Friday, March 08 | 8:00AM - 11:30AM
Cell Cycle and Metabolism. Session Sponsored by Wyeth/Genet
ics Institute

Room: Rio Grande C-D

Speaker 8 of 8
Jie Chen, University of Illinois, Urbana-Champaign, USA
Short Talk: Regulation of mTOR Signaling by Phosphatidic Acid and Phospholipase D Pathways

Friday, March 08 | 8:00AM - 12:00PM
Beta-Catenin Signaling and Target Genes
This session is from Wnt and Beta-Catenin Signaling
Room: Rio Grande A-B

Speaker 1 of 10
Jeffery R. Barrow, Brigham Young University, USA
The Role of Wnt/beta-Catenin Signaling in the Establishment and Maintenance of the Apical Ectodermal Ridge


Friday, March 08 | 8:00AM - 12:00PM
Beta-Catenin Signaling and Target Genes
This session is from Wnt and Beta-Catenin Signaling
Room: Rio Grande A-B

Speaker 2 of 10
Joerg Huelsken, Ecole Polytechnique Fédérale de Lausanne, Switzerland
Short Talk: Beta-Catenin Controls Stem Cell Differentiation in the Skin


Friday, March 08 | 8:00AM - 12:00PM
Beta-Catenin Signaling and Target Genes
This session is from Wnt and Beta-Catenin Signaling
Room: Rio Grande A-B

Speaker 3 of 10
Marian Waterman, University of California, Irvine, USA
Expression of LEF/TCFs in Colon Cancer


Friday, March 08 | 8:00AM - 12:00PM
Beta-Catenin Signaling and Target Genes
This session is from Wnt and Beta-Catenin Signaling
Room: Rio Grande A-B

Speaker 4 of 10
Michael Kahn, Pacific Northwest Research Foundation, USA
Short Talk: Small Molecule Inhibitors of Tcf-4/Catenin Transcription


Friday, March 08 | 8:00AM - 12:00PM
Beta-Catenin Signaling and Target Genes
This session is from Wnt and Beta-Catenin Signaling
Room: Rio Grande A-B

Speaker 5 of 10
William I. Weis, Stanford University, USA
Biochemical and Structural Analysis of beta-Catenin and its Interactions


Friday, March 08 | 8:00AM - 12:00PM
Beta-Catenin Signaling and Target Genes
This session is from Wnt and Beta-Catenin Signaling
Room: Rio Grande A-B

Speaker 6 of 10
Wenqing Xu, University of Washington, USA
Short Talk: Structural Basis of beta-Catenin/Tcf and beta-Catenin/ICAT Interactions


Friday, March 08 | 8:00AM - 12:00PM
Beta-Catenin Signaling and Target Genes
This session is from Wnt and Beta-Catenin Signaling
Room: Rio Grande A-B

Speaker 7 of 10
* Jacqueline S. Papkoff, JSP3 Consulting, USA
A Genomics Approach for Identification and Validation of Therapeutic Targets in the Beta-Catenin Signal Transduction Pathway


Friday, March 08 | 8:00AM - 12:00PM
Beta-Catenin Signaling and Target Genes
This session is from Wnt and Beta-Catenin Signaling
Room: Rio Grande A-B

Speaker 8 of 10
Marta Ines Gallego, National Institutes of Health, USA
Short Talk: Targeted Expression of HGF in Mouse Mammary Epithelium Induces Squamous Metaplasias and Adenocarcinomas Through the Stabilization of Beta-Catenin.


Friday, March 08 | 8:00AM - 12:00PM
Beta-Catenin Signaling and Target Genes
This session is from Wnt and Beta-Catenin Signaling
Room: Rio Grande A-B

Speaker 9 of 10
Steve W. Wilson, University College London, UK
Wnt Signals Regulate Both Mesodermal Cell Movements and Anterior-Posterior Patterning of the Brain in the Zebrafish Embryo


Friday, March 08 | 8:00AM - 12:00PM
Beta-Catenin Signaling and Target Genes
This session is from Wnt and Beta-Catenin Signaling
Room: Rio Grande A-B

Speaker 10 of 10
Thomas Schwarz-Romond, European Molecular Biology Organization (EMBO), Germany
Short Talk: The Novel Ankyrin Repeat Protein Diversin Acts in the Wnt Signalling Pathway and Controls Embryonic Axis Formation


Friday, March 08 | 9:20AM - 9:40AM
Coffee Break
Room: Bataan


Friday, March 08 | 11:30AM - 2:00PM
Poster Setup
Room: Rio Grande


Friday, March 08 | 2:00PM - 10:30PM
Poster Viewing
Room: Rio Grande


Friday, March 08 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Rio Grande


Friday, March 08 | 5:00PM - 7:30PM
Development (Joint)
Room: Bataan

Speaker 1 of 5
* Elaine V. Fuchs, Rockefeller University, USA
Wnt Signaling in the Skin

Friday, March 08 | 5:00PM - 7:30PM
Development (Joint)
Room: Bataan

Speaker 2 of 5
Eric N. Olson, University of Texas Southwestern Medical Center, USA
Signaling Pathways that Control Muscle Development

Friday, March 08 | 5:00PM - 7:30PM
Development (Joint)
Room: Bataan

Speaker 3 of 5
Rolf Kemler, Max Planck Institute, Germany
Beta-catenin Signaling in Early Mouse Development

Friday, March 08 | 5:00PM - 7:30PM
Development (Joint)
Room: Bataan

Speaker 4 of 5
Marc Vidal, Dana-Farber Cancer Institute, USA
Toward a Proteome Atlas for C. elegans

Friday, March 08 | 5:00PM - 7:30PM
Development (Joint)
Room: Bataan

Speaker 5 of 5
Ilaria Rebay, Whitehead Institute for Biomedical Research, USA
Short Talk: Eyes Absent Mediates Cross-Talk Between a Network of
Retinal Determination Genes and the Receptor Tyrosine Kinase Signaling Pathway


Friday, March 08 | 7:30PM - 8:30PM
Welcome Mixer
Room: Rio Grande


Friday, March 08 | 8:30PM - 10:30PM
Poster Session 3
Room: Rio Grande


Friday, March 08 | 8:30PM - 9:30PM
Cash Bar
Room: Rio Grande


Saturday, March 09 | 7:00AM - 8:00AM
Breakfast
Room: Bataan


Saturday, March 09 | 8:00AM - 11:30AM
Stress and Survival. Session Sponsored by Wyeth/Genetics In
stitute

Room: Rio Grande C-D

Speaker 1 of 7
* Gary L. Johnson, UNC Chapel Hill, USA
Cellular Functions of MEKK

Saturday, March 09 | 8:00AM - 11:30AM
Stress and Survival. Session Sponsored by Wyeth/Genetics In
stitute

Room: Rio Grande C-D

Speaker 2 of 7
Michael Karin, University of California, San Diego, USA
IKK – A Master Regulator of Innate and Adaptive Immune Responses

Saturday, March 09 | 8:00AM - 11:30AM
Stress and Survival. Session Sponsored by Wyeth/Genetics In
stitute

Room: Rio Grande C-D

Speaker 3 of 7
Jiahuai Han, The Scripps Research Institute, USA
MAP Kinase Kinase-Independent Activation of p38alpha Mediated by TAB1-Dependent Autophosphorylation of p38alpha

Saturday, March 09 | 8:00AM - 11:30AM
Stress and Survival. Session Sponsored by Wyeth/Genetics In
stitute

Room: Rio Grande C-D

Speaker 4 of 7
Elizabeth J. Goldsmith, University of Texas Southwestern Medical Center Dallas, USA
MAP Kinase Interactions

Saturday, March 09 | 8:00AM - 11:30AM
Stress and Survival. Session Sponsored by Wyeth/Genetics In
stitute

Room: Rio Grande C-D

Speaker 5 of 7
Roger J. Davis, HHMI/University of Massachusetts Medical School, USA
Signal Transduction by JNK

Saturday, March 09 | 8:00AM - 11:30AM
Stress and Survival. Session Sponsored by Wyeth/Genetics In
stitute

Room: Rio Grande C-D

Speaker 6 of 7
Hideki Nishitoh, University of Tokyo, Japan
Short Talk: The Role of ASK1 in Stress Signaling

Saturday, March 09 | 8:00AM - 11:30AM
Stress and Survival. Session Sponsored by Wyeth/Genetics In
stitute

Room: Rio Grande C-D

Speaker 7 of 7

Short Talk: Small Molecule Inhibitors of JNK Inhibit Tumor Growth

Saturday, March 09 | 8:00AM - 11:45AM
Regulation of Wnt Receptors
This session is from Wnt and Beta-Catenin Signaling
Room: Rio Grande A-B

Speaker 1 of 9
* Scott B. Selleck, University of Arizona, USA
Positive and Negative Regulation of Multiple Growth Factor Signaling Pathways by Cell Surface Proteoglycans


Saturday, March 09 | 8:00AM - 11:45AM
Regulation of Wnt Receptors
This session is from Wnt and Beta-Catenin Signaling
Room: Rio Grande A-B

Speaker 2 of 9
Julie T. Tai, CV Therapeutics, USA
Short Talk: Down Regulation of Frzb1 and the Activation of Wnt/beta-Catenin Signal Transduction Pathway in Rat Balloon Vascular Injury Model


Saturday, March 09 | 8:00AM - 11:45AM
Regulation of Wnt Receptors
This session is from Wnt and Beta-Catenin Signaling
Room: Rio Grande A-B

Speaker 3 of 9
Craig C. Malbon, Stony Brook University, USA
Frizzled Signaling and Heterotrimeric G-Proteins


Saturday, March 09 | 8:00AM - 11:45AM
Regulation of Wnt Receptors
This session is from Wnt and Beta-Catenin Signaling
Room: Rio Grande A-B

Speaker 4 of 9
Jeanine M. D'Armiento, Columbia University, USA
Short Talk: sFRP1 Expression Induces MMP and is Associated with Pulmonary Emphysema


Saturday, March 09 | 8:00AM - 11:45AM
Regulation of Wnt Receptors
This session is from Wnt and Beta-Catenin Signaling
Room: Rio Grande A-B

Speaker 5 of 9
Stuart A. Aaronson, Mount Sinai Medical Center, USA
Dkk-1 and sFRP Wnt Inhibitors


Saturday, March 09 | 8:00AM - 11:45AM
Regulation of Wnt Receptors
This session is from Wnt and Beta-Catenin Signaling
Room: Rio Grande A-B

Speaker 6 of 9
Daniel Pinto, Netherland Institute for Develepmental Biology, Netherlands
Short Talk: Consequences of Targeted Expression of Dkk-1, a Specific Inhibitor of the Wnt/Beta-Catenin Signaling Pathway, in the Intestinal Mucosa of Transgenic Mice


Saturday, March 09 | 8:00AM - 11:45AM
Regulation of Wnt Receptors
This session is from Wnt and Beta-Catenin Signaling
Room: Rio Grande A-B

Speaker 7 of 9
Xi He, Harvard Medical School, USA
Wnt Signaling Pathways in Early Vertebrate Embryogenesis


Saturday, March 09 | 8:00AM - 11:45AM
Regulation of Wnt Receptors
This session is from Wnt and Beta-Catenin Signaling
Room: Rio Grande A-B

Speaker 8 of 9
J. Lawrence Marsh, University of California, Irvine, USA
Short Talk: Cross Regulation of Wnts and BMPs and Implications for Oncogenesis


Saturday, March 09 | 8:00AM - 11:45AM
Regulation of Wnt Receptors
This session is from Wnt and Beta-Catenin Signaling
Room: Rio Grande A-B

Speaker 9 of 9
Junichi Hanai, Beth Israel Deaconess Medical Center, USA
Short Talk: Endostatin Functions by Inhibiting beta-Catenin Signaling.


Saturday, March 09 | 9:20AM - 9:40AM
Coffee Break
Room: Bataan


Saturday, March 09 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Bataan


Saturday, March 09 | 5:00PM - 7:30PM
Issues Arising: Emerging Concepts and Technologies
Room: Rio Grande C-D

Speaker 1 of 7
* Nancy L. Allbritton, University of Washington, USA
Measurement of Enzyme Activation in Single Cells

Saturday, March 09 | 5:00PM - 7:30PM
Issues Arising: Emerging Concepts and Technologies
Room: Rio Grande C-D

Speaker 2 of 7
Jonathan D. Violin, Trevena Inc., USA
Short Talk: Spatiotemporal Imaging of Conformational Changes of Protein Kinase C

Saturday, March 09 | 5:00PM - 7:30PM
Issues Arising: Emerging Concepts and Technologies
Room: Rio Grande C-D

Speaker 3 of 7
Kevan M. Shokat, University of California, San Francisco, USA
Unnatural Ligands for Engineered Receptors: New Tools for Chemical Genetics

Saturday, March 09 | 5:00PM - 7:30PM
Issues Arising: Emerging Concepts and Technologies
Room: Rio Grande C-D

Speaker 4 of 7
Andrew J. Link, Vanderbilt University School of Medicine, USA
Comprehensive Analysis of Protein Complexes Using Mass Spectrometry

Saturday, March 09 | 5:00PM - 7:30PM
Issues Arising: Emerging Concepts and Technologies
Room: Rio Grande C-D

Speaker 5 of 7
Forest M. White, Massachusetts Institute of Technology, USA
Short Talk: Phosphoproteome Analysis by Mass Spectrometry: Application to S. cerevisiae

Saturday, March 09 | 5:00PM - 7:30PM
Issues Arising: Emerging Concepts and Technologies
Room: Rio Grande C-D

Speaker 6 of 7
Peter J. Kennelly, Virginia Polytechnic Institute & State University, USA
Short Talk: A Protein Kinase from the Archaea (Archaebacteria)

Saturday, March 09 | 5:00PM - 7:30PM
Issues Arising: Emerging Concepts and Technologies
Room: Rio Grande C-D

Speaker 7 of 7
Scott D. Seiwert, Alios BioPharma, Inc., USA
Short Talk: Monitoring Protein Phosphorylation with Array-Compatible Reagents

Saturday, March 09 | 5:00PM - 7:30PM
Interactions of Wnt Pathway Components
This session is from Wnt and Beta-Catenin Signaling
Room: Rio Grande A-B

Speaker 1 of 6
* Mark Peifer, University of North Carolina at Chapel Hill, USA
Cell Adhesion and Cytoskeletal Regulation in Embryogenesis and Oncogenesis


Saturday, March 09 | 5:00PM - 7:30PM
Interactions of Wnt Pathway Components
This session is from Wnt and Beta-Catenin Signaling
Room: Rio Grande A-B

Speaker 2 of 6
Ken-Ichi Takemaru, Stony Brook University, USA
Short Talk: Chibby, a Novel beta-Catenin-Associated Antagonist of the Wnt/Wingless Pathway


Saturday, March 09 | 5:00PM - 7:30PM
Interactions of Wnt Pathway Components
This session is from Wnt and Beta-Catenin Signaling
Room: Rio Grande A-B

Speaker 3 of 6
Akira Kikuchi, Hiroshima University, Japan
Regulation of beta-Catenin Signaling by Idax and Axam


Saturday, March 09 | 5:00PM - 7:30PM
Interactions of Wnt Pathway Components
This session is from Wnt and Beta-Catenin Signaling
Room: Rio Grande A-B

Speaker 4 of 6
Yoshimi Endo, NCI, National Institutes of Health, USA
Short Talk: Dickkopf-1 and Dickkopf-2 Inhibit the Wnt-Canonical Pathway in Metanephric Mesenchyme


Saturday, March 09 | 5:00PM - 7:30PM
Interactions of Wnt Pathway Components
This session is from Wnt and Beta-Catenin Signaling
Room: Rio Grande A-B

Speaker 5 of 6
Eric R. Fearon, University of Michigan Medical Center, USA
Role of APC and Catenin Defects in Cancer


Saturday, March 09 | 5:00PM - 7:30PM
Interactions of Wnt Pathway Components
This session is from Wnt and Beta-Catenin Signaling
Room: Rio Grande A-B

Speaker 6 of 6
Juergen Behrens, Nikolaus-Fiebiger Center, Germany
Short Talk: Negative Feedback Loop of Wnt Signaling Through Upregulation of Conductin/Axin2 in Colorectal and Liver Tumors


Saturday, March 09 | 7:30PM - 8:30PM
Welcome Mixer
Room: Bataan


Saturday, March 09 | 8:30PM - 11:30PM
Entertainment
Room: Bataan


Saturday, March 09 | 8:30PM - 11:30PM
Cash Bar
Room: Bataan


Sunday, March 10 | 10:21AM - 10:21AM
Departure


*Session Chair
†Invited, not yet responded.