Web Desc
Molecular Mechanisms of Leukocyte Trafficking
joint with Inflammatory Paradigms and the Vasculature II
Organizer(s): Steven D. Rosen, Geoffrey S. Kansas, Elisabetta Dejana and Samuel C. Silverstein
Date: April 09 - 14, 2002
Location: Sheraton Steamboat Resort, Steamboat Springs, CO, USA
Sponsored by ICOS Corporation and The Director's Sponsor Fund
Summary of Meeting:
The Keystone meeting on ‘Molecular Mechanisms of Leukocyte Trafficking’ will be a comprehensive gathering of the world's foremost scientists working in a cutting-edge basic science area with important ramifications for human disease. This meeting is a reprise of a highly successful joint meeting on 'Molecular Mechanisms of Leukocyte Trafficking' and 'Endothelium,' held in March 1998. The past few years have seen continued advances in the understanding of how leukocytes extravasate and migrate within tissues. There has been further elucidation of the participation of selectins and their ligands; chemokines and their receptors; integrins; and Ig superfamily molecules. A number of novel strategies for anti-inflammatory therapeutics have already emerged from these disciplines and more are likely to follow. The meeting will bring together scientists working in a diverse range of topics in leukocyte and vascular biology. The resulting interactions are likely to stimulate new approaches to the critical remaining problems in trafficking research.
Discounted Abstract Deadline: December 10 2001
Discounted Registration Deadline: February 8 2002
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1 R13 AI51316-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Tuesday, April 09 | 4:00PM - 7:00PM
Registration
Room: Foyer


Tuesday, April 09 | 6:15PM - 7:15PM
Welcome
Room: Foyer


Tuesday, April 09 | 7:15PM - 7:30PM
Orientation
Room: Sunshine


Tuesday, April 09 | 7:30PM - 8:30PM
Keynote Address
Room: Sunshine

Speaker 1 of 1
Eugene C. Butcher, Stanford University, USA
Chemokines and the Systemic Organization of the Immune System

Wednesday, April 10 | 7:00AM - 8:00AM
Breakfast
Room: 3 Saddles/Sevens


Wednesday, April 10 | 8:00AM - 11:00AM
Different Views of Cell-Cell Interactions
Room: Sunshine

Speaker 1 of 4
* Michael L. Dustin, University of Oxford, UK
The Structure of the Immunological Synapse

Wednesday, April 10 | 8:00AM - 11:00AM
Different Views of Cell-Cell Interactions
Room: Sunshine

Speaker 2 of 4
Timothy A. Springer, Immune Disease Institute, Harvard University, USA
Conformational Regulation of Integrin Structure and Function

Wednesday, April 10 | 8:00AM - 11:00AM
Different Views of Cell-Cell Interactions
Room: Sunshine

Speaker 3 of 4
Paul S. Frenette, Albert Einstein College of Medicine, USA
Adhesion Mechanisms of Sickle Cells and Progenitor Cells in the Microvasculature

Wednesday, April 10 | 8:00AM - 11:00AM
Different Views of Cell-Cell Interactions
Room: Sunshine

Speaker 4 of 4
Yvonne Yvonne Jones, University of Oxford, UK
Three-Dimensional Structure of Cell Adhesion Molecules

Wednesday, April 10 | 8:00AM - 11:00AM
Stress Responses and the Vasculature I
This session is from Inflammatory Paradigms and the
Room: Storm Peak

Speaker 1 of 5
* Momtaz K. Wassef, National Institutes of Health, USA


Wednesday, April 10 | 8:00AM - 11:00AM
Stress Responses and the Vasculature I
This session is from Inflammatory Paradigms and the
Room: Storm Peak

Speaker 2 of 5
Tucker Collins, Children's Hospital Boston, USA
Transcriptional Regulation of Vascular Stress Responses


Wednesday, April 10 | 8:00AM - 11:00AM
Stress Responses and the Vasculature I
This session is from Inflammatory Paradigms and the
Room: Storm Peak

Speaker 3 of 5
Judith A. Berliner, University of California, Los Angeles, USA
Novel Lipid Mediators of Atherogenesis


Wednesday, April 10 | 8:00AM - 11:00AM
Stress Responses and the Vasculature I
This session is from Inflammatory Paradigms and the
Room: Storm Peak

Speaker 4 of 5
David M. Stern, Columbia University College of Physicians & Surgeons, USA
Amyloid Angiopathy and the RAGE: Interactions of Amyloid-beta with the Blood Brain Barrier and Neurons


Wednesday, April 10 | 8:00AM - 11:00AM
Stress Responses and the Vasculature I
This session is from Inflammatory Paradigms and the
Room: Storm Peak

Speaker 5 of 5
Richard O. Hynes, Massachusetts Institute of Technology, USA
Roles of Vascular Adhesion Receptors in Tumor Progression


Wednesday, April 10 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Wednesday, April 10 | 11:00AM - 1:00PM
Poster Setup
Room: Twilight/Mt. Werner


Wednesday, April 10 | 1:00PM - 10:00PM
Poster Viewing
Room: Twilight/Mt. Werner


Wednesday, April 10 | 2:30PM - 4:30PM
Workshop 1: Vascular Complications of Diabetes: The Clinical
Perspective
This session is from Inflammatory Paradigms and the
Room: Storm Peak

Speaker 1 of 8
* Steven P. Marso, Mid-America Heart Institute, USA
Type 2 Diabetes Mellitus and Cardiovascular Disease: Framing the Clinical Issues


Wednesday, April 10 | 2:30PM - 4:30PM
Workshop 1: Vascular Complications of Diabetes: The Clinical
Perspective
This session is from Inflammatory Paradigms and the
Room: Storm Peak

Speaker 2 of 8
Charles Kunsch, Abbott Laboratories, USA
Laminar Shear Stress Induction of the Antioxidant Response Element (ARE) in Endothelial Cells: Role of ARE-Mediated Gene Expression in Vascular Protection


Wednesday, April 10 | 2:30PM - 4:30PM
Workshop 1: Vascular Complications of Diabetes: The Clinical
Perspective
This session is from Inflammatory Paradigms and the
Room: Storm Peak

Speaker 3 of 8
Jean B. Regard, Johns Hopkins University, USA
L119: A Novel Endothelial Immediate Early Gene


Wednesday, April 10 | 2:30PM - 4:30PM
Workshop 1: Vascular Complications of Diabetes: The Clinical
Perspective
This session is from Inflammatory Paradigms and the
Room: Storm Peak

Speaker 4 of 8
Justin C. Mason, Imperial College School of Medicine, UK
Complement-Mediated Vascular Endothelial Injury is Inhibited by Statins Through Upregulation of Expression of Complement Inhibitory Proteins


Wednesday, April 10 | 2:30PM - 4:30PM
Workshop 1: Vascular Complications of Diabetes: The Clinical
Perspective
This session is from Inflammatory Paradigms and the
Room: Storm Peak

Speaker 5 of 8
Craig M. Stolen, University of Turku, Finland
Genetic Manipulation of Semicarbazide-Sensitive Amine Oxidation in Mice


Wednesday, April 10 | 2:30PM - 4:30PM
Workshop 1: Vascular Complications of Diabetes: The Clinical
Perspective
This session is from Inflammatory Paradigms and the
Room: Storm Peak

Speaker 6 of 8
Deborah Stroka, University of Bern, Switzerland
HIF-1 Mediated Responses to Hypoxia and Inflammation in the Vasculature


Wednesday, April 10 | 2:30PM - 4:30PM
Workshop 1: Vascular Complications of Diabetes: The Clinical
Perspective
This session is from Inflammatory Paradigms and the
Room: Storm Peak

Speaker 7 of 8
Anna M. Randi, Imperial College London, UK
Anti-Inflammatory Effect of Peroxisome-Proliferator Activated Receptor (PPAR) gamma Agonist GW347845 in TNF-Stimulated HUVECs


Wednesday, April 10 | 2:30PM - 4:30PM
Workshop 1: Vascular Complications of Diabetes: The Clinical
Perspective
This session is from Inflammatory Paradigms and the
Room: Storm Peak

Speaker 8 of 8
Jonathan E. Shelton, University of Alabama at Birmingham, USA
Effects of Lipid Lowering Therapy on the Vascular Response to Injury in a Model of Type 2 Diabetes


Wednesday, April 10 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Foyer


Wednesday, April 10 | 5:00PM - 7:00PM
Selectins and Their Ligands
Room: Sunshine

Speaker 1 of 3
* Rodger P. McEver, Oklahoma Medical Research Foundation, USA
Interactions of Selectins with PSGL-1

Wednesday, April 10 | 5:00PM - 7:00PM
Selectins and Their Ligands
Room: Sunshine

Speaker 2 of 3
Bruce Furie, Beth Israel Deaconess Medical Center, USA
In vivo Real Time Imaging Of Arterial Thrombus Formation Reveals P-Selectin and Psgl-1-Mediated Tissue Factor Accumulation as a Mechanism for Fibrin Clot Generation

Wednesday, April 10 | 5:00PM - 7:00PM
Selectins and Their Ligands
Room: Sunshine

Speaker 3 of 3
Raymond T. Camphausen, Wyeth Pharmaceuticals, USA
Structural Studies of the Interactions of the Selectins with Their Physiological Ligands

Wednesday, April 10 | 5:00PM - 7:00PM
Angiotensin
This session is from Inflammatory Paradigms and the
Room: Storm Peak

Speaker 1 of 3
* R. Wayne Alexander, Emory University Hospital, USA
Renin Angiotensin System and Vascular Disease


Wednesday, April 10 | 5:00PM - 7:00PM
Angiotensin
This session is from Inflammatory Paradigms and the
Room: Storm Peak

Speaker 2 of 3
Bradford C. Berk, University of Rochester Medical Center, USA
Angiotensin II, Oxidative Stress and Signal Transduction Events: Role of PDE1A1


Wednesday, April 10 | 5:00PM - 7:00PM
Angiotensin
This session is from Inflammatory Paradigms and the
Room: Storm Peak

Speaker 3 of 3
W. Robert Taylor, Emory University School of Medicine, USA
Atherosclerosis and Angiotensin II


Wednesday, April 10 | 7:00PM - 8:00PM
Welcome Mixer
Room: Foyer


Wednesday, April 10 | 7:00PM - 9:00PM
Cash Bar
Room: Foyer


Wednesday, April 10 | 8:00PM - 10:00PM
Poster Session 1
Room: Twilight/Mt. Werner


Thursday, April 11 | 7:00AM - 8:00AM
Breakfast
Room: 3 Saddles/Sevens


Thursday, April 11 | 8:00AM - 11:00AM
Molecular Glycobiology of Selectin Ligands
Room: Sunshine

Speaker 1 of 4
* Steven D. Rosen, University of California, San Francisco, USA
Sulfotransferases and L-Selectin Ligands

Thursday, April 11 | 8:00AM - 11:00AM
Molecular Glycobiology of Selectin Ligands
Room: Sunshine

Speaker 2 of 4
John B. Lowe, Genentech, Inc., USA
Glycan Fucosylation in Leukocyte Biology

Thursday, April 11 | 8:00AM - 11:00AM
Molecular Glycobiology of Selectin Ligands
Room: Sunshine

Speaker 3 of 4
Jamey D. Marth, Sanford-Burnham Medical Research Institute, USA
Biology of Sialyltransferases in Leukocyte Traffic, Immunity, Apoptosis and Hemostasis

Thursday, April 11 | 8:00AM - 11:00AM
Molecular Glycobiology of Selectin Ligands
Room: Sunshine

Speaker 4 of 4
Minoru Fukuda, Sanford-Burnham Medical Research Institute, USA
Structural Diversity of Oligosaccharides that Provides Functional Diversity

Thursday, April 11 | 8:00AM - 11:00AM
Chemokines and Receptors
This session is from Inflammatory Paradigms and the
Room: Storm Peak

Speaker 1 of 4
Christian W. Schindler, Columbia University, USA
IL-6 in a Murine Model of Atherosclerosis


Thursday, April 11 | 8:00AM - 11:00AM
Chemokines and Receptors
This session is from Inflammatory Paradigms and the
Room: Storm Peak

Speaker 2 of 4
Michael Farzan, The Scripps Research Institute, USA
Chemokine Receptors for HIV-1 and P. Vivax Malaria


Thursday, April 11 | 8:00AM - 11:00AM
Chemokines and Receptors
This session is from Inflammatory Paradigms and the
Room: Storm Peak

Speaker 3 of 4
* Israel F. Charo, ChemoCentryx, Inc., USA
Chemokine Control of Trafficking in Atherosclerosis


Thursday, April 11 | 8:00AM - 11:00AM
Chemokines and Receptors
This session is from Inflammatory Paradigms and the
Room: Storm Peak

Speaker 4 of 4
Mark B. Taubman, Mount Sinai School of Medicine, USA
Chemokine Receptors as Activators of Vascular Smooth Muscle


Thursday, April 11 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Thursday, April 11 | 11:00AM - 1:00PM
Poster Setup
Room: Twilight/Mt. Werner


Thursday, April 11 | 1:00PM - 10:00PM
Poster Viewing
Room: Twilight/Mt. Werner


Thursday, April 11 | 2:30PM - 4:30PM
Workshop 2: Chemokines, Leukocyte-Endothelial Interactions a
nd Atherosclerosis
This session is from Inflammatory Paradigms and the
Room: Storm Peak

Speaker 1 of 6
* Martha K. Cathcart, Cleveland Clinic Foundation, USA
Lipid Regulation of Monocyte Chemotaxis to MCP1


Thursday, April 11 | 2:30PM - 4:30PM
Workshop 2: Chemokines, Leukocyte-Endothelial Interactions a
nd Atherosclerosis
This session is from Inflammatory Paradigms and the
Room: Storm Peak

Speaker 2 of 6
Ronen Alon, Weizmann Institute of Science, Israel
The CD81 Tetraspanin Upregulates Leukocyte Integrin Clustering at Subsecond Contacts and Promotes Chemokine-Triggered Adhesion Under Shear Flow


Thursday, April 11 | 2:30PM - 4:30PM
Workshop 2: Chemokines, Leukocyte-Endothelial Interactions a
nd Atherosclerosis
This session is from Inflammatory Paradigms and the
Room: Storm Peak

Speaker 3 of 6
Marschall S. Runge, University of North Carolina at Chapel Hill, USA
Oxidative Signals in Atherosclerosis


Thursday, April 11 | 2:30PM - 4:30PM
Workshop 2: Chemokines, Leukocyte-Endothelial Interactions a
nd Atherosclerosis
This session is from Inflammatory Paradigms and the
Room: Storm Peak

Speaker 4 of 6
Peter Gough, GlaxoSmithKline, USA
Macrophage-Specific Retroviral Expression Vectors as Tools for Studying Macrophage Function in vivo.


Thursday, April 11 | 2:30PM - 4:30PM
Workshop 2: Chemokines, Leukocyte-Endothelial Interactions a
nd Atherosclerosis
This session is from Inflammatory Paradigms and the
Room: Storm Peak

Speaker 5 of 6
Guy Chisolm, Cleveland Clinic Foundation, USA
Regulation of Tissue Factor in Vascular Smooth Muscle Cells: Role of Lipoprotein-Borne Bioactive Phospholipids


Thursday, April 11 | 2:30PM - 4:30PM
Workshop 2: Chemokines, Leukocyte-Endothelial Interactions a
nd Atherosclerosis
This session is from Inflammatory Paradigms and the
Room: Storm Peak

Speaker 6 of 6
Min Peter Kim, National Institutes of Health, USA
Angiotensin II Increases Matrix Metalloproteinase -1 and -9 by Monocytes Stimulated with TNF-alpha and GM-CSF


Thursday, April 11 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Foyer


Thursday, April 11 | 5:00PM - 7:00PM
Selectins and Their Ligands II
Room: Sunshine

Speaker 1 of 3
* Geoffrey S. Kansas, Northwestern University Medical School, USA
Control of Selectin Ligand Biosynthesis in Th1 Cells

Thursday, April 11 | 5:00PM - 7:00PM
Selectins and Their Ligands II
Room: Sunshine

Speaker 2 of 3
Thomas F. Tedder, Duke University Medical Center, USA
L-Selectin Endoproteolytic Release: Dogma, Data and Reality

Thursday, April 11 | 5:00PM - 7:00PM
Selectins and Their Ligands II
Room: Sunshine

Speaker 3 of 3
Denisa D. Wagner, Harvard Medical School, USA
Selectins and Other Leukocyte Adhesion Receptors

Thursday, April 11 | 5:00PM - 7:00PM
Candidate Genes in the Regulation of Chronic Vasculopathies
This session is from Inflammatory Paradigms and the
Room: Storm Peak

Speaker 1 of 4
* David M. Stern, Columbia University College of Physicians & Surgeons, USA


Thursday, April 11 | 5:00PM - 7:00PM
Candidate Genes in the Regulation of Chronic Vasculopathies
This session is from Inflammatory Paradigms and the
Room: Storm Peak

Speaker 2 of 4
Jerry L. Nadler, Eastern Virginia Medical School, USA
12-Lipoxygenase, Atherosclerosis and Restenosis


Thursday, April 11 | 5:00PM - 7:00PM
Candidate Genes in the Regulation of Chronic Vasculopathies
This session is from Inflammatory Paradigms and the
Room: Storm Peak

Speaker 3 of 4
Margarete Mehrabian, University of California, Los Angeles, USA
The Role of 5-Lipoxygenase and Atherosclerosis


Thursday, April 11 | 5:00PM - 7:00PM
Candidate Genes in the Regulation of Chronic Vasculopathies
This session is from Inflammatory Paradigms and the
Room: Storm Peak

Speaker 4 of 4
Ann Marie Schmidt, New York University Langone Medical Center, USA
RAGE: Insights into Proinflammatory Mechanisms in Diabetes and Immune/Inflammatory Disorders


Thursday, April 11 | 7:00PM - 8:00PM
Welcome Mixer
Room: Foyer


Thursday, April 11 | 7:00PM - 9:00PM
Cash Bar
Room: Foyer


Thursday, April 11 | 8:00PM - 10:00PM
Poster Session 2
Room: Twilight/Mt. Werner


Friday, April 12 | 7:00AM - 8:00AM
Breakfast
Room: 3 Saddles/Sevens


Friday, April 12 | 8:00AM - 11:00AM
Chemokines, Cytokines and Immune Responses
Room: Sunshine

Speaker 1 of 4
* Jason G. Cyster, HHMI/University of California, San Francisco, USA
Role of Homeostatic Chemokines in Immunity

Friday, April 12 | 8:00AM - 11:00AM
Chemokines, Cytokines and Immune Responses
Room: Sunshine

Speaker 2 of 4
Michael D. Gunn, Duke University Medical Center, USA
Chemokines, Dendritic Cell Migration, and the Regulation of Immune Response

Friday, April 12 | 8:00AM - 11:00AM
Chemokines, Cytokines and Immune Responses
Room: Sunshine

Speaker 3 of 4
Martin Lipp, Max-Delbrueck-Center, MDC, Germany
Systemic Regulatory Immune Functions of Homeostatic Chemokine Receptors

Friday, April 12 | 8:00AM - 11:00AM
Chemokines, Cytokines and Immune Responses
Room: Sunshine

Speaker 4 of 4
Nancy H. Ruddle, Yale University School of Medicine, USA
Lymphoid Organ Neogenesis and Leukocyte Trafficking

Friday, April 12 | 8:00AM - 11:00AM
Leukocyte-Vessel Wall Interactions: What's New?
This session is from Inflammatory Paradigms and the
Room: Storm Peak

Speaker 1 of 5
* John M. Harlan, Harbor View Medical Center, USA


Friday, April 12 | 8:00AM - 11:00AM
Leukocyte-Vessel Wall Interactions: What's New?
This session is from Inflammatory Paradigms and the
Room: Storm Peak

Speaker 2 of 5
Victor Kotelianski, Promedior, USA
Atherosclerotic Plaque Plasticity: Importance of alpha1beta1 Integrin and TGF-beta


Friday, April 12 | 8:00AM - 11:00AM
Leukocyte-Vessel Wall Interactions: What's New?
This session is from Inflammatory Paradigms and the
Room: Storm Peak

Speaker 3 of 5
Donald E. Staunton, ICOS Corporation, USA
Regulation of Leukocyte Integrin Affinity and Function at the IDAS


Friday, April 12 | 8:00AM - 11:00AM
Leukocyte-Vessel Wall Interactions: What's New?
This session is from Inflammatory Paradigms and the
Room: Storm Peak

Speaker 4 of 5
Claire M. Doerschuk, Case Western Reserve University, USA
Neutrophil-Endothelial Cell Adhesion and Signaling


Friday, April 12 | 8:00AM - 11:00AM
Leukocyte-Vessel Wall Interactions: What's New?
This session is from Inflammatory Paradigms and the
Room: Storm Peak

Speaker 5 of 5
Antonin de Fougerolles, Ablynx NV, Belgium
Role of Collagen-Binding Integrin alpha1beta1 in Leukocyte Trafficking


Friday, April 12 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Friday, April 12 | 11:00AM - 1:00PM
Poster Setup
Room: Twilight/Mt. Werner


Friday, April 12 | 1:00PM - 10:00PM
Poster Viewing
Room: Twilight/Mt.Werner


Friday, April 12 | 2:30PM - 4:30PM
Workshop 3: Vascular Smooth Muscle Cell Biology and Restenos
is
This session is from Inflammatory Paradigms and the
Room: Storm Peak

Speaker 1 of 7
* Gary H. Gibbons, NHLBI, National Institutes of Health, USA
Preventing Restenosis: Translating Mechanistic Insights into Novel Therapeutics


Friday, April 12 | 2:30PM - 4:30PM
Workshop 3: Vascular Smooth Muscle Cell Biology and Restenos
is
This session is from Inflammatory Paradigms and the
Room: Storm Peak

Speaker 2 of 7
John F. Schmedtje, Coeurative, Inc., USA
Cardiovascular Cyclooxygenase-2 in Hypoxia


Friday, April 12 | 2:30PM - 4:30PM
Workshop 3: Vascular Smooth Muscle Cell Biology and Restenos
is
This session is from Inflammatory Paradigms and the
Room: Storm Peak

Speaker 3 of 7
Uwe Schonbeck, Brigham and Women's Hospital, USA
CD40 Signaling and Atherosclerosis


Friday, April 12 | 2:30PM - 4:30PM
Workshop 3: Vascular Smooth Muscle Cell Biology and Restenos
is
This session is from Inflammatory Paradigms and the
Room: Storm Peak

Speaker 4 of 7
Mario B. Marrero, Georgia Regents University, USA
S100B Augments the Angiotensin II-Induced Activation of JAK2 in Vascular Smooth Muscle Cells Via Activation Of PLD2.


Friday, April 12 | 2:30PM - 4:30PM
Workshop 3: Vascular Smooth Muscle Cell Biology and Restenos
is
This session is from Inflammatory Paradigms and the
Room: Storm Peak

Speaker 5 of 7
Wang Min, University of Rochester, USA
Role of ASK1 in Endothelial Cell Function


Friday, April 12 | 2:30PM - 4:30PM
Workshop 3: Vascular Smooth Muscle Cell Biology and Restenos
is
This session is from Inflammatory Paradigms and the
Room: Storm Peak

Speaker 6 of 7
Dominique P.V. de Kleijn, University Medical Center Utrecht, Netherlands
Activation of Toll-Like Receptor 4 in Adventitial Cells Induces Neointima Formation; The Adventitial Fibroblast as Local Immunoregulatory Cell


Friday, April 12 | 2:30PM - 4:30PM
Workshop 3: Vascular Smooth Muscle Cell Biology and Restenos
is
This session is from Inflammatory Paradigms and the
Room: Storm Peak

Speaker 7 of 7
Russell M. Medford, AtheroGenics, Inc., USA
Inflammatory Mediators in Restenosis: New Therapeutic Strategies


Friday, April 12 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Foyer


Friday, April 12 | 5:00PM - 7:00PM
In vivo Analysis of Leukocyte-Endothelial Interactions
Room: Sunshine

Speaker 1 of 3
* Ulrich H. Von Andrian, Harvard Medical School, USA
Homing And Cellular Traffic In Lymphoid Tissues

Friday, April 12 | 5:00PM - 7:00PM
In vivo Analysis of Leukocyte-Endothelial Interactions
Room: Sunshine

Speaker 2 of 3
Klaus Ley, La Jolla Institute for Allergy and Immunology, USA
Integration of Signals from G-Protein Coupled Receptors, Selectin and Integrin Engagement by Rolling Neutrophils

Friday, April 12 | 5:00PM - 7:00PM
In vivo Analysis of Leukocyte-Endothelial Interactions
Room: Sunshine

Speaker 3 of 3
Paul Kubes, University of Calgary, Canada
Complexities of the Leukocyte Recruitment Cascade In Vivo

Friday, April 12 | 5:00PM - 7:00PM
Nitric Oxide-Vessel Wall Interactions
This session is from Inflammatory Paradigms and the
Room: Storm Peak

Speaker 1 of 3
Eric J. Smart, University of Kentucky, USA
High-Density Lipoprotein Binding to Scavenger Receptor Class B, Type I Activates Endothelial Nitric Oxide Synthase in a Ceramide-Dependent Manner


Friday, April 12 | 5:00PM - 7:00PM
Nitric Oxide-Vessel Wall Interactions
This session is from Inflammatory Paradigms and the
Room: Storm Peak

Speaker 2 of 3
* Joseph Loscalzo, Brigham and Women's Hospital, Harvard Medical School, USA
Thiol and S-Nitrosothiol Homeostasis in Vasculature


Friday, April 12 | 5:00PM - 7:00PM
Nitric Oxide-Vessel Wall Interactions
This session is from Inflammatory Paradigms and the
Room: Storm Peak

Speaker 3 of 3
Timothy R. Billiar, University of Pittsburgh Medical Center Presbyterian Hospital, USA
iNOS Regulation of the Vascular Injury Response


Friday, April 12 | 7:00PM - 8:00PM
Welcome Mixer
Room: Foyer


Friday, April 12 | 7:00PM - 9:00PM
Cash Bar
Room: Foyer


Friday, April 12 | 8:00PM - 10:00PM
Poster Session 3
Room: Twilight/Mt. Werner


Saturday, April 13 | 7:00AM - 8:00AM
Breakfast
Room: 3 Saddles/Sevens


Saturday, April 13 | 8:00AM - 11:00AM
Mechanisms of Transendothelial Migration
Room: Sunshine

Speaker 1 of 4
* Sonia A. Cunningham, Texas Biotechnology Corporation, USA
JAM2 Interactions with Integrin

Saturday, April 13 | 8:00AM - 11:00AM
Mechanisms of Transendothelial Migration
Room: Sunshine

Speaker 2 of 4
Beat A. Imhof, Centre Médical Universitaire, Switzerland
Facilitation of Leukocyte Transmigration by JAM-2


Saturday, April 13 | 8:00AM - 11:00AM
Mechanisms of Transendothelial Migration
Room: Sunshine

Speaker 3 of 4
Samuel C. Silverstein, Columbia University College of Physicians & Surgeons, USA
How Many Neutrophils are Enough? A Biophysical Explanation for the Association Between Neutropenia and Bacterial Infection

Saturday, April 13 | 8:00AM - 11:00AM
Mechanisms of Transendothelial Migration
Room: Sunshine

Speaker 4 of 4
Anne J. Ridley, King's College London, UK
Rho GTPase Signaling in Endothelial Cells

Saturday, April 13 | 8:00AM - 11:00AM
Immunologic Injury
This session is from Inflammatory Paradigms and the
Room: Storm Peak

Speaker 1 of 4
* Jeffrey L. Platt, University of Michigan, USA
Complement Mediated Blood Vessel Injury


Saturday, April 13 | 8:00AM - 11:00AM
Immunologic Injury
This session is from Inflammatory Paradigms and the
Room: Storm Peak

Speaker 2 of 4
Jordan S. Pober, Yale University School of Medicine, USA
T Lymphocyte-Mediated Blood Vessel Injury


Saturday, April 13 | 8:00AM - 11:00AM
Immunologic Injury
This session is from Inflammatory Paradigms and the
Room: Storm Peak

Speaker 3 of 4
Wayne W. Hancock, Children's Hospital of Philadelphia, USA
The Role of Antibody in Accelerated Arteriosclerosis


Saturday, April 13 | 8:00AM - 11:00AM
Immunologic Injury
This session is from Inflammatory Paradigms and the
Room: Storm Peak

Speaker 4 of 4
Thomas M. Coffman, NUS Duke Singapore, Singapore
Pro-Inflammatory Actions of Angiotensin II in Vascular Disease


Saturday, April 13 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Saturday, April 13 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Foyer


Saturday, April 13 | 5:00PM - 7:00PM
Novel Models of Leukocyte Trafficking
Room: Sunshine/Mt. Werner

Speaker 1 of 3
* Paul R. Crocker, University of Dundee, UK
Siglecs in Adhesion and Signaling

Saturday, April 13 | 5:00PM - 7:00PM
Novel Models of Leukocyte Trafficking
Room: Sunshine/Mt. Werner

Speaker 2 of 3
Mark H. Siegelman, University of Texas Southwestern Medical Center, USA
Defining a New Activation Marker for T Cells on the Path to Extravasation: Hyaluronan Interactions with Activated CD44

Saturday, April 13 | 5:00PM - 7:00PM
Novel Models of Leukocyte Trafficking
Room: Sunshine/Mt. Werner

Speaker 3 of 3
Masayuki Miyasaka, Osaka University, Japan
Genetic Profiling of High Endothelial Venule Cells – Search for Novel HEV Molecules Involved in Lymphocyte Homing

Saturday, April 13 | 7:00PM - 8:00PM
Welcome Mixer
Room: Foyer


Saturday, April 13 | 7:00PM - 11:00PM
Cash Bar
Room: Foyer


Saturday, April 13 | 8:00PM - 11:00PM
Entertainment
Room: Storm Peak


Sunday, April 14 | 10:26AM - 10:26AM
Departure


*Session Chair.